Principles and Practice of Sleep Medicine

Principles and Practice of Sleep Medicine

6th Edition - December 29, 2015
  • Authors: Meir Kryger, Thomas Roth, William Dement
  • eBook ISBN: 9780323377522

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For nearly 30 years, Dr. Meir Kryger’s must-have guide to sleep medicine has been the gold standard in this fast-changing field. This essential, full-color reference includes more than 20 unique sections and over 170 chapters covering every aspect of sleep disorders, giving you the authoritative guidance you need to offer your patients the best possible care. For this updated 6th edition, extensive additional online material enhances the value of Principles and Practice of Sleep Medicine to your practice.

Key Features

  • Evidence-based content helps you make the most well-informed clinical decisions.
  • An ideal resource for preparing for the sleep medicine fellowship examination.

Table of Contents

  • Section 1: Normal Sleep and Its Variance

    1. History of Sleep Physiology and Medicine

    2. Normal Human Sleep: An Overview

    3. Normal Aging

    4. Daytime Sleepiness and Alertness

    5. Sleep Deprivation

    6. Genetics of Normal Human Sleep

    Section 2: Sleep Mechanisms and Phylogeny

    7. Neural Control of Sleep in Mammals

    8. Rapid Eye Movement Sleep

    9. Novel Techniques for identifying Sleep Mechanisms and Disorders

    10. Sleep in Animals: A State of Adaptive Inactivity


    Section 3: Physiology in Sleep

    11. Relevance of Sleep Physiology for Sleep Medicine Clinicians

    12. What Brain Imaging Reveals about Sleep Generation and Maintenance?

    13. Cardiovascular Physiology and Coupling with Respiration: Central and Autonomic Regulation

    14. Cardiovascular Physiology: Autonomic Control in Health and in Sleep Disorders

    15. Respiratory Physiology: Central Neural Control of Respiratory Neurons and Motoneurons during Sleep

    16. Respiratory Physiology: Understanding the Control of Ventilation

    17. Physiology of Upper and Lower Airways

    18. Respiratory Physiology: Sleep at High Altitudes

    19. Sleep and Host Defense

    20. Endocrine Physiology in Relation to Sleep and Sleep Disturbances

    21. Thermoregulation in Sleep and Hibernation

    22. Memory Processing in Relation to Sleep

    23. Sensory and Motor Processing During Sleep and Wakefulness

    24. Opiate Action on Sleep and Breathing

    25. Pathophysiology of Sleep-wake Disturbances After Traumatic Brain Injury


    Section 4: Genetics and Genomic Basis of Sleep

    26. Introduction: Genetics and Genomics of Sleep

    27. Genetics and Genomics of Circadian Clocks

    28. Genetics and Genomic Basis of Sleep in Simple Model Organisms

    29. Genetics and Genomic Basis of Sleep in Rodents

    30. Genetics and Genomic Basis of Sleep in Healthy Humans

    31. Genetics and Genomic Basis of Sleep Disorders in Humans


    Section 5: Chronobiology

    32. Introduction: Master Circadian Clock and Master Circadian Rhythm

    33. Anatomy of the Mammalian Circadian System

    34. Physiology of the Mammalian Circadian System

    35. Human Circadian Timing System and Sleep-Wake Regulation

    36. Sleep Homeostasis and Models of Sleep Regulation

    37. Circadian Rhythms in Sleepiness, Alertness, and Performance

    38. Central and Peripheral Circadian Clocks

    39. Circadian Dysregulation and Mental and Physical Health

    40. Circadian Disorders of the Sleep-Wake Cycle


    Section 6: Pharmacology

    41. Hypnotic Medications: Mechanisms of Action and Pharmacologic Effects

    42. Clinical Pharmacology of Other Drugs Used as Hypnotics

    43. Wake-Promoting Medications: Basic Mechanisms and Pharmacology

    44. Wake-Promoting Medications: Efficacy and Adverse Effects

    45. Drugs That Disturb Sleep and Wakefulness

    46. Effects of Hypnotic Drugs on Driving Performance


    Section 7: Psychobiology and Dreaming

    47. Introduction

    48. Why We Dream

    49. Dream Content: Quantitative Findings

