Principles of Nucleic Acid Structure

Principles of Nucleic Acid Structure

1st Edition - October 15, 2007

Write a review

  • Author: Stephen Neidle
  • eBook ISBN: 9780080553528

Purchase options

Purchase options
DRM-free (EPub, PDF, Mobi)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order

Description

This unique and practical resource provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussion of x-ray crystallography, NMR, molecular modelling, and databases. Its focus is on a survey of structures especially important for biomedical research and pharmacological applications. To aid novices, Principles of Nucleic Acid Structure includes an introduction to technical lingo used to describe nucleic acid structure and conformations (roll, slide, twist, buckle, etc.). This completely updated edition features expanded coverage of the latest advances relevant to recognition of DNA and RNA by small molecules and proteins. In particular, the reader will find extensive new discussions on: RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes, and short interfering RNA (siRNA). This handy guide ends with a complete list of resources, including relevant online databases and software.

Key Features

  • Completely updated with expanded discussion of topics such as RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes, and short interfering RNA (siRNA)
  • Includes a complete list of resources, including relevant online databases and software
  • Defines technical lingo for novices

Readership

Researchers in biochemistry, as well as for advanced undergraduate and graduate students studying nucleic acid structure and function.

Table of Contents

  • Methods for Studying Nucleic Acid Structure.
    The building-blocks of DNA and RNA.
    DNA Structure as Observed in Fibres and Crystals.
    DNA-DNA recognition: non-standard and higher-order DNA structures.
    Principles of small molecule-DNA Recognition.
    The RNA structural world.
    Principles of Protein-DNA Recognition.

Product details

  • No. of pages: 302
  • Language: English
  • Copyright: © Academic Press 2007
  • Published: October 15, 2007
  • Imprint: Academic Press
  • eBook ISBN: 9780080553528

About the Author

Stephen Neidle

Stephen Neidle
Stephen Neidle is an Emeritus Professor of Chemical Biology at University College London, where he has also been the Director of Research in the School of Pharmacy. He has published over 500 primary papers and reviews and is a principal inventor on 14 patent filings. He has also written and edited several books on nucleic acids and anti-cancer drugs.

Affiliations and Expertise

Emeritus Professor of Chemical Biology, The School of Pharmacy, University College London, UK

Ratings and Reviews

Write a review

There are currently no reviews for "Principles of Nucleic Acid Structure"