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This revised second edition covers the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development, focusing on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. Authors drawn from academia, the pharmaceutical industry and government agencies cover the spectrum of material, including pharmacokinetic practice questions, covered by the basic science section of the certifying examination offered by the American Board of Clinical Pharmacology. This unique reference is recommended by the Board as a study text and includes modules on drug discovery and development to assist students as well as practicing pharmacologists.
- Unique breadth of coverage ranging from drug discovery and development to individualization and quality assessment of drug therapy
- Unusual cohesive of presentation that stems from author participation in an ongoing popular NIH course
- Instructive linkage of pharmacokinetic theory and applications with provision of sample problems for self-study
- Wide-ranging perspective of authors drawn from the ranks of Federal agencies, academia and the pharmaceutical industry
- Expanded coverage of pharmacogenetics
- Expanded coverage of drug transporters and their role in interactions
- Inclusion of new material on enzyme induction mechanisms in chapters on drug metabolism and drug interactions
- A new chapter on drug discovery that focuses on oncologic agents
- Inclusion of therapeutic antibodies in chapter on biotechnology products
Clinical pharmacologists, pharmacologists, clinicians, pharmaceutical industry and government regulatory agencies
PART 1: PHARMACOKINETICS
2. Clinical pharmacokinetics
3. Compartmental analysis of drug distribution
4. Drug absorption and bioavailability
5. Effects of renal disease on pharmacokinetics
6. Kinetics of hemodialysis and hemofiltration
7. Effects of liver disease on pharmacokinetics
8. Noncompartmental vs. compartmental approaches to pharmacokinetic analysis
9. Distributed models of drug kinetics
10. Population pharmacokinetics
PART 2: DRUG METABOLISM AND TRANSPORT
11. Pathways of drug metabolism
12. Biochemical mechanisms of drug toxicity
13. Chemical assay of drugs and drug metabolites
14. Equilibrative and concentrative transport
16. Drug interactions
PART 3: ASSESSMENT OF DRUG EFFECTS
17. Physiological and laboratory markers of drug effect
18. Dose response and concentration response analysis
19. Kinetics of pharmacologic effect
20. Disease progression models
PART 4: OPTIMIZING AND EVALUATING PATIENT THERAPY
21. Sex differences in pharmacokinetics and pharmacodynamics
22. Drug therapy in pregnant and nursing women
23. Drug therapy in neonates and pediatric patients
24. Drug therapy in the elderly
25. Clinical analysis of adverse drug reactions
26. Quality assessment of drug therapy
PART 5: DRUG DISCOVERY AND DEVELOPMENT
27. Project management
28. Drug discovery
29. Pre-clinical development
30. Animal scale up
31. Phase I studies
32. PK and PD considerations in the development of biotechnology products and large molecules
33. Design of clinical development programs
34. Good design practices for clinical trials
35. Role of the FDA in guiding drug development
I. Table of Laplace Transforms
II. Answers to Study Problems
- No. of pages:
- © Academic Press 2007
- 20th September 2006
- Academic Press
- eBook ISBN:
- Hardcover ISBN:
Arthur J. Atkinson Jr. was the lead editor to the previous two editions and on the editorial board of the first edition. He was in the Department of Molecular Pharmacology & Biochemistry, Feinberg School of Medicine, Northwestern University, Chicago, IL
Department of Molecular Pharmacology and Biochemistry, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
National Institute on Aging, Baltimore, Maryland, U.S.A.
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA
National Institute of Health, Bethesda, Maryland, U.S.A.
National Institute of Mental Health, Bethesda, Maryland, U.S.A.
"Recent advances in pharmacogenetics, membrane transport, and biotechnology warrant a second edition of this excellent book...This will serve as an excellent text for an advanced course in principles of clinical pharmacology for graduate students, physicians, and PharmDs. Because of recent advances, the second edition is welcome." --Thomas L. Pazdernik, PhD, University of Kansas Medical Center, FOR DOODY'S (4 Stars)
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