Principles and Practice of Ovarian Tissue Cryopreservation and Transplantation
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Principles and Practice of Ovarian Tissue Cryopreservation and Transplantation

1st Edition - May 20, 2022

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  • Editor: Kutluk Oktay
  • eBook ISBN: 9780128233450
  • Paperback ISBN: 9780128233443

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Description

Principles and Practice of Ovarian Tissue Cryopreservation and Transplantation provides methods and techniques of ovarian tissue harvesting and cryopreservation, including instructional videos. This book will benefit a wide audience, guiding infertility specialists, fellows, residents, reproductive surgeons, reproductive endocrinologists, pediatric surgeons, embryologists, infertility nurses and gynecologists. Ovarian cryopreservation and transplantation is rapidly gaining acceptance as a successful and established fertility preservation strategy in cancer patients and beyond. Unlike other fertility preservation strategies, it can be performed in children as well as adults, and can be helpful in restoring natural ovarian function and fertility, hence this is a welcomed resource on the topic.

Key Features

  • Provides instructional videos, materials and an equipment list for ovarian tissue harvesting and cryopreservation, along with protocols for ovarian tissue cryopreservation thawing and transplantation
  • Presents instructional video coverage of ovarian tissue cryopreservation for use at fertility centers around the globe
  • Fulfills a specific niche in the literature, providing a comprehensive reference on ovarian tissue freezing and transplantation
  • Includes a foreword written by a cancer survivor who successfully received this procedure

Readership

Infertility specialists, fellows, residents, reproductive surgeons, reproductive endocrinologists, pediatric surgeons, embryologists, infertility nurses, and gynecologists

