Principles of Gender-Specific Medicine - 2nd Edition - ISBN: 9780123742711, 9780080921501

Principles of Gender-Specific Medicine

2nd Edition

Editors: Marianne J. Legato
eBook ISBN: 9780080921501
Hardcover ISBN: 9780123742711
Imprint: Academic Press
Published Date: 19th November 2009
Page Count: 800
Sales tax will be calculated at check-out Price includes VAT/GST
Price includes VAT/GST

Institutional Subscription

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.


The field of gender-specific medicine examines how normal human biology and physiology differ between men and women and how the diagnosis and treatment of disease differs as a function of gender. This revealing research covers various conditions that predominantly occur in men as well conditions that predominantly occur in women. Among the areas of greatest difference are cardiovascular disease, mood disorders, the immune system, lung cancer as a consequence of smoking, osteoporosis, diabetes, obesity, and infectious diseases.

The Second Edition of Principles of Gender-Specific Medicine focuses on the essentials of gender-specific medicine and the current study of sex and gender differences in human physiology and pathophysiology. New section editors, new chapter authors, and new chapters have been added to reflect the most up-to-date clinical research and practice.

Key Features

    • Offers insight into how the gender-specific risks of one organ system’s disease affects the health of other organ systems
      • Outlines the sex-specific differences of normal anatomy and physiology
      • Illustrates the gender-specific features and quantifies "gender" and "sex" as risk factors across all major diseases
      • Qualifies and analyzes the results of new drug therapies designed with gender-specific differences in mind: ex, hormone therapy in men and women for the prevention and treatment of cardiovascular disease
      • All chapters progress translationally from the basic science to the clinical applications of gender-specific therapies, drugs, or treatments
      • Sections on drug metabolism, aging, and meta-analysis of data incorporated into all disease-specific chapters



      Researchers and practitioners in physiology, cardiology, neurology, respiratory medicine, gastroenterology, endocrinology, oncology, immunology, nutrition, and metabolism who research and/or teach gender-specific medicine or sex-based biology. Graduate students and medical fellow trainees in these areas. Specialists and/or general practitioners who treat gender-specific diseases.

      Table of Contents

      Section 1: Gender and Normal Development


      George M. Lazarus

      Chapter 1 - The Effects of Gender in Neonatal Medicine

      Tove S. Rosen, David Bateman

      Chapter 2 - Sexual Development, Growth, and Puberty in Children

      Gaya S. Aranoff, Jennifer J. Bell

      Chapter 3 - Gender Differences in Pediatric Pulmonary Disease

      Beverley J. Sheares

      Chapter 4 - Gender-Specific Aspects of Pediatric Hematology and Oncology

      James H. Garvin Jr

      Chapter 5 - Gender Differences in Neurological Conditions of Children

      David M. Kaufman

      Chapter 6 - Gender and Sports: Past, Present, and Future

      Jordan D. Metzl

      Section 2: Gender and the Nervous System


      William Byne

      Chapter 7 - Gender Differences in the Functional Organization of the Brain

      Ruben C. Gur, Tamara Bockow, Raquel E. Gur

      Chapter 8 - Sexual Differentiation of Brain Structure and Function

      Margaret M. McCarthy

      Chapter 9 - The Sexed and Gendered Brain

      William Byne

      Chapter 10 - Age and Gender-Specific Patterns of Neurologic Illness

      Joan Amatniek, Karin Sorra, Lauren Frey, W. Allen Hauser

      Chapter 11 - Gender Differences in Stroke

      Rebecca F. Gottesman, Argye E. Hillis

      Chapter 12 - Gender Differences in Disorders that Present to Psychiatry

      Mary V. Seeman

      Chapter 13 - Hormone Replacement Therapy and Cognitive Function

      Mary Sano, Diane Jacobs, Katya Gaynor

      Section 3: Cardiovascular Disease


      Paula A. Johnson

      Chapter 14 - Gender and the Heart: Sex-Specific Differences in the Normal Myocardial Anatomy and Physiology

      Marianne J. Legato, Jaswinder K. Leghe

      Chapter 15 - Gender-Specific Aspects of Selected Coronary Heart Disease Risk Factors: A Summary of the Epidemiologic Evidence

      Shari S. Bassuk, JoAnn E. Manson

      Chapter 16 - Dyslipidemia Management in Women and Men: Exploring Potential Gender Differences

      Kavita Sharma, Christian D. Nagy, Roger S. Blumenthal

      Chapter 17 - Gender Differences in the Role of Stress and Emotion in Cardiovascular Function and Disease

      David E. Anderson, Margaret A. Chesney

      Chapter 18 - The Role of Sex and Gender in Cardiothoracic Surgery

      Sandhya K. Balaram, Justin D. Blasberg

      Section 4: Pulmonology


      Marilyn K. Glassberg

      Chapter 19 - Gender Differences in Asthma

      Robert H. Lim, Lester Kobzik

      Chapter 20 - Gender Issues in Venous Thromboembolism

      Susan Murin, Kathryn Bilello, Lisa Moores, Aaron Holley

      Chapter 21 - Sleep in Women: Gender Differences in Health and Disease

      Shirin Shafazand

      Chapter 22 - Are Women More Susceptible to Chronic Obstructive Pulmonary Disease?

      Kenneth R. Chapman

      Chapter 23 - The Gender-Specific Aspects of Lung Cancer

      Rebecca L. Toonkel, Charles A. Powell

      Chapter 24 - Gender-Specific Considerations in Pulmonary Hypertension

      Deborah Shure

      Chapter 25 - Sex and Gender Differences in Pulmonary Manifestations of Autoimmune Disease

      Muddassir Aliniazee, Marilyn K. Glassberg

      Chapter 26 - Benign Metastasizing Leiomyoma and Lymphangioleiomyomatosis: Lung Diseases of Women

      Muddassir Aliniazee, Marilyn K. Glassberg

      Chapter 27 - Gender Differences in Susceptibility, Outcomes, and Pathophysiology of Sepsis

      Kristy A. Bauman, MeiLan K. Han

      Section 5: Gastroenterology


      Linda A. Lee

      Chapter 28 - Inflammatory Bowel Disease in Women

      Melissa Munsell, Marc Sonenshine, Mary L. Harris

      Chapter 29 - Disorders of Defecation in Women

      Susan L. Gearhart

      Chapter 30 - Idiopathic Gastroparesis: Gender Aspects

      Henry P. Parkman

      Chapter 31 - Liver Disease in Women

      Karen Krok, Ayman Koteish

      Section 6: Reproductive Biology


      Lauri J. Romanzi

      Chapter 32 - Gender Differences in Irritable Bowel Syndrome

      Octavia Pickett-Blakely, Linda A. Lee, Gerald Mullin

      Chapter 33 - Contraception

      Karen Feisullin, Carolyn Westhoff

      Chapter 34 - Infertility: The Male

      Howard H. Kim, Peter N. Schlegel, Marc Goldstein

      Chapter 35 - Infertility and In Vitro Fertilization

      Elizabeth Barbieri, Sonya Kashyap, Pak H. Chung

      Chapter 36 - Female Sexual Health

      Barbara D. Bartlik, Julie A. Kolzet, Nazia Ahmad, Tahmina Parveen, Sarah Alvi

      Chapter 37 - Male Sexual Dysfunction

      Serkan Deveci, John P. Mulhall

      Chapter 38 - Pelvic Pain: Urogenital Female Disorders

      Andrew T. Goldstein, Lara J. Burrows

      Chapter 39 - Lower Urogenital Tract Dysfunction in Men and Women

      Doreen E. Chung, Alexis E. Te, Renuka Tyagi

      Chapter 40 - Aging and the Lower Urogenital System

      Catherine E. DuBeau

      Chapter 41 - Menopause

      Gloria Bachmann, Nora J. Doty

      Section 7: Oncology


      Nancy E. Davidson

      Chapter 42 - The Differences between Male and Female Breast Cancer

      Coral Omene, Amy Tiersten

      Chapter 43 - Difference in Germ Cell Tumors of the Reproductive Tract in Men and Women

