Principles of Molecular Virology

Preface to the Fifth Edition Chapter 1 Introduction What Are Viruses? Are viruses alive? The History of Virology Living Host Systems Cell Culture Methods Serological/Immunological Methods Ultrastructural Studies Molecular Biology Summary Chapter 2 Particles The Function and Formation of Virus Particles Capsid symmetry and virus architecture Helical capsids Icosahedral (isometric) capsids Enveloped viruses Complex virus structures Protein-nucleic acid interactions and genome packaging Virus receptors: recognition and binding Other interactions of the virus capsid with the host cell Summary Chapter 3 Genomes The Structure and Complexity of Virus Genomes Molecular genetics Virus genetics Virus mutants Genetic interactions between viruses Nongenetic interactions between viruses Small DNA genomes Large DNA genomes Positive-strand RNA viruses Negative-strand RNA viruses Segmented and multipartite virus genomes Reverse transcription and transposition Evolution and epidemiology Summary Chapter 4 Replication Overview of Virus Replication Investigation of Virus Replication The Replication Cycle Attachment Penetration Uncoating Genome replication and gene expression Assembly Maturation Release Summary Chapter 5 Expression Expression of Genetic Information Control of Prokaryote Gene Expression Control of Expression in Bacteriophage ? Control of Eukaryote Gene Expression Genome Coding Strategies Class I: Double-stranded DNA Class II: Single-stranded DNA Class III: Double-stranded RNA Class IV: Single-stra