Principles of Gender-Specific Medicine

Principles of Gender-Specific Medicine

Gender in the Genomic Era

2nd Edition - October 29, 2009

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  • Editor: Marianne Legato
  • eBook ISBN: 9780080921501

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The field of gender-specific medicine examines how normal human biology and physiology differ between men and women and how the diagnosis and treatment of disease differs as a function of gender. This revealing research covers various conditions that predominantly occur in men as well conditions that predominantly occur in women. Among the areas of greatest difference are cardiovascular disease, mood disorders, the immune system, lung cancer as a consequence of smoking, osteoporosis, diabetes, obesity, and infectious diseases. The Second Edition of Principles of Gender-Specific Medicine focuses on the essentials of gender-specific medicine and the current study of sex and gender differences in human physiology and pathophysiology. New section editors, new chapter authors, and new chapters have been added to reflect the most up-to-date clinical research and practice.

Key Features

  • Offers insight into how the gender-specific risks of one organ system’s disease affects the health of other organ systems
  • Outlines the sex-specific differences of normal anatomy and physiology
  • Illustrates the gender-specific features and quantifies "gender" and "sex" as risk factors across all major diseases
  • Qualifies and analyzes the results of new drug therapies designed with gender-specific differences in mind: ex, hormone therapy in men and women for the prevention and treatment of cardiovascular disease
  • All chapters progress translationally from the basic science to the clinical applications of gender-specific therapies, drugs, or treatments
  • Sections on drug metabolism, aging, and meta-analysis of data incorporated into all disease-specific chapters


Researchers and practitioners in physiology, cardiology, neurology, respiratory medicine, gastroenterology, endocrinology, oncology, immunology, nutrition, and metabolism who research and/or teach gender-specific medicine or sex-based biology. Graduate students and medical fellow trainees in these areas. Specialists and/or general practitioners who treat gender-specific diseases

Table of Contents

  • Section 1: Gender and Normal Development


    George M. Lazarus

    Chapter 1 - The Effects of Gender in Neonatal Medicine

    Tove S. Rosen, David Bateman

    Chapter 2 - Sexual Development, Growth, and Puberty in Children

    Gaya S. Aranoff, Jennifer J. Bell

    Chapter 3 - Gender Differences in Pediatric Pulmonary Disease

    Beverley J. Sheares

    Chapter 4 - Gender-Specific Aspects of Pediatric Hematology and Oncology

    James H. Garvin Jr

    Chapter 5 - Gender Differences in Neurological Conditions of Children

    David M. Kaufman

    Chapter 6 - Gender and Sports: Past, Present, and Future

    Jordan D. Metzl

    Section 2: Gender and the Nervous System


    William Byne

    Chapter 7 - Gender Differences in the Functional Organization of the Brain

    Ruben C. Gur, Tamara Bockow, Raquel E. Gur

    Chapter 8 - Sexual Differentiation of Brain Structure and Function

    Margaret M. McCarthy

    Chapter 9 - The Sexed and Gendered Brain

    William Byne

    Chapter 10 - Age and Gender-Specific Patterns of Neurologic Illness

    Joan Amatniek, Karin Sorra, Lauren Frey, W. Allen Hauser

    Chapter 11 - Gender Differences in Stroke

    Rebecca F. Gottesman, Argye E. Hillis

    Chapter 12 - Gender Differences in Disorders that Present to Psychiatry

    Mary V. Seeman

    Chapter 13 - Hormone Replacement Therapy and Cognitive Function

    Mary Sano, Diane Jacobs, Katya Gaynor

    Section 3: Cardiovascular Disease


    Paula A. Johnson

    Chapter 14 - Gender and the Heart: Sex-Specific Differences in the Normal Myocardial Anatomy and Physiology

    Marianne J. Legato, Jaswinder K. Leghe

    Chapter 15 - Gender-Specific Aspects of Selected Coronary Heart Disease Risk Factors: A Summary of the Epidemiologic Evidence

