Principles of Nutrigenetics and Nutrigenomics - 1st Edition - ISBN: 9780128045725

Principles of Nutrigenetics and Nutrigenomics

1st Edition

Fundamentals of Individualized Nutrition

Editors: Raffaele Caterina Alfredo Martinez Martin Kohlmeier
Hardcover ISBN: 9780128045725
Imprint: Academic Press
Published Date: 1st September 2019
Page Count: 736
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Principles of Nutrigenetics and Nutrigenomics is the most comprehensive foundational text on the complex topics of nutrigenetics and nutrigenomics. Edited by three leaders in the field with contributions from researchers around the world, the book covers how the genetic make-up influences the response to foods and nutrients and how nutrients affect gene expression. 

This book is broken into four parts providing a valuable overview of genetics,  nutrigenetics, and nutrigenomics, and a conclusion that will help translate research into practice. With an overview of the background, evidence, challenges, and opportunities in the field, readers will come away with a strong understanding of how this new science is the frontier of medical nutrition. Principles of Nutrigenetics and Nutrigenomics is a valuable reference for students and researchers studying nutrition, genetics, medicine, and related fields.

Key Features

  • Provides a uniquely foundational, comprehensive, and systematic approach with full evidence-based coverage of established and emerging topics in nutrigenetics and nutrigenomics
  • Includes a valuable guide to ethics for genetic testing for nutritional advice
  • Provides definitions, methods, summaries, figures, and tables to help students, researchers, and faculty grasp key concepts in each chapter
  • Works together with a companion website that includes slide decks, images, questions, and other teaching and learning aids designed to facilitate communication and comprehension of the content presented in the book


Researchers and students studying nutrition, genetics, genomics, personalized nutrition; clinicians including physicians, dieticians; food scientists and supplement pioneering personalized functional food and nutraceuticals product development

Table of Contents

Section 1: The Biological Basis of Heritability and Diversity
1. The nature of traits, genes and variation
2. Epigenetic Mechanisms
3. Genotyping and sequencing
4. RNA analyses
5. Proteomic analyses
6. Metabolomic analyses
7. Epigenetics Methodology
8. Metagenomics
9. The role of nutrition in DNA damage and DNA repair
10. Study design in genetic epidemiology
11. Analytical methods in genetic epidemiology
12. Epistemology of nutrigenetic knowledge
13. Molecular biology of genetic variants

Section 2: Nutrigenetics
14. Genomics of Eating Behavior and Appetite Regulation
15. (14 BIS) Control of food intake and physiologic functions by food tastants through ectopic taste receptors
16. Energy
17. Carbohydrates
18. Protein metabolism
19. Amino Acids - Inborn Errors / Amino Acids - Polymorphic Variations in Metabolism
20. Monounsaturated and Saturated Fatty Acids
21. Omega-3 and omega-6 fatty acids
22. Cholesterol and plant sterols
23. Phytanic acid
24. Alcohol
25. Vitamin A and other carotenoids
26. Vitamin D
27. Vitamin E
28. Vitamin K
29. Vitamin C
30. Vitamin B2 (Riboflavin)
31. Niacin
32. Folate, vitamin B6, B12
33. Biotin and pantothenate
34. Choline
35. Electrolytes
36. Iron
37. Trace elements
38. Polyphenols
39. Caffeine
40. Epigenetics in food allergies: the missing piece of the puzzle
41. Genetic variations impacting the response to defined diets
42. Genetic variations in the response to weight-loss diets
43. Perinatal nutrition
44. Gut microbiota and their influence on the response to foods
45. Aging
46. Body composition, obesity and anorexia
47. Genetic variations in the response to exercise: impact on physical fitness and performance
48. Cognitive function
49. Hyperuricemia and gout
50. Cardiovascular disease
51. Hemostasis and thrombosi
52. Diabetes mellitus
53. Nutrigenetics of Cancer
54. Bone health
55. Psychiatric diseases
56. Genetics of Chrononutrition
57. Genetics of impact on immunocompetence
58. Nutrigenetics and the liver