    50. Brain Correlates of Sucessful Dream Recall

    51. Neurobiology of Dreaming

    52. Lucid Dreaming

    53. Nightmares and Nightmare Function

    54. Incorporation of waking Experiences into Dreams

    55. Dreams and Nightmares in Posttraumatic Stress Disorder

    56. Emotion, Motivation, and Reward in Relation to Dreaming


    Section 8: Impact, Presentation, and Diagnosis

    57. Approach to the Patient with Disordered Sleep

    58. Cardinal Manifestations of Sleep Disorders

    59. Physical Examination in Sleep Medicine

    60. Use of Clinical Tools and Tests in Sleep Medicine

    61. Classification of Sleep Disorders

    62. Epidemiology of Sleep Medicine

    63. Sleep Medicine, Public Policy, and Public Health

    64. Sleep and Athletic Performance



    Section 9: Legal Topics in Sleep Medicine

    65. Sleep Forensics: Criminal Culpability for Sleep-Related Violence

    66. Legal Obligations of Persons Who Have Sleep Disorders or Who Treat or Hire Them

    67. Legal Aspects of Fatigue-and Safety-Sensitive Professions

    68. Sleep Medicine Clinical Practice and Compliance – United States

    69. Sleep Medicine Clinical Practice and Compliance – Europe


    Section 10: Occupational Sleep Medicine

    70. Introduction

    71. Performance Deficits During Sleep Loss and Their Operational Consequences

    72. Sleep and Performance Prediction Modeling

    73. Fatigue Risk Management Systems

    74. Drowsiness in Transportation Workers

    75. Shift Work, Shift-Work Disorder, and Jet Lag

    76. Sleep Problems in First Responders and in Deployed Military Personnel

    77. Sleep, Occupational stress, and Burnout

    78. Optimizing Shift Scheduling

    79. Obstructive Sleep Apnea in the Workplace


    Section 11: Insonmnia

    80. Insomnia: Recent Developments and Future Directions

    81. Insomnia: Epidemiology and Risk Factors

    82. Etiology and Pathophysiology of Insomnia

    83. Insomnia Diagnosis Assessment, and Evaluation

    84. Insomnia and Health

    85. Cognitive Behavioral Therapies for Insomnia I: Approaches and Efficacy

    86. Psychological and Behavioral Treatments for Insomnia II: Implementation and Specific Population

    87. Pharmacologic Treatment of Insomnia: Benzodiazepine Receptor Agonists

    88. Pharmacologic Treatment of Insomnia: Other Medication


    Section 12: Neurological Disorders

    89. Narcolepsy: Genetic, Immunology, and Pathophysiology

    90. Narcolepsy: Diagnosis and Management

    91. Idiopathic Hypersomnia

    92. Parkinsonism

    93. Sleep and Stroke

    94. Sleep and Neuromuscular Diseases

    95. Restless Legs Syndrome and Periodic Limb Movements During Sleep

    96. Alzheimer's Disease and Other Dementias

    97. Epilepsy, Sleep, and Sleep Disorders

    98. Other Neurological Disorders

    99. Sleep Disorders after Traumatic Brain Injury

    100. Kleine-Levin Syndrome


    Section 13: Parasomnias

    101. Parasomnias: Overview and Approach

    102. Non-Rapid Eye Movement Parasomnias: Clinical Spectrum, Diagnostic Features, and Management

    103. Rapid Eye Movement Sleep Parasomnias

    104. Nightmares and Dream Disturbances

    105. Other Parasomnias

    106. Sleep-Related Movement Disorders and Their Unique Motor Manifestations


    Section 14: Sleep Breathing Disorders

    107. Sleep Related Breathing Disorders: Classification

    108. Sleep Breathing Disorders: Clinical Overview

    109. Central Sleep Apnea: Definitions, and Pathophysiology, Genetics, and Epidemiology

    110. Central Sleep Apnea: Diagnosis and Management

    111. Anatomy and Physiology of Upper Airway Obstruction

    112. Snoring and Pathologic Upper Airway Resistance Syndromes

    113. Obstructive Sleep Apnea: Phenotypes and Genetics

    114. Obstructive Sleep Apnea: Clinical Features, Evaluation, and Principles of Management

    115. Positive Airway Pressure Treatment for Obstructive Sleep Apnea

    116. Medical and Device Treatment for Obstructive Sleep Apnea: Alternative, Adjunctive, and Complementary Therapies

