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Principles of Bone Biology - 3rd Edition - ISBN: 9780123738844, 9780080568751

Principles of Bone Biology

3rd Edition

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Editors: John Bilezikian Lawrence Raisz T. John Martin
Hardcover ISBN: 9780123738844
eBook ISBN: 9780080568751
Imprint: Academic Press
Published Date: 29th September 2008
Page Count: 1900
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Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders.

Key Features

  • Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants…it is all in one source written by the experts in the field
  • The essential resource for anyone involved in the study of bones and bone diseases
  • Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics
  • Readers can easily search and locate information quickly as it will be online with this new edition


Academic and medical libraries as well as professionals in bone biology, endocrinology, and osteology

Table of Contents

Part I Basic Principles A. Cell Biology

Chapter 1:
Structure, Modeling and Remodeling of Bone / The Size and Shape of Bone as a Site of Metabolic Bone Activity Ego Seeman

Chapter 2: Biomechanics of Bone Elise Morgan

Chapter 3: Embryonic Development of Bone and the Molecular Regulation of Intramembranous and Endochondral Bone Formation Andrew Karaplis

Chapter 4: Mesenchymal Stem Cells & Osteoblast Lineage Jane Aubin

Chapter 5: Transcriptional Control of Osteoblast Differentiation and Function Thorsten Schinke

Chapter 6: Wnt Signaling and Bone Mark Johnson

Chapter 7: Sclerostin and Bone Rutger van Bezooijen

Chapter 8: The Osteocyte Jenneke Klein-Nulend

Chapter 9: Cells of Bone: Osteoplast Generation Tatsuo Suda

Chapter 10: Osteoclast Function: Biology and Mechanisms Kalervo Vaananen

Chapter 11: RANK Signaling Hiroshi Takanayagi

Chapter12: Regulating Bone Resorption Roland Baron

Chapter 13: Apoptosis in Bone Cells Stavros Manolagas

Chapter 14: Skeletal Gene Expression in Nuclear Microenvironments Gary Stein

B. Biochemistry

Chapter 15: Type I Collagen: Structure, Synthesis, and Regulation Benoit de Crombrugghe

Chapter 16: Collagen Crosslinking & Metabolism Simon Robins

Chapter 17: Bone Matrix Proteoglycans & Glycoproteins Pamela Robey

Chapter 18: Osteopontin Masaki Noda

Chapter 19: Bone Proteinases Nicola Partridge

Chapter 20: Integrins and Other Cell Surface Attachment Molecules of Bone Cells Michael Horton

Chapter 21: Intercellular Junctions and Cell-Cell Communication in the Skeletal System Roberto Civitelli

C. Bone Remodeling and Mineral Homeostasis

Chapter 22: Histomorphometric Analysis of Bone Remodeling David Dempster

Chapter 23: Phosphorus Homeostasis & Related Disorders Marc Drezner

Chapter 24: Magnesium Homeostasis Robert Rude

Chapter 25: Metals in Bone: Aluminum, Boron, Cadmium, Chromium, Lead, Silicon, & Stro Felix Bronner

Chapter 26: Biology of the Extracellular Ca2+-Sensing Receptor Edward Brown

D. The Hormones of Bone

Chapter 27: Receptors for Parathyroid Hormone (PTH) and PTH-Related Protein John Potts

Chapter 28: Parathyroid Hormone - Molecular Biology Hank Kronenberg

Chapter 29: Parathyroid Hormone-Receptor Interactions Mike Rosenblatt

Chapter 30: Actions of Parathyroid Hormone on the Vasculature and Cardiovascular System John Bilezikian

Chapter 31: The Vascular and Cardiovascular Actions of PTH John Bilezikian

Chapter 32: PTH and PTHrP Actions on Kidney and Bone Peter Friedman

Chapter 33: Physiological Actions of Parathyroid Hormone and PTH-Related Protein John Wysolmerski

Chapter 34: Vascular, Cardiovascular and Neurological Actions of Parathyroid-Related Protein Thomas Clemens

Chapter 35: Vitamin D Nuclear Receptor (VDR) and Plasma Vitamin D-Binding Protein (DBP) Structures and Ligand Shape Preferences for Genomic and Rapid Biological Responses Tony Norman

Chapter 36: Vitamin D Gene Regulation Sylvia Christakos

Chapter 37: Photobiology and Non-Calcemic Actions of Vitamin D Mike Holick

Chapter 38: Calcitonin Structure and Molecular Biology of the Calcitonin Receptor / Calcitonin Gene Family and Receptors: Structure, Molecular Biology, and Effects Bob Gagel

