This comprehensive work discusses novel biomolecular surfaces that have been engineered to either control or measure cell function at the atomic, molecular, and cellular levels. Each chapter presents real results, concepts, and expert perspectives of how cells interact with biomolecular surfaces, with particular emphasis on interactions within complex mechanical environments such as in the cardiovascular system. In addition, the book provides detailed coverage of inflammation and cellular immune response as a useful model for how engineering concepts and tools may be effectively applied to complex systems in biomedicine.

Key Features

-Accessible to biologists looking for new ways to model their results and engineers interested in biomedical applications -Useful to researchers in biomaterials, inflammation, and vascular biology -Excellent resource for graduate students as a textbook in cell & tissue engineering or cell mechanics courses


Biomedical engineers, cell and molecular biologists, and graduate students in cell and tissue engineering

Table of Contents

Partial Contents: PART I. NEUTROPHIL ADHESION Adhesion of flowing neutrophils to model vessel surfaces Bond formation during cell compression A flow chamber for capillary networks Membrane dynamics during neutrophil recruitment Hydrodynamic recruitment of cells to reactive surfaces PART II: CELL-SUBSTRATE ADHESION Cell tensegrity models and cell-substrate interactions Use of hydrodynamic shear stress to analyze cell adhesion Traction forces exerted by endothelial cells Control of endothelial cell adhesion by mechanotransmission PART III. ENGINEERED BIOMIMETIC SURFACES Realistic atomistic modeling of protein adsorption to ceramic biomaterials Cell responses to micro- and nano-topography


No. of pages:
© 2006
Academic Press
eBook ISBN:
Print ISBN:

About the editor

Michael King

Affiliations and Expertise

Cornell University, Ithaca, NY, USA