Principles of Regenerative Medicine

Principles of Regenerative Medicine

1st Edition - November 19, 2007

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  • Editors: Anthony Atala, Anthony Atala, Robert Lanza, Robert Nerem, James Thomson
  • eBook ISBN: 9780080555959

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Description

Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure.

Key Features

* Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology
* The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine
* New discoveries from leading researchers on restoration of diseased tissues and organs

Readership

Advanced researchers in bioengineering, stem cell biology, and developmental biology.

Table of Contents

  • Introduction to Regenerative Medicine

    1
    Current and Future Perspectives of Regenerative Medicine
    Anthony Atala
    Mark E. Furth

    2
    Fundamentals of Cell-Based Therapies
    Ross Tubo

    3
    Stem Cell Research in Regenerative Medicine
    Robert M. Nerem
    AM Doyle
    T Ahsan

    Biologic and Molecular Basis of Regenerative Medicine

    4
    Molecular Organization of Cells
    Carol A. Erickson
    Jon D. Ahlstrom

    5
    Cell-ECM Interactions in Repair and Regeneration
    Manuela Martins-Green
    M. Petreaca

    6
    Developmental Mechanisms of Regeneration and Strategies of Regenerative Medicien
    David L. Stocum

    7
    Molecular Basis of Pluripotency
    Ali H. Brivanlou
    Ariel J. Levine

    8
    How Cells Change Their Phenotype
    Peter Andrews
    Paul J. Gokhale

    9
    Somatic Cloning and Epigenetic Reprogramming in Mammals
    Heiner Niemann
    Christine Wrenzycki
    Wilfried A. Kues
    Andrea Lucas-Hahn
    Joseph W. Warnwath

    10
    Transgenic Cloned Goats and Cows for the Production of Therapeutic Proteins
    Harry Meade
    William Gavin
    LiHow Chen
    David L. Melican
    Carol A. Ziomek
    Yann Echelard

    Cells and Tissue Development

    11
    Genetic Approaches in Human Embryonic Stem Cells and Their Derivatives: Prospect for Regenerative Medicine
    Mickie Bhatia
    Junfeng Ji
    Bonan Zhong

    12
    Embryonic Stem Cells: Derivation and Properties
    James Thomson
    Junying Yu

    13
    Stem Cells Derived from Amniotic Fluid and Placenta
    Paolo De Coppi
    Georg Van Dyke
    M. Minhaj Siddiqui
    Anthony Atala

    14
    Stem Cells Derived from Cord Blood
    Julie Allickson

    15
    Multipotent Adult Progenitor Cells: Isolation and Induction
    Catherine Verfaillie

    16
    Bone Marrow Stem Cells: Properties and Pluripotency
    Ren Ke Li
    Munira Xaymardan
    Massimo Cimini
    Richard D. Weisel

    17
    Hematopoietic Stem Cells: Properties , Markers and Therapeutics
    M.A Goodell
    S.M. Chambers
    K.K. Lin

    18
    Neural Stem Cells: Multipotency Beyond Self-renewal and Phenotypic Differentiation
    Evan Snyder
    Yang D. Teng
    Peter M. Black
    F.N. Santos
    Deniz Konya
    Kook In Park
    Richard L. Sidman

    19
    Mesenchymal Stem Cells
    Daniel Gazit
    Zumila Gazit
    Hadi Aslan
    Yossi Gafni
    Nadav Kimelman
    Gadi Pelled

    20
    Stem Cells and Maturational Lineage Biology: Implications for Clinical, Research and Commercial Programs
    Lola Reid
    Hsin-lei Yao
    N. Cheng

    21
    Skeletal Muscle Stem Cells
    Helen Blau
    Jason H. Pomerantz

    22
    Islet Cell Therapy and Pancreatic Stem Cells
    Camillo Ricordi
    Juan Dominguez-Bendala
    Antonello Pileggi

    23
    Regenerative Medicine for Diseases of the Retina
    Thomas A. Reh
    Deepak Lamba

    24
    Peripheral Blood Stem Cells
    Shay Soker
    Gunter Schuch
    J. Koudy Williams

    25
    Prospects of Somatic cell Nuclear Transfer Derived Embryonic Stem Cells in Regenerative Medicine
    Jose Cibelli
    Z. Beyhan

    26
    Somatic Cells: Growth and Expansion Potential of T Lymphocytes
    Rita B. Effros

    27
    Mechanical and Chemical Determinants of Tissue Development
    David Kaplan
    Jonathan A. Kluge
    Gary G. Leisk

    28
    Morphogenesis, Bone morphogenetic Proteins and Regenerative Medicine
    A. Hari Reddi

    29
    Physical Stress as a Factor in Tissue Growth and Remodeling
    Robert Guldberg
    Christopher S. Gemmiti
    Yash Kolambkar
    Blaise Porter

    30
    Engineering Cellular Microenvironments
    Christopher S. Chen
    Wendy F. Liu
    Elliot E. Hui
    Sangeeta N. Bhatia

    31
    Applications of Nanotechnology for Regenerative Medicine
    Ben Harrison

    32
    Gene Chips in Regenerative Medicine
    Jason Hipp
    Anthony Atala

    Biomaterials for Regenerative Medicine

    33
    Design Principles in Biomaterials and Scaffolds
    Tae Gwan Park
    Hyukjin Lee

    34
    Natural Polymers
    Stephen Badylak

    35
    Synthetic Polymers
    A.G. Mikos
    M.C. Hacker

    36
    Hybrid, Composite, and Complex Biomaterials for Scaffolds
    Hae Bang Lee
    Gilson Khang
    Hee Kim
    Moon Suk Kim

    37
    Surface Modification of Biomaterials
    Andres Garcia

    38
    Cell-Substrate Interactions in Regenerative Medicine
    Kam W. Leong
    Aparna Nori
    Evelyn K.F. Yim
    Sulin Chen

    39
    Histogenesis in Three Dimensional Scaffolds
    Jennifer West
    Nicole M. Bergman

    40
    Biocompatibility and Bioresponse to Biomaterials
    James Anderson

    41
    Healing
    William J. Lindblad

    42
    Precision Control of Proteins at Interfaces for Tissue Engineering and Regenerative Medicine
    Buddy Ratner

    Therapeutic Applications: Cell Therapy

    43
    Biomineralization and Bone Regeneration
    Peter X. Ma
    Jiang Hu
    Xiaohua Liu


    44
    Blood Substitutes: Reverse Evolution from Oxygen Carrying to Non-Oxygen Carrying Plasma Expanders
    Mark Van Dyke
    Amy Tsai
    Marcos Intaglietta

    45
    Articular Cartilage
    Myron Spector
    Francois Ng kee Kwong

    46
    Implantation of myogenic Cells in Skeletal Muscles
    Jacques Tremblay
    Daniel Skuk

    47
    Clinical Islet Transplantation
    A.M. James Shapiro
    Juliet A. Emamaulle

    48
    Cell-Based Repair for Regeneration and Neovascularization: What, Why, How and Where are We Going in the Next 5 - 10 Years?
    Andrey G. Zenovich

    49
    Retinal pigment epithelium derived from embryonic stem cells
    Irina Klimanskaya

    50
    Cell Therapies for Bone Regeneration
    Scott P. Bruder
    Rehan N. Khanzada
    Chantal E. Holy
    F. Jerry Volenec

    51
    Cell-Based Therapies for Musculoskeletal Repair
    Rocky Tuan
    Wan -Ju Li
    David P. Patterson
    George T.J. Huang
    Kiran Gollapudi

    52
    Hepatocyte Transplantation
    Steven C. Strom
    Ewa C.S. Ellis

    53
    Bioartificial Livers
    Lola Reid
    Randall E. McClelland

    54
    Neuronal Transplantation for Stroke
    Douglas Kondziolka
    Lawrence Wechsler

    55
    Cell-Based Drug Delivery
    Grace Lim

    Therapeutic Applications: Tissue Therapy

    56
    Fetal Tissues
    Chester Koh
    Seyung Chung

    57
    Engineering of Large Diameter Vessels
    George Christ
    Saami K. Yazdani

    58
    Engineering of Small Diameter Vessels
    Robert Tranquillo
    Chrysanthi Williams

    59
    Vascular Assembly in Engineered and Natural Tissues
    Larry V. McIntire
    Eric M Brey

    60
    Cardiac Tissue
    Michael V. Sefton
    Milica Radisic

    61
    Regenerative Medicine in the Cornea
    May Griffith
    Heather Sheardown

    62
    Alimentary Tract
    Mike Chen

    63
    Liver Cell-based Therapy in Regnerative Medicine - Bioreactors as Enabling Technology
    Jorg Gerlach
    Mariah Hout
    Keneth Gage
    Katrin Zeilinger

