Principles of Tissue Engineering - 3rd Edition - ISBN: 9780123706157, 9780080548845

Principles of Tissue Engineering

3rd Edition

eBook ISBN: 9780080548845
Hardcover ISBN: 9780123706157
Imprint: Academic Press
Published Date: 22nd August 2007
Page Count: 1344
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First published in 1997, Principles of Tissue Engineering is the widely recognized definitive resource in the field. The third edition provides a much needed update of the rapid progress that has been achieved in the field, combining the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation by the world’s experts of what is currently known about each specific organ system. This edition includes greatly expanded focus on stem cells, including adult and embryonic stem cells and progenitor populations that may soon lead to new tissue engineering therapies for heart disease, diabetes, and a wide variety of other diseases that afflict humanity. This up-to-date coverage of stem cell biology and other emerging technologies is complemented by a series of new chapters on recent clinical experience in applying tissue engineering. The result is a comprehensive textbook that we believe will be useful to students and experts alike.

Key Features

New to this edition: Includes new chapters on biomaterial-protein interactions, nanocomposite and three-dimensional scaffolds, skin substitutes, spinal cord, vision enhancement, and heart valves Expanded coverage of adult and embryonic stem cells of the cardiovascular, hematopoietic, musculoskeletal, nervous, and other organ systems


Basic and clinical researchers in fields such as biology, chemistry, materials science, and engineering with an interest in tissue engineering.

