
Principles of Gender-Specific Medicine
Sex and Gender Specific Biology in the Postgenomic Era
Description
Key Features
- Covers the most important developments in biomedical research in the past decade, with a thoughtful analysis of how they impact patient care
- Discusses the feasibility and usefulness of personalized medicine, the limits and promise of genetic editing, the basis for variation in sexual identity and how artificial intelligence and technology will affect basic human function as well as correcting disability
- Promotes and facilitates discussions about the ethics and governance issues that surround much of what science is now able to do at the most basic levels of human’s physiology
Readership
Table of Contents
Section 1: The new science of epigenetics and the sex-specific mechanisms of gene regulation
1. Overview of various perceptions of epigenetics
2. Sex differences in gene expression in the brain
3. Epigenetics of sex differences in the brain
4. Advances in studying epigenetics biomarkers of prognostic potential for clinical research, epigenetics of rRNA Genes
5. Single cell look at epigenetic inheritance mechanisms
6. Review of the epigenetics evolution
7. Epigenetics of human disease
8. Malignant transformation and epigenetics
9. The role of transposable elements in human diseaseSection 2: How is sex established?
10. Searching for sex in the genome
11. Concept of the “sexome”
12. Ovarian formation
13. How XX and XY supporting cells initiate sex determinationSection 3: What is the role of the environment in shaping the phenome?
14. Early life environment and the epigenome
15. Mechanisms of transmission of sex-specific epigenetic changes to subsequent generations
16. Gene-environment interactions related to epigenetic and classical genetic mechanisms
17. Environmental epigenetics
18. The concept of the exposomeSection 4: New concepts of the biology that produces deviations in sexual development, sexual dysphoria and homosexuality
19. The role of epigenetics in delineating the biological basis of human sexual orientation
20. The epigenetic factors that may canalize homosexuality
21. Molecular biology of sexualization of the brainSection 5: Commentary on the much-touted discipline of personalized medicine
22. Deciphering individual molecular biology to prevent, detect and treat human disease
23. Traditionally constructed large epidemiologic studies
24. Geneome sequencing and analysis at the expense of more useful large epidemiologic studies
25. Biological sex in the pursuit of personalized medicine
26. Underserved communities and personalized medicine
27. Value, pitfalls, and opportunities of pursuing personalized medicineSection 6: The integration of technology into the human body
28. The use of AI/technology to diagnose and treat disease
29. Cyborgs and the evolution of man + machine
30. Overview of the developments and achievements in orthotic and prosthetic technology
31. Use of brain implants to treat neurological problems
32. The Use of technology to augment the human competence
33. The fascinating concept of the post human
34. The future of human intelligence
35. Neural interface that will last a lifetime to generate neural prosthetic devices to possibly enhance brain function
36. Application of cyborg technology and theory to space travel by humans
37. Use of personalized medicine to supplement the lack of sex-specific information in the young field of space medicineSection 7: CRISPR-Cas9 technology
38. Problems/inadequacies/limitations of CRISPRP-Cas9 Genome Editing
39. iochemistry and Molecular Biology Education
40. First steps on making changes in mitochondrial DNA
41. Mitochondrial genetic manipulation
42. Strategy for manipulating the mitochondrial genome with cytidine deaminase toxin
43. The ethics and governance of genetic engineering
Product details
- No. of pages: 800
- Language: English
- Copyright: © Academic Press 2023
- Published: August 1, 2022
- Imprint: Academic Press
- Hardcover ISBN: 9780323885348
About the Editor
Marianne Legato
Affiliations and Expertise
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