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Principles of Cloning - 1st Edition - ISBN: 9780121745974, 9780080492155

Principles of Cloning

1st Edition

Editors: Jose Cibelli Robert Lanza Keith Campbell Michael West
Hardcover ISBN: 9780121745974
Paperback ISBN: 9781493300280
eBook ISBN: 9780080492155
Imprint: Academic Press
Published Date: 9th August 2002
Page Count: 531
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Principles of Cloning is the first comprehensive book on animal cloning since the creation of Dolly. The contributing authors are the principal investigators on each of the animal species cloned to date, and are expertly qualified to present the state-of-the-art information in their respective areas. Editors Cibelli, Lanza and West garnered worldwide spotlight late in 2001 when their company, Advanced Cell Technology, announced the successful engineering of the world's first cloned human embryo. The trio was featured in the US News & World Report December 2001 cover story, "The First Human Clone." The book presents the basic biological mechanisms of how cloning works and progresses to discuss current and potential applications in basic biology, agriculture, biotechnology, and medicine.

Key Features

@introbul:Key Features @bul:* First and most comprehensive book on animal cloning

  • Chapters written by the world' expert in each area
  • From the early experiments in amphibia to the latest one in mammals, everything is included in this book and told by the researcher that did it and how they did it
  • Basic biological mechanisms on how cloning works and all their current and potential applications
  • Cloning applications on basic biology, agriculture, biotechnology and medicine are included
  • Editors are the pioneers in the field


Bioengineers, biochemists, cell biologists, bone biologists, and geneticists.

Table of Contents

List of Contributors. Preface. Introduction. Historical Perspective.

PART ONE-BASIC BIOLOGICAL PROCESES Activation of Mammalian Oocytes.
The Nucleus.
Nuclear Reprogramming: Biological and Technological Constraints. Plasticity of somatic nucleus by epigenetic reprogramming via cell Hybridization.
Cell Cycle. Determinants of Pluripotency in Mammals. Cloning and Aging.

PART TWO-METHODS Micromanipulation Techniques for Cloning.
Microinsemination and Nuclear Transfer with Male Germ Cells. Development of viable mammalian embryos in vitro: Evolution of sequential media. Genetic and Phenotypic Similarity Among Members of Mammalian Clonal Sets.
Genetic Modification and Cloning in Mammals.
Pregnancy and Neonatal Care of Clone Animals.
Donor Cell Type and Cloning Efficiency in Mammals.

PART THREE-CLONING BY SPECIES The Cloning of Amphibians.
Cloning of Fish.
Cloning of Mice.
Cloning of Rabbits.
Nuclear Transfer in Swine.
Cloning of Cattle.
Cloning of Sheep. Cloning of Goats.

PART FOUR-CURRENTLY SOUGHT AFTER SPECIES Cloning of Endangered Species. Cloning of Rats.


PART SIX-APPLICATIONS Nuclear Transfer for Stem Cells (CRNT).
Current Research and Commercial Applications of Cloning Technology. Transgenic Cloned Goats and the Production of Therapeutic Proteins.

PART SEVEN-ETHICAL AND LEGAL AFFAIRS Ethical Implications of Cloning.

FINAL REMARKS Mammalian Cloning- Challenges for the Future.


No. of pages:
© Academic Press 2002
9th August 2002
Academic Press
Hardcover ISBN:
Paperback ISBN:
eBook ISBN:

About the Editors

Jose Cibelli

Dr. Jose Cibelli is internationally recognized as one of the pioneers in the area of cloning for the production of animals and embryonic stem cells. Dr. Cibelli and his colleagues were responsible for the generation of the world's first transgenic cloned calves, the first stem cells by nuclear transfer in bovine, and the first embryonic stem cells by parthenogenesis in primates. His work has been published in numerous scientific journals including Science, Nature Biotechnology, Nature Medicine, Nature Methods, PNAS, and JAMA. He has testified about cloning in public forums sponsored by the US Food and Drug administration, the USA National Academy of Sciences, Canadian House of Commons, the USA Department of Agriculture, the United Nations Commission for Human Rights and the British Royal Society. He is currently Professor of Animal Biotechnology at Michigan State University, USA.

Affiliations and Expertise

Cellular Reprogramming Laboratory Michigan State University Ann Arbor, MI, USA

Robert Lanza

Robert Lanza

Robert Lanza, M.D. is currently Head of Astellas Global Regenerative Medicine, Chief Scientific Officer of AIRM and an adjunct professor at the Wake Forest Institute for Regenerative Medicine. Time magazine recognized him as one of the “100 Most Influential People in the World,” and Prospect magazine named him one of the Top 50 “World Thinkers.” His research focuses on stem cells and their potential to provide therapies for some of the world's most deadly and debilitating conditions. He has hundreds of scientific publications and over 30 books, including definitive references in the fields of tissue engineering and regenerative medicine. He is a former Fulbright Scholar, and studied with polio-pioneer Jonas Salk and Nobel laureates Gerald Edelman and Rodney Porter. He also worked closely (and co-authored a series of papers) with psychologist BF Skinner and heart transplant-pioneer Christiaan Barnard. Dr. Lanza received his undergraduate and medical degrees from the University of Pennsylvania, where he was both a University Scholar and Benjamin Franklin Scholar. Lanza was part of the team that cloned the world’s first human embryo, the first endangered species, and published the first-ever reports of pluripotent stem cell use in humans.

Affiliations and Expertise

Astellas Institute for Regenerative Medicine, Westborough, MA, USA

Keith Campbell

Affiliations and Expertise

The University of Nottingham, UK

Michael West

Affiliations and Expertise

BioTime Inc., Alameda, CA, USA

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