Principles of Human Organs-on-Chips

1st Edition - January 17, 2023
Editor: Masoud Mozafari
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 3 5 3 6 - 2
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 3 6 1 0 - 9

Principles of Human Organs-on-Chips covers all aspects of microfluidic organ-on-a-chip systems, from fabrication to application and commercialization. Organ-on-a-chip models ar… Read more

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Principles of Human Organs-on-Chips covers all aspects of microfluidic organ-on-a-chip systems, from fabrication to application and commercialization. Organ-on-a-chip models are created to mimic the structural, microenvironmental and physiological functions of human organs, providing the potential to bypass some cell and animal testing methods. This is a useful platform with widespread applications, frequently in drug screening and pathological studies.

This book offers a comprehensive and authoritative reference on microfluidic organs-on-chips, spanning all key aspects from fabrication methods, cell culture systems and cell-based analysis, to dedicated chapters on specific tissue types and their associated organ-on-a-chip models, as well as their use as disease models, drug screening platforms and more.

Principles of Human Organs-on-Chips helps materials scientists and biomedical engineers to better understand the specific requirements and challenges in the design and fabrication of organ-on-a-chip devices. This book also bridges the knowledge gap between medical device design and subsequent clinical applications, allowing medical professionals to easily learn about related engineering concepts and techniques.

Cover image
Title page
Table of Contents
Copyright
Contributors
Foreword
Preface
Chapter 1. Techniques and materials for the fabrication of microfluidic devices
1.1. Introduction
1.2. Theory of microfluidics
1.3. Materials consideration for organ-on-a-chip devices
1.4. Fabrication techniques and their materials
1.5. Outlook
Chapter 2. Critical factors affecting cells behavior in microfluidic chips
2.1. Introduction
2.2. Cellular microenvironment
2.3. Components of cellular microenvironment
2.4. External stimuli
2.5. Summary
Chapter 3. Cell-based assays on microfluidic chips
3.1. Introduction
3.2. Significance of cell-based assay
3.3. Microfluidic cell-based assay systems
3.4. Applications of microfluidic cell-based assays
3.5. Conclusions
Chapter 4. Cell culture techniques in microfluidic chips
4.1. Overview on cell culture
4.2. Microenvironmental factors affecting cell culture
4.3. Microfluidic systems for culture based on substrate material
4.4. Cell culture techniques in microfluidic systems
4.5. Conventional matrix-free 3D culture methods with microfluidics
4.6. Matrix-based 3D culture in microfluidics
4.7. Microfluidic platforms for cell culture based on fluid flow type
4.8. Digital microfluidics
4.9. Coculture, organs-on-a-chip, and organoids-on-a-chip
4.10. Conclusion
Chapter 5. Advances in skin-on-a-chip and skin tissue engineering
5.1. Background
5.2. Tissue engineering of human skin
5.3. Skin-on-a-chip systems and applications
5.4. Remaining challenges
Chapter 6. Blood vessels-on-a-chip
6.1. Introduction
6.2. Design of microfluidic devices
6.3. Microfluidic cell culture systems designed for mechanical stimuli
6.4. Analyzing vascular phenomena using model systems
6.5. Conclusions
Chapter 7. Liver-on-a-chip
7.1. Introduction
7.2. Liver physiology
7.3. Considerations for higher physiological relevancy in an LOC
7.4. LOC studies
7.5. MOC
7.6. Conclusions
Nomenclature
Chapter 8. Lung-on-a-chip
8.1. Introduction
8.2. Fabrication and system parameters
8.3. Lung-on-chip
8.4. Concluding remarks and future perspectives
Chapter 9. Kidney-on-a-chip
9.1. Introduction
9.2. Kidney-on-a-chip
9.3. Applications of kidney-on-a-chip systems
9.4. Current challenges and future outlook
9.5. Conclusions
Chapter 10. Eye-on-a-chip
10.1. Introduction
10.2. Anatomical structure of the eye, diseases, and treatments
10.3. Engineered models
10.4. Fabrication technique of tissue models
10.5. Recent studies and advances of eye-on-the-chips
10.6. Outlook
Chapter 11. Pancreas-on-a-chip
11.1. Introduction
11.2. Physiology of pancreatic islets
11.3. Design considerations of a POC
11.4. Microenvironment of the islets
11.5. Trapping site for islets
11.6. Integration of analytical tools
11.7. Applications of POCs
11.8. Drug development
11.9. Islet quality assurance for transplantation
11.10. Patient-specific POC
11.11. MOC
11.12. Conclusions
Nomenclature
Chapter 12. Musculoskeletal tissue-on-a-chip
12.1. Introduction
12.2. Bone-on-a-chip devices: challenges and future direction
Chapter 13. Tumour-on-a-chip
13.1. Introduction
13.2. Features of tumor microenvironment
13.3. Cancer progression
13.4. Standard preclinical models for engineering cancer in vitro
13.5. Bioprinting technologies
13.6. Conclusion and future perspectives
Index

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Masoud Mozafari