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Principles of Bone Biology - 4th Edition - ISBN: 9780128148419, 9780128148426

Principles of Bone Biology

4th Edition

Editors: John Bilezikian T. John Martin Thomas Clemens Clifford Rosen
Book ISBN: 9780128148419
eBook ISBN: 9780128148426
Imprint: Academic Press
Published Date: 23rd August 2019
Page Count: 2024
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Preface from the first edition (1996): "The world of modern science is undergoing a number of spectacular events that are redefining our understanding of ourselves. As with any revolution, we should take stock of where we have been, where we are, and where we are going. Our special world of bone biology is participating in and taking advantage of the larger global revolution in modern science… we assembled experts from all over the world and asked them to focus on the current state of knowledge and the prospects for new knowledge in their area of expertise. To this end, Principles of Bone Biology was conceived." - John P. Bilezikian, Lawrence G. Raisz, Gideon A. Rodan

Praise for the previous edition: "Students, teachers, and practitioners will benefit from reading it, and investigators will use it as a reference work; it will certainly be consulted frequently." --The New England Journal of Medicine

For over two decades, "Big Gray" has been the go-to repository of knowledge in the disciplines related to bone and mineral metabolism. The fourth edition is a must-have for students new to the field; young investigators at the graduate or postgraduate level beginning their research careers; established scientists who need to keep up with the changing nature of the field, looking to enrich their own research programs, or who are changing their career direction; clinicians who want ready access to up-to-date relevant basic science.

This new edition builds on the successful formula from previous editions, taking the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. Principles of Bone Biology, Fourth Edition provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. Bone research continues to generate enormous attention, due to the broad public health implications of osteoporosis and related bone disorders. This classic, fully updated, two volume reference is designed for anyone involved in the study of bone biology.

Key Features

  • Provides a "one-stop" shopping paradise. Anything you want to find about bone biology is here and written by the world’s experts
  • THE essential resource for anyone involved in the study of the skeleton and metabolic bone diseases
  • Covers everything from the basic scientific concepts to the underlying principles of therapeutics and management
  • Allows readers to easily search and locate information quickly in the online format
  • Volumes include: Basic Principles; Molecular Mechanisms of Metabolic Bone Disease; Pharmacological Mechanisms of Therapeutics; Methods in Bone Research


Biomedical researchers, research clinicians, graduate students, and fellows in the fields of endocrinology, bone biology, osteology, and rheumatology

Table of Contents

Volume 1
Part I: Basic principles
Section A Cell biology
1. Molecular and cellular regulation of intramembranous and endochondral bone formation during embryogenesis
2. Skeletal stem cells: tissue-specific stem/progenitor cells of cartilage, bone, stroma, and marrow adipocytes
3. Bone marrow and the hematopoietic stem cell niche
4. The osteoblast lineage: its actions and communication mechanisms
5. Osteoclasts
6. The osteocyte
7. Transcriptional control of osteoblast differentiation and function
8. Wnt signaling and bone cell activity
9. Vascular and nerve interactions
10. Coupling of bone formation and resorption
11. Modeling and remodeling: the cellular machinery responsible for bone’s material and structural strength during growth, aging, and drug therapy
12. Aging and bone

Section B Biochemistry
13. Type I collagen structure, synthesis, and regulation
14. Collagen cross-linking and bone pathobiology
15. Secreted noncollagenous proteins of bone
16. Bone proteinases
17. Integrins and other cell surface attachment molecules of bone cells
18. Intercellular junctions and cellecell communication in the skeletal system

Section C Bone remodeling and mineral homeostasis
19. Histomorphometric analysis of bone remodeling
20. Phosphorus homeostasis and related disorders
21. Magnesium homeostasis
22. Metal ion toxicity in the skeleton: lead and aluminum
23. Biology of the extracellular calcium-sensing receptor

Section D Endocrine and paracrine regulation of bone
24. Parathyroid hormone molecular biology
25. Paracrine parathyroid hormonee related protein in bone: physiology and pharmacology
26. Cardiovascular actions of parathyroid hormone/parathyroid hormoneerelated protein signaling
27. Parathyroid hormone and parathyroid hormoneerelated protein actions on bone and kidney
28. Receptors for parathyroid hormone and parathyroid hormoneerelated protein
29. Structure and function of the vitamin D-binding proteins
30. Vitamin D gene regulation
31. Nonskeletal effects of vitamin D: current status and potential paths forward
32. Cellular actions of parathyroid hormone on bone
33. Calcitonin peptides
34. Regulation of bone remodeling by central and peripheral nervous signals

Section E Other systemic hormones that influence bone metabolism
35. Estrogens and progestins
36. Physiological actions of parathyroid hormone-related protein in epidermal, mammary, reproductive, and pancreatic tissues
37. The pharmacology of selective estrogen receptor modulators: past and present
38. Thyroid hormone and bone
39. Basic and clinical aspects of glucocorticoid action in bone
40. Diabetes and bone
41. Androgen receptor expression and steroid action in bone

Section F Local regulators
42. Growth hormone, insulin-like growth factors, and IGF binding proteins

Volume 2
43. The periodontium
44. Notch and its ligands
45. Fibroblast growth factor (FGF) and FGF receptor families in bone
46. Vascular endothelial growth factor and boneevascular interactions
47. Transforming growth factor-b and skeletal homeostasis
48. Bone morphogenetic proteins
49. Extraskeletal effects of RANK ligand
50. Local regulators of bone
51. Prostaglandins and bone metabolism

Part II: Molecular mechanisms of metabolic bone disease
52. The molecular actions of parathyroid hormone/parathyroid hormoneerelated protein receptor type 1 and their implications
53. Multiple endocrine neoplasia type 1
54. Parathyroid hormone-related peptide and other mediators of skeletal manifestations of malignancy
55. Localized osteolysis
56. Genetic regulation of parathyroid gland development
57. Genetic disorders caused by mutations in the parathyroid hormone/parathyroid hormonee related peptide receptor, its ligands, and downstream effector molecules
58. Molecular basis of parathyroid hormone overexpression
59. Diseases resulting from defects in the G protein Gsa
60. Renal osteodystrophy and chronic kidney diseaseemineral bone disorder
61. Osteogenesis imperfecta
62. Hereditary deficiencies in vitamin D action
63. Fibroblast growth factor 23
64. Tumor-induced osteomalacia
65. Osteopetrosis
66. Hypophosphatasia: nature’s window on alkaline phosphatase function in humans
67. Paget’s disease of bone
68. Genetic determinants of bone mass and osteoporotic fracture

Part III: Pharmacological mechanisms of therapeutics
69. Pharmacologic mechanisms of therapeutics: parathyroid hormone
70. Calcium
71. Drugs acting on the calcium receptor: calcimimetics and calcilytics
72. Clinical and translational pharmacology of bisphosphonates
73. Pharmacological mechanisms of therapeutics: receptor activator of nuclear factorekappa B ligand inhibition
74. Pharmacologic basis of sclerostin inhibition
75. Vitamin D and its analogs
76. Mechanisms of exercise effects on bone quantity and quality

Part IV: Methods in bone research
77. Application of genetically modified animals in bone research
78. Bone turnover markers
79. Microimaging
80. Macroimaging
81. Methods in lineage tracing
82. Bone histomorphometry in rodents
83. Bone strength testing in rodents
84. Regulation of energy metabolism by bone-derived hormones


No. of pages:
© Academic Press 2020
23rd August 2019
Academic Press
Book ISBN:
eBook ISBN:

About the Editors

John Bilezikian

Dr. Bilezikian is Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia University Medical Center. He belongs to the American Society for Bone and Mineral Research (President 1995-1996), and the International Society of Clinical Densitometry (President, 1999-2001). He serves on the Board of Governors of the International Osteoporosis Foundation (1998-present) and on its Committee of Scientific Advisors (2001-present) and is Chair of the Endocrine Fellows Foundation. He served as Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism (2000-2004) and as Senior Associate Editor of the Journal of Bone and Mineral Research (2008-2012). He is Executive Advisory Editor of Bone Research (2013-present). He served as co-chair of the last three NIH Workshops on Primary Hyperparathyroidism (2002, 2008, 2013).

Dr. Bilezikian is the recipient of the Distinguished Physician Award of the Endocrine Society, the Frederic C. Bartter Award of the American Society for Bone and Mineral Research (ASBMR) for Excellence in Clinical Research and the First Annual Global Leadership Award of the International Society of Clinical Densitometry. In 2009, he received the Gideon A. Rodan Excellence in Mentorship Award from the ASBMR. He received the Laureate Distinguished Educator Award of The Endocrine Society in 2014. In 2014, he was made honorary member of the Brazilian Society of Endocrinology and Metabolism. His publications number over 700.

Affiliations and Expertise

Columbia University, NY, USA

T. John Martin

Dr. Martin has served on 12 state and national committees and boards, been an international lecturer for nearly 20 years, and his work has been extensively published in a total of 420 original papers, 178 reviews, chapters and editorials, and seven books. He was appointed as Officer of the Order of Australia, elected to fellowships of the Australian Academy and the Royal Society and received 12 prestigious career awards, including the Eric Susman Prize from the Royal Australasian College of Physician. He has had 12 patents granted and held eight international visiting appointments in the United Kingdom, United States, and Switzerland. An outstanding contribution to science includes the cloning of parathyroid hormone related protein.

Affiliations and Expertise

St. Vincent’s Institute of Medical Research, Melbourne, Australia

Thomas Clemens

Thomas Clemens works at the Johns Hopkins University in the Department of Orthopaedic Surgery, Baltimore, MD, USA

Affiliations and Expertise

Johns Hopkins University, Department of Orthopedic Surgery, Baltimore, MD, USA

Clifford Rosen

Dr. Rosen is Professor and Senior Scientists at The Jackson Laboratory, Bar Harbor, Maine, where his group studies the role of insulin-like growth factors on bone and the genetics of osteoporosis in inbred strains of mice. In 2007 he joined the Maine Medical Center Research Institute in Scarborough, Maine. He is also the former Director of the Maine Center for Osteoporosis Research and Education, St. Joseph Hospital, Bangor.

Dr. Rosen is a Past President of the American Society of Bone and Mineral Research (ASBMR). He served five years as the First Editor in Chief of the Journal of Clinical Densitometry, the official journal for the International Society of Clinical Densitometry, and currently serves as Associate Editor of the Journal of Bone and Mineral Research. His publications exceed 270 manuscripts published in a wide spectrum of clinical and basic science journals.

Affiliations and Expertise

Maine Center for Osteoporosis Research and Education, St. Joseph Hospital, Bangor, Maine, USA


Review of the previous edition:
"Students, teachers, and practitioners will benefit from reading it, and investigators will use it as a reference work; it will certainly be consulted frequently." --The New England Journal of Medicine

Ratings and Reviews