Table of Contents

INTRODUCTION TO TISSUE ENGINEERING<BR id=""CRLF""><BR id=""CRLF"">1. The History and Scope of Tissue Engineering<BR id=""CRLF"">Joseph P. Vacanti and Charles A. Vacanti <BR id=""CRLF""><BR id=""CRLF"">2. The Challenge of Imitating Nature<BR id=""CRLF"">Robert M. Nerem <BR id=""CRLF""><BR id=""CRLF"">3. Moving into the Clinic <BR id=""CRLF"">Alan J. Russell and Timothy Bertram<BR id=""CRLF""><BR id=""CRLF"">4. Future Perspectives<BR id=""CRLF"">Mark E. Furth and Anthony Atala<BR id=""CRLF""><BR id=""CRLF"">PART ONE: THE BASIS OF GROWTH AND DIFFERENTIATION<BR id=""CRLF""><BR id=""CRLF"">5. Molecular Biology of the Cell<BR id=""CRLF"">Jonathan Slack <BR id=""CRLF""><BR id=""CRLF"">6. Organization of Cells into Higher-Ordered Structures <BR id=""CRLF"">Jon D. Ahlstrom and Carol A. Erickson<BR id=""CRLF""><BR id=""CRLF"">7. Dynamics of Cell-ECM Interactions<BR id=""CRLF"">M. Petreaca and Manuela Martins-Green<BR id=""CRLF""><BR id=""CRLF"">8. Matrix Molecules and Their Ligands<BR id=""CRLF"">Bjorn Reino Olsen <BR id=""CRLF""><BR id=""CRLF"">9. Morphogenesis and Tissue Engineering<BR id=""CRLF"">A.H. Reddi <BR id=""CRLF""><BR id=""CRLF"">10. Gene Expression, Cell Determination and Differentiation<BR id=""CRLF"">William Nikovits, Jr. and Frank E. Stockdale<BR id=""CRLF""><BR id=""CRLF"">PART TWO: IN VITRO CONTROL OF TISSUE DEVELOPMENT <BR id=""CRLF""><BR id=""CRLF"">11. Engineering Functional Tissues<BR id=""CRLF"">Lisa E. Freed and Farshid Guilak <BR id=""CRLF""><BR id=""CRLF"">12. Principles of Tissue Culture and Bioreactor Design<BR id=""CRLF"">R.I. Freshney, B. Obradovic, W. Grayson, C. Cannizzaro and Gordana Vunjak-Novakovic<BR id=""CRLF""><BR id=""CRLF"">13. Regulation of Cell Behavior by Extracellular Proteins<BR id=""CRLF"">Amy Bradshaw and E. Helene Sage<BR id=""CRLF""><BR id=""CRLF"">14. Growth Factors <BR id=""CRLF"">Thomas F. Deuel and Yunchao Chang<BR id=""CRLF""><BR id=""CRLF"">15. Mechanochemical Control of Cell Fate Switching<BR id=""CRLF"">Donald E. Ingber <BR id=""CRLF""><BR id=""CRLF"">PART THREE: IN VIVO SYNTHESIS OF TISSUES AND ORGANS<BR id=""CRLF""><BR id=""CRLF"">16. In Vivo Synthesis of Tissues and Organs<BR id=""CRLF"">Brendan A. Harley and Ioannis V. Yannas<BR id=""CRLF""><BR id=""CRLF""><BR id=""CRLF"">PART FOUR: MODELS FOR TISSUE ENGINEERING<BR id=""CRLF""><BR id=""CRLF"">17. Models as Precursors for Prosthetic Devices<BR id=""CRLF"">Eugene Bell <BR id=""CRLF""><BR id=""CRLF"">18. Quantitative Aspects<BR id=""CRLF"">Alan J. Grodzinsky, Roger D. Kamm, and Douglas A. Lauffenburger<BR id=""CRLF""><BR id=""CRLF"">PART FIVE: BIOMATERIALS IN TISSUE ENGINEERING<BR id=""CRLF""><BR id=""CRLF"">19. Micro-Scale Patterning of Cells and Their Environment <BR id=""CRLF"">Xingyu Jiang, Shuichi Takayama, Robert G. Chapman, Ravi S. Kane and George M. Whitesides<BR id=""CRLF""><BR id=""CRLF"">20. Cell Interactions with Polymers<BR id=""CRLF"">W. Mark Saltzman and Themis R. Kyriakides<BR id=""CRLF""><BR id=""CRLF"">21. Matrix Effects<BR id=""CRLF"">Jeffrey A. Hubbell <BR id=""CRLF""><BR id=""CRLF"">22. Polymer Scaffold Fabrication <BR id=""CRLF"">Matthew B. Murphy and Antonios G. Mikos<BR id=""CRLF""><BR id=""CRLF"">23. Biodegradable Polymers <BR id=""CRLF"">James M. Pachence, Michael P. Bohrer and Joachim Kohn<BR id=""CRLF""><BR id=""CRLF"">24. Micro- and Nanofabricated Scaffolds<BR id=""CRLF"">Christopher J. Bettinger, Jeffrey T. Borenstein and Robert Langer <BR id=""CRLF""><BR id=""CRLF"">25. Three-Dimensional Scaffolds<BR id=""CRLF"">Ying Luo, George Engelmayr, Debra T. Auguste, Lino da Silva Ferreira, Jeffrey M. Karp, Rajiv Saigal and Robert Langer<BR id=""CRLF""><BR id=""CRLF""><BR id=""CRLF"">PART SIX: TRANSPLANTATION OF ENGINEERED CELLS AND TISSUES<BR id=""CRLF""><BR id=""CRLF"">26. Tissue Engineering and Transplantation in the Fetus<BR id=""CRLF"">Dario O. Fauza <BR id=""CRLF""><BR id=""CRLF"">27. Immunomodulation <BR id=""CRLF"">Denise L. Faustman <BR id=""CRLF""><BR id=""CRLF"">28. Immunoisolation<BR id=""CRLF"">Beth A. Zielinski and Michael J. Lysaght <BR id=""CRLF""><BR id=""CRLF"">29. Engineering Challenges in Immunobarrier Device Development<BR id=""CRLF"">Amy S. Lewis and Clark K. Colton<BR id=""CRLF""><BR id=""CRLF""><BR id=""CRLF"">PART SEVEN: STEM CELLS <BR id=""CRLF""><BR id=""CRLF"">30. Embryonic Stem Cells<BR id=""CRLF"">Alan Trounson<BR id=""CRLF""><BR id=""CRLF"">31. Adult Epithelial Tissue Stem Cells<BR id=""CRLF"">Christopher S. Potten and James W. Wilson <BR id=""CRLF""><BR id=""CRLF"">32. Embryonic Stem Cells as a Cell Source for Tissue Engineering<BR id=""CRLF"">Ali Khademhosseini, Jeffrey M. Karp, Sharon Gerecht, Lino Ferreira, Gordana Vunjak-Novakovic and Robert Langer<BR id=""CRLF""><BR id=""CRLF"">33. Postnatal Stem Cells<BR id=""CRLF"">Pamela Gehron Robey and Paulo Bianco <BR id=""CRLF""><BR id=""CRLF"">PART EIGHT: GENE THERAPY<BR id=""CRLF""><BR id=""CRLF"">34. Gene Therapy<BR id=""CRLF"">Ronald G. Crystal and Stefan Worgall<BR id=""CRLF""><BR id=""CRLF"">35. Gene Delivery into Cells and Tissues<BR id=""CRLF"">Ales Prokop and Jeffrey M. Davidson <BR id=""CRLF""><BR id=""CRLF""><BR id=""CRLF"">PART NINE: BREAST<BR id=""CRLF""><BR id=""CRLF"">36. Breast Reconstruction<BR id=""CRLF"">Lamont Cathey, Kuen Yong Lee, Walter D. Holder, David J. Mooney and Craig R. Halberstadt<BR id=""CRLF""><BR id=""CRLF"">PART TEN: CARDIOVASCULAR SYSTEM<BR id=""CRLF""><BR id=""CRLF"">37. Progenitor Cells and Cardiac Homeostasis<BR id=""CRLF"">Annarosa Leri, Toru Hosoda, Marcello Rota, Claudia Bearzi, Konrad Urbanek, Roberto Bolli, Jan Kejstura and Piero Anversa<BR id=""CRLF""><BR id=""CRLF"">38. Cardiac-Tissue Engineering<BR id=""CRLF"">M. Radisic, H. Park and G. Vunjak-Novakovic <BR id=""CRLF""><BR id=""CRLF"">39. Blood Vessels <BR id=""CRLF"">Luke Brewster, Eric M. Brey and Howard P. Greisler<BR id=""CRLF""><BR id=""CRLF"">40. Heart Valves <BR id=""CRLF"">Peter Marc Fong, Jason Park and Christopher Kane Breuer<BR id=""CRLF""><BR id=""CRLF""><BR id=""CRLF"">PART ELEVEN: ENDOCRINOLOGY AND METABOLISM<BR id=""CRLF""><BR id=""CRLF"">41. Generation of Islets from Stem Cells<BR id=""CRLF"">Bernat Soria, Abdelkrim Hmadcha, Francisco J. Bedoya and Juan R. Tejedo<BR id=""CRLF""><BR id=""CRLF"">42. Bioartificial Pancreas <BR id=""CRLF"">Athanassios Sambanis <BR id=""CRLF""><BR id=""CRLF"">43. Engineering Pancreatic Beta-Cells <BR id=""CRLF"">Hee-Sook Jun and Ji-Won Yoon <BR id=""CRLF""><BR id=""CRLF"">44. Thymus and Parathyroid Organogenesis<BR id=""CRLF"">Craig Scott Nowell, Ellen Richie, Nancy Ruth Manley and Catherine Clare Blackburn<BR id=""CRLF""><BR id=""CRLF"">PART TWELVE: GASTROINTESTINAL SYSTEM<BR id=""CRLF""><BR id=""CRLF"">45. Adult Stem Cells in Normal Gastrointestinal Function and Inflammatory Disease <BR id=""CRLF"">Mairi Brittan and Nicholas A. Wright<BR id=""CRLF""><BR id=""CRLF"">46. Alimentary Tract <BR id=""CRLF"">Shaun M. Kunisaki and Joseph Vacanti<BR id=""CRLF""><BR id=""CRLF"">47. Liver Stem Cells<BR id=""CRLF"">Eric Lagasse <BR id=""CRLF""><BR id=""CRLF"">48. Liver <BR id=""CRLF"">Gregory H. Underhill, Salman R. Khetani, Alice A. Chen and Sangeeta N. Bhatia<BR id=""CRLF""><BR id=""CRLF"">PART THIRTEEN: HEMATOPOIETIC SYSTEM<BR id=""CRLF""><BR id=""CRLF"">49. Hematopoietic Stem Cells<BR id=""CRLF"">Malcolm A.S. Moore <BR id=""CRLF""><BR id=""CRLF"">50. Red Blood Cell Substitutes <BR id=""CRLF"">Thomas M. S. Chang <BR id=""CRLF""><BR id=""CRLF"">51. Lymphoid Cells<BR id=""CRLF"">Una Chen <BR id=""CRLF""><BR id=""CRLF"">PART FOURTEEN: KIDNEY AND GENITOURINARY SYSTEM<BR id=""CRLF""><BR id=""CRLF"">52. Stem Cells in Kidney Development and Regeneration<BR id=""CRLF"">Gregory R. Dressler <BR id=""CRLF""><BR id=""CRLF"">53. Renal Replacement Devices<BR id=""CRLF"">H. David Humes <BR id=""CRLF""><BR id=""CRLF"">54. Genitourinary System <BR id=""CRLF"">Anthony Atala <BR id=""CRLF""><BR id=""CRLF"">PART FIFTEEN: MUSCULOSKELETAL SYSTEM<BR id=""CRLF""><BR id=""CRLF"">55. Mesenchymal Stem Cells<BR id=""CRLF"">Faye H. Chen, Lin Song, Robert L. Mauck, Wan-Ju Li and Rocky S. Tuan<BR id=""CRLF""><BR id=""CRLF"">56. Bone Regeneration<BR id=""CRLF"">Chantal E. Holy, F. Jerry Volenec, Jeffrey Geesin and Scott P. Bruder<BR id=""CRLF""><BR id=""CRLF"">57. Bone and Cartilage Reconstruction <BR id=""CRLF"">Wei Liu, Wenjie Zhang and Yilin Cao<BR id=""CRLF""><BR id=""CRLF"">58. Regeneration and Replacement of the Intervertebral Disc<BR id=""CRLF"">Lori A. Setton, Lawrence J. Bonassar and Koichi Masuda<BR id=""CRLF""><BR id=""CRLF"">59. Articular Cartilage Injury <BR id=""CRLF"">Joseph A. Buckwalter, J.L. Marsh, T. Brown, A. Amendola and J.A. Martin<BR id=""CRLF""><BR id=""CRLF"">60. Tendons and Ligaments <BR id=""CRLF"">Francine Goulet, Lucie Germain, A. Robin Poole and Francois A. Auger<BR id=""CRLF""><BR id=""CRLF"">61. Mechanosensory Mechanisms in Bone<BR id=""CRLF"">Upma Sharma, Antonios G. Mikos and Stephen C. Cowin<BR id=""CRLF""><BR id=""CRLF"">62. Skeletal-Tissue Engineering<BR id=""CRLF"">Matthew D. Kwan, Derrick C. Wan and Michael T. Longaker<BR id=""CRLF""><BR id=""CRLF""><BR id=""CRLF"">PART SIXTEEN: NERVOUS SYSTEM<BR id=""CRLF""><BR id=""CRLF"">63. Neural Stem Cells <BR id=""CRLF"">Lorenz Studer <BR id=""CRLF""><BR id=""CRLF"">64. Brain Implants <BR id=""CRLF"">Lars U. Wahlberg <BR id=""CRLF""><BR id=""CRLF"">65. Spinal Cord Injury<BR id=""CRLF"">John W. McDonald and Daniel Becker <BR id=""CRLF""><BR id=""CRLF"">66. Protection and Repair