Principles of Tissue Engineering

2nd Edition

Print ISBN: 9780124366305
eBook ISBN: 9780080539676
Imprint: Academic Press
Published Date: 4th May 2000
Page Count: 995
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The opportunity that tissue engineering provides for medicine is extraordinary. In the United States alone, over half-a-trillion dollars are spent each year to care for patients who suffer from tissue loss or dysfunction. Although numerous books and reviews have been written on tissue engineering, none has been as comprehensive in its defining of the field. Principles of Tissue Engineering combines in one volume the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation of applications of tissue engineering to diseases affecting specific organ systems. The first edition of the book, published in 1997, is the definite reference in the field. Since that time, however, the discipline has grown tremendously, and few experts would have been able to predict the explosion in our knowledge of gene expression, cell growth and differentiation, the variety of stem cells, new polymers and materials that are now available, or even the successful introduction of the first tissue-engineered products into the marketplace. There was a need for a new edition, and this need has been met with a product that defines and captures the sense of excitement, understanding and anticipation that has followed from the evolution of this fascinating and important field.

Key Features

@introbul:Key Features @bul:* Provides vast, detailed analysis of research on all of the major systems of the human body, e.g., skin, muscle, cardiovascular, hematopoietic, and nerves

  • Essential to anyone working in the field
  • Educates and directs both the novice and advanced researcher
  • Provides vast, detailed analysis of research with all of the major systems of the human body, e.g. skin, muscle, cardiovascular, hematopoietic, and nerves
  • Has new chapters written by leaders in the latest areas of research, such as fetal tissue engineering and the universal cell
  • Considered the definitive reference in the field
  • List of contributors reads like a "who's who" of tissue engineering, and includes Robert Langer, Joseph Vacanti, Charles Vacanti, Robert Nerem, A. Hari Reddi, Gail Naughton, George Whitesides, Doug Lauffenburger, and Eugene Bell, among others


Students, research scientists, and physicians with an interest in tissue engineering.

Table of Contents

Contributors. Foreword by C.A. Vacanti. Preface to the Second Edition. Preface to the First Edition. Tissue Engineering in Perspective, E. Bell.

Introduction to Tissue Engineering: The History and Scope of Tissue Engineering, J.P. Vavanti and C.A. Vacanti. The Challenge of Imitating Nature, R.M. Nerem.

Part I: The Basis of Growth and Differentiation: Organization of Cells into Higher Ordered Structures, C.A. Erickson. Dynamics of Cell-ECM Interactions, M.Martins-Green. Matrix Molecules and Their Ligands, B.R. Olsen. Inductive Phenomena, M. Hebrok and D. A. Melton. Morphogenesis and Tissue Engineering, A.H. Reddi. Cell Determination and Differentiation, L.W. Browder.

Part II: In Vitro Control of Tissue Development: Mechanical and Chemical Determinants of Tissue Development, D.E. Inger. Animal Cell Culture, G.H. Sato and D.W. Barnes. Regulation of Cell Behavior by Matricellular Proteins, A.D. Bradshaw and E.H. Sage. Growth Factors, T.F. Deuel and N. Zhang. Tissue Engineering Bioreactors, L.E. Freed and G. Vunjak-Novakovic. Tissue Assembly in Microgravity, B.R. Unsworth and P.I. Lelkes.

Part III: In Vivo Synthesis of Tissues and Organs:

In Vivo Synthesis of Tissues and Organs, L.V. Yannas.

Part IV: Models for Tissue Engineering: Organotypic and Histiotypic Models of Engineered Tissues, E. Bell. Quantitative Aspects of Tissue Engineering: Basic Issues in Kinetics, Trans


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© Academic Press 2000
Academic Press
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"It is comprehensive and up to date...the whole project represents a remarkable effort, coping as it does with an explosion of knowledge in this area. ...there are quite a number of reviews of this field, or parts of it, but relatively few text books, and certainly none as comprehensive as this. ...This is a timely book and truly reflects the enormous effort that is being put into tissue engineering at the present time. Highly recommended." @source:--E.J. Wood in RETINOIDS (2001)