    64
    Kidney-Intracorporeal
    James Yoo

    65
    Kidney
    H. David Humes
    William H. Fissell

    66
    Genitourinary System
    Anthony Atala

    67
    Tissue Engineering of the Reproductive System
    Roger De Filippo

    68
    Therapeutic Opportunities for Bone Grafting
    Jeffrey O. Hollinger
    John P. Schmitz
    Thomas A. Einhorn
    Gary E. Friedlaender
    Chris R. Brown
    Scott D. Bowden
    Samuel Lynch

    69
    Cartilage Tissue Engineering
    Jennifer Elisseeff
    Paulesh Shah
    Alexander Hillel
    Ronald Silverman

    70
    Phalanges and Small Joints
    Makoto Komura
    James Yoo

    71
    Functional Tissue Engineering of Ligament and Tendon Injuries
    Savio L.-Y. Woo
    Alejandro J. Almarza

    72
    Tissue Therapy: Implications of Regenerative Medicine for Skeletal Muscle
    Johnny Huard
    Shen Wei

    73
    Central Nervous System
    Molly Shoichet
    Jordan H. Wosnick
    M. Douglas Baumann

    74
    Peripheral Nerve Regeneration
    Ravi Bellamkonda
    Mahesh C. Dodla

    75
    Dental Tissue Engineering
    Pamela Yelick
    Yan Lin

    76
    Innovative Regenerative Medicine Approaches to Skin Cell-Based Therapy for Patiens with Burn Injuries
    Jorg Gerlach
    Steven E. Wolf
    Christa Johnen
    Bernd Hartman

    77
    Military Needs and Solutions in Regenerative Medicine
    Alan Russell
    Sara Wargo

    Regulations and Ethics

    78
    Ethical Considerations
    Louis M. Guenin

    79
    Religious Considerations
    Laurie Zoloth

    80
    U.S. Stem Cell Research Policy: An Introduction
    Josephine Johnston

    81
    Overview of FDA Regulatory Process
    Celia Witten
    Ashok Batra
    Charles N. Durfor
    Stephen H. Hilbert
    Davis S. Kaplan
    Donald Fink
    Deborah Vavoie
    Ellen Maher
    Richard McFarland

    82
    Current Issues in U.S. Patent Law
    Patrea Pabst

Product details

  • No. of pages: 1472
  • Language: English
  • Copyright: © Academic Press 2007
  • Published: November 19, 2007
  • Imprint: Academic Press
  • eBook ISBN: 9780080555959

About the Editors

Anthony Atala

Anthony Atala, M.D., is the Director of the Wake Forest Institute for Regenerative Medicine, and the W.H. Boyce Professor and Chair of the Department of Urology at Wake Forest University. Dr. Atala is a practicing surgeon and a researcher in the area of regenerative medicine. His current work focuses on growing new human cells, tissues and organs.

Dr. Atala works with several journals and serves in various roles, including Editor-in-Chief of Current Stem Cell Research and Therapy, and Therapeutic Advances in Urology; as Associate Editor of the Journal of Tissue Engineering and Regenerative Medicine, The Journal of Rejuvenation Research, Nanotechnology in Engineering and Medicine, Gene Therapy and Regulation, and Current Reviews in Urology; as Executive Board Member or Section Editor of the journal Tissue Engineering and International Journal of Artificial Organs, and as Editorial Board member of the International Journal of Stem Cells, Stem Cell Review Letters, Expert Opinion on Biological Therapy, Biomedical Materials, Recent Patents on Regenerative Medicine, the Journal of the American College of Surgeons, the Journal of Urology, BMC Urology, Urology, and Current Opinion in Urology.

Dr. Atala is a recipient of the US Congress funded Christopher Columbus Foundation Award, bestowed on a living American who is currently working on a discovery that will significantly affect society, and the Gold Cystoscope Award for advances in his field. Dr. Atala was named by Scientific American as a Medical Treatments Leader of the Year for his contributions to the fields of cell, tissue and organ regeneration. In 2006, he was named by Fast Company magazine as one of 50 people who “will change how we work and live over the next 10 years. Dr. Atala’s work was listed as Discover Magazine`s Number 1 Top Science Story of the Year in the field of medicine, and as Time Magazine’s top 10 medical breakthroughs of the year in 2007. A Time Magazine poll ranked Dr. Atala as the 56th most influential person of the year in 2007. Esquire Magazine in 2008 named Dr. Atala one of the 75 most influential persons of the 21st century. Fast Company Magazine named Dr. Atala one of 100 Most Creative People in Business in 2009. Dr. Atala was featured in U.S. News & World Report as one of “14 Medical Pioneers Who Aren’t Holding Back.”

