Principles of Nutrigenetics and Nutrigenomics
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Principles of Nutrigenetics and Nutrigenomics

Fundamentals of Individualized Nutrition

1st Edition - September 19, 2019

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  • Editors: Raffaele Caterina, Alfredo Martinez, Martin Kohlmeier
  • Hardcover ISBN: 9780128045725
  • eBook ISBN: 9780128045879

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Description

Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is the most comprehensive foundational text on the complex topics of nutrigenetics and nutrigenomics. Edited by three leaders in the field with contributions from the most well-cited researchers conducting groundbreaking research in the field, the book covers how the genetic makeup influences the response to foods and nutrients and how nutrients affect gene expression. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is broken into four parts providing a valuable overview of genetics, nutrigenetics, and nutrigenomics, and a conclusion that helps to translate research into practice. With an overview of the background, evidence, challenges, and opportunities in the field, readers will come away with a strong understanding of how this new science is the frontier of medical nutrition. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is a valuable reference for students and researchers studying nutrition, genetics, medicine, and related fields.

Key Features

  • Uniquely foundational, comprehensive, and systematic approach with full evidence-based coverage of established and emerging topics in nutrigenetics and nutrigenomics
  • Includes a valuable guide to ethics for genetic testing for nutritional advice
  • Chapters include definitions, methods, summaries, figures, and tables to help students, researchers, and faculty grasp key concepts
  • Companion website includes slide decks, images, questions, and other teaching and learning aids designed to facilitate communication and comprehension of the content presented in the book

Readership

Researchers and students studying nutrition, genetics, genomics, personalized nutrition; clinicians including physicians, dieticians; food scientists and supplement professionals pioneering personalized functional food and nutraceuticals product development

Table of Contents

  • Preface
    Catherina Geissler

    Introduction
    Raffaele De Caterina, J. Alfredo Martinez and Martin Kohlmeier

    Section 1: The biological basis of heritability and diversity
    1. The nature of traits, genes and variation
    Jose Luis, Vizmanos, Nick Cross and Francisco J. Novo
    2. Molecular biology of genetic variants
    Martin Kohlmeier
    3. Regulation of Gene Expression
    Maria L. Bonet and Andreu Palou
    4. The role of nutrition in DNA replication, DNA damage prevention and DNA repair
    Michael Fenech
    5. Genotyping and sequencing
    Xabier Aguirre and others
    6. RNA analyses
    Angel Gil, Francisco Javier Ruiz-Ojeda Sr. and Julio Plaza Díaz
    7. Methods in Nutrigenomics for precision nutrition
    Adela Chirita-Emandi and Mihai Niculescu
    8. Epigenetics: Methodology and tools for nutrition research
    María Luisa Mansego, J. Alfredo Martinez and Fermin I. Milagro
    9. Proteomic analyses
    Fernando J. Corrales and Leticia Odriozola
    10. Metabolomic analyses
    Susan Sumner
    11. Metagenomics
    Isabel Moreno-Indias and Francisco José Tinahones
    12. A Broader View on Omics and Systems Biology
    Cristina Andres-Lacueva and others
    13. Study design in genomic epidemiology
    Jose L. Santos and Fernando Rivadenerira
    14. Epistemology of nutrigenetic knowledge
    Martin Kohlmeier

