Principles of Gender-Specific Medicine

Principles of Gender-Specific Medicine

Gender in the Genomic Era

3rd Edition - May 15, 2017

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  • Editor: Marianne Legato
  • eBook ISBN: 9780128035429
  • Hardcover ISBN: 9780128035061

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The announcement that we had decoded the human genome in 2000 ushered in a new and unique era in biomedical research and clinical medicine. This Third Edition of Principles of Gender-Specific Medicine focuses, as in the past two editions, on the essentials of sexual dimorphism in human physiology and pathophysiology, but emphasizes the latest information about molecular biology and genomic science in a variety of disciplines. Thus, this edition is a departure from the previous two; the editor solicited individual manuscripts from innovative scientists in a variety of fields rather than the traditional arrangement of sections devoted to the various subspecialties of medicine edited by section chiefs. Wherever it was available, these authors incorporated the latest information about the impact of the genome and the elements that modify its expression on human physiology and illness. All chapters progress translationally from basic science to the clinical applications of gender-specific therapy and suggest the most important topics for future investigation. This book is essential reading for all biomedical investigators and medical educators involved in gender-specific medicine. It will also be useful for primary care practitioners who need information about the importance of sex and gender in the prevention, diagnosis and treatment of illness. Winner of the 2018 PROSE Award in Clinical Medicine from the Association of American Publishers!

Key Features

  • Outlines sex-specific differences in normal human function and explains the impact of age, hormones, and environment on the incidence and outcome of illness
  • Reflects the latest information about the molecular basis of the sexual dimorphism in human physiology and the experience of disease
  • Reviews the implications of our ever-improving ability to describe the genetic basis of vulnerability to disease and our capacity to alter the genome itself
  • Illustrates the importance of new NIH guidelines that urge the inclusion of sex as a variable in research protocols


Researchers, practitioners, and graduate students in physiology, cardiology, neurology, respiratory medicine, gastroenterology, endocrinology, oncology, immunology, and emergency medicine who research and/or teach gender-specific medicine or sex-based biology

Table of Contents

  • 1. Normal and variant sex development

    Olaf Hiort

    2. Gender Diagnoses

    Jack Drescher

    3. Gender Identity in Disorders of Sex Development

    Leanna W. Mah, Yvonne Y. Chan, and Jennifer H. Yang

    4. Female sexual function: the role of animal models in assessing female sexual dysfunction

    Lesley Marson and Ursula Wesselman

    5. Fertility Treatment and Preservation in Transgender Men and Women

    Dov Feldberg

    6. Standards of Care for the Health of Transsexual, Transgender and Gender-Nonconforming People: An Introduction

    Eli Coleman

    7. Sex-dependent and -independent Mechanisms in External Genitalia Development

    Congxing Lin and Liang Ma

    8. The Transsexual Adult

    Swaytha Yalamanchi, Betiel Fesseha, Adrian Dobs

    9. Sexual and gender minority individuals in health care: strategies to include sexual orientation and gender identity in health professions education

    Alexandra Muller

    10. Sex Influences Exist at All Levels of Human Brain Function

    Larry Cahill

    11. Sex differences in the brain: Focus on developmental mechanisms

    Margaret M McCarthy

    12. Sexual dimorphisms in the nervous system of the nematode Caenorhabditis elegans

    Meital Oren-Suissa and Oliver Hobert

    13. Oxytocin and Brain Plasticity

    Robert C. Froemke and Ioana Carcea

    14. Emotion and Gender-specific neural processing in men and women

    Sarah Whittle, Julian G. Simmons and Nicholas B. Allen

    15. Behind the Mask: the experience of assessment, diagnosis and living with autism for girls and young women

    Siobhan Tierney and Jan Burns

    16. The significance of gender in perinatal medicine

    Kristie Hadley, Eyal Sheiner

    17. Intrauterine Development of Sex Differences – Fetal Programming

    Marek Glezerman

    18. Battle of the sexes: How the selection of spermatozoa in the female reproductive tract manipulates the sex ratio of offspring

    Lisa M. Thurston, William V. Holt and Alireza Fazeli

    19. All Cells have a sex: Studies of sex chromosome function at the cellular level

    Neil A. Bradbury

    20. Sex-specific implications of exposure to an adverse intrauterine environment

    Catherine E. M. Aiken

    21. Immune response – Impact of biological sex and gender

    Sabine Oertelt-Prigione

    22. Geoepidemiology and the Impact of Sex on Autoimmune Diseases

    Ana Lleo

    23. Gender and gene regulation in human immunity

    Michelle R. Longmire and Howard Chang

    24. Sex and gender specific aspects - from cells to cardiovascular disease

    Vera Regitz-Zagrosek

    25. Estrogen: Impact on Cardiomyocytes and the Heart

    Jin Kyung Kim

    26. The Sexually Dimorphic Characteristics of the Pathophysiology and Treatment of Atrial Fibrillation

    Uma Avula, Meghana Noonavath and Elaine Wan

    27. Gender Differences in Chronic Obstructive Pulmonary Disease- Current Knowledge and Deficits

    Santosh K. Nepal and Shambhu Aryal

    28. Cancer: Gender differences at the molecular level

    Mehmet Tevfik Dorak

    29. An Updated Overview of the Gender-Specific Response to Infection

    Tiffany Guess and Erin McClelland

    30. Gender Based Differences in Mortality in Indian Children Aged 5 to 14 years

    Claire K. Nguyen and Shaun K. Morris

    31. Consideration of biological sex in translating regenerative stem cell therapies

    Galina Shapiro, Gadi Pelled, Dan Gazit

    32. Adipose-derived Stem Cells in Regenerative Medicine

    Hiroshi Mizuno, Morikuni Tobita, Rei Ogawa, Hakan Orbay, Juri Fujimura, Shimpei Ono, Natsuko Kakudo, Kenji Kusumoto and Hiko Hyakusoku

    33. Sex, Gender and Pain

    Roger B. Fillingim

    34. Sex and gender differences in trauma victims presenting for treatment

    Dorte M. Christiansen

    35. Women Do Worse Than Men – Gender-Specific Differences in Burn Patients

    Ines Ana Ederer, Florian Hackl and Reinhard Pauzenberger

    36. Exercise physiology in Men & Women

    Anne-Marie Lundsgaard, Andreas M. Fritzen and Bente Kiens

    37. Musculoskeletal complaints in male and female instrumental musicians

    Laura M. Kok, B.M.A. Huisstede and Rob G.H.H. Nelissen

    38. Nutritional Genomics and Biological Sex

    Jose M. Ordovas

    39. Microbiome: Impact of gender on function & characteristics of gut microbiome

    Veena Taneja

    40. Sex and Gender Differences in Sleep Disorders: An Overview

    Fidaa Shaib and Hrayr Attarian

    41. Gender differences in bladder and kidney cancers

    Stephan M. Korn and Shahrokh F. Shariat

    42. The complex challenge of blood pressure regulation: influences of sex and aging on sympathetic mechanisms

    Emma C. Hart and Nisha Charkoudian

    43. Gender at the Interface of Renal Aging: Physiological and Pathological Perspectives

    Davide Bolignano and Anna Pisano

    44. Gender differences in mobility of elderly: Measurements and interventions to improve mobility

    Emil Jovanov, Karen H.Frith, Priyanka Madhushri, Amy Hunter, Sharon Saunderson Coffey, Aleksandar Milenkovic

    45. Personalized Medicine in Space Flight, Part I: The Space Context and Standard Clinical Approaches

    Schmidt MA, Goodwin TJ, Cuttino M

    46. Personalized Medicine in Space Flight, Part II: Personalized Precision Medicine Approaches

    Schmidt MA, Goodwin TJ, Cuttino M

    47. Robots and Gender

    Tatsuya Nomura

    48. Cyborgs: Understanding and Mutual Treatment

    Kevin Warwick

    49. Personalized Medicine and Challenges in Research and Clinical Implementation

    Susanne B. Haga

    50. Biological Sex Differences in Humans and their Importance in Pharmaceutical Drug Discovery and Development

    Ibis Sánchez-Serrano

Product details

  • No. of pages: 792
  • Language: English
  • Copyright: © Academic Press 2017
  • Published: May 15, 2017
  • Imprint: Academic Press
  • eBook ISBN: 9780128035429
  • Hardcover ISBN: 9780128035061

About the Editor

Marianne Legato

Dr. Marianne Legato, Professor Emerita of Clinical Medicine at Columbia University is an internationally known academic physician, author, lecturer, and specialist in gender-specific medicine. She is founding member of the International Society for Gender Medicine and also the founder and director of The Partnership for Gender-Specific Medicine at Columbia University and its next iteration, The Foundation for Gender-Specific Medicine. She has published extensively on gender and sex specific medicine, both scientifically and for the lay public. She is also the founding editor of the journal Gender Medicine, and the journal Gender and the Genome, published for the scientific community. In 1992, Dr. Legato won the American Heart Association’s Blakeslee Award for the best book written for the lay public on cardiovascular disease. She is a practicing internist in New York City and has been listed each year in New York Magazine’s "Best Doctors" since the feature’s inception in 1993.

Affiliations and Expertise

Emerita Professor, Clinical Medicine, Columbia University College of Physicians & Surgeons and Adjunct Professor, Medicine at Johns Hopkins Medical School

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