Principles of Clinical Pharmacology

2nd Edition

Editors: Arthur Atkinson, Jr. Darrell Abernethy Charles Daniels Robert Dedrick Sanford Markey
Hardcover ISBN: 9780123694171
eBook ISBN: 9780080466422
Imprint: Academic Press
Published Date: 19th September 2006
Page Count: 568
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Description

This revised second edition covers the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development, focusing on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. Authors drawn from academia, the pharmaceutical industry and government agencies cover the spectrum of material, including pharmacokinetic practice questions, covered by the basic science section of the certifying examination offered by the American Board of Clinical Pharmacology. This unique reference is recommended by the Board as a study text and includes modules on drug discovery and development to assist students as well as practicing pharmacologists.

Key Features

  • Unique breadth of coverage ranging from drug discovery and development to individualization and quality assessment of drug therapy.
  • Unusual cohesive of presentation that stems from author participation in an ongoing popular NIH course.
  • Instructive linkage of pharmacokinetic theory and applications with provision of sample problems for self-study.
  • Wide-ranging perspective of authors drawn from the ranks of Federal agencies, academia and the pharmaceutical industry.
  • Expanded coverage of pharmacogenetics
  • Expanded coverage of drug transporters and their role in interactions
  • Inclusion of new material on enzyme induction mechanisms in chapters on drug metabolism and drug interactions
  • A new chapter on drug discovery that focuses on oncologic agents
  • Inclusion of therapeutic antibodies in chapter on biotechnology products

Readership

Clinical pharmacologists, pharmacologists, clinicians, pharmaceutical industry and government regulatory agencies

Table of Contents

Tentative TOC: Chapter 1 Introduction
PART 1: PHARMACOKINETICS: Chapter 2 Clinical pharmacokinetics Chapter 3 Compartmental analysis of drug distribution Chapter 4 Drug absorption and bioavailability Chapter 5 Effects of renal disease on pharmacokinetics Chapter 6 Kinetics of hemodialysis and hemofiltration Chapter 7 Effects of liver disease on pharmacokinetics Chapter 8 Noncompartmental vs. compartmental approaches to pharmacokinetic analysis Chapter 9 Distributed models of drug kinetics Chapter 10 Population pharmacokinetics PART 2: DRUG METABOLISM AND TRANSPORT: Chapter 11 Pathways of drug metabolism Chapter 12 Biochemical mechanisms of drug toxicity Chapter 13 Chemical assay of drugs and drug metabolites Chapter 14 Equilibrative and concentrative transport Chapter 15 Pharmacogenetics Chapter 16 Drug interactions PART 3: ASSESSMENT OF DRUG EFFECTS: Chapter 17 Physiological and laboratory markers of drug effect Chapter 18 Dose response and concentration response analysis Chapter 19 Kinetics of pharmacologic effect Chapter 20 Disease progression models PART 4: OPTIMIZING AND EVALUATING PATIENT THERAPY: Chapter 21 Sex differences in pharmacokinetics and pharmacodynamics Chapter 22 Drug therapy in pregnant and nursing women Chapter 23 Drug therapy in neonates and pediatric patients Chapter 24 Drug therapy in the elderly Chapter 25 Clinical analysis of adverse drug reactions Chapter 26 Quality assessment of drug therapy PART 5: DRUG DISCOVERY AND DEVELOPMENT: Chapter 27 Project management Chapter 28 Drug discover

Details

No. of pages:
568
Language:
English
Copyright:
© Academic Press 2007
Published:
Imprint:
Academic Press
eBook ISBN:
9780080466422
Hardcover ISBN:
9780123694171

About the Editor

Arthur Atkinson, Jr.

Affiliations and Expertise

Northwestern University, Chicago, Illinois , U.S.A.

Darrell Abernethy

Affiliations and Expertise

National Institute on Aging, Baltimore, Maryland, U.S.A.

Charles Daniels

Affiliations and Expertise

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA

Robert Dedrick

Affiliations and Expertise

National Institute of Health, Bethesda, Maryland, U.S.A.

Sanford Markey

Affiliations and Expertise

National Institute of Mental Health, Bethesda, Maryland, U.S.A.

Reviews

"Recent advances in pharmacogenetics, membrane transport, and biotechnology warrant a second edition of this excellent book...This will serve as an excellent text for an advanced course in principles of clinical pharmacology for graduate students, physicians, and PharmDs. Because of recent advances, the second edition is welcome." - Thomas L. Pazdernik, PhD, University of Kansas Medical Center, FOR DOODY'S (4 Stars)