      Nicole LaNatra, Amy Tiersten

      Chapter 44 - Gender Differences in Hereditary Cancer Syndromes: Risks, Management, and Testing for Inherited Predisposition to Cancer

      Wendy K. Chung

      Section 8: Infectious Disease


      Michael Rendel

      Chapter 45 - Gender Differences in Emerging Infectious Diseases

      Sharon Lewin

      Chapter 46 - Sexually Transmitted Infections in Men and Women

      Anne M. Rompalo, Khalil G. Ghanem

      Chapter 47 - Infections in Pregnancy

      Emilia Mia Sordillo, Bruce Polsky

      Chapter 48 - Adult Immunization in Women and Men

      Sally L. Hodder, Debra Chew, Shobha Swaminathan

      Section 9: Immunology


      Robert G. Lahita

      Chapter 49 - Gender Differences in Autoimmune Diseases: Immune Mechanisms and Clinical Applications

      Nabih I. Abdou, Virginia Rider

      Chapter 50 - Hormones and Cytokines: Gender-Specific Effects

      Maurizio Cutolo

      Chapter 51 - Prolactin and Autoimmunity

      Sara E. Walker

      Chapter 52 - Sex Hormones and Immune Function

      Robert G. Lahita

      Chapter 53 - Pregnancy and Autoimmune Rheumatic Disease

      Carl A. Laskin, Christine A. Clark, Karen A. Spitzer

      Chapter 54 - Oral Contraceptives and Autoimmune Diseases

      Taraneh Mehrani, Michelle Petri

      Chapter 55 - Gender-Specific Issues in Organ Transplantation

      Hilary Sanfey

      Section 10: Endocrinology


      Adrian Dobs

      Chapter 56 - Endogenous Sex Hormones and Risk of Type 2 Diabetes Mellitus in Men and Women

      Sherita Hill Golden

      Chapter 57 - Thyroid Disorders and Pregnancy

      Matthew Kim

      Chapter 58 - Sexual Function and Dysfunction in Men and Women

      Karen Elizabeth Boyle, Arthur L. Burnett

      Chapter 59 - Osteoporosis in Men and Women

      Kendall F. Moseley, Suzanne M. Jan de Beur

      Chapter 60 – Testosterone Replacement Therapy in Men and Women

      Diala El-Maouche, Adrian Dobs


      No. of pages:
      © Academic Press 2010
      Academic Press
      eBook ISBN:
      Hardcover ISBN:

      About the Editor

      Marianne J. Legato

      Dr. Marianne Legato, Professor Emerita of Clinical Medicine at Columbia University is an internationally known academic physician, author, lecturer, and specialist in gender-specific medicine. She is founding member of the International Society for Gender Medicine and also the founder and director of The Partnership for Gender-Specific Medicine at Columbia University and its next iteration, The Foundation for Gender-Specific Medicine. These enterprises are the first collaborations between academic medicine and the private sector focused solely on gender-specific medicine: the science of how normal human biology differs between men and women and of how the diagnosis and treatment of disease differs as a function of gender and sex. Her ground breaking-reference, Principles of Gender-Specific Medicine: Gender in the Genomic Era, is now in its third edition. She has published extensively on Gender and Sex Specific Medicine, both scientifically and for the lay public. She is also the founding editor of the journal Gender Medicine, and the journal Gender and the Genome, published for the scientific community. In 1992, Dr. Legato won the American Heart Association’s Blakeslee Award for the best book written for the lay public on cardiovascular disease. She is a practicing internist in New York City and has been listed each year in New York Magazine’s "Best Doctors" since the feature’s inception in 1993.

      Affiliations and Expertise

      MD, PhD (hon.c.), FACP, Professor Emerita of Clinical Medicine, Columbia University College of Medicine, New York, NY, USA; Adjunct Professor of Medicine, Johns Hopkins University, Department of Medicine, Baltimore, MD, USA

      Ratings and Reviews