Chapter 39: Amylin and Calcitonin Gene-Related Peptide Jill Cornish

E. Other Systemic Hormones That Influence Bone Metabolism

Chapter 40: Estrogens & Progestins Russell Turner

Chapter 41: The Pharmacology of Selective Estrogen Receptor Modulators Henry Bryant

Chapter 42: Mechanisms of Estrogen Action in Bone Roberto Pacifici

Chapter 43: Thyroid Hormone & Bone Paula Stern

Chapter 44: Clinical and Basic Aspects of Glucocorticoid Action in Bone Barbara Kream

Chapter 45: Effects of Diabetetes & Insulin on Bone Physiology Johan Verhaeghe

Chapter 46: Androgens:Receptor Expression and Steroid Action in Bone Kristine Wiren

Chapter 47: Kinins & Neuro-Osteogenic Factors Ulf Lerner

Chapter 48: Regulation of Bone Remodeling by Central and Peripheral Nervous Signals Patricia Ducy

F. Local Regulators

Chapter 49: Insulin-like Growth Factors and the IGF Binding Proteins: Implications for Bone Biology Cliff Rosen

Chapter 50: Platelet-Derived Growth Factor & the Skeleton Ernesto Canalis

Chapter 51: Fibroblast Growth Factor (FGF) and FGF Receptor Families in Bone Marja Hurley

Chapter 52: Vascular Endothelial Growth Factor and Osteogenic-Angiogenic Coupling Dwight Towler

Chapter 53: Transforming Growth Factor-â Sarah Dallas

Chapter 54: Bone Morphogenetic Proteins and the Skeleton Vicki Rosen

Chapter 55: Bone Morphogenetic Protein Receptors & Actions Kohei Miyazono

Chapter 56: Colony-Stimulating Factor-1 Willy Hofstetter

Chapter 57: Local Regulators of Bone: IL-1, TNF, Lymphotoxin, Interferon-?, IL-8, IL-10, IL-4, the LIF/IL-6 Family, and Additional Cytokines Mark Horowitz

Chapter 58: Prostaglandins & Bone Metabolism Carol Pilbeam

Part II Molecular Mechanisms of Metabolic Bone Disease

Chapter 59: Skeletal Effects of Nitric Oxide: Novel Agent for Osteoporosis Sunil Wimalawansa

Chapter 60: Molecular Basis of PTH Overexpression Andy Arnold

Chapter 61: Familial Benign Hypocalciuric Hypercalcemia and Neonatal Primary Hyperparathyroidism Ghada EI-Hajj Fuleihan

Chapter 62: Multiple Endocrine Neoplasia Type I Maria Luisa Brandi

Chapter 63: Parathyroid Hormone-Related Peptide and Other Systemic Factors in Skeletal Manifestations of Malignancy David Goltzman

Chapter 64: Local Factors in Skeletal Malignancy Greg Mundy

Chapter 65: Genetic Regulation of the Parathyroid Gland Development Raj Thakker

Chapter 66: Jansen's Metaphyseal Chondrodysplasia & Blomstrand's Lethal Chondrodysplasia: Two Genetic Disorders Caused by PTH/PTHrP Receptor Mutations Harald Jueppner

Chapter 67: Diseases Resulting from Defects in the G Protein Gs Lee Weinstein

Chapter 68: Renal Osteodystrophy – Pathogenic Mechanisms and Therapeutic Options Bill Goodman

Chapter 69: Osteogenesis Imperfecta David Rowe

Chapter 70: Hereditary Deficiencies in Vitamin D Action Uri Liberman

Chapter 71: Oncogenic Osteomalacia Suzanne Jan de Beur

Chapter 72: Osteopetrosis Lyndon Key

Chapter 73: Hypophosphatasia: Nature's Window on Alkaline Phosphatase Function in Humans Michael Whyte

Chapter 74: Paget's Disease of Bone Fred Singer

Chapter 75: Genetic Determinants of Bone Mass and Osteoporotic Fracture Stuart Ralston

Chapter 76: Pathophysiology of Osteoporosis Bilezikian, Raisz, Martin

Chapter 77: Evaluation of Risk for Osteoporosis Fracture Stuart Silverman

Part III Pharmacological Mechanisms of Therapeutics

Chapter 78: Parathyroid Hormone Dave Hanley

Chapter 79: Calcium Robert Heaney

Chapter 80: Drugs Acting on the Calcium Receptor Calcimimetics and Calcilytics Edward Nemeth

Chapter 81: Bisphosphonates: Mechanisms of Action Graham Russell

Chapter 82: The Pharmacology of Estrogens in Osteoporosis Robert Lindsay

Chapter 83: Vitamin D & Analogs Glenville Jones

Chapter 84: Estrogen Effects on Bone in the Male Skeleton Luigi Gennari

Chapter 85: Mechanisms of Exercise Effects on Bone Quantity and Quality Clint Rubin

Part IV Methods in Bone Research

Chapter 86: Application of Transgenic Mice to Problems of Skeletal Bone Stephen Clark

Chapter 87: Biochemical Markers of Bone Metabolism Markus Seibel

Chapter 88: Methods and Clinical Issues in Bone Densitometry Glen Blake

Chapter 89: Controversial Issues in Bone Densitometry Paul Miller

Chapter 90: Macro and Micro Imaging of Bone Architecture Klaus Engelke, Sven Prevrhal, and Harry K. Genant


No. of pages:
© Academic Press 2008
29th September 2008
Academic Press
Hardcover ISBN:
eBook ISBN:

About the Editors

John Bilezikian

John P. Bilezikian, MD, the Dorothy L. and Daniel H. Silberberg Professor of Medicine and Professor of Pharmacology at the College of Physicians & Surgeons, Columbia University is Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia University Medical Center. Dr. Bilezikian received his undergraduate training at Harvard College and his medical training at the College of Physicians & Surgeons. He completed four years of house staff training (internship, residency and Chief Residency) on the Medical Service at Columbia Presbyterian Medical Center. Dr. Bilezikian received his training in Metabolic Bone Diseases and in Endocrinology at the NIH in the Mineral Metabolism Branch under the tutelage of Dr. Gerald Aurbach. Dr. Bilezikian belongs to a number of professional societies including the American Society for Bone and Mineral Research, of which he served as President, 1995-1996 and the International Society of Clinical Densitometry, of which he served as President, 1999-2001. He serves on the Board of Governors of the International Osteoporosis Foundation (1998-present) and on its Committee of Scientific Advisors (2001-present). He is Chair of the Endocrine Fellows Foundation. He served as Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism (2000-2004) and as Senior Associate Editor of the Journal of Bone and Mineral Research (2008-2012). He is Executive Advisory Editor of Bone Research (2013-present). His books include Editor-in-Chief of The Parathyroids [1994, 2001, 2014], and co-editor of The Aging Skeleton (1999), Dynamics of Bone and Cartilage Metabolism (1999, 2006), Principles of Bone Biology (1996, 2002, 2008) and Osteoporosis in Men (2010). He served as co-chair of the last three NIH Workshops on Primary Hyperparathyroidism (2002, 2008, 2013). He is the recipient of the Distinguished Physician Award of the Endocrine Society, the Frederic C. Bartter Award of the American Society for Bone and Mineral Research (ASBMR) for Excellence in Clinical Research and the First Annual Global Leadership Award of the International Society of Clinical Densitometry. In 2009, he received the Gideon A. Rodan Excellence in Mentorship Award from the ASBMR. He received the Laureate Distinguished Educator Award of The Endocrine Society in 2014. In 2014, he was made honorary member of the Brazilian Society of Endocrinology and Metabolism. His publications number over 700.

Affiliations and Expertise

Columbia University, New York, New York, U.S.A.

Lawrence Raisz

Dr. Raisz is Professor of Medicine and Program Director of the General Clinical Research Center at the University of Connecticut Health Center. He has been carrying out laboratory and clinical studies in the field of osteoporosis and bone metabolism for over 40 years. He has mentored a large number of investigators in these areas both here at the University of Connecticut and previously at the University of Rochester School of Medicine. His current studies include an analysis of the effects of estrogen and androgen on the expression of cytokines and growth factors in bone, which is being carried out in both humans and animal models, studies of the role of prostaglandins in bone metabolism using transgenic mice, studies on the effects of progestins on bone turnover in postmenopausal women and tissue culture and animal studies on new antiresorptive and anabolic agents carried out in collaboration with the pharmaceutical industry.

Affiliations and Expertise

University of Connecticut, Farmington, U.S.A.

T. John Martin

Dr. Martin has served on 12 state and national committees and boards, been an international lecturer for nearly 20 years, and his work has been extensively published in a total of 420 original papers, 178 reviews, chapters and editorials, and seven books. He was appointed as Officer of the Order of Australia, elected to fellowships of the Australian Academy and the Royal Society and received 12 prestigious career awards, including the Eric Susman Prize from the Royal Australasian College of Physician. He has had 12 patents granted and held eight international visiting appointments in the United Kingdom, United States, and Switzerland. An outstanding contribution to science includes the cloning of parathyroid hormone related protein.

Affiliations and Expertise

St. Vincent’s Institute of Medical Research, Melbourne, Australia


Praise for the previous edition:
"Students, teachers, and practitioners will benefit from reading it, and investigators will use it as a reference work; it will certainly be consulted frequently." --The New England Journal of Medicine

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