    Section 2: Nutrigenetics
    15. Nutrigenetics and the early life origins of health and disease: effects of protein restriction
    Simon Langley-Evans
    16. Perinatal nutrition
    Paul Cordero Sánchez, M Vinciguerra and Jude Oben
    17. Epigenetics Mechanisms
    Sang Woon Choi and Lara K. Hyde
    18. Genetics of Chrononutrition
    Marta Garaulet
    19. Newborn screening
    Adela Chirita-Emandi
    20. Genomics of Eating Behavior and Appetite Regulation
    Nanette I. Steinle
    21. Genetics of Body Composition: From Severe Obesity to Extreme Leanness
    Jose L. Santos and Victor Cortés
    22. Genetic regulation of energy homeostasis: obesity implications
    Itziar Abete, Navas-Carretero, Zulet MA and Martínez JA
    23. Genetic variations in the response to weight-loss diets
    Daniel A. de Luis, Aller R, Izaola O, Martínez JA
    24. Genetic variations in the response to exercise: impact on physical fitness and performance
    Louis Perusse
    25. Genetic variations impacting the response to defined diets
    Tiange Wang and Lu Qi
    26. Carbohydrates
    Ana Ramírez de Molina and Clara Ibáñez
    27. Monounsaturated and Saturated Fatty Acids
    Jose M. Ordovás
    28. Omega-3 and omega-6 fatty acids 
    William S. Harris
    29. Blood cholesterol to Blood cholesterol and Plant Sterols
    Itzel Vazquez-Vidal  and Peter Jones
    30. Genetic Individuality and Alcoholic Consumption
    Rosa M. Lamuela-Raventós, Ramón Estruch Riba and Richard Kirwan
    31. Vitamin A and other carotenoids
    Johannes von Lintig and Darwin Babino
    32. Vitamin D
    Karina Fischer
    33. Vitamin E
    Patrick Borel, Charles Desmarchelier
    34. Vitamin K
    Jorg Saupe
    35. Vitamins as Cofactors for Energy Homeostasis: Biotin, Thiamine and Pantothenic Acid
    Antonio Velázquez-Arellano and Alain de J. Hernández-Vazquez
    36. Vitamin C
    Martin Kohlmeier
    37. Vitamin B2
    Annet M. Bosch
    38. Niacin
    George Rasti, Nicolas G. Simonet and Alejandro Vaquero
    39. Folate, vitamin B6, vitamin B12
    Natalia Krupenko
    40. Choline 
    Steven H. Zeisel
    41. Electrolytes
    Olivia Dong
    42. Iron
    Martin Kohlmeier
    43. Trace elements
    Martin Kohlmeier
    44. Polyphenols and Nutrigenetic/Nutrigenomic Associations with Obesity-Related Metabolic Diseases
    Myung-Sook Choi and Eun-Young Kwon
    45. Caffeine
    Raffaele De Caterina
    46. Phytanic acid
    Ronald J.A. Wanders
    47. Cognitive function
    Carol L. Cheatham
    48. Cardiovascular Disease
    Raffaele De Caterina and Rosalinda Madonna
    49. Hemostasis and thrombosis
    Antonio Capurso and Cristiano Capurso
    50. Diabetes mellitus
    Helen M. Roche
    51. Bone health
    Jose-Luis Perez-Castrillon and Jose A. Riancho
    52. Nutrients and Genes in the Liver
    Marice Cariello, Eleno Piccinin, Oihane García-Irigoyen and Antonio Moschetta
    53. Hyperuricemia and gout
    Venkata Saroja Voruganti and Geetha Chittoor
    54. Aging
    Deyang Yu, Luigi Fontana and D.W Lamming
    55. Epigenetics in food allergies: the missing piece of the puzzle
    Shimrit Bar-El and Ram Reifen
    56. Gut microbiota and their influence on the response to foods
    Yolanda Sanz, Kevin Portune and Alfonso Benítez-Paez

    Section 3: Nutrigenomics
    57. Nutrients and Gene Expression in Development
    Dolores Busso, Nicolas Santander, Francisca Salas and Jose L. Santos
    58. Nutrients and gene expression in Obesity
    Fermin I. Milagro, Moreno-Aliaga MJ and Martinez JA
    59. Nutrients and gene expression in Diabetes
    Dominique Langin
    60. Gene expression in dyslipidemias 
    Rui Curi and Catia Lira Amaral
    61. Nutrients and gene expression in Inflammation 
    Charles N. Serhan
    62. Nutrients and gene expression in Cardiovascular Disease
    Raffaele De Caterina
    63. Nutrients and Gene Expression in Cancer
    Ana B. Crujeiras and David de Lorenzo
    64. Nutrients and Gene Expression Affecting Bone Metabolism
    Jose-Luis Perez-Castrillon and others