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Dedication
  • Contributors
  • Foreword: A Child’s Journey Through Cancer, Ovarian Tissue Freezing, Adulthood, Ovarian Transplantation, and Childbirth
  • Abbreviations
  • Introduction
  • Reference
  • Chapter 1: Scientific History of Ovarian Tissue Cryopreservation and Transplantation
  • Abstract
  • Introduction
  • Historical Evolution of Ovarian Tissue Cryopreservation
  • Evolution of Ovarian Transplantation
  • Animal Model Experiments
  • Human Ovarian Xenografting
  • First Ovarian Tissue Transplantation with Cryopreserved Tissue
  • Evolution of Heterotopic Ovarian Transplantation
  • Subsequent Evolution of Human Ovarian Tissue Transplantation and Livebirths
  • Summary and Conclusions
  • References
  • Chapter 2: Animal Models of Ovarian Transplantation
  • Abstract
  • Introduction
  • The Development of Ovarian Cryopreservation for Fertility Preservation
  • The Whole Ovary Cryopreservation Approach
  • Other Uses of Animal Models in Fertility Preservation
  • Summary and Conclusions
  • References
  • Chapter 3: Overall Approach to Fertility Preservation and Indications for Ovarian Tissue Harvesting and Cryopreservation
  • Abstract
  • Introduction
  • Indications for Fertility Preservation
  • What Are the Options for Fertility Preservation in Females?
  • Patient Selection for Ovarian Tissue Cryopreservation
  • SUMMARY AND Conclusions
  • References
  • Chapter 4: Regulatory Aspects of Ovarian Tissue Cryopreservation and Transplantation: How to Set Up a Program in Your Center
  • Abstract
  • Introduction
  • How to Set Up a Program for Ovarian Tissue Cryopreservation and What Is Needed
  • Medical Considerations and Patient Selection
  • Surgical Techniques and Amount of Tissue to Retrieve
  • Laboratory Procedures and Requirements for Cryostorage
  • Ovarian Tissue Transplantation
  • Documentation and Follow-Up
  • Guide to Starting a New Program for Ovarian Tissue Cryopreservation
  • Summary and Conclusions
  • References
  • Chapter 5: Ovarian Reserve and Early Follicle Development: Prerequisite Knowledge for Understanding Ovarian Tissue Harvesting for Cryopreservation
  • Abstract
  • Introduction and Clinical Relevance
  • Overview of Follicular Recruitment and Growth
  • Factors Affecting Follicular Recruitment
  • Growth Factors and Local Follicular Cell-Cell Interactions
  • Genetic Abnormalities
  • DNA Repair
  • Environmental Factors Regulating Primordial Follicle Recruitment and Loss
  • Dietary Patterns
  • Noncoding RNA Regulators
  • Mitochondria
  • Summary and Conclusions
  • References
  • Chapter 6: Methods and Techniques of Ovarian Tissue Harvesting and Preparation Before Cryopreservation
  • Abstract
  • Ovarian Tissue Harvesting
  • Centralized Service and Transportation of Ovarian Tissue
  • Preparation of Ovarian Tissue Before Cryopreservation
  • Summary and Conclusions
  • References
  • Chapter 7: Oocyte Retrieval and In Vitro Maturation From the Harvested Tissue Before Cryopreservation
  • Abstract
  • In Vitro Maturation (IVM)
  • Laboratory Procedures
  • Clinical Procedures for IVM during In Vitro Fertilization
  • IVM During Ovarian Tissue Freezing
  • Future Prospects for IVM
  • Summary and Conclusions
  • References
  • Chapter 8: A Primer on Cryobiology and Cryoprotectants for Ovarian Tissue Freezing
  • Abstract
  • Acknowledgments
  • Introduction
  • Terminology Used in Cryobiology
  • Basic Aspects of Slow Freezing
  • Basic Aspects of Vitrification
  • Cryoprotectants
  • Summary and Conclusions
  • References
  • Chapter 9: Methods of Ovarian Tissue Cryopreservation: Slow Freezing
  • Abstract
  • Introduction
  • Ovarian Tissue Cryopreservation and Transplantation
  • Principles of Cryopreservation
  • Ice Formation and the Use of Cryoprotectants
  • Slow Freezing and Protocol Standardization
  • Survival After Thawing
  • Restoration of the Ovarian Function Posttransplantation
  • Pregnancy Rates After Transplantation of Slow Frozen Ovarian Tissue
  • Summary and Conclusions
  • References
  • Chapter 10: Methods of Ovarian Tissue Cryopreservation: Vitrification
  • Abstract
  • Introduction
  • Comparison of the Freezing Processes Used for Slow Freezing and Vitrification
  • History of Cryopreservation of Embryos and Oocytes by Slow Freezing and Vitrification
  • Cryopreservation of Ovarian Tissue by Slow Freezing and Vitrification
  • Is the High Concentration of Cryoprotectant in Vitrification Solutions Cytotoxic?
  • Ovarian Tissue Cryopreservation by Vitrification at St. Marianna University
  • Ovarian Tissue Vitrification and Thawing Procedures
  • Summary and Conclusions
  • References
  • Chapter 11: Preoperative Evaluation and Preparation for Ovarian Tissue Transplant Surgery
  • Abstract
  • Introduction
  • Ovarian Transplant Candidate: First Visit
  • Medical and Fertility Evaluation Prior to the Transplant
  • Ovarian Tissue Evaluation Prior to Transplant
  • Determining the Type and Site of the Autotransplant
  • Team Rehearsals Before the Transplantation Procedure
  • Pharmacological Preparation Before the Transplant
  • Summary and Conclusions
  • References
  • Chapter 12: Assessment of the Risk of Cancer Cell Reintroduction Prior to Ovarian Tissue Autotransplantation
  • Abstract
  • Introduction
  • Risks of Ovarian Tissue Cryopreservation and Autotransplantation in Cancer Patients
  • Minimal Residual Disease (MRD) Protocols for Specific Hematological and High-Risk Cancer Diagnoses
  • Ovarian Tissue Cryopreservation for Leukemia Patients
  • Future Alternatives to Reduce MRD Risk and Increase Safety of Ovarian Tissue Cryopreservation in Leukemia Patients
  • Summary and Conclusions
  • References
  • Chapter 13: Ovarian Cryopreservation for Transplantation With Prepubertal and Adolescent Girls
  • Abstract
  • Introduction
  • Cancers of children and adolescents
  • Treatments of childhood and adolescent Cancers
  • Which Patients Should Be Offered Fertility Preservation?
  • Fertility Preservation Consultation
  • Ovarian Tissue Cryopreservation
  • Autotransplantation of Cryopreserved Ovarian Tissue From Patients Aged ≤18 Years: Published Data
  • Summary and Conclusions
  • References
  • Chapter 14: Surgical Approach to Orthotopic Ovarian Tissue Transplantation
  • Abstract
  • Introduction
  • Initial Studies of Orthotopic Ovarian Transplantation
  • Laparoscopic Orthotopic Ovarian Transplantation: Preoperative Preparation
  • Recipient Site and Ovarian Cortical Tissue Preparation
  • Problems With Neovascularization Injury
  • Ovarian Tissue Transplantation Using an Extracellular Tissue Matrix Scaffold
  • Implementation of Agents to Improve Neovascularization During Ovarian Transplantation
  • Stem Cell Treatment to Improve Neovascularization During Ovarian Transplantation
  • Use of Gonadotropins in Enhancing Ovarian Transplantation Success
  • Orthotopic Transplantation Techniques
  • Orthotopic Ovarian Transplantation Techniques
  • Summary and Conclusions
  • References
  • Chapter 15: Surgical Approach to Laparoscopic and Robot-Assisted Ovarian Tissue Transplantation
  • Abstract
  • Introduction
  • Ovarian Tissue Harvesting, Transport, and Cryopreservation
  • Laparoscopic Ovarian Transplantation Techniques
  • Robot-Assisted Ovarian Transplantation With Alloderm
  • Summary and Conclusions
  • References
  • Chapter 16: Surgical Approach to Heterotopic Ovarian Tissue Transplantation
  • Abstract
  • Introduction and Historical Context
  • Surgical Site Review
  • Distinctions in Terminology
  • Graft Sites Reported in the Literature
  • Techniques of Heterotopic Grafting
  • Advantages of Heterotopic Sites
  • Functionality of Heterotopic Grafts
  • Our Case Series: Rozen et al., 2021
  • Summary and Conclusions
  • References
  • Further Reading
  • Chapter 17: Approach to Follow Up After Ovarian Transplantation
  • Abstract
  • Introduction
  • Immediate and Short-Term Postsurgical Follow-Up
  • Mid-Term Follow-Up
  • Long-Term Follow-Up
  • Summary and Conclusions
  • References
  • Chapter 18: Approach to Ovarian Stimulation and In Vitro Fertilization in Patients With Transplanted Ovarian Tissue
  • Abstract
  • Introduction
  • Current IN VITRO FERTILIZATION (IVF) Outcomes in Women With Ovarian Autotransplants
  • Approach to Ovarian Stimulation and Retrieval for IVF in Ovarian Autotransplant Recipients
  • Efforts to Improve Oocyte Quality in Extrapelvic Ovarian Transplants
  • Approach to Embryology in Ovarian Autotransplant Patients
  • Summary and Conclusions
  • References
  • Chapter 19: Ovarian Tissue Cryopreservation for Delaying Childbearing and Menopause
  • Abstract
  • Introduction
  • RISK-BENEFIT ASSESSMENT and Effectiveness
  • Approaches to Improve Ovarian Transplant Longevity
  • UTILITY OF OVARIAN TISSUE FREEZING TO DELAY CHILDBEARING
  • UTILITY OF OVARIAN TISSUE FREEZING TO DELAY OR TREAT MENOPAUSE
  • Safety and ethical aspects
  • Final Considerations and Guidelines
  • References
  • Chapter 20: In Vitro Growth and Maturation of Human Primordial Follicles From Cryopreserved Tissue
  • Abstract
  • Introduction
  • Primordial Follicle Culture
  • Growing Preantral Follicles In Vitro
  • Optimizing Culture Conditions
  • Meiotic Maturation
  • Culturing Different Tissue Sources
  • Summary and Conclusions
  • References
  • Chapter 21: Psychosocial and Ethical Aspects of Ovarian Tissue Cryopreservation in Children and Adults
  • Abstract
  • Parental Decision Making About Ovarian Tissue Cryopreservation
  • Disposition of Unused Tissue
  • Posthumous Use of Tissue
  • Ovarian Tissue Cryopreservation Considerations in Nononcologic Populations
  • Barriers and Facilitators to Ovarian Tissue Cryopreservation
  • Summary and Conclusions
  • References
  • Chapter 22: Future Aspects of Ovarian Cryopreservation and Transplantation
  • Abstract
  • Introduction
  • Improving Ovarian Tissue Cryopreservation Methods
  • Enhancing Ovarian Graft Longevity
  • Advancing Surgical Techniques
  • In Vitro Growth of Primordial Follicles
  • Regenerative Approaches
  • Summary and Conclusions
  • References
  • Appendix1: Instructional Videos for Ovarian Tissue Harvesting, Cryopreservation, and Patient Counseling
  • Abstract and Introduction
  • References
  • Appendix2: Materials, Equipment, and Protocols for Ovarian Tissue Cryopreservation and Thawing
  • INTRODUCTION AND ABSTRACT
  • Ovarian Tissue Cryopreservation
  • Ovarian Tissue Thawing™
  • References
  • Appendix3: Materials, Equipment, and Operating Room Set-Up for Ovarian Tissue Transplantation
  • Introduction
  • Setting Up for Ovarian Tissue Thawing and Transplantation
  • Index
  • Memoriam

