Principles of Bone Biology

Principles of Bone Biology

2nd Edition - January 9, 2002

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  • Editors: John Bilezikian, Lawrence Raisz, Gideon Rodan
  • eBook ISBN: 9780080539607

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Principles of Bone Biology is the essential resource for anyone involved in the study of bones. It is the most comprehensive, complete, up-to-date source of information on all aspects of bones and bone biology in one convenient source. Written and published in less than one year, it will become an indispensable resource for any scientific or medical library. This, second edition, details countless advances over the past five years, both by updating old chapters and providing additional material. It takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics.

Key Features

The most current and timely source of information about the biology and pathology of bone
Provides succinct coverage of the subject
Contributors include over 200 of the most respected researchers in the field
Extensive table of contents and index for easy reference
Easy-to-read and highly informative to both the newcomer and the initiated to the field
Spans the spectrum from molecular biology to in vivo pharmacology
Complete bibliography with each entry fully referenced for additional background reading
First edition was selected by Doody Publishing as one of the 250 Best Health Science books published in 1996


Researchers, professionals, and academic clinicians in bone, endocrinology, and related disciplines.

Table of Contents


    Cell Biology
    The Structure & Development of the Skeleton
    Biomechanics of Bone
    Embryonic Development of Bone and the Molecular Regulation of Intramembranous and Endochondral Bone Formation
    Mesenchymal Stem Cells & Osteoblast Lineage
    Transcriptional Control of Osteoblast Differentiation and Function
    The Osteocyte
    Cells of Bone: Osteoclast Generation
    Osteoclast Function
    Integrin and Calcitonin Receptor Signaling in the Regulation of the Cytoskeleton and Function of Osteoclasts
    Apoptosis in Bone Cells
    Involvement of Nuclear Architecture in Regulating Gene Expression in Bone Cells

    Type I Collagen: Structure, Synthesis, and Regulation
    Collagen Crosslinking & Metabolism
    Bone Matrix Proteoglycans & Glycoproteins
    Bone Proteinases
    Cell Surface Attachment Molecules
    Intercellular Junctions and Cell-Cell Communication in Bone

    Bone Remodeling and Mineral Homeostasis
    Histomorphometric Analysis of Bone Remodeling
    Phosphorus Homeostasis & Related Disorders
    Magnesium Homeostasis
    Metals in Bone: Aluminum, Boron, Cadmium, Chromium, Lead, Silicon, & Strontium
    The Biology of the Extracellular Ca2+-Sensing Receptor (CaR)

    The Hormones of Bone
    Receptors for Parathyroid Hormone and Parathyroid Hormone-Related Peptide
    Parathyroid Hormone - Molecular Biology
    Parathyroid Hormone-Receptor Interactions
    Actions of Parathyroid Hormone
    Renal and Skeletal Actions of PTH and PTHrP
    Physiological Actions of PTH and PTHRP: Epidermal, Mammary, Reproductive and Pancreatic Issues
    Vascular, Cardiovascular and Neurological Actions of PTHrP
    Nuclear Receptor Structure (VDR) and Ligand Specificities for Genomic and Rapid Biological Responses
    Vitamin D Gene Regulation
    Photobiology and Non-Calcemic Actions of Vitamin D
    The Structure and Molecular Biology of the Calcitonin Receptor
    Physiology & Pathophysiology of Calcitonin
    Amylin & CGRP

    Other Systemic Hormones That Influence Bone Metabolism
    Estrogens & Progestins
    Selective Estrogen Receptor Modulators (SERMs)
    Mechanisms of Estrogen Action in Bone
    Thyroid Hormone & Bone
    Clinical and Basic Aspects of Glucocorticoid Action in Bone
    Effects of Diabetes & Insulin on Bone Physiology
    Androgens: Receptor Expression and Steroid Action in Bone
    Kinins & Neuro-Osteogenic Factors

