Principles of Cloning

Principles of Cloning

1st Edition - August 9, 2002

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  • Editors: Jose Cibelli, Robert Lanza, Keith Campbell, Michael West
  • eBook ISBN: 9780080492155

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Description

Principles of Cloning is the first comprehensive book on animal cloning since the creation of Dolly. The contributing authors are the principal investigators on each of the animal species cloned to date, and are expertly qualified to present the state-of-the-art information in their respective areas. Editors Cibelli, Lanza and West garnered worldwide spotlight late in 2001 when their company, Advanced Cell Technology, announced the successful engineering of the world's first cloned human embryo. The trio was featured in the US News & World Report December 2001 cover story, "The First Human Clone." The book presents the basic biological mechanisms of how cloning works and progresses to discuss current and potential applications in basic biology, agriculture, biotechnology, and medicine.

Key Features

@introbul:Key Features
@bul:* First and most comprehensive book on animal cloning
* Chapters written by the world' expert in each area
* From the early experiments in amphibia to the latest one in mammals, everything is included in this book and told by the researcher that did it and how they did it
* Basic biological mechanisms on how cloning works and all their current and potential applications
* Cloning applications on basic biology, agriculture, biotechnology and medicine are included
* Editors are the pioneers in the field

Readership

Bioengineers, biochemists, cell biologists, bone biologists, and geneticists.

Table of Contents

  • List of Contributors.
    Preface.
    Introduction.
    Historical Perspective.

    PART ONE-BASIC BIOLOGICAL PROCESES
    Activation of Mammalian Oocytes.
    The Nucleus.
    Nuclear Reprogramming: Biological and Technological Constraints.
    Plasticity of somatic nucleus by epigenetic reprogramming via cell Hybridization.
    Cell Cycle.
    Determinants of Pluripotency in Mammals.
    Cloning and Aging.

    PART TWO-METHODS
    Micromanipulation Techniques for Cloning.
    Microinsemination and Nuclear Transfer with Male Germ Cells.
    Development of viable mammalian embryos in vitro: Evolution of sequential media.
    Genetic and Phenotypic Similarity Among Members of Mammalian Clonal Sets.
    Genetic Modification and Cloning in Mammals.
    Pregnancy and Neonatal Care of Clone Animals.
    Donor Cell Type and Cloning Efficiency in Mammals.

    PART THREE-CLONING BY SPECIES
    The Cloning of Amphibians.
    Cloning of Fish.
    Cloning of Mice.
    Cloning of Rabbits.
    Nuclear Transfer in Swine.
    Cloning of Cattle.
    Cloning of Sheep.
    Cloning of Goats.

    PART FOUR-CURRENTLY SOUGHT AFTER SPECIES
    Cloning of Endangered Species.
    Cloning of Rats.

    PART FIVE-NUCLEAR TRANSFER IN PRIMATES
    Cloning in Non-Human Primates.

    PART SIX-APPLICATIONS
    Nuclear Transfer for Stem Cells (CRNT).
    Current Research and Commercial Applications of Cloning Technology.
    Transgenic Cloned Goats and the Production of Therapeutic Proteins.

    PART SEVEN-ETHICAL AND LEGAL AFFAIRS
    Ethical Implications of Cloning.

    FINAL REMARKS
    Mammalian Cloning- Challenges for the Future.

Product details

  • No. of pages: 531
  • Language: English
  • Copyright: © Academic Press 2002
  • Published: August 9, 2002
  • Imprint: Academic Press
  • eBook ISBN: 9780080492155

About the Editors

Jose Cibelli

Dr. Cibelli is Professor of Animal Biotechnology at Michigan State University. He heads the Cellular Reprogramming Laboratory in the Departments of Animal Science and Physiology since 2003. From 2010 to 2017 he was also the Scientific Director of LARCel, a laboratory of cellular reprogramming dedicated to generating human pluripotent cells under GMP conditions for preclinical studies in Andalucia, Spain. Dr. Cibelli is internationally recognized as one of the pioneers in the area of cellular reprogramming using oocyte-driven protocols. Dr. Cibelli together with his colleagues, were responsible for the generation of the world's first transgenic cloned calves, the first stem cells by nuclear transfer in bovine, the first embryonic stem cells by parthenogenesis in primates and the generation of the first cell line of iPSCs using oocyte factors alone. His work has been published un numerous scientific journals including Science, Nature Biotechnology, Nature Medicine, Nature Methods, PNAS, Cell Stem Cell and JAMA.

Affiliations and Expertise

Cellular Reprogramming Laboratory Michigan State University Ann Arbor, MI, USA

Robert Lanza

Robert Lanza
Robert Lanza is an American scientist and author whose research spans the range of natural science, from biology to theoretical physics. TIME magazine recognized him as one of the “100 Most Influential People in the World,” and Prospect magazine named him one of the Top 50 “World Thinkers.” He has hundreds of scientific publications and over 30 books, including definitive references in the fields of stem cells, tissue engineering, and regenerative medicine. He’s a former Fulbright Scholar and studied with polio-pioneer Jonas Salk and Nobel laureates Gerald Edelman (known for his work on the biological basis of consciousness) and Rodney Porter. He also worked closely (and co-authored papers in Science on self-awareness and symbolic communication) with noted Harvard psychologist BF Skinner. Dr. Lanza was part of the team that cloned the world’s first human embryo, the first endangered species, and published the first-ever reports of pluripotent stem cell use in humans.

Affiliations and Expertise

Astellas Institute for Regenerative Medicine, Westborough, MA, USA

Keith Campbell

Affiliations and Expertise

The University of Nottingham, UK

Michael West

Affiliations and Expertise

BioTime Inc., Alameda, CA, USA

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