Principles and Practice of Sleep Medicine

4th Edition

Authors: Meir Kryger Thomas Roth William Dement
Hardcover ISBN: 9780721607979
eBook ISBN: 9781437713121
Imprint: Saunders
Published Date: 18th March 2005
Page Count: 1552

Table of Contents

I. Principles of Sleep Medicine

Normal Sleep and Its Variations

1. History of Sleep Physiology and Medicine
2. Normal Human Sleep: An Overview
3. Normal Aging
4. Daytime Sleepiness and Alertness
5. Acute Sleep Deprivation
6. Chronic Sleep Deprivation
7. Phylogeny of Sleep Regulation
8. Mammalian Sleep
Sleep Mechanisms
9. Brain Electrical Activity and Sensory Processing During Waking and Sleep States
10. REM sleep
11. Basic Mechanisms of Sleep-Wake States
12. Control of Motoneurons during sleep
13. Sleep-Promoting Mechanisms in Mammals
Physiology in Sleep
14. Physiologic Regulation in Sleep
15. Cardiovascular Physiology: Central and Autonomic Regulation
16. Cardiovascular Physiology: The Peripheral Circulation
17. Respiratory Physiology: Central Neural Control
18. Respiratory Physiology: Control of Ventilation
19. Respiratory Physiology: Breathing in Normal Subjects
20. Respiratory Physiology: Sleep at High Altitudes
21. Host Defense
22. Endocrine Physiology
23. Gastrointestinal Physiology
24. Temperature Thermoregulation and Sleep
25. Neural Mechanisms of Sleep-Related Penile Erections
26. Master Circadian Clock: Master Circadian Rhythm
27. Circadian Rhythms in Mammals: Formal Properties and Environmental Influences
28. Anatomy of the Mammalian Circadian System
29. Physiology of the Mammalian Circadian System
30. Molecular Genetic Basis for Mammalian Circadian Rhythms
31. The Human Circadian Timing System and Sleep-Wake Regulation
32. Melatonin in the Regulation of Sleep and Circadian Rhythms
33. Sleep Homeostasis and Models of Sleep Regulation
34. Interaction of Sleep Homeostasis and Circadian Rhythmicity-- Dependent or Independent Systems?
35. Circadian Rhythms in Sleepiness, Alertness and Performance
36. Hypn


This authoritative guide to sleep medicine is also available as an e-dition, book (ISBN: 1416003207) plus updated online reference!

The new edition of this definitive resource has been completely revised and updated to provide all of the latest scientific and clinical advances. Drs. Kryger, Roth, and Dement—and over 170 international experts—discuss the most recent data, management guidelines, and treatments for a full range of sleep problems. Representing a wide variety of specialties, including pulmonary, neurology, psychiatry, cardiology, internal medicine, otolaryngology, and primary care, this "who's who" of experts delivers the most compelling, readable, and scientifically accurate source of sleep medicine available today.

Key Features

  • Includes user-friendly synopses of important background information before all basic science chapters.
  • Provides expert coverage of narcolepsy movement disorders breathing disorders gastrointestinal problems neurological conditions psychiatric disturbances substance abuse * and more.


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eBook ISBN:
Hardcover ISBN:


"A must-have!"-JAMA- March 2006

About the Authors

Meir Kryger Author

Affiliations and Expertise

Professor, Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, Connecticut

Thomas Roth Author

Affiliations and Expertise

Division Head, Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, Michigan

William Dement Author

Affiliations and Expertise

Lowell W. and Josephine Q. Berry Professor of Psychiatry and Behavioral Sciences; Stanford University School of Medicine, Sleep Sciences and Medicine, Stanford, California