Dr. Atala has led or served several national professional and government committees, including the National Institutes of Health working group on Cells and Developmental Biology, and the National Institutes of Health Bioengineering Consortium. He is currently an NIH “Quantum Grant” awardee. Dr. Atala heads a team of over 250 physicians and researchers. Ten applications of technologies developed in Dr. Atala's laboratory have been used clinically. He is the editor of nine books, including Minimally Invasive Urology, Methods of Tissue Engineering, Principles of Regenerative Medicine, and Foundations of Regenerative Medicine, and has published more than 300 journal articles and has applied for or received over 200 national and international patents.

Affiliations and Expertise

Director, Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA

Anthony Atala

Anthony Atala, M.D., is the Director of the Wake Forest Institute for Regenerative Medicine, and the W.H. Boyce Professor and Chair of the Department of Urology at Wake Forest University. Dr. Atala is a practicing surgeon and a researcher in the area of regenerative medicine. His current work focuses on growing new human cells, tissues and organs.

Dr. Atala works with several journals and serves in various roles, including Editor-in-Chief of Current Stem Cell Research and Therapy, and Therapeutic Advances in Urology; as Associate Editor of the Journal of Tissue Engineering and Regenerative Medicine, The Journal of Rejuvenation Research, Nanotechnology in Engineering and Medicine, Gene Therapy and Regulation, and Current Reviews in Urology; as Executive Board Member or Section Editor of the journal Tissue Engineering and International Journal of Artificial Organs, and as Editorial Board member of the International Journal of Stem Cells, Stem Cell Review Letters, Expert Opinion on Biological Therapy, Biomedical Materials, Recent Patents on Regenerative Medicine, the Journal of the American College of Surgeons, the Journal of Urology, BMC Urology, Urology, and Current Opinion in Urology.

Dr. Atala is a recipient of the US Congress funded Christopher Columbus Foundation Award, bestowed on a living American who is currently working on a discovery that will significantly affect society, and the Gold Cystoscope Award for advances in his field. Dr. Atala was named by Scientific American as a Medical Treatments Leader of the Year for his contributions to the fields of cell, tissue and organ regeneration. In 2006, he was named by Fast Company magazine as one of 50 people who “will change how we work and live over the next 10 years. Dr. Atala’s work was listed as Discover Magazine`s Number 1 Top Science Story of the Year in the field of medicine, and as Time Magazine’s top 10 medical breakthroughs of the year in 2007. A Time Magazine poll ranked Dr. Atala as the 56th most influential person of the year in 2007. Esquire Magazine in 2008 named Dr. Atala one of the 75 most influential persons of the 21st century. Fast Company Magazine named Dr. Atala one of 100 Most Creative People in Business in 2009. Dr. Atala was featured in U.S. News & World Report as one of “14 Medical Pioneers Who Aren’t Holding Back.”

Dr. Atala has led or served several national professional and government committees, including the National Institutes of Health working group on Cells and Developmental Biology, and the National Institutes of Health Bioengineering Consortium. He is currently an NIH “Quantum Grant” awardee. Dr. Atala heads a team of over 250 physicians and researchers. Ten applications of technologies developed in Dr. Atala's laboratory have been used clinically. He is the editor of nine books, including Minimally Invasive Urology, Methods of Tissue Engineering, Principles of Regenerative Medicine, and Foundations of Regenerative Medicine, and has published more than 300 journal articles and has applied for or received over 200 national and international patents.

Affiliations and Expertise

Director, Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA

Robert Lanza

Robert Lanza
Robert Lanza is an American scientist and author whose research spans the range of natural science, from biology to theoretical physics. TIME magazine recognized him as one of the “100 Most Influential People in the World,” and Prospect magazine named him one of the Top 50 “World Thinkers.” He has hundreds of scientific publications and over 30 books, including definitive references in the fields of stem cells, tissue engineering, and regenerative medicine. He’s a former Fulbright Scholar and studied with polio-pioneer Jonas Salk and Nobel laureates Gerald Edelman (known for his work on the biological basis of consciousness) and Rodney Porter. He also worked closely (and co-authored papers in Science on self-awareness and symbolic communication) with noted Harvard psychologist BF Skinner. Dr. Lanza was part of the team that cloned the world’s first human embryo, the first endangered species, and published the first-ever reports of pluripotent stem cell use in humans.

Affiliations and Expertise

Astellas Institute for Regenerative Medicine, Westborough, MA, USA

Robert Nerem

James Thomson

Affiliations and Expertise

Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, USA

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