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Principles and Technologies for Electromagnetic Energy Based Therapies - 1st Edition - ISBN: 9780128205945

Principles and Technologies for Electromagnetic Energy Based Therapies

1st Edition

Editors: Govindarajan Srimathveeravalli Punit Prakash
Paperback ISBN: 9780128205945
Imprint: Academic Press
Published Date: 1st November 2021
Page Count: 500
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Principles and Technologies for Electromagnetic Energy Based Therapies covers the theoretical foundations of electromagnetic-energy based therapies, principles for design of practical devices and systems, techniques for in vitro and in vivo testing of devices, and clinical application examples of contemporary therapies employing non-ionizing electromagnetic energy. The book provides in-depth coverage of: pulsed electric fields, radiofrequency heating systems, tumor treating fields, and microwave heating technology. Devices and systems for electrical stimulation of neural and cardiac issue are covered as well. Lastly, the book describes and discusses issues that are relevant to engineers who develop and translate these technologies to clinical applications.

Readers can access information on incorporation of preclinical testing, clinical studies and IP protection in this book, along with in-depth technical background for engineers on electromagnetic phenomena within the human body and selected therapies. It covers both engineering and biological/medical materials and gives a full perspective on electromagnetics therapies. Unique features include content on tumor treating fields and the development and translation of biomedical devices.

Key Features

  • Provides in-depth technical background on electromagnetic energy-based therapies, along with real world examples on how to design devices and systems for delivering electromagnetic energy-based therapies
  • Includes guidance on issues that are relevant for translating the technology to the market, such as intellectual property, regulatory issues, and preclinical testing
  • Companion site includes COMSOL models, MATLAB code, and lab protocols


Readers who seek an introduction to electromagnetic energy-based treatments, with emphasis on ablation therapy. Upper level undergraduate and/or graduate level courses teaching the principles of electromagnetic field based therapeutic technologies. Medical device engineers and clinical support specialists, and clinicians who seeking to learn more about the technical foundations of electromagnetic field-based therapy

Table of Contents

Section 1: Introduction and Theoretical Foundations
1. History, development and application of electromagnetic fields in medicine
2. Biophysical principles of electromagnetic field interactions with biological tissues
3. Computational methods for the modeling of electromagnetic fields in biological
3a. Low frequency, electrical spectrum (pulsed electric fields, TTF, RF)
3b. High frequency, electromagnetic spectrum (MW)
4. Thermal effects of electromagnetic fields
5. Tissue property determinants of electromagnetic therapies

Section 2: Pulsed Electric Fields
6. Introduction to PEF therapy and its applications
7. Working principles of PEF therapy
8. Instrumentation for PEF therapy
9. In vitro and in vivo testing of PEF therapy
10. Clinical application of PEF: Oncology
11. Clinical application of PEF: Other

Section 3: Radiofrequency Energy
12. Introduction to RF energy and its applications
13. Working principles of RF therapy
14. Instrumentation for RF therapy
15. In vitro and in vivo testing of RF therapy
16. Clinical application of PEF: Oncology
17. Clinical application of PEF: Other

Section 3: Tumor Treating Fields
18. Introduction to TTF and its applications
19. Working principles of TTF therapy
20. Instrumentation for TTF therapy
21. In vitro and in vivo testing of TTF therapy
22. Clinical application of TTF: Oncology

Section 4: Microwave Energy
23. Introduction to MW energy and its applications
24. Working principles of MW therapy
25. Instrumentation for MW therapy
26. In vitro and in vivo testing of MW therapy
27. Clinical application of MW: Oncology
28. Clinical application of MW: Other

Section 5: Non-Ablative Applications
29. Brain stimulation
30. Peripheral nerve stimulation
31. Cardiac pacemaker and defibrillators
32. Pain control
33. Emerging topics

Section 6: Development and Translation
34. Regulatory and approvals
35. Preclinical testing
36. Clinical trials and design
37 IP protection
38. Case study 1
39. Case study 2


No. of pages:
© Academic Press 2021
1st November 2021
Academic Press
Paperback ISBN:

About the Editors

Govindarajan Srimathveeravalli

Dr. Srimathveeravalli joined University of Massachusetts at Amherst in Spring 2019 after serving as a faculty in the Dept. of Radiology at Memorial Sloan Kettering Cancer Center for six years. His lab develops medical devices and technology to advance minimally invasive, image-guided therapy of cancer, and non-malignant diseases. His lab studies the interaction between non-ionizing energy and tissue biology, with emphasis on the differential response of various components of the tumor microenvironment to energy delivery. He uses computer based simulation models and mathematical models to optimize energy parameters and to guide applicator design for energy delivery in vitro and in vivo. His lab seeks to identify and understand signaling pathways evoked due to energy delivery and tests adjuvants to improve treatment outcomes. Findings from his lab has applications in tumor ablation, cancer immunotherapy, drug delivery and tissue engineering, with near-term translational potential. Dr. Srimathveeravalli got his PhD in mechanical engineering from the University at Buffalo and received postdoctoral training on cancer research and image-guided therapy at Memorial Sloan Kettering Cancer Center. His lab is supported by grants from the NIH, the Society of Interventional Radiology, Dept of Defense, industrial contracts, and various philanthropic foundations.

Affiliations and Expertise

University of Massachusetts Amherst, Amherst, USA.

Punit Prakash

Dr. Prakash is Associate Professor and holder of the Paul L. Spainhour Professorship in Electrical Engineering at Kansas State University. He received a Bachelor of Science in Electrical and Computer Engineering from Worcester Polytechnic Institute in May 2004, and a PhD in biomedical engineering from the University of WisconsinMadison in 2008. He completed postdoctoral training in hyperthermia physics at the University of California, San Francisco. Since 2012, he has been with the Department of Electrical and Computer Engineering at Kansas State University, where he is also an affiliate of the Johnson Center for Cancer Research. Dr. Prakash’s research is focused on developing technologies for enabling precise image-guided medical interventions. Current research thrusts include: (i) development of minimally-invasive microwave/radiofrequency devices with spatial control of energy delivery for thermal tissue ablation; (ii) multiphysics and multiscale computational modeling for analysis of thermal therapies; and (iii) integration of medical instrumentation with high-field MRI for characterization of therapeutic interventions in small-animal experimental models. His research is currently supported by grants from the National Institutes for Health (NIH), National Science Foundation (NSF), and the medical device industry.

Affiliations and Expertise

Kansas State University, Manhattan, USA.

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