Principles of Tissue Engineering - 3rd Edition - ISBN: 9780123706157, 9780080548845

Principles of Tissue Engineering

3rd Edition

Editors: Robert Lanza Robert Langer Joseph Vacanti
eBook ISBN: 9780080548845
Hardcover ISBN: 9780123706157
Imprint: Academic Press
Published Date: 22nd August 2007
Page Count: 1344
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First published in 1997, Principles of Tissue Engineering is the widely recognized definitive resource in the field. The third edition provides a much needed update of the rapid progress that has been achieved in the field, combining the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation by the world’s experts of what is currently known about each specific organ system. This edition includes greatly expanded focus on stem cells, including adult and embryonic stem cells and progenitor populations that may soon lead to new tissue engineering therapies for heart disease, diabetes, and a wide variety of other diseases that afflict humanity. This up-to-date coverage of stem cell biology and other emerging technologies is complemented by a series of new chapters on recent clinical experience in applying tissue engineering. The result is a comprehensive textbook that we believe will be useful to students and experts alike.

Key Features

New to this edition: Includes new chapters on biomaterial-protein interactions, nanocomposite and three-dimensional scaffolds, skin substitutes, spinal cord, vision enhancement, and heart valves Expanded coverage of adult and embryonic stem cells of the cardiovascular, hematopoietic, musculoskeletal, nervous, and other organ systems


Basic and clinical researchers in fields such as biology, chemistry, materials science, and engineering with an interest in tissue engineering.

