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Principles of Gender-Specific Medicine - 3rd Edition - ISBN: 9780128035061, 9780128035429

Principles of Gender-Specific Medicine

3rd Edition

Gender in the Genomic Era

Editor: Marianne Legato
eBook ISBN: 9780128035429
Hardcover ISBN: 9780128035061
Imprint: Academic Press
Published Date: 15th May 2017
Page Count: 792
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The announcement that we had decoded the human genome in 2000 ushered in a new and unique era in biomedical research and clinical medicine. This Third Edition of Principles of Gender-Specific Medicine focuses, as in the past two editions, on the essentials of sexual dimorphism in human physiology and pathophysiology, but emphasizes the latest information about molecular biology and genomic science in a variety of disciplines. Thus, this edition is a departure from the previous two; the editor solicited individual manuscripts from innovative scientists in a variety of fields rather than the traditional arrangement of sections devoted to the various subspecialties of medicine edited by section chiefs. Wherever it was available, these authors incorporated the latest information about the impact of the genome and the elements that modify its expression on human physiology and illness. All chapters progress translationally from basic science to the clinical applications of gender-specific therapy and suggest the most important topics for future investigation.

This book is essential reading for all biomedical investigators and medical educators involved in gender-specific medicine. It will also be useful for primary care practitioners who need information about the importance of sex and gender in the prevention, diagnosis and treatment of illness.

Winner of the 2018 PROSE Award in Clinical Medicine from the Association of American Publishers!

Key Features

  • Outlines sex-specific differences in normal human function and explains the impact of age, hormones, and environment on the incidence and outcome of illness
  • Reflects the latest information about the molecular basis of the sexual dimorphism in human physiology and the experience of disease
  • Reviews the implications of our ever-improving ability to describe the genetic basis of vulnerability to disease and our capacity to alter the genome itself
  • Illustrates the importance of new NIH guidelines that urge the inclusion of sex as a variable in research protocols


Researchers, practitioners, and graduate students in physiology, cardiology, neurology, respiratory medicine, gastroenterology, endocrinology, oncology, immunology, and emergency medicine who research and/or teach gender-specific medicine or sex-based biology

Table of Contents

1. Normal and variant sex development

Olaf Hiort

2. Gender Diagnoses

Jack Drescher

3. Gender Identity in Disorders of Sex Development

Leanna W. Mah, Yvonne Y. Chan, and Jennifer H. Yang

4. Female sexual function: the role of animal models in assessing female sexual dysfunction

Lesley Marson and Ursula Wesselman

5. Fertility Treatment and Preservation in Transgender Men and Women

Dov Feldberg

6. Standards of Care for the Health of Transsexual, Transgender and Gender-Nonconforming People: An Introduction

Eli Coleman

7. Sex-dependent and -independent Mechanisms in External Genitalia Development

Congxing Lin and Liang Ma

8. The Transsexual Adult

Swaytha Yalamanchi, Betiel Fesseha, Adrian Dobs

9. Sexual and gender minority individuals in health care: strategies to include sexual orientation and gender identity in health professions education

Alexandra Muller

10. Sex Influences Exist at All Levels of Human Brain Function

Larry Cahill

11. Sex differences in the brain: Focus on developmental mechanisms

Margaret M McCarthy

12. Sexual dimorphisms in the nervous system of the nematode Caenorhabditis elegans

Meital Oren-Suissa and Oliver Hobert

13. Oxytocin and Brain Plasticity

Robert C. Froemke and Ioana Carcea

14. Emotion and Gender-specific neural processing in men and women

Sarah Whittle, Julian G. Simmons and Nicholas B. Allen

15. Behind the Mask: the experience of assessment, diagnosis and living with autism for girls and young women

Siobhan Tierney and Jan Burns

16. The significance of gender in perinatal medicine

Kristie Hadley, Eyal Sheiner

17. Intrauterine Development of Sex Differences – Fetal Programming

Marek Glezerman

18. Battle of the sexes: How the selection of spermatozoa in the female reproductive tract manipulates the sex ratio of offspring

Lisa M. Thurston, William V. Holt and Alireza Fazeli

19. All Cells have a sex: Studies of sex chromosome function at the cellular level

Neil A. Bradbury

20. Sex-specific implications of exposure to an adverse intrauterine environment

Catherine E. M. Aiken

21. Immune response – Impact of biological sex and gender

Sabine Oertelt-Prigione

22. Geoepidemiology and the Impact of Sex on Autoimmune Diseases

Ana Lleo

23. Gender and gene regulation in human immunity

Michelle R. Longmire and Howard Chang

24. Sex and gender specific aspects - from cells to cardiovascular disease

Vera Regitz-Zagrosek

25. Estrogen: Impact on Cardiomyocytes and the Heart

Jin Kyung Kim

26. The Sexually Dimorphic Characteristics of the Pathophysiology and Treatment of Atrial Fibrillation

Uma Avula, Meghana Noonavath and Elaine Wan

27. Gender Differences in Chronic Obstructive Pulmonary Disease- Current Knowledge and Deficits

Santosh K. Nepal and Shambhu Aryal

28. Cancer: Gender differences at the molecular level

Mehmet Tevfik Dorak

29. An Updated Overview of the Gender-Specific Response to Infection

Tiffany Guess and Erin McClelland

30. Gender Based Differences in Mortality in Indian Children Aged 5 to 14 years

Claire K. Nguyen and Shaun K. Morris

31. Consideration of biological sex in translating regenerative stem cell therapies

Galina Shapiro, Gadi Pelled, Dan Gazit

32. Adipose-derived Stem Cells in Regenerative Medicine

Hiroshi Mizuno, Morikuni Tobita, Rei Ogawa, Hakan Orbay, Juri Fujimura, Shimpei Ono, Natsuko Kakudo, Kenji Kusumoto and Hiko Hyakusoku

33. Sex, Gender and Pain

Roger B. Fillingim

34. Sex and gender differences in trauma victims presenting for treatment

Dorte M. Christiansen

35. Women Do Worse Than Men – Gender-Specific Differences in Burn Patients

Ines Ana Ederer, Florian Hackl and Reinhard Pauzenberger

36. Exercise physiology in Men & Women

Anne-Marie Lundsgaard, Andreas M. Fritzen and Bente Kiens

37. Musculoskeletal complaints in male and female instrumental musicians

Laura M. Kok, B.M.A. Huisstede and Rob G.H.H. Nelissen

38. Nutritional Genomics and Biological Sex

Jose M. Ordovas

39. Microbiome: Impact of gender on function & characteristics of gut microbiome

Veena Taneja

40. Sex and Gender Differences in Sleep Disorders: An Overview

Fidaa Shaib and Hrayr Attarian

41. Gender differences in bladder and kidney cancers

Stephan M. Korn and Shahrokh F. Shariat

42. The complex challenge of blood pressure regulation: influences of sex and aging on sympathetic mechanisms

Emma C. Hart and Nisha Charkoudian

43. Gender at the Interface of Renal Aging: Physiological and Pathological Perspectives

Davide Bolignano and Anna Pisano

44. Gender differences in mobility of elderly: Measurements and interventions to improve mobility

Emil Jovanov, Karen H.Frith, Priyanka Madhushri, Amy Hunter, Sharon Saunderson Coffey, Aleksandar Milenkovic

45. Personalized Medicine in Space Flight, Part I: The Space Context and Standard Clinical Approaches

Schmidt MA, Goodwin TJ, Cuttino M

46. Personalized Medicine in Space Flight, Part II: Personalized Precision Medicine Approaches

Schmidt MA, Goodwin TJ, Cuttino M

47. Robots and Gender

Tatsuya Nomura

48. Cyborgs: Understanding and Mutual Treatment

Kevin Warwick

49. Personalized Medicine and Challenges in Research and Clinical Implementation

Susanne B. Haga

50. Biological Sex Differences in Humans and their Importance in Pharmaceutical Drug Discovery and Development

Ibis Sánchez-Serrano


No. of pages:
© Academic Press 2017
15th May 2017
Academic Press
eBook ISBN:
Hardcover ISBN:

About the Editor

Marianne Legato

Dr. Marianne Legato, Professor Emerita of Clinical Medicine at Columbia University is an internationally known academic physician, author, lecturer, and specialist in gender-specific medicine. She is founding member of the International Society for Gender Medicine and also the founder and director of The Partnership for Gender-Specific Medicine at Columbia University and its next iteration, The Foundation for Gender-Specific Medicine. She has published extensively on gender and sex specific medicine, both scientifically and for the lay public. She is also the founding editor of the journal Gender Medicine, and the journal Gender and the Genome, published for the scientific community. In 1992, Dr. Legato won the American Heart Association’s Blakeslee Award for the best book written for the lay public on cardiovascular disease. She is a practicing internist in New York City and has been listed each year in New York Magazine’s "Best Doctors" since the feature’s inception in 1993.

Affiliations and Expertise

Professor Emerita of Clinical Medicine at Columbia University; New York, NY, U.S.A.


2018 PROSE Awards - Winner, Award for Clinical Medicine: Association of American Publishers


"As much as the first edition of Principles of Gender-Specific Medicine defined the field of sex and gender health a decade ago, this third edition redefines it taking into account the evolution and complexity of genomic, hormonal and immunological science of sex differences.  Marianne Legato uses an innovative approach to organizing cutting edge topics outside of the typical format of medical textbooks, which aids the reader in viewing the science in novel ways.  Even for those working in the field of sex and gender based medicine, there is so much to learn from this rich collection of experts and content. Thank you once again Marianne Legato!" --Alyson J. McGregor, MD, MA, FACEP , Director, Division of Sex and Gender in Emergency Medicine (SGEM), Director, Sex and Gender in Emergency Medicine (SGEM) Fellowship, Associate Professor of Emergency Medicine, Warren Alpert Medical School of Brown University

"The name Marianne Legato has become almost synonymous with Gender and Sex-specific Medicine. She was founder and Editor-in Chief of the first scientific journal dedicated to this new science (and has recently founded a new journal – “Gender and the Genome”). She was and is Editor-in-Chief of the first textbook on Gender Medicine, which appears now in the present third edition and she has been a scout in promoting Gender Medicine throughout the world. Her books have been eye-openers for many of us and this new edition of Principles of Gender-Specific Medicine is again a breakthrough. It includes carefully chosen contributions from leading scholars, researchers and clinicians from all over the globe, who present the state-of-the-art in their respective fields. What "The Harrison" is for Internal Medicine, what "The Williams" is for Obstetrics and what the "The DSM-5" is for Psychiatry, "The Legato" is for Gender Medicine – an absolutely essential Must Have and Must Read for any professional who deals with the differences in physiology and pathophysiology between males and females." --Marek Glezerman, MD, Professor Emeritus of Obstetrics and Gynecology, Chairman of the Ethics Committee, Sackler School of Medicine, Tel Aviv University

"The new Principles of Gender-Specific Medicine, edited by Dr. Marianne Legato from Columbia University, is a compilation of the most up-to-date topics in sex and gender difference research.  The chapters cover the major genomic, cellular, molecular and whole body “hot” topics in the field.  In addition, there are innovative pieces such as “Robots and Gender” by Tatsuya Nomura. Get this book and keep it on your shelf as a ready reference for state-of-the-art research in sex and gender differences that will inspire current and future scientists for years to come." --Jane F. Reckelhoff, PhD, Billy S. Guyton Distinguished Professor, Chair, Department of Biochemistry, Director, Women's Health Research Center, Director, Research Development, Office of Research and Sponsored Programs, University of Mississippi Medical Center

Ratings and Reviews