Section 3: Nutrigenomics
59. Regulation of Gene Expression
60. Nutrients and gene expression in Obesity
61. Nutrients and gene expressio in Diabetes
62. Gene expression in dyslipemias
63. Nutrients and gene expression in Inflammation
64. Nutrients and gene expression in Cardiovascular Disease
65. Nutrients and Gene Expression in Cancer
66. Nutrients and Gene Expression Affecting Bone Metabolism
67. Nutrients and gene expression in developmental (in embroyonic and fetal development)
68. Methods in Nutrigenomics
69. A broader view on Omics and Systems Biology

Section 4: Traditional Nutrigentics and Nutrigenomics
70. When is the evidence sufficient for use in practice
71. Newborn Screening
72. Nutrigenetics-Based Intervention Studies
73. Genome-based nutrition guidance
74. Nutripharmacogentics
75. Food technology solutions
76. Setting genome-directed guidelines and algorithms
77. Direct-to-consumer services
78. Ethical considerations in nutrigenetics and nutrigenomics "
79. Privacy risks and protective measures
80. Legal frameworks in different countries
81. Impact of Nutrigenetics and Nutrigenomics on Society
82. Vitamins as Cofactors for Energy Homeostatsis and its Genetic Control


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© Academic Press 2020
Academic Press
Hardcover ISBN:

About the Editor

Raffaele Caterina

Raffaele De Caterina, MD, PhD, FESC, is a professor of cardiology and director of University Cardiology Division at the G. d'Annunzio University, Chieti, Italy. He is also a consultant and scientific advisor for the Fondazione “G. Monasterio”, Pisa, Italy, and director of the Section of Experimental Cardiology, Center of Excellence on Aging, “G. d’Annunzio” University. He has served as president of the International Society on Nutrigenetics/Nutrigenomics (ISNN) and vice-president of the European Society of Cardiology (2008-2010). He has been editor-in-chief of the journal Vascular Pharmacology since January 2011 and has published over 490 peer-reviewed manuscripts, over 150 book chapters, and 12 books. Professor De Caterina’s current research interests include nutrigenetics and nutrigenomics, thrombosis, atherosclerosis, cardiovascular pharmacology, atrial fibrillation, and pathogenesis of coronary artery disease.

Affiliations and Expertise

University Cardiology Division, G. d’Annunzio University, Chieti, Italy

Alfredo Martinez

Alfredo Martinez, MD, PhD, is a professor of nutrition at the University of Navarra in Pamplona, Spain, where he is the head of the Department of Physiology and Nutrition. He is the current president of the International Society on Nutrigenetics/Nutrigenomics (ISNN) and president-elect of the International Union of Nutritional Sciences. He has published over 620 peer-reviewed papers and serves on the editorial boards of Nutritional Neurosciences, Annals of Nutrition and Metabolism, Nutrition, European Journal of Nutrition, Nutrition and Metabolism, Current Food and Nutrition, and the Journal of Nutrigenetics and Nutrigenomics. His research interests include nutritional and hormonal control in obesity and associated complications, nutritional utilization of functional foods, evaluation of nutritional status in different populations, nutritional/clinical interactions between nutrition and genetics, and nutritionally-oriented epidemiological surveys.

Affiliations and Expertise

Department of Nutrition, University of Navarra, Pamplona, Spain

Martin Kohlmeier

Martin Kohlmeier

Martin Kohlmeier, MD, PhD is a professor at the University of North Carolina at Chapel Hill, is director of the Nutrition in Medicine project, and heads the Nutrigenetics laboratory at the UNC Nutrition Research Institute. His nutrition research has focused on the importance of inherited variation as a modulator of nutrient disposition and on the assessment of nutritional status of normal populations and its impact on health. He has identified low endogenous cholesterol synthesis as a cause of increased cholesterol sensitivity, the apolipoprotein E polymorphism as the main genetic modulator of vitamin K status, lactase persistence as a modulator of phytoestrogen bioavailability, and a very common MTHFD1 variant as a predictor of choline requirements. He has developed online tools that provide genotype-specific personalized nutrition guidance without revealing genetic information.

Affiliations and Expertise

Department of Nutrition, University of North Carolina Schools of Medicine and Public Health, Chapel Hill, NC, USA

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