of Audition<BR id=""CRLF"">Richard Altschuler, Yehoash Raphael, David C. Martin, Jochen Schacht, David J. Anderson and Josef M. Miller<BR id=""CRLF""><BR id=""CRLF"">PART SEVENTEEN: OPHTHALMIC APPLICATIONS<BR id=""CRLF""><BR id=""CRLF"">67. Stem Cells in the Eye<BR id=""CRLF"">Michael E. Boulton, Julie Albon and Maria B. Grant<BR id=""CRLF""><BR id=""CRLF"">68. Corneal-Tissue Replacement<BR id=""CRLF"">Jeffrey W. Ruberti, James D. Zieske and Vickery Trinkaus-Randall <BR id=""CRLF""><BR id=""CRLF"">69. Vision Enhancement Systems<BR id=""CRLF"">Gislin Dagnelie <BR id=""CRLF""><BR id=""CRLF""><BR id=""CRLF"">PART EIGHTEEN: ORAL/DENTAL APPLICATIONS<BR id=""CRLF""><BR id=""CRLF"">70. Biological Tooth Replacement and Repair<BR id=""CRLF"">Anthony J. (Tony) Smith and Paul T. Sharpe<BR id=""CRLF""><BR id=""CRLF"">71. Oral and Maxillofacial Surgery<BR id=""CRLF"">Simon Young, Kyriacos A. Athanasiou, Antonios G. Mikos and Mark Eu-Kien Wong<BR id=""CRLF""><BR id=""CRLF"">72. Periodontal-Tissue Engineering<BR id=""CRLF"">Hai Zhang, Hanson K. Fong, William V. Giannobile and Martha J. Somerman<BR id=""CRLF""><BR id=""CRLF""><BR id=""CRLF"">PART NINETEEN: RESPIRATORY SYSTEM<BR id=""CRLF""><BR id=""CRLF"">73. Progenitor Cells in the Respiratory System<BR id=""CRLF"">Valérie Besnard and Jeffrey A. Whitsett<BR id=""CRLF""><BR id=""CRLF"">74. Lungs <BR id=""CRLF"">Anne E. Bishop and Julia A. Polak<BR id=""CRLF""><BR id=""CRLF""><BR id=""CRLF"">PART TWENTY: SKIN<BR id=""CRLF""><BR id=""CRLF"">75. Cutaneous Stem Cells <BR id=""CRLF"">George Cotsarelis <BR id=""CRLF""><BR id=""CRLF"">76. Wound Repair<BR id=""CRLF"">Kaustabh Ghosh and Richard A.F. Clark<BR id=""CRLF""><BR id=""CRLF"">77. Bioengineered Skin Constructs<BR id=""CRLF"">Vincent Falanga and Katie Faria<BR id=""CRLF""><BR id=""CRLF""><BR id=""CRLF"">PART TWENTY-ONE: CLINICAL EXPERIENCE<BR id=""CRLF""><BR id=""CRLF"">78.Current State of Clinical Application <BR id=""CRLF"">Shaun M. Kunisaki and Dario O. Fauza<BR id=""CRLF""><BR id=""CRLF"">79. Tissue-Engineered Skin Products<BR id=""CRLF"">Jonathan Mansbridge <BR id=""CRLF""><BR id=""CRLF"">80. Tissue-Engineered Cartilage Products<BR id=""CRLF"">David W. Levine <BR id=""CRLF""><BR id=""CRLF"">81. Tissue-Engineered Bone Products<BR id=""CRLF"">John F. Kay <BR id=""CRLF""><BR id=""CRLF"">82. Tissue-Engineered Cardiovascular Products<BR id=""CRLF"">Thomas Eschenhagen, Herrmann Reichenspurner and Wolfmram-Hubertus Zimmermann<BR id=""CRLF""><BR id=""CRLF"">83. Tissue-Engineered Organs <BR id=""CRLF"">Steve J. Hodges and Anthony Atala <BR id=""CRLF""><BR id=""CRLF"">PART TWENTY-TWO: REGULATION AND ETHICS<BR id=""CRLF""><BR id=""CRLF"">84. The Tissue-Engineering Industry<BR id=""CRLF"">Michael J. Lysaght, Elizabeth Deweerd and Ana Jaklenec<BR id=""CRLF""><BR id=""CRLF"">85. The Regulatory Path From Concept to Market<BR id=""CRLF"">Kiki B. Hellman <BR id=""CRLF"">86. Ethical Issues<BR id=""CRLF"">Laurie Zoloth <BR id=""CRLF""><BR id=""CRLF"">Epilogue <BR id=""CRLF"">Joseph P. Vacanti


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© Academic Press 2007
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