Table of Contents

INTRODUCTION TO TISSUE ENGINEERING<BR id=""CRLF""><BR id=""CRLF"">1. The History and Scope of Tissue Engineering<BR id=""CRLF"">Joseph P. Vacanti and Charles A. Vacanti <BR id=""CRLF""><BR id=""CRLF"">2. The Challenge of Imitating Nature<BR id=""CRLF"">Robert M. Nerem <BR id=""CRLF""><BR id=""CRLF"">3. Moving into the Clinic <BR id=""CRLF"">Alan J. Russell and Timothy Bertram<BR id=""CRLF""><BR id=""CRLF"">4. Future Perspectives<BR id=""CRLF"">Mark E. Furth and Anthony Atala<BR id=""CRLF""><BR id=""CRLF"">PART ONE: THE BASIS OF GROWTH AND DIFFERENTIATION<BR id=""CRLF""><BR id=""CRLF"">5. Molecular Biology of the Cell<BR id=""CRLF"">Jonathan Slack <BR id=""CRLF""><BR id=""CRLF"">6. Organization of Cells into Higher-Ordered Structures <BR id=""CRLF"">Jon D. Ahlstrom and Carol A. Erickson<BR id=""CRLF""><BR id=""CRLF"">7. Dynamics of Cell-ECM Interactions<BR id=""CRLF"">M. Petreaca and Manuela Martins-Green<BR id=""CRLF""><BR id=""CRLF"">8. Matrix Molecules and Their Ligands<BR id=""CRLF"">Bjorn Reino Olsen <BR id=""CRLF""><BR id=""CRLF"">9. Morphogenesis and Tissue Engineering<BR id=""CRLF"">A.H. Reddi <BR id=""CRLF""><BR id=""CRLF"">10. Gene Expression, Cell Determination and Differentiation<BR id=""CRLF"">William Nikovits, Jr. and Frank E. Stockdale<BR id=""CRLF""><BR id=""CRLF"">PART TWO: IN VITRO CONTROL OF TISSUE DEVELOPMENT <BR id=""CRLF""><BR id=""CRLF"">11. Engineering Functional Tissues<BR id=""CRLF"">Lisa E. Freed and Farshid Guilak <BR id=""CRLF""><BR id=""CRLF"">12. Principles of Tissue Culture and Bioreactor Design<BR id=""CRLF"">R.I. Freshney, B. Obradovic, W. Grayson, C. Cannizzaro and Gordana Vunjak-Novakovic<BR id=""CRLF""><BR id=""CRLF"">13. Regulation of Cell Behavior by Extracellular Proteins<BR id=""CRLF"">Amy Bradshaw and E. Helene Sage<BR id=""CRLF""><BR id=""CRLF"">14. Growth Factors <BR id=""CRLF"">Thomas F. Deuel and Yunchao Chang<BR id=""CRLF""><BR id=""CRLF"">15. Mechanochemical Control of Cell Fate Switching<BR id=""CRLF"">Donald E. Ingber <BR id=""CRLF""><BR id=""CRLF"">PART THREE: IN VIVO SYNTHESIS OF TISSUES AND ORGANS<BR id=""CRLF""><BR id=""CRLF"">16. In Vivo Synthesis of Tissues and Organs<BR id=""CRLF"">Brendan A. Harley and Ioannis V. Yannas<BR id=""CRLF""><BR id=""CRLF""><BR id=""CRLF"">PART FOUR: MODELS FOR TISSUE ENGINEERING<BR id=""CRLF""><BR id=""CRLF"">17. Models as Precursors for Prosthetic Devices<BR id=""CRLF"">Eugene Bell <BR id=""CRLF""><BR id=""CRLF"">18. Quantitative Aspects<BR id=""CRLF"">Alan J. Grodzinsky, Roger D. Kamm, and Douglas A. Lauffenburger<BR id=""CRLF""><BR id=""CRLF"">PART FIVE: BIOMATERIALS IN TISSUE ENGINEERING<BR id=""CRLF""><BR id=""CRLF"">19. Micro-Scale Patterning of Cells and Their Environment <BR id=""CRLF"">Xingyu Jiang, Shuichi Takayama, Robert G. Chapman, Ravi S. Kane and George M. Whitesides<BR id=""CRLF""><BR id=""CRLF"">20. Cell Interactions with Polymers<BR id=""CRLF"">W. Mark Saltzman and Themis R. Kyriakides<BR id=""CRLF""><BR id=""CRLF"">21. Matrix Effects<BR id=""CRLF"">Jeffrey A. Hubbell <BR id=""CRLF""><BR id=""CRLF"">22. Polymer Scaffold Fabrication <BR