This unique and practical resource provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussion of x-ray crystallography, NMR, molecular modelling, and databases. Its focus is on a survey of structures especially important for biomedical research and pharmacological applications. To aid novices, the book includes an introduction to technical lingo used to describe nucleic acid structure and conformations (roll, slide, twist, buckle, etc.). This completely updated edition features expanded coverage of the latest advances relevant to recognition of DNA and RNA by small molecules and proteins. In particular, the reader will find extensive new discussions on: RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes, and short interfering RNA (siRNA). This handy guide ends with a complete list of resources, including relevant online databases and software.
- Completely updated with expanded discussion of topics such as RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes, and short interfering RNA (siRNA)
- Includes a complete list of resources, including relevant online databases and software
- Defines technical lingo for novices
Researchers in biochemistry, as well as for advanced undergraduate and graduate students studying nucleic acid structure and function.
Methods for Studying Nucleic Acid Structure. The building-blocks of DNA and RNA. DNA Structure as Observed in Fibres and Crystals. DNA-DNA recognition: non-standard and higher-order DNA structures. Principles of small molecule-DNA Recognition. The RNA structural world. Principles of Protein-DNA Recognition.
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- © Academic Press 2008
- 15th October 2007
- Academic Press
- eBook ISBN:
- Paperback ISBN:
Stephen Neidle, DSc, PhD, ARCS, FRSC, Director of Cancer Research UK Biomolecular Structure Group, Director of the Centre for Cancer Medicines, Professor of Chemical Biology, The School of Pharmacy, University College London, UK
The School of Pharmacy, University College London, UK
Review of the previous edition: "Stephen Neidle's excellent new introductory textbook will prove to be very timely, and provides a calm, balanced and objective study of the major advances."--Crystallography News