    Section 4: Translational nutrigenetics and nutrigenomics
    65. Nutrigenetics-based intervention studies
    Rodrigo San-Cristobal, Santiago Navas-Carretero, Martin Kohlmeier and J. Alfredo Martinez
    66. Genome-based nutrition guidance
    Martin Kohlmeier
    67. Nutrigenomics of food pesticides
    Rosita Gabbianelli and Laura Bordoni
    68. Pharmaconutrigenetics: the impact of genetics on nutrient-drug interactions
    Olivia Dong and Tim Wiltshire
    69. Setting genome-directed guidelines and algorithms
    Martin Kohlmeier
    70. Direct-to-consumer services 
    Lynnette Ferguson
    71. Privacy risks and protective measures 
    Francesco Visioli
    72. Ethical considerations in nutrigenetics and nutrigenomics
    Ulf Gorman
    73. Impact of Nutrigenetics and Nutrigenomics on Society
    Artemis Simopoulous

Product details

  • No. of pages: 586
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: September 19, 2019
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128045725
  • eBook ISBN: 9780128045879

About the Editors

Raffaele Caterina

Raffaele De Caterina is a Professor of Cardiology at the University of Pisa and Director of the University Cardiology Division at Pisa University Hospital, Pisa, Italy. He has been President of the International Society on Nutrigenetics/Nutrigenomics (2009-2013) and vice-President of the European Society of Cardiology (2008-2010). He is Editor-in-Chief of the journal Vascular Pharmacology and author of over 600 peer-reviewed manuscripts. His major research interests include cardiovascular pharmacology, atrial fibrillation, coronary artery disease, and cardiovascular thrombosis, as well as nutrigenetics and nutrigenomics.

Affiliations and Expertise

University Cardiology Division, University of Pisa, Pisa, Italy

Alfredo Martinez

Prof. J. Alfredo Martínez has been involved in several landmark intervention trials and more than 50 national and international projects. He has supervised more than 70 PhD students and published more than 800 peer-reviewed manuscripts and book chapters in the areas of obesity and personalized nutrition, including precision nutritional omics. His works have been cited more than 26,000 times, and his HFactor is over 64. He has been President of the International Society of Nutrigenetics/Nutrigenomics (2015-2017) and is President of the International Union of Nutritional Sciences (IUNS) for the 2017-2021 period. Prof. Martínez has enjoyed training or invited stays at the University of Nottingham, Berkeley College, MIT, Harvard University, Oxford University, and King’s College London. He has been an advisor for EU Projects or a guest speaker or main keynote lecturer in important forums concerning precision nutrition in obesity and cardiometabolic diseases, including IUNS, ISNN, OMS, FAO, IAEA, NIH, SLAN, and FENS.

Affiliations and Expertise

Department of Nutrition, University of Navarra, Pamplona, Spain IMDEA food (CEI UAM + CSIC) and CIBERobn, Madrid, Spain

Martin Kohlmeier

Martin Kohlmeier
Dr. Martin Kohlmeier, MD, PhD, is a Professor of Nutrition; Director of the Human Research Core and the Nutrigenetics Laboratory at the UNC Nutrition Research Institute in Kannapolis, NC; Director of Nutrition in Medicine for online nutrition education of medical students and health professionals; visiting fellow of Wolfson College at Cambridge University, UK; founding Editor-in-Chief of BMJ Nutrition, Prevention and Health; and President of the International Society of Nutrigenetics/Nutrigenomics (ISNN). His professional interests include investigating genotype-specific nutrition responses of humans in health and disease, developing decision-support algorithms and tools for precision nutrition, and teaching health care professionals how to use nutrigenetics in practice. His previously authored textbooks in the field include Nutrigenetics (Academic Press, 2013) and Nutrient Metabolism (2nd Edition, Academic Press, 2015).

Affiliations and Expertise

UNC Nutrition Research Institute, and Department of Nutrition, University of North Carolina School of Medicine and Gillings School of Global Public Health, Chapel Hill, NC, USA

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