Principles of Tissue Engineering

Principles of Tissue Engineering

3rd Edition - August 22, 2007

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  • Editors: Robert Lanza, Robert Langer, Joseph Vacanti
  • eBook ISBN: 9780080548845

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Description

First published in 1997, Principles of Tissue Engineering is the widely recognized definitive resource in the field. The third edition provides a much needed update of the rapid progress that has been achieved in the field, combining the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation by the world’s experts of what is currently known about each specific organ system. This edition includes greatly expanded focus on stem cells, including adult and embryonic stem cells and progenitor populations that may soon lead to new tissue engineering therapies for heart disease, diabetes, and a wide variety of other diseases that afflict humanity. This up-to-date coverage of stem cell biology and other emerging technologies is complemented by a series of new chapters on recent clinical experience in applying tissue engineering. The result is a comprehensive textbook that we believe will be useful to students and experts alike.

Key Features

New to this edition:
*Includes new chapters on biomaterial-protein interactions, nanocomposite and three-dimensional scaffolds, skin substitutes, spinal cord, vision enhancement, and heart valves
*Expanded coverage of adult and embryonic stem cells of the cardiovascular, hematopoietic, musculoskeletal, nervous, and other organ systems

Readership

Basic and clinical researchers in fields such as biology, chemistry, materials science, and engineering with an interest in tissue engineering.

Table of Contents

  • INTRODUCTION TO TISSUE ENGINEERING

    1. The History and Scope of Tissue Engineering
    Joseph P. Vacanti and Charles A. Vacanti

    2. The Challenge of Imitating Nature
    Robert M. Nerem

    3. Moving into the Clinic
    Alan J. Russell and Timothy Bertram

    4. Future Perspectives
    Mark E. Furth and Anthony Atala

    PART ONE: THE BASIS OF GROWTH AND DIFFERENTIATION

    5. Molecular Biology of the Cell
    Jonathan Slack

    6. Organization of Cells into Higher-Ordered Structures
    Jon D. Ahlstrom and Carol A. Erickson

    7. Dynamics of Cell-ECM Interactions
    M. Petreaca and Manuela Martins-Green

    8. Matrix Molecules and Their Ligands
    Bjorn Reino Olsen

    9. Morphogenesis and Tissue Engineering
    A.H. Reddi

    10. Gene Expression, Cell Determination and Differentiation
    William Nikovits, Jr. and Frank E. Stockdale

    PART TWO: IN VITRO CONTROL OF TISSUE DEVELOPMENT

    11. Engineering Functional Tissues
    Lisa E. Freed and Farshid Guilak

    12. Principles of Tissue Culture and Bioreactor Design
    R.I. Freshney, B. Obradovic, W. Grayson, C. Cannizzaro and Gordana Vunjak-Novakovic

    13. Regulation of Cell Behavior by Extracellular Proteins
    Amy Bradshaw and E. Helene Sage

    14. Growth Factors
    Thomas F. Deuel and Yunchao Chang

    15. Mechanochemical Control of Cell Fate Switching
    Donald E. Ingber

    PART THREE: IN VIVO SYNTHESIS OF TISSUES AND ORGANS

    16. In Vivo Synthesis of Tissues and Organs
    Brendan A. Harley and Ioannis V. Yannas


    PART FOUR: MODELS FOR TISSUE ENGINEERING

    17. Models as Precursors for Prosthetic Devices
    Eugene Bell

    18. Quantitative Aspects
    Alan J. Grodzinsky, Roger D. Kamm, and Douglas A. Lauffenburger

    PART FIVE: BIOMATERIALS IN TISSUE ENGINEERING

    19. Micro-Scale Patterning of Cells and Their Environment
    Xingyu Jiang, Shuichi Takayama, Robert G. Chapman, Ravi S. Kane and George M. Whitesides

