- Print ISBN 9780123854711
- Electronic ISBN 9780123854728
Principles of Clinical Pharmacology is a successful survey covering the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This essential reference continues to focus on the basics of clinical pharmacology for the development, evaluation, and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the third edition has been thoroughly updated to provide readers with an ideal reference covering the wide range of important topics impacting clinical pharmacology as the discipline plays an increasingly significant role in drug development and regulatory science.
The Third Edition has been endorsed by the American Society for Clinical Pharmacology and Therapeutics
* Includes new chapters on imaging and the pharmacogenetic basis of adverse drug reactions.
* Offers an expanded regulatory section that addresses US and international issues and guidelines.
* Provides extended coverage of earlier chapters on transporters, pharmacogenetics and biomarkers and also illustrates the impact of gender on drug response.
* Presents a broadened discussion of clinical trials from Phase 1 to incorporate Phases II and III.
Preface to the First Edition
Preface to the Third Edition
Chapter 1. Introduction to Clinical Pharmacology
Additional Sources of Information
Part I: Pharmacokinetics
Chapter 2. Clinical Pharmacokinetics
The Target Concentration Strategy
Concepts Underlying Clinical Pharmacokinetics
Mathematical Basis of Clinical Pharmacokinetics
Chapter 3. Compartmental Analysis of Drug Distribution
Fit-for-Purpose Modeling of Drug Distribution
Physiological Significance of Drug Distribution Volumes
Physiological Basis of Multicompartmental Models of Drug Distribution
Clinical Consequences of Different Drug Distribution Patterns
Estimating Model Parameters from Experimental Data
Chapter 4. Drug Absorption and Bioavailability
Kinetics of Drug Absorption After Oral Administration
Chapter 5. Effect of Renal Disease on Pharmacokinetics
Drug Dosing in Patients with Impaired Renal Function
Effects of Renal Disease on Renal Drug Excretion Mechanisms
Effects of Impaired Renal Function on Non-Renal Metabolism
Effects of Renal Disease on Drug Distribution
Effects of Renal Disease on Drug Absorption
Chapter 6. Pharmacokinetics in Patients Requiring Renal Replacement Therapy
Kinetics of Intermittent Hemodialysis
Kinetics of Continuous and Sustained Renal Replacement Therapy
Chapter 7. Effect of Liver Disease on Pharmacokinetics
"…this is an excellent textbook that provides a comprehensive overview of the fundamentals and state of the art of clinical pharmacology. It will be an invaluable reference source for many current and future scientists in the field."--Clinical Pharmacology & Therapeutics, June 2013