id=""CRLF"">Matthew B. Murphy and Antonios G. Mikos<BR id=""CRLF""><BR id=""CRLF"">23. Biodegradable Polymers <BR id=""CRLF"">James M. Pachence, Michael P. Bohrer and Joachim Kohn<BR id=""CRLF""><BR id=""CRLF"">24. Micro- and Nanofabricated Scaffolds<BR id=""CRLF"">Christopher J. Bettinger, Jeffrey T. Borenstein and Robert Langer <BR id=""CRLF""><BR id=""CRLF"">25. Three-Dimensional Scaffolds<BR id=""CRLF"">Ying Luo, George Engelmayr, Debra T. Auguste, Lino da Silva Ferreira, Jeffrey M. Karp, Rajiv Saigal and Robert Langer<BR id=""CRLF""><BR id=""CRLF""><BR id=""CRLF"">PART SIX: TRANSPLANTATION OF ENGINEERED CELLS AND TISSUES<BR id=""CRLF""><BR id=""CRLF"">26. Tissue Engineering and Transplantation in the Fetus<BR id=""CRLF"">Dario O. Fauza <BR id=""CRLF""><BR id=""CRLF"">27. Immunomodulation <BR id=""CRLF"">Denise L. Faustman <BR id=""CRLF""><BR id=""CRLF"">28. Immunoisolation<BR id=""CRLF"">Beth A. Zielinski and Michael J. Lysaght <BR id=""CRLF""><BR id=""CRLF"">29. Engineering Challenges in Immunobarrier Device Development<BR id=""CRLF"">Amy S. Lewis and Clark K. Colton<BR id=""CRLF""><BR id=""CRLF""><BR id=""CRLF"">PART SEVEN: STEM CELLS <BR id=""CRLF""><BR id=""CRLF"">30. Embryonic Stem Cells<BR id=""CRLF"">Alan Trounson<BR id=""CRLF""><BR id=""CRLF"">31. Adult Epithelial Tissue Stem Cells<BR id=""CRLF"">Christopher S. Potten and James W. Wilson <BR id=""CRLF""><BR id=""CRLF"">32. Embryonic Stem Cells as a Cell Source for Tissue Engineering<BR id=""CRLF"">Ali Khademhosseini, Jeffrey M. Karp, Sharon Gerecht, Lino Ferreira, Gordana Vunjak-Novakovic and Robert Langer<BR id=""CRLF""><BR id=""CRLF"">33. Postnatal Stem Cells<BR id=""CRLF"">Pamela Gehron Robey and Paulo Bianco <BR id=""CRLF""><BR id=""CRLF"">PART EIGHT: GENE THERAPY<BR id=""CRLF""><BR id=""CRLF"">34. Gene Therapy<BR id=""CRLF"">Ronald G. Crystal and Stefan Worgall<BR id=""CRLF""><BR id=""CRLF"">35. Gene Delivery into Cells and Tissues<BR id=""CRLF"">Ales Prokop and Jeffrey M. Davidson <BR id=""CRLF""><BR id=""CRLF""><BR id=""CRLF"">PART NINE: BREAST<BR id=""CRLF""><BR id=""CRLF"">36. Breast Reconstruction<BR id=""CRLF"">Lamont Cathey, Kuen Yong Lee, Walter D. Holder, David J. Mooney and Craig R. Halberstadt<BR id=""CRLF""><BR id=""CRLF"">PART TEN: CARDIOVASCULAR SYSTEM<BR id=""CRLF""><BR id=""CRLF"">37. Progenitor Cells and Cardiac Homeostasis<BR id=""CRLF"">Annarosa Leri, Toru Hosoda, Marcello Rota, Claudia Bearzi, Konrad Urbanek, Roberto Bolli, Jan Kejstura and Piero Anversa<BR id=""CRLF""><BR id=""CRLF"">38. Cardiac-Tissue Engineering<BR id=""CRLF"">M. Radisic, H. Park and G. Vunjak-Novakovic <BR id=""CRLF""><BR id=""CRLF"">39. Blood Vessels <BR id=""CRLF"">Luke Brewster, Eric M. Brey and Howard P. Greisler<BR id=""CRLF""><BR id=""CRLF"">40. Heart Valves <BR id=""CRLF"">Peter Marc Fong, Jason Park and Christopher Kane Breuer<BR id=""CRLF""><BR id=""CRLF""><BR id=""CRLF"">PART ELEVEN: ENDOCRINOLOGY AND METABOLISM<BR id=""CRLF""><BR id=""CRLF"">41. Generation of Islets from Stem Cells<BR id=""CRLF"">Bernat Soria, Abdelkrim Hmadcha, Francisco J. Bedoya and Juan R. Tejedo<BR id=""CRLF""><BR id=""CRLF"">42. Bioartificial Pancreas <BR id=""CRLF"">Athanassios Sambanis <BR id=""CRLF""><BR id=""CRLF"">43. Engineering Pancreatic Beta-Cells <BR id=""CRLF"">Hee-Sook Jun and Ji-Won Yoon <BR id=""CRLF""><BR id=""CRLF"">44. Thymus and Parathyroid Organogenesis<BR id=""CRLF"">Craig Scott Nowell, Ellen Richie, Nancy Ruth Manley and Catherine Clare Blackburn<BR id=""CRLF""><BR id=""CRLF"">PART TWELVE: GASTROINTESTINAL SYSTEM<BR id=""CRLF""><BR id=""CRLF"">45. Adult Stem Cells in Normal Gastrointestinal Function and Inflammatory Disease <BR id=""CRLF"">Mairi Brittan and Nicholas A. Wright<BR id=""CRLF""><BR id=""CRLF"">46. Alimentary Tract <BR id=""CRLF"">Shaun M. Kunisaki and Joseph Vacanti<BR id=""CRLF""><BR id=""CRLF"">47. Liver Stem Cells<BR id=""CRLF"">Eric Lagasse <BR id=""CRLF""><BR id=""CRLF"">48. Liver <BR id=""CRLF"">Gregory H. Underhill, Salman R. Khetani, Alice A. Chen and Sangeeta N. Bhatia<BR id=""CRLF""><BR id=""CRLF"">PART THIRTEEN: HEMATOPOIETIC SYSTEM<BR id=""CRLF""><BR id=""CRLF"">49. Hematopoietic Stem Cells<BR id=""CRLF"">Malcolm A.S. Moore <BR id=""CRLF""><BR id=""CRLF"">50. Red Blood Cell Substitutes <BR id=""CRLF"">Thomas M. S. Chang <BR id=""CRLF""><BR id=""CRLF"">51. Lymphoid Cells<BR id=""CRLF"">Una Chen <BR id=""CRLF""><BR id=""CRLF"">PART FOURTEEN: KIDNEY AND GENITOURINARY SYSTEM<BR id=""CRLF""><BR id=""CRLF"">52. Stem Cells in Kidney Development and Regeneration<BR id=""CRLF"">Gregory R. Dressler <BR id=""CRLF""><BR id=""CRLF"">53. Renal Replacement Devices<BR id=""CRLF"">H. David Humes <BR id=""CRLF""><BR id=""CRLF"">54. Genitourinary System <BR id=""CRLF"">Anthony Atala <BR id=""CRLF""><BR id=""CRLF"">PART FIFTEEN: MUSCULOSKELETAL SYSTEM<BR id=""CRLF""><BR id=""CRLF"">55. Mesenchymal Stem Cells<BR id=""CRLF"">Faye H. Chen, Lin Song, Robert L. Mauck, Wan-Ju Li and Rocky S. Tuan<BR id=""CRLF""><BR id=""CRLF"">56. Bone Regeneration<BR id=""CRLF"">Chantal E. Holy, F. Jerry Volenec, Jeffrey Geesin and Scott P. Bruder<BR id=""CRLF""><BR id=""CRLF"">57. Bone and Cartilage Reconstruction <BR id=""CRLF"">Wei Liu, Wenjie Zhang and Yilin Cao<BR id=""CRLF""><BR id=""CRLF"">58. Regeneration and Replacement of the Intervertebral Disc<BR id=""CRLF"">Lori A. Setton, Lawrence J. Bonassar and Koichi Masuda<BR id=""CRLF""><BR id=""CRLF"">59. Articular Cartilage Injury <BR id=""CRLF"">Joseph A. Buckwalter, J.L. Marsh, T. Brown, A. Amendola and J.A. Martin<BR id=""CRLF""><BR id=""CRLF"">60. Tendons and Ligaments <BR id=""CRLF"">Francine Goulet, Lucie Germain, A. Robin Poole and Francois A. Auger<BR id=""CRLF""><BR id=""CRLF"">61. Mechanosensory Mechanisms in Bone<BR id=""CRLF"">Upma Sharma, Antonios G. Mikos and Stephen C. Cowin<BR id=""CRLF""><BR id=""CRLF"">62. Skeletal-Tissue Engineering<BR id=""CRLF"">Matthew D. Kwan, Derrick C. Wan and Michael T. Longaker<BR id=""CRLF""><BR id=""CRLF""><BR id=""CRLF"">PART SIXTEEN: NERVOUS SYSTEM<BR id=""CRLF""><BR id=""CRLF"">63. Neural Stem Cells <BR id=""CRLF"">Lorenz Studer <BR id=""CRLF""><BR id=""CRLF"">64. Brain Implants <BR id=""CRLF"">Lars U. Wahlberg <BR id=""CRLF""><BR id=""CRLF"">65. Spinal Cord Injury<BR id=""CRLF"">John W. McDonald and Daniel Becker <BR id=""CRLF""><BR id=""CRLF"">66. Protection and Repair of Audition<BR id=""CRLF"">Richard Altschuler, Yehoash Raphael, David C. Martin, Jochen Schacht, David J. Anderson and Josef M. Miller<BR id=""CRLF""><BR id=""CRLF"">PART SEVENTEEN: OPHTHALMIC APPLICATIONS<BR id=""CRLF""><BR id=""CRLF"">67. Stem Cells in the Eye<BR id=""CRLF"">Michael E. Boulton, Julie Albon and Maria B. Grant<BR id=""CRLF""><BR id=""CRLF"">68. Corneal-Tissue Replacement<BR id=""CRLF"">Jeffrey W. Ruberti, James D. Zieske and Vickery Trinkaus-Randall <BR id=""CRLF""><BR id=""CRLF"">69. Vision Enhancement Systems<BR id=""CRLF"">Gislin Dagnelie <BR id=""CRLF""><BR id=""CRLF""><BR id=""CRLF"">PART EIGHTEEN: ORAL/DENTAL APPLICATIONS<BR id=""CRLF""><BR id=""CRLF"">70. Biological Tooth Replacement and Repair<BR id=""CRLF"">Anthony J. (Tony) Smith and Paul T. Sharpe<BR id=""CRLF""><BR id=""CRLF"">71. Oral and Maxillofacial Surgery<BR id=""CRLF"">Simon Young, Kyriacos A. Athanasiou, Antonios G. Mikos and Mark Eu-Kien Wong<BR id=""CRLF""><BR id=""CRLF"">72. Periodontal-Tissue Engineering<BR id=""CRLF"">Hai Zhang, Hanson K. Fong, William V. Giannobile and Martha J. Somerman<BR id=""CRLF""><BR id=""CRLF""><BR id=""CRLF"">PART NINETEEN: RESPIRATORY SYSTEM<BR id=""CRLF""><BR id=""CRLF"">73. Progenitor Cells in the Respiratory System<BR id=""CRLF"">Valérie Besnard and Jeffrey A. Whitsett<BR id=""CRLF""><BR id=""CRLF"">74. Lungs <BR id=""CRLF"">Anne E. Bishop and Julia A. Polak<BR id=""CRLF""><BR id=""CRLF""><BR id=""CRLF"">PART TWENTY: SKIN<BR id=""CRLF""><BR id=""CRLF"">75. Cutaneous Stem Cells <BR id=""CRLF"">George Cotsarelis <BR id=""CRLF""><BR id=""CRLF"">76. Wound Repair<BR id=""CRLF"">Kaustabh Ghosh and Richard A.F. Clark<BR id=""CRLF""><BR id=""CRLF"">77. Bioengineered Skin Constructs<BR id=""CRLF"">Vincent Falanga and Katie Faria<BR id=""CRLF""><BR id=""CRLF""><BR id=""CRLF"">PART TWENTY-ONE: CLINICAL EXPERIENCE<BR id=""CRLF""><BR id=""CRLF"">78.Current State of Clinical Application <BR id=""CRLF"">Shaun M. Kunisaki and Dario O. Fauza<BR id=""CRLF""><BR id=""CRLF"">79. Tissue-Engineered Skin Products<BR id=""CRLF"">Jonathan Mansbridge <BR id=""CRLF""><BR id=""CRLF"">80. Tissue-Engineered Cartilage Products<BR id=""CRLF"">David W. Levine <BR id=""CRLF""><BR id=""CRLF"">81. Tissue-Engineered Bone Products<BR id=""CRLF"">John F. Kay <BR id=""CRLF""><BR id=""CRLF"">82. Tissue-Engineered Cardiovascular Products<BR id=""CRLF"">Thomas Eschenhagen, Herrmann Reichenspurner and Wolfmram-Hubertus Zimmermann<BR id=""CRLF""><BR id=""CRLF"">83. Tissue-Engineered Organs <BR id=""CRLF"">Steve J. Hodges and Anthony Atala <BR id=""CRLF""><BR id=""CRLF"">PART TWENTY-TWO: REGULATION AND ETHICS<BR id=""CRLF""><BR id=""CRLF"">84. The Tissue-Engineering Industry<BR id=""CRLF"">Michael J. Lysaght, Elizabeth Deweerd and Ana Jaklenec<BR id=""CRLF""><BR id=""CRLF"">85. The Regulatory Path From Concept to Market<BR id=""CRLF"">Kiki B. Hellman <BR id=""CRLF"">86. Ethical Issues<BR id=""CRLF"">Laurie Zoloth <BR id=""CRLF""><BR id=""CRLF"">Epilogue <BR id=""CRLF"">Joseph P. Vacanti


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© Academic Press 2007
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About the Editor

Robert Lanza

Robert Lanza, M.D. is currently Chief Scientific Officer at Advanced Cell Technology, and Adjunct Professor of Surgical Sciences at Wake Forest University School of Medicine. He has several hundred scientific publications and patents, and over 30 books, including Principles of Tissue Engineering (1st through 4th Editions), Methods of Tissue Engineering, Principles of Cloning (1st and 2nd Editions), Essentials of Stem Cell Biology (1st and 2nd Editions), XENO, Yearbook of Cell & Tissue Transplantation, One World: The Health & Survival of the Human Species in the 21st Century (as editor, with forewords by C. Everett Koop and former President Jimmy Carter), and Medical Science & the Advancement of World Health. Dr. Lanza received his B.A. and M.D. degrees from the University of Pennsylvania, where he was both a University Scholar and Benjamin Franklin Scholar. He is a former Fulbright Scholar, and studied as a student in the laboratory of Richard Hynes (MIT), Jonas Salk (The Salk Institute), and Nobel laureates Gerald Edelman (Rockefeller University) and Rodney Porter (Oxford University). He also worked closely (and coauthored a series of papers) with the late Harvard psychologist B.F. Skinner and heart transplant pioneer Christiaan Barnard. Dr. Lanza's current area of research focuses on the use of stem cells in regenerative medicine.

Affiliations and Expertise

Advanced Cell Technology, MA, USA

Robert Langer

Robert Langer received honorary doctorates from the ETH (Switzerland) in 1996 and the Technion (Israel) in 1997. Dr. Langer is the Kenneth J. Germeshausen Professor of Chemical and Biomedical Engineering at MIT. He received a Bachelor’s Degree from Cornell University in 1970 and a Sc.D. from MIT in 1974, both in chemical engineering. Dr. Langer has written 590 articles, 400 abstracts, 350 patents, and has edited 12 books.Dr. Langer has received over 70 major awards, including the Gairdner Foundation International Award, the Lemelson-MIT prize, the American Chemical Society (ACS) Polymer Chemistry and Applied Polymer Science Awards, Creative Polymer Chemistry Award (ACS, Polymer Division), the Pearlman Memorial Lectureship Award (ACD, Biochemical Technology Division), and the A.I.Ch.E’s Walker, Professional Progress, Bioengineering, and Stine Materials Science and Engineering Awards. In 1989, Dr. Langer was elected to the Institute of Medicine and the National Academy of Sciences, and in 1992 he was elected to both the National Academy of Engineering and to the National Academy of Sciences. He is the only active member of all 3 United States National Academies.

Affiliations and Expertise

Massachusetts Institute of Technology, Cambridge, U.S.A.

Joseph Vacanti

Dr. Joseph P. Vacanti received his M.D. degree from the university of Nebraska in 1974. He received his training in general surgery at the Massachusetts General Hospital from 1974 through 1981 and in pediatric surgery at The Children’s Hospital, Boston from 1981 through 1983. He then received clinical training in transplantation from the University of Pittsburgh. He spent two years in the laboratories of Dr. M. Judah Folkman working in the filed on angiogenesis from 1977 through 1979. Upon completion of his training, Dr. Vacanti joined the staff in surgery at children’s Hospital in Boston and began clinical programs in pediatric liver transplantation and extracorporeal membrane oxygenation. In the laboratory, he continued studies in and began work in the filed of tissue engineering in 1985. Dr. Vacanti is now John Homans Professor of Surgery at Harvard Medical School, Visiting surgeon at Massachusetts General Hospital, director of the Wellman 6 Surgical laboratories, director of the Laboratory of Tissue Engineering and Organ Fabrication and Director of Pediatric Transplantation at Massachusetts General Hospital, Boston. He has authored more than 120 original reports, 30 book chapters, and 197 abstracts. He has more than 25 patents or patents pending in the United States, Europe, and Japan.

Affiliations and Expertise

Harvard Medical School and the Massachusetts General Hospital, Boston, U.S.A.

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