    20. Cell Interactions with Polymers
    W. Mark Saltzman and Themis R. Kyriakides

    21. Matrix Effects
    Jeffrey A. Hubbell

    22. Polymer Scaffold Fabrication
    Matthew B. Murphy and Antonios G. Mikos

    23. Biodegradable Polymers
    James M. Pachence, Michael P. Bohrer and Joachim Kohn

    24. Micro- and Nanofabricated Scaffolds
    Christopher J. Bettinger, Jeffrey T. Borenstein and Robert Langer

    25. Three-Dimensional Scaffolds
    Ying Luo, George Engelmayr, Debra T. Auguste, Lino da Silva Ferreira, Jeffrey M. Karp, Rajiv Saigal and Robert Langer


    PART SIX: TRANSPLANTATION OF ENGINEERED CELLS AND TISSUES

    26. Tissue Engineering and Transplantation in the Fetus
    Dario O. Fauza

    27. Immunomodulation
    Denise L. Faustman

    28. Immunoisolation
    Beth A. Zielinski and Michael J. Lysaght

    29. Engineering Challenges in Immunobarrier Device Development
    Amy S. Lewis and Clark K. Colton


    PART SEVEN: STEM CELLS

    30. Embryonic Stem Cells
    Alan Trounson

    31. Adult Epithelial Tissue Stem Cells
    Christopher S. Potten and James W. Wilson

    32. Embryonic Stem Cells as a Cell Source for Tissue Engineering
    Ali Khademhosseini, Jeffrey M. Karp, Sharon Gerecht, Lino Ferreira, Gordana Vunjak-Novakovic and Robert Langer

    33. Postnatal Stem Cells
    Pamela Gehron Robey and Paulo Bianco

    PART EIGHT: GENE THERAPY

    34. Gene Therapy
    Ronald G. Crystal and Stefan Worgall

    35. Gene Delivery into Cells and Tissues
    Ales Prokop and Jeffrey M. Davidson


    PART NINE: BREAST

    36. Breast Reconstruction
    Lamont Cathey, Kuen Yong Lee, Walter D. Holder, David J. Mooney and Craig R. Halberstadt

    PART TEN: CARDIOVASCULAR SYSTEM

    37. Progenitor Cells and Cardiac Homeostasis
    Annarosa Leri, Toru Hosoda, Marcello Rota, Claudia Bearzi, Konrad Urbanek, Roberto Bolli, Jan Kejstura and Piero Anversa

    38. Cardiac-Tissue Engineering
    M. Radisic, H. Park and G. Vunjak-Novakovic

    39. Blood Vessels
    Luke Brewster, Eric M. Brey and Howard P. Greisler

    40. Heart Valves
    Peter Marc Fong, Jason Park and Christopher Kane Breuer


    PART ELEVEN: ENDOCRINOLOGY AND METABOLISM

    41. Generation of Islets from Stem Cells
    Bernat Soria, Abdelkrim Hmadcha, Francisco J. Bedoya and Juan R. Tejedo

    42. Bioartificial Pancreas
    Athanassios Sambanis

    43. Engineering Pancreatic Beta-Cells
    Hee-Sook Jun and Ji-Won Yoon

    44. Thymus and Parathyroid Organogenesis
    Craig Scott Nowell, Ellen Richie, Nancy Ruth Manley and Catherine Clare Blackburn

    PART TWELVE: GASTROINTESTINAL SYSTEM

    45. Adult Stem Cells in Normal Gastrointestinal Function and Inflammatory Disease
    Mairi Brittan and Nicholas A. Wright