    117. Obstructive Sleep Apnea and the Central Nervous System: Neural Adaptive Processes, Cognition and Performance

    118. Obstructive Sleep Apnea and Metabolic Disorders

    119. Overlap Syndromes of Sleep and Breathing Disorders

    120. Obesity Hypoventilation Syndrome

    121. Obstructive Sleep Apnea, Obesity, and Bariatric Surgery

    122. Sleep and Breathing at High Altitude


    Section 15: Cardiovascular Disorders

    123. Sleep and Cardiovascular Disease: Present and Future

    124. Sleep-Related Cardiac Risk

    125. Cardiac Arrythmogenesis during Sleep: Mechanisms, Diagnosis, and Therapy

    126. Cardiovascular Effects of Sleep-Related Breathing Disorders

    127. Systemic and Pulmonary Hypertension in Obstructive Sleep Apnea

    128 Coronary Artery Disease and Obstructive Sleep Apnea

    129. Heart Failure


    Section 16: Other Medical Disorders

    130. Sleep and Fatigue in Cancer Patients

    131. Fibromyalgia and Chronic Fatigue Syndromes

    132. Endocrine Disorders

    133. Pain and Sleep

    134. Sleep and Chronic Kidney Disease

    135. Sleep in Critically Ill Patients


    Section 17: Psychiatric Disorders

    136. Anxiety Disorders and Posttraumatic Stress Disorder

    137. Unipolar Major Depression

    138. Bipolar Disorder

    139. Schizophrenia

    140. Medication and Substance Abuse

    141. Sleep Disturbances in Attention-Deficit/Hyperactivity Disorder


    Section 18: Dentistry and Otolaryngology in Sleep Medicine

    142. Role of Dentistry and Otolaryngology in Sleep Medicine

    143. Orophayngeal Growth & Skeletal Malformations

    144. Sleep Bruxism: Definition, Prevalence, Classification, Etiology, and Consequences

    145. Sleep Bruxism: Diagnostic Considerations

    146. Orofacial Pain and Temporomandibular Disorders in Relation to Sleep-Disordered Breathing and Sleep Bruxism

    147. Oral Appliances for the Treatment of Obstructive Sleep Apnea-Hypopnea Syndrome and for Concomitant Sleep Bruxism

    148. Anesthesia in Upper Airway Surgery for Obstructive Sleep Apnea

    149. Upper Airway Surgery to Treat Obstructive sleep-Disordered Breathing

    150. Pharmacotherapy, Complementary, Alternative Medicine for Sleep Bruxism


    Section 19: Sleep in Older Adults

    151. Psychiatric and Medical Comorbidities, and Effects of Medications in Older Adults

    152. Obstructive Sleep Apnea in Older Adults

    153. Insomnia in Older Adults

    154. Circadian Rhythms in Older Adults


    Section 20: Sleep in Women

    155. Sex Differences and Menstrual-Related Changes in Sleep and Circadian Rhythms

    156. Sleep and Sleep Disorders Associated with Pregnancy

    157.Sleep-Disordered Breathing in Pregnancy

    158. Postpartum Period and Early Motherhood

    159. Sleep and Menopause


    Section 21: Instrumentation and Methodology

    160. Polysomnography and Beyond

    161. Sleep Stage Scoring

    162. Central Nervous System Arousals & Cyclic Alternating Patterns

    163. Neurologic Monitoring Techniques

    164. Monitoring Techniques for Evaluating Suspected Sleep-Related Breathing Disorders

    165. Home Sleep Testing

    166. Cardiopulmonary Coupling Sleep Spectrograms

    167. Pulse Wave Analysis During Sleep

    168. Recording and Scoring Sleep-Related Movements

    169. Evaluating Sleepiness

    170. Chronobiologic Monitoring Techniques

    171. Actigraphy

Product details

  • No. of pages: 1784
  • Language: English
  • Copyright: © Elsevier 2016
  • Published: December 29, 2015
  • Imprint: Elsevier
  • eBook ISBN: 9780323377522

About the Authors

Meir Kryger

Affiliations and Expertise

Professor, Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, Connecticut

Thomas Roth

Affiliations and Expertise

Director, Sleep Disorders Center, Henry Ford Hospital, Detroit, Michigan

William Dement

Affiliations and Expertise

Lowell W. and Josephine Q. Berry Professor of Psychiatry and Behavioral Sciences; Stanford University School of Medicine, Sleep Sciences and Medicine, Stanford, California