    Shari S. Bassuk, JoAnn E. Manson

    Chapter 16 - Dyslipidemia Management in Women and Men: Exploring Potential Gender Differences

    Kavita Sharma, Christian D. Nagy, Roger S. Blumenthal

    Chapter 17 - Gender Differences in the Role of Stress and Emotion in Cardiovascular Function and Disease

    David E. Anderson, Margaret A. Chesney

    Chapter 18 - The Role of Sex and Gender in Cardiothoracic Surgery

    Sandhya K. Balaram, Justin D. Blasberg

    Section 4: Pulmonology


    Marilyn K. Glassberg

    Chapter 19 - Gender Differences in Asthma

    Robert H. Lim, Lester Kobzik

    Chapter 20 - Gender Issues in Venous Thromboembolism

    Susan Murin, Kathryn Bilello, Lisa Moores, Aaron Holley

    Chapter 21 - Sleep in Women: Gender Differences in Health and Disease

    Shirin Shafazand

    Chapter 22 - Are Women More Susceptible to Chronic Obstructive Pulmonary Disease?

    Kenneth R. Chapman

    Chapter 23 - The Gender-Specific Aspects of Lung Cancer

    Rebecca L. Toonkel, Charles A. Powell

    Chapter 24 - Gender-Specific Considerations in Pulmonary Hypertension

    Deborah Shure

    Chapter 25 - Sex and Gender Differences in Pulmonary Manifestations of Autoimmune Disease

    Muddassir Aliniazee, Marilyn K. Glassberg

    Chapter 26 - Benign Metastasizing Leiomyoma and Lymphangioleiomyomatosis: Lung Diseases of Women

    Muddassir Aliniazee, Marilyn K. Glassberg

    Chapter 27 - Gender Differences in Susceptibility, Outcomes, and Pathophysiology of Sepsis

    Kristy A. Bauman, MeiLan K. Han

    Section 5: Gastroenterology


    Linda A. Lee

    Chapter 28 - Inflammatory Bowel Disease in Women

    Melissa Munsell, Marc Sonenshine, Mary L. Harris

    Chapter 29 - Disorders of Defecation in Women

    Susan L. Gearhart

    Chapter 30 - Idiopathic Gastroparesis: Gender Aspects

    Henry P. Parkman

    Chapter 31 - Liver Disease in Women

    Karen Krok, Ayman Koteish

    Section 6: Reproductive Biology


    Lauri J. Romanzi

    Chapter 32 - Gender Differences in Irritable Bowel Syndrome

    Octavia Pickett-Blakely, Linda A. Lee, Gerald Mullin

    Chapter 33 - Contraception

    Karen Feisullin, Carolyn Westhoff

    Chapter 34 - Infertility: The Male

    Howard H. Kim, Peter N. Schlegel, Marc Goldstein

    Chapter 35 - Infertility and In Vitro Fertilization

    Elizabeth Barbieri, Sonya Kashyap, Pak H. Chung

    Chapter 36 - Female Sexual Health

    Barbara D. Bartlik, Julie A. Kolzet, Nazia Ahmad, Tahmina Parveen, Sarah Alvi

    Chapter 37 - Male Sexual Dysfunction

    Serkan Deveci, John P. Mulhall

    Chapter 38 - Pelvic Pain: Urogenital Female Disorders

    Andrew T. Goldstein, Lara J. Burrows

    Chapter 39 - Lower Urogenital Tract Dysfunction in Men and Women

    Doreen E. Chung, Alexis E. Te, Renuka Tyagi

    Chapter 40 - Aging and the Lower Urogenital System

    Catherine E. DuBeau

    Chapter 41 - Menopause

    Gloria Bachmann, Nora J. Doty

    Section 7: Oncology


    Nancy E. Davidson

    Chapter 42 - The Differences between Male and Female Breast Cancer

    Coral Omene, Amy Tiersten

    Chapter 43 - Difference in Germ Cell Tumors of the Reproductive Tract in Men and Women

    Nicole LaNatra, Amy Tiersten

    Chapter 44 - Gender Differences in Hereditary Cancer Syndromes: Risks, Management, and Testing for Inherited Predisposition to Cancer

    Wendy K. Chung

    Section 8: Infectious Disease


    Michael Rendel

    Chapter 45 - Gender Differences in Emerging Infectious Diseases

    Sharon Lewin

    Chapter 46 - Sexually Transmitted Infections in Men and Women

    Anne M. Rompalo, Khalil G. Ghanem

    Chapter 47 - Infections in Pregnancy

    Emilia Mia Sordillo, Bruce Polsky

    Chapter 48 - Adult Immunization in Women and Men

    Sally L. Hodder, Debra Chew, Shobha Swaminathan

    Section 9: Immunology


    Robert G. Lahita

    Chapter 49 - Gender Differences in Autoimmune Diseases: Immune Mechanisms and Clinical Applications

    Nabih I. Abdou, Virginia Rider

    Chapter 50 - Hormones and Cytokines: Gender-Specific Effects

    Maurizio Cutolo

    Chapter 51 - Prolactin and Autoimmunity

    Sara E. Walker

    Chapter 52 - Sex Hormones and Immune Function

    Robert G. Lahita

    Chapter 53 - Pregnancy and Autoimmune Rheumatic Disease

    Carl A. Laskin, Christine A. Clark, Karen A. Spitzer

    Chapter 54 - Oral Contraceptives and Autoimmune Diseases

    Taraneh Mehrani, Michelle Petri

    Chapter 55 - Gender-Specific Issues in Organ Transplantation

    Hilary Sanfey

    Section 10: Endocrinology


    Adrian Dobs

    Chapter 56 - Endogenous Sex Hormones and Risk of Type 2 Diabetes Mellitus in Men and Women

    Sherita Hill Golden

    Chapter 57 - Thyroid Disorders and Pregnancy

    Matthew Kim

    Chapter 58 - Sexual Function and Dysfunction in Men and Women

    Karen Elizabeth Boyle, Arthur L. Burnett

    Chapter 59 - Osteoporosis in Men and Women

    Kendall F. Moseley, Suzanne M. Jan de Beur

    Chapter 60 – Testosterone Replacement Therapy in Men and Women

    Diala El-Maouche, Adrian Dobs

Product details

  • No. of pages: 800
  • Language: English
  • Copyright: © Academic Press 2009
  • Published: October 29, 2009
  • Imprint: Academic Press
  • eBook ISBN: 9780080921501

About the Editor

Marianne Legato

Dr. Marianne Legato, Emerita Professor of Clinical Medicine at Columbia University, is an internationally known academic physician, author, lecturer, and specialist in gender-specific medicine. She is founding member of the International Society for Gender Medicine and the founder and director of The Partnership for Gender-Specific Medicine at Columbia University and its next iteration, The Foundation for Gender-Specific Medicine. She has published extensively on gender and sex specific medicine, both for the scientific community and for the lay public. She is also the founding editor of the Journal Gender Medicine, and the journal Gender and the Genome. In 1992, Dr. Legato won the American Heart Association’s Blakeslee Award for the best book written for the lay public on cardiovascular disease. The third edition of her textbook, Principles of Gender-Specific Medicine and her most recent book, The Plasticity of Sex., both won Prose awards from the American Association of Editors in 2021 and 2022 respectively. She is a practicing internist in New York City and has been listed each year in New York Magazine and Castle Connolly’s lists "Best Doctors" since their inception in 1993.

Affiliations and Expertise

Emerita Professor, Clinical Medicine, Columbia University College of Physicians & Surgeons and Adjunct Professor, Medicine at Johns Hopkins Medical School

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  • JenThompson Wed Dec 12 2018

    Gender Sex and the Spectrum of Idenity

    Amazing a must own. Thank you for an amazing resource.