    Local Regulators
    The Role of Insulin-like Growth Factors & Binding Proteins in Bone Cell Biology
    Platelet-Derived Growth Factor & the Skeleton
    Fibroblast Growth Factor and Fibroblast Growth Factor Receptor Families in Bone
    Vascular Endothelial Growth Factors
    Transforming Growth Factor (beta
    Bone Morphogenetic Proteins
    Bone Morphogenetic Protein Receptors & Actions
    Colony-Stimulating Factors
    Local Regulators of Bone: IL-1, TNF, Lymphotoxin, Interferon-?, IL-8, IL-10, IL-4, the LIF/IL-6 Family, and Additional Cytokines
    Prostaglandins & Bone Metabolism
    Nitric Oxide and other Vasoactive Agents


    Molecular Basis of PTH Overexpression
    Familial Benign Hypocalciuric Hypercalcemia and Neonatal Primary Hyperparathyroidism
    Multiple Endocrine Neoplasia Type I
    The Role of the RET Proto-oncogene in Multiple Endocrine Neoplasia Type 2
    Systemic Factors in Skeletal Manifestations of Malignancy
    Local Factors in Skeletal Malignancy
    Molecular Basis of PTH Underexpression
    Jansen's Metaphyseal Chondrodysplasia & Blomstrand's Lethal Chondrodysplasia: Two Genetic Disorders Caused by PTH/PTHrP Receptor Mutations
    Signal Transduction via G Proteins; Pseudohypoparathyroidism
    Other Skeletal Diseases Resulting from G Protein Defects - Fibrous Dysplasia & McCune-Albright Syndrome
    Osteogenesis Imperfecta
    Hereditary Deficiencies in Vitamin D Action
    Oncogenic Osteomalacia
    Hypophosphatasia: Nature's Window on Alkaline Phosphatase Function in Man
    Paget's Disease of Bone
    Genetic Determinants of Bone Mass
    Pathophysiology of Osteoporosis
    Evaluation of Risk for Osteoporosis Fractures


    Pharmacologic Mechanisms of Therapeutics: Parathyroid Hormone
    Calcium Receptors as Novel Drug Targets
    Bisphosphonates: Mechanisms of Action
    Fluoride in Osteoporosis
    The Pharmacology of Estrogens in Osteoporosis
    Pharmacologic Mechanisms of Therapeutics: Vitamin D & Analogs
    Molecular and Clinical Pharmacology of Calcitonin
    Growth Hormone and Insulin-like Growth Factor-I Treatment for Metabolic Bone Diseases
    Anabolic Steroid Effects on Bone in Women
    Estrogen Effects on Bone in the Male Skeleton
    Mechanisms of Exercise Effects on Bone


    Application of Transgenic Mice to Problems of Skeletal Bone
    Use of Cultured Osteoblastic Cells to Identify and Characterize Transcriptional Regulatory Complexes
    Current Methodologic Issues in Cell & Tissue Culture
    Biochemical Markers of Bone Metabolism
    Methods and Clinical Issues in Bone Densitometry and Quantitative Ultrasonometry
    Controversies in Bone Mass Measurement
    Macro and Micro Imaging of Bone Architecture
    Transilial Bone Biopsy
    Animal Models in Osteoporosis Research
    Defining the Genetics of Osteoporosis - Using the Mouse to Understand Man

Product details

  • No. of pages: 1696
  • Language: English
  • Copyright: © Academic Press 2002
  • Published: January 9, 2002
  • Imprint: Academic Press
  • eBook ISBN: 9780080539607

About the Editors

John Bilezikian

John P. Bilezikian, MD, the Dorothy L. and Daniel H. Silberberg Professor of Medicine and Professor of Pharmacology at the College of Physicians & Surgeons, Columbia University is Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia University Medical Center. Dr. Bilezikian received his undergraduate training at Harvard College and his medical training at the College of Physicians & Surgeons. He completed four years of house staff training (internship, residency and Chief Residency) on the Medical Service at Columbia Presbyterian Medical Center. Dr. Bilezikian received his training in Metabolic Bone Diseases and in Endocrinology at the NIH in the Mineral Metabolism Branch under the tutelage of Dr. Gerald Aurbach. Dr. Bilezikian belongs to a number of professional societies including the American Society for Bone and Mineral Research, of which he served as President, 1995-1996 and the International Society of Clinical Densitometry, of which he served as President, 1999-2001. He serves on the Board of Governors of the International Osteoporosis Foundation (1998-present) and on its Committee of Scientific Advisors (2001-present). He is Chair of the Endocrine Fellows Foundation. He served as Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism (2000-2004) and as Senior Associate Editor of the Journal of Bone and Mineral Research (2008-2012). He is Executive Advisory Editor of Bone Research (2013-present). His books include Editor-in-Chief of The Parathyroids [1994, 2001, 2014], and co-editor of The Aging Skeleton (1999), Dynamics of Bone and Cartilage Metabolism (1999, 2006), Principles of Bone Biology (1996, 2002, 2008) and Osteoporosis in Men (2010). He served as co-chair of the last three NIH Workshops on Primary Hyperparathyroidism (2002, 2008, 2013). He is the recipient of the Distinguished Physician Award of the Endocrine Society, the Frederic C. Bartter Award of the American Society for Bone and Mineral Research (ASBMR) for Excellence in Clinical Research and the First Annual Global Leadership Award of the International Society of Clinical Densitometry. In 2009, he received the Gideon A. Rodan Excellence in Mentorship Award from the ASBMR. He received the Laureate Distinguished Educator Award of The Endocrine Society in 2014. In 2014, he was made honorary member of the Brazilian Society of Endocrinology and Metabolism. His publications number over 700.

Affiliations and Expertise

Columbia University, New York, New York, U.S.A.

Lawrence Raisz

Dr. Raisz is Professor of Medicine and Program Director of the General Clinical Research Center at the University of Connecticut Health Center. He has been carrying out laboratory and clinical studies in the field of osteoporosis and bone metabolism for over 40 years. He has mentored a large number of investigators in these areas both here at the University of Connecticut and previously at the University of Rochester School of Medicine. His current studies include an analysis of the effects of estrogen and androgen on the expression of cytokines and growth factors in bone, which is being carried out in both humans and animal models, studies of the role of prostaglandins in bone metabolism using transgenic mice, studies on the effects of progestins on bone turnover in postmenopausal women and tissue culture and animal studies on new antiresorptive and anabolic agents carried out in collaboration with the pharmaceutical industry.

Affiliations and Expertise

University of Connecticut, Farmington, U.S.A.

Gideon Rodan

Dr. Rodan graduated from the Hebrew University Medical School (Jerusalem) in 1965, had two years residency in oncology and obtained a Ph.D. in chemistry in 1970 from the Weizmann Institute of Science, Israel. In 1970, he joined the University of Connecticut, where he became chairman of the Department of Oral Biology in 1978. In 1985, he was recruited by Merck to head the Department of Bone Biology and Osteoporosis Research and, since 1986, holds a joint appointment at the University of Pennsylvania as Adjunct Professor of Pathology.

The scientific contributions of Dr. Rodan and his colleagues include: establishment and characterization of osteoblastic cell lines in culture, which helped define the osteoblastic phenotype, the sequential expression of phenotypic genes, the interaction between osteoblasts and osteoclasts, and the development of a sensitive parathyroid hormone bioassay, which eventually led to the purification of parathyroid hormone-related peptide; other contributions include bone cell responses to mechanical stimuli and the role of prostaglandin E in that process. At Merck, Dr. Rodan initiated the effort which led to the development of the osteoporosis drug Fosamax and contributed to the understanding of the mode of action of bisphosphonates.

Dr. Rodan has served on NIH study sections, council and other advisory panels; he has been an Associate Editor of the Journal of Bone and Mineral Research, is currently Associate Editor of Bone, and member of several editorial boards. Dr. Rodan has been council member, program chairman and president of ASBMR; member of the Board of Directors of the National Osteoporosis Foundation and is currently president elect of the International Bone and Mineral Society. Dr. Rodan is the recipient of the Kennedy prize from the Weizmann Institute of science, the Neuman prize from the ASBMR, the Pioneer Award of the National Osteoporosis Foundation and the Goldhaber award of Harvard School of Dental Medicine.

Affiliations and Expertise

Merck Research Labs, West Point, Pennsylvania, U.S.A.

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