Principles of Clinical Pharmacology

3rd Edition

Editors: Arthur Atkinson, Jr. Shiew-Mei Huang Juan Lertora Sanford Markey
Hardcover ISBN: 9780123854711
eBook ISBN: 9780123854728
Imprint: Academic Press
Published Date: 18th September 2012
Page Count: 652
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Principles of Clinical Pharmacology is a successful survey covering the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This essential reference continues to focus on the basics of clinical pharmacology for the development, evaluation, and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the third edition has been thoroughly updated to provide readers with an ideal reference covering the wide range of important topics impacting clinical pharmacology as the discipline plays an increasingly significant role in drug development and regulatory science.

The Third Edition has been endorsed by the American Society for Clinical Pharmacology and Therapeutics

Key Features

  • Includes new chapters on imaging and the pharmacogenetic basis of adverse drug reactions
  • Offers an expanded regulatory section that addresses US and international issues and guidelines
  • Provides extended coverage of earlier chapters on transporters, pharmacogenetics and biomarkers and also illustrates the impact of gender on drug response
  • Presents a broadened discussion of clinical trials from Phase 1 to incorporate Phases II and III


Clinical pharmacologists, pharmacologists, clinicians and scientists working in the pharmaceutical industry and government regulatory agencies

Table of Contents

Preface to the First Edition

Preface to the Third Edition


Chapter 1. Introduction to Clinical Pharmacology




Additional Sources of Information

Part I: Pharmacokinetics

Chapter 2. Clinical Pharmacokinetics

The Target Concentration Strategy

Concepts Underlying Clinical Pharmacokinetics

Mathematical Basis of Clinical Pharmacokinetics


Study Problems

Chapter 3. Compartmental Analysis of Drug Distribution

Fit-for-Purpose Modeling of Drug Distribution

Physiological Significance of Drug Distribution Volumes

Physiological Basis of Multicompartmental Models of Drug Distribution

Clinical Consequences of Different Drug Distribution Patterns

Estimating Model Parameters from Experimental Data


Study Problems

Computer-Based Tutorials

Chapter 4. Drug Absorption and Bioavailability

Drug Absorption


Kinetics of Drug Absorption After Oral Administration


Study Problems

Computer-Based Tutorials

Chapter 5. Effect of Renal Disease on Pharmacokinetics

Drug Dosing in Patients with Impaired Renal Function

Effects of Renal Disease on Renal Drug Excretion Mechanisms

Effects of Impaired Renal Function on Non-Renal Metabolism

Effects of Renal Disease on Drug Distribution

Effects of Renal Disease on Drug Absorption


Study Problem

Chapter 6. Pharmacokinetics in Patients Requiring Renal Replacement Therapy

Kinetics of Intermittent Hemodialysis

Kinetics of Continuous and Sustained Renal Replacement Therapy

Clinical Considerations


Computer-Based Tutorial

Chapter 7. Effect of Liver Disease on Pharmacokinetics

Hepatic Elim


No. of pages:
© Academic Press 2013
Academic Press
eBook ISBN:
Hardcover ISBN:

About the Editor

Arthur Atkinson, Jr.

Affiliations and Expertise

Northwestern University, Chicago, Illinois , U.S.A.

Shiew-Mei Huang

Affiliations and Expertise

FDA, Silver Spring, Maryland, U.S.A.

Juan Lertora

Affiliations and Expertise

NIH Clinical Center, Bethesda, MD, U.S.A.

Sanford Markey

Affiliations and Expertise

National Institute of Mental Health, Bethesda, Maryland, U.S.A.


"…this is an excellent textbook that provides a comprehensive overview of the fundamentals and state of the art of clinical pharmacology. It will be an invaluable reference source for many current and future scientists in the field." --Clinical Pharmacology and Therapeutics, June 2013

"Recent advances in pharmacogenetics, membrane transport, and biotechnology warrant a second edition of this excellent book...This will serve as an excellent text for an advanced course in principles of clinical pharmacology for graduate students, physicians, and PharmDs. Because of recent advances, the second edition is welcome. (4 Stars)" --Doody's