    46. Alimentary Tract
    Shaun M. Kunisaki and Joseph Vacanti

    47. Liver Stem Cells
    Eric Lagasse

    48. Liver
    Gregory H. Underhill, Salman R. Khetani, Alice A. Chen and Sangeeta N. Bhatia

    PART THIRTEEN: HEMATOPOIETIC SYSTEM

    49. Hematopoietic Stem Cells
    Malcolm A.S. Moore

    50. Red Blood Cell Substitutes
    Thomas M. S. Chang

    51. Lymphoid Cells
    Una Chen

    PART FOURTEEN: KIDNEY AND GENITOURINARY SYSTEM

    52. Stem Cells in Kidney Development and Regeneration
    Gregory R. Dressler

    53. Renal Replacement Devices
    H. David Humes

    54. Genitourinary System
    Anthony Atala

    PART FIFTEEN: MUSCULOSKELETAL SYSTEM

    55. Mesenchymal Stem Cells
    Faye H. Chen, Lin Song, Robert L. Mauck, Wan-Ju Li and Rocky S. Tuan

    56. Bone Regeneration
    Chantal E. Holy, F. Jerry Volenec, Jeffrey Geesin and Scott P. Bruder

    57. Bone and Cartilage Reconstruction
    Wei Liu, Wenjie Zhang and Yilin Cao

    58. Regeneration and Replacement of the Intervertebral Disc
    Lori A. Setton, Lawrence J. Bonassar and Koichi Masuda

    59. Articular Cartilage Injury
    Joseph A. Buckwalter, J.L. Marsh, T. Brown, A. Amendola and J.A. Martin

    60. Tendons and Ligaments
    Francine Goulet, Lucie Germain, A. Robin Poole and Francois A. Auger

    61. Mechanosensory Mechanisms in Bone
    Upma Sharma, Antonios G. Mikos and Stephen C. Cowin

    62. Skeletal-Tissue Engineering
    Matthew D. Kwan, Derrick C. Wan and Michael T. Longaker


    PART SIXTEEN: NERVOUS SYSTEM

    63. Neural Stem Cells
    Lorenz Studer

    64. Brain Implants
    Lars U. Wahlberg

    65. Spinal Cord Injury
    John W. McDonald and Daniel Becker

    66. Protection and Repair of Audition
    Richard Altschuler, Yehoash Raphael, David C. Martin, Jochen Schacht, David J. Anderson and Josef M. Miller

    PART SEVENTEEN: OPHTHALMIC APPLICATIONS

    67. Stem Cells in the Eye
    Michael E. Boulton, Julie Albon and Maria B. Grant

    68. Corneal-Tissue Replacement
    Jeffrey W. Ruberti, James D. Zieske and Vickery Trinkaus-Randall

    69. Vision Enhancement Systems
    Gislin Dagnelie


    PART EIGHTEEN: ORAL/DENTAL APPLICATIONS

    70. Biological Tooth Replacement and Repair
    Anthony J. (Tony) Smith and Paul T. Sharpe

    71. Oral and Maxillofacial Surgery
    Simon Young, Kyriacos A. Athanasiou, Antonios G. Mikos and Mark Eu-Kien Wong

    72. Periodontal-Tissue Engineering
    Hai Zhang, Hanson K. Fong, William V. Giannobile and Martha J. Somerman


    PART NINETEEN: RESPIRATORY SYSTEM

    73. Progenitor Cells in the Respiratory System
    Valérie Besnard and Jeffrey A. Whitsett

    74. Lungs
    Anne E. Bishop and Julia A. Polak


    PART TWENTY: SKIN

    75. Cutaneous Stem Cells
    George Cotsarelis

    76. Wound Repair
    Kaustabh Ghosh and Richard A.F. Clark

    77. Bioengineered Skin Constructs
    Vincent Falanga and Katie Faria


    PART TWENTY-ONE: CLINICAL EXPERIENCE

    78.Current State of Clinical Application
    Shaun M. Kunisaki and Dario O. Fauza

    79. Tissue-Engineered Skin Products
    Jonathan Mansbridge

    80. Tissue-Engineered Cartilage Products
    David W. Levine

    81. Tissue-Engineered Bone Products
    John F. Kay

    82. Tissue-Engineered Cardiovascular Products
    Thomas Eschenhagen, Herrmann Reichenspurner and Wolfmram-Hubertus Zimmermann

    83. Tissue-Engineered Organs
    Steve J. Hodges and Anthony Atala

    PART TWENTY-TWO: REGULATION AND ETHICS

    84. The Tissue-Engineering Industry
    Michael J. Lysaght, Elizabeth Deweerd and Ana Jaklenec

    85. The Regulatory Path From Concept to Market
    Kiki B. Hellman
    86. Ethical Issues
    Laurie Zoloth

    Epilogue
    Joseph P. Vacanti

Product details

  • No. of pages: 1344
  • Language: English
  • Copyright: © Academic Press 2007
  • Published: August 22, 2007
  • Imprint: Academic Press
  • eBook ISBN: 9780080548845

About the Editors

Robert Lanza

Robert Lanza
Robert Lanza is an American scientist and author whose research spans the range of natural science, from biology to theoretical physics. TIME magazine recognized him as one of the “100 Most Influential People in the World,” and Prospect magazine named him one of the Top 50 “World Thinkers.” He has hundreds of scientific publications and over 30 books, including definitive references in the fields of stem cells, tissue engineering, and regenerative medicine. He is a former Fulbright Scholar and studied with polio-pioneer Jonas Salk and Nobel laureates Gerald Edelman (known for his work on the biological basis of consciousness) and Rodney Porter. He also worked closely (and co-authored papers in Science on self-awareness and symbolic communication) with noted Harvard psychologist BF Skinner. Dr. Lanza was part of the team that cloned the world’s first human embryo, the first endangered species, and published the first-ever reports of pluripotent stem cell use in humans. Currently Dr. Lanza is the Head of Astellas Global Regenerative Medicine and Chief Scientific Officer of the Astellas Institute for Regenerative Medicine. He is also an Adjunct Professor at Wake Forest University School of Medicine and has authored over 200+ articles and over a dozen books.

Affiliations and Expertise

Astellas Institute for Regenerative Medicine, Westborough, MA, USA

Robert Langer

Robert Langer
Robert Langer received honorary doctorates from the ETH (Switzerland) in 1996 and the Technion (Israel) in 1997. Dr. Langer is the Kenneth J. Germeshausen Professor of Chemical and Biomedical Engineering at MIT. He received a Bachelor’s Degree from Cornell University in 1970 and a Sc.D. from MIT in 1974, both in chemical engineering. Dr. Langer has written 590 articles, 400 abstracts, 350 patents, and has edited 12 books.Dr. Langer has received over 70 major awards, including the Gairdner Foundation International Award, the Lemelson-MIT prize, the American Chemical Society (ACS) Polymer Chemistry and Applied Polymer Science Awards, Creative Polymer Chemistry Award (ACS, Polymer Division), the Pearlman Memorial Lectureship Award (ACD, Biochemical Technology Division), and the A.I.Ch.E’s Walker, Professional Progress, Bioengineering, and Stine Materials Science and Engineering Awards. In 1989, Dr. Langer was elected to the Institute of Medicine and the National Academy of Sciences, and in 1992 he was elected to both the National Academy of Engineering and to the National Academy of Sciences. He is the only active member of all 3 United States National Academies.

Affiliations and Expertise

Massachusetts Institute of Technology, Cambridge, USA

Joseph Vacanti

Dr. Joseph P. Vacanti received his M.D. degree from the university of Nebraska in 1974. He received his training in general surgery at the Massachusetts General Hospital from 1974 through 1981 and in pediatric surgery at The Children’s Hospital, Boston from 1981 through 1983. He then received clinical training in transplantation from the University of Pittsburgh. He spent two years in the laboratories of Dr. M. Judah Folkman working in the filed on angiogenesis from 1977 through 1979. Upon completion of his training, Dr. Vacanti joined the staff in surgery at children’s Hospital in Boston and began clinical programs in pediatric liver transplantation and extracorporeal membrane oxygenation. In the laboratory, he continued studies in and began work in the filed of tissue engineering in 1985. Dr. Vacanti is now John Homans Professor of Surgery at Harvard Medical School, Visiting surgeon at Massachusetts General Hospital, director of the Wellman 6 Surgical laboratories, director of the Laboratory of Tissue Engineering and Organ Fabrication and Director of Pediatric Transplantation at Massachusetts General Hospital, Boston. He has authored more than 120 original reports, 30 book chapters, and 197 abstracts. He has more than 25 patents or patents pending in the United States, Europe, and Japan.

Affiliations and Expertise

Harvard Medical School and the Massachusetts General Hospital, Boston, USA

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