Principles of Bone Biology

4th Edition - August 22, 2019
Editors: John P. Bilezikian, T. John Martin, Thomas L. Clemens, Clifford Rosen
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 1 4 8 4 1 - 9
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 1 4 8 4 2 - 6

Preface from the first edition (1996): "The world of modern science is undergoing a number of spectacular events that are redefining our understanding of ourselves. As with any re… Read more

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Preface from the first edition (1996): "The world of modern science is undergoing a number of spectacular events that are redefining our understanding of ourselves. As with any revolution, we should take stock of where we have been, where we are, and where we are going. Our special world of bone biology is participating in and taking advantage of the larger global revolution in modern science… we assembled experts from all over the world and asked them to focus on the current state of knowledge and the prospects for new knowledge in their area of expertise. To this end,　Principles of Bone Biology　was conceived." - John P. Bilezikian, Lawrence G. Raisz, Gideon A. Rodan

Praise for the previous edition

: "Students, teachers, and practitioners will benefit from reading it, and investigators will use it as a reference work; it will certainly be consulted frequently." --The New England Journal of Medicine

For over two decades, "Big Gray" has been the go-to repository of knowledge in the disciplines related to bone and mineral metabolism. The fourth edition is a must-have for students new to the field; young investigators at the graduate or postgraduate level beginning their research careers; established scientists who need to keep up with the changing nature of the field, looking to enrich their own research programs, or who are changing their career direction; clinicians who want ready access to up-to-date relevant basic science.

This new edition builds on the successful formula from previous editions, taking the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. Principles of Bone Biology, Fourth Edition provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. Bone research continues to generate enormous attention, due to the broad public health implications of osteoporosis and related bone disorders. This classic, fully updated, two volume reference is designed for anyone involved in the study of bone biology.

Volume 1
Part I: Basic principles
Section A Cell biology

1. Molecular and cellular regulation of intramembranous and endochondral bone formation during embryogenesis

2. Skeletal stem cells: tissue-specific stem/progenitor cells of cartilage, bone, stroma, and marrow adipocytes

3. Bone marrow and the hematopoietic stem cell niche

4. The osteoblast lineage: its actions and communication mechanisms

5. Osteoclasts

6. The osteocyte

7. Transcriptional control of osteoblast differentiation and function

8. Wnt signaling and bone cell activity

9. Vascular and nerve interactions

10. Coupling of bone formation and resorption

11. Modeling and remodeling: the cellular machinery responsible for bone’s material and structural strength during growth, aging, and drug therapy

12. Aging and bone

Section B Biochemistry

13. Type I collagen structure, synthesis, and regulation

14. Collagen cross-linking and bone pathobiology

15. Secreted noncollagenous proteins of bone

16. Bone proteinases

17. Integrins and other cell surface attachment molecules of bone cells

18. Intercellular junctions and cellecell communication in the skeletal system

Section C Bone remodeling and mineral homeostasis

19. Histomorphometric analysis of bone remodeling

20. Phosphorus homeostasis and related disorders

21. Magnesium homeostasis

22. Metal ion toxicity in the skeleton: lead and aluminum

23. Biology of the extracellular calcium-sensing receptor

Section D Endocrine and paracrine regulation of bone

24. Parathyroid hormone molecular biology

25. Paracrine parathyroid hormonee related protein in bone: physiology and pharmacology

26. Cardiovascular actions of parathyroid hormone/parathyroid hormoneerelated protein signaling

27. Parathyroid hormone and parathyroid hormoneerelated protein actions on bone and kidney

28. Receptors for parathyroid hormone and parathyroid hormoneerelated protein

29. Structure and function of the vitamin D-binding proteins

30. Vitamin D gene regulation

31. Nonskeletal effects of vitamin D: current status and potential paths forward

32. Cellular actions of parathyroid hormone on bone

33. Calcitonin peptides

34. Regulation of bone remodeling by central and peripheral nervous signals

Section E Other systemic hormones that influence bone metabolism

35. Estrogens and progestins

36. Physiological actions of parathyroid hormone-related protein in epidermal, mammary, reproductive, and pancreatic tissues

37. The pharmacology of selective estrogen receptor modulators: past and present

38. Thyroid hormone and bone

39. Basic and clinical aspects of glucocorticoid action in bone

40. Diabetes and bone

41. Androgen receptor expression and steroid action in bone

Section F Local regulators

42. Growth hormone, insulin-like growth factors, and IGF binding proteins

Volume 2

43. The periodontium

44. Notch and its ligands

45. Fibroblast growth factor (FGF) and FGF receptor families in bone

46. Vascular endothelial growth factor and boneevascular interactions

47. Transforming growth factor-b and skeletal homeostasis

48. Bone morphogenetic proteins

49. Extraskeletal effects of RANK ligand

50. Local regulators of bone

51. Prostaglandins and bone metabolism

Part II: Molecular mechanisms of metabolic bone disease

52. The molecular actions of parathyroid hormone/parathyroid hormoneerelated protein receptor type 1 and their implications

53. Multiple endocrine neoplasia type 1

54. Parathyroid hormone-related peptide and other mediators of skeletal manifestations of malignancy

55. Localized osteolysis

56. Genetic regulation of parathyroid gland development

57. Genetic disorders caused by mutations in the parathyroid hormone/parathyroid hormonee related peptide receptor, its ligands, and downstream effector molecules

58. Molecular basis of parathyroid hormone overexpression

59. Diseases resulting from defects in the G protein Gsa

60. Renal osteodystrophy and chronic kidney diseaseemineral bone disorder

61. Osteogenesis imperfecta

62. Hereditary deficiencies in vitamin D action

63. Fibroblast growth factor 23

64. Tumor-induced osteomalacia

65. Osteopetrosis

66. Hypophosphatasia: nature’s window on alkaline phosphatase function in humans

67. Paget’s disease of bone

68. Genetic determinants of bone mass and osteoporotic fracture

Part III: Pharmacological mechanisms of therapeutics

69. Pharmacologic mechanisms of therapeutics: parathyroid hormone

70. Calcium

71. Drugs acting on the calcium receptor: calcimimetics and calcilytics

72. Clinical and translational pharmacology of bisphosphonates

73. Pharmacological mechanisms of therapeutics: receptor activator of nuclear factorekappa B ligand inhibition

74. Pharmacologic basis of sclerostin inhibition

75. Vitamin D and its analogs

76. Mechanisms of exercise effects on bone quantity and quality

Part IV: Methods in bone research

77. Application of genetically modified animals in bone research

78. Bone turnover markers

79. Microimaging

80. Macroimaging

81. Methods in lineage tracing

82. Bone histomorphometry in rodents

83. Bone strength testing in rodents

84. Regulation of energy metabolism by bone-derived hormones

John P. Bilezikian

Dr. Bilezikian is Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia University Medical Center. He belongs to the American Society for Bone and Mineral Research (President 1995-1996), and the International Society of Clinical Densitometry (President, 1999-2001). He serves on the Board of Governors of the International Osteoporosis Foundation (1998-present) and on its Committee of Scientific Advisors (2001-present) and is Chair of the Endocrine Fellows Foundation. He served as Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism (2000-2004) and as Senior Associate Editor of the Journal of Bone and Mineral Research (2008-2012). He is Executive Advisory Editor of Bone Research (2013-present). He served as co-chair of the last three NIH Workshops on Primary Hyperparathyroidism (2002, 2008, 2013).

Dr. Bilezikian is the recipient of the Distinguished Physician Award of the Endocrine Society, the Frederic C. Bartter Award of the American Society for Bone and Mineral Research (ASBMR) for Excellence in Clinical Research and the First Annual Global Leadership Award of the International Society of Clinical Densitometry. In 2009, he received the Gideon A. Rodan Excellence in Mentorship Award from the ASBMR. He received the Laureate Distinguished Educator Award of The Endocrine Society in 2014. In 2014, he was made honorary member of the Brazilian Society of Endocrinology and Metabolism. His publications number over 700.

Affiliations and expertise

Columbia University, NY, USA

T. John Martin

Dr. Martin has served on 12 state and national committees and boards, been an international lecturer for nearly 20 years, and his work has been extensively published in a total of 420 original papers, 178 reviews, chapters and editorials, and seven books. He was appointed as Officer of the Order of Australia, elected to fellowships of the Australian Academy and the Royal Society and received 12 prestigious career awards, including the Eric Susman Prize from the Royal Australasian College of Physician. He has had 12 patents granted and held eight international visiting appointments in the United Kingdom, United States, and Switzerland. An outstanding contribution to science includes the cloning of parathyroid hormone related protein.

Affiliations and expertise

St. Vincent’s Institute of Medical Research, Melbourne, Australia

Thomas L. Clemens

Thomas Clemens works at the Johns Hopkins University in the Department of Orthopaedic Surgery, Baltimore, MD, USA

Affiliations and expertise

Johns Hopkins University, Department of Orthopedic Surgery, Baltimore, MD, USA

Clifford Rosen

Dr. Rosen is Professor and Senior Scientists at The Jackson Laboratory, Bar Harbor, Maine, where his group studies the role of insulin-like growth factors on bone and the genetics of osteoporosis in inbred strains of mice. In 2007 he joined the Maine Medical Center Research Institute in Scarborough, Maine. He is also the former Director of the Maine Center for Osteoporosis Research and Education, St. Joseph Hospital, Bangor.

Dr. Rosen is a Past President of the American Society of Bone and Mineral Research (ASBMR). He served five years as the First Editor in Chief of the Journal of Clinical Densitometry, the official journal for the International Society of Clinical Densitometry, and currently serves as Associate Editor of the Journal of Bone and Mineral Research. His publications exceed 270 manuscripts published in a wide spectrum of clinical and basic science journals.

Affiliations and expertise

Maine Center for Osteoporosis Research and Education, St. Joseph Hospital, Bangor, Maine, USA