Product details

  • No. of pages: 278
  • Language: English
  • Copyright: © Elsevier 2022
  • Published: May 20, 2022
  • Imprint: Elsevier
  • eBook ISBN: 9780128233450
  • Paperback ISBN: 9780128233443

About the Editor

Kutluk Oktay

Kutluk Oktay, MD, PhD is a leading, global expert in fertility preservation and a renowned ovarian biologist. Dr. Oktay developed and performed the world’s first ovarian transplants and pioneered innovative ovarian stimulation protocols for cancer patients. He discovered the role of BRCA function and DNA repair in ovarian and oocyte aging. He has been continuously funded by the National Institute of Health and other sources over the past 15 years and has received numerous national and international awards from professional societies and patient organizations for his contributions. He has published over 200 manuscripts and book chapters and is the co-chair of American Society for Clinical Oncology Fertility Preservation Guidelines Committee.

Affiliations and Expertise

Laboratory of Molecular Reproduction and Fertility Preservation, Yale School of Medicine, New Haven, CT, USA

Ratings and Reviews

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  • Richard B. Fri Nov 18 2022

    An authoritative book written by a pioneer in the field

    This book provides everything from basic science to clinical details needed to understand and perform ovarian tissue cryopreservation. In addition, it contains regulatory and practical advice on how to set up a fertility preservation program. The foreword is written by a childhood leukemia survivor, whose ovarian tissue was cryopreserved before cancer treatments. As an adult, she had a successful ovarian transplantation, which resulted in a successful pregnancy—an eye-opener to read her story. The book also contains sