Description

Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders.

Key Features

  • Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants…it is all in one source written by the experts in the field
  • The essential resource for anyone involved in the study of bones and bone diseases
  • Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics
  • Readers can easily search and locate information quickly as it will be online with this new edition

Readership

Academic and medical libraries as well as professionals in bone biology, endocrinology, and osteology

Table of Contents

Part I Basic Principles A. Cell Biology Chapter 1: Structure, Modeling and Remodeling of Bone / The Size and Shape of Bone as a Site of Metabolic Bone Activity Ego Seeman Chapter 2: Biomechanics of Bone Elise Morgan Chapter 3: Embryonic Development of Bone and the Molecular Regulation of Intramembranous and Endochondral Bone Formation Andrew Karaplis Chapter 4: Mesenchymal Stem Cells & Osteoblast Lineage Jane Aubin Chapter 5: Transcriptional Control of Osteoblast Differentiation and Function Thorsten Schinke Chapter 6: Wnt Signaling and Bone Mark Johnson Chapter 7: Sclerostin and Bone Rutger van Bezooijen Chapter 8: The Osteocyte Jenneke Klein-Nulend Chapter 9: Cells of Bone: Osteoplast Generation Tatsuo Suda Chapter 10: Osteoclast Function: Biology and Mechanisms Kalervo Vaananen Chapter 11: RANK Signaling Hiroshi Takanayagi Chapter12: Regulating Bone Resorption Roland Baron Chapter 13: Apoptosis in Bone Cells Stavros Manolagas Chapter 14: Skeletal Gene Expression in Nuclear Microenvironments Gary Stein B. Biochemistry Chapter 15: Type I Collagen: Structure, Synthesis, and Regulation Benoit de

Details

No. of pages:
1900
Language:
English
Copyright:
© 2008
Published:
Imprint:
Academic Press
Print ISBN:
9780123738844
eBook ISBN:
9780080568751

About the editors

John Bilezikian

John P. Bilezikian, MD, the Dorothy L. and Daniel H. Silberberg Professor of Medicine and Professor of Pharmacology at the College of Physicians & Surgeons, Columbia University is Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia University Medical Center. Dr. Bilezikian received his undergraduate training at Harvard College and his medical training at the College of Physicians & Surgeons. He completed four years of house staff training (internship, residency and Chief Residency) on the Medical Service at Columbia Presbyterian Medical Center. Dr. Bilezikian received his training in Metabolic Bone Diseases and in Endocrinology at the NIH in the Mineral Metabolism Branch under the tutelage of Dr. Gerald Aurbach. Dr. Bilezikian belongs to a number of professional societies including the American Society for Bone and Mineral Research, of which he served as President, 1995-1996 and the International Society of Clinical Densitometry, of which he served as President, 1999-2001. He serves on the Board of Governors of the International Osteoporosis Foundation (1998-present) and on its Committee of Scientific Advisors (2001-present). He is Chair of the Endocrine Fellows Foundation. He served as Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism (2000-2004) and as Senior Associate Editor of the Journal of Bone and Mineral Research (2008-2012). He is Executive Advisory Editor of Bone Research (2013-present). His books include Editor-in-Chief of The Parathyroids [1994, 2001, 2014], and co-editor of The Aging Skeleton (1999), Dynamics of Bone and Cartilage Metabolism (1999, 2006), Principles of Bone Biology (1996, 2002, 2008) and Osteoporosis in Men (2010). He served as co-chair of the last three NIH Workshops on Primary Hyperparathyroidism (2002, 2008, 2013). He is the recipient of the Distinguished Physician Award of the Endocrine Society, the Frederic C. Bartter Award of the American Society for Bone and

Affiliations and Expertise

Columbia University, New York, New York, U.S.A.

Lawrence Raisz

Dr. Raisz is Professor of Medicine and Program Director of the General Clinical Research Center at the University of Connecticut Health Center. He has been carrying out laboratory and clinical studies in the field of osteoporosis and bone metabolism for over 40 years. He has mentored a large number of investigators in these areas both here at the University of Connecticut and previously at the University of Rochester School of Medicine. His current studies include an analysis of the effects of estrogen and androgen on the expression of cytokines and growth factors in bone, which is being carried out in both humans and animal models, studies of the role of prostaglandins in bone metabolism using transgenic mice, studies on the effects of progestins on bone turnover in postmenopausal women and tissue culture and animal studies on new antiresorptive and anabolic agents carried out in collaboration with the pharmaceutical industry.

Affiliations and Expertise

University of Connecticut, Farmington, U.S.A.

T. John Martin

Affiliations and Expertise

St. Vincent’s Institute of Medical Research, Melbourne, AUSTRALIA

Reviews

Praise for the previous edition:
"Students, teachers, and practitioners will benefit from reading it, and investigators will use it as a reference work; it will certainly be consulted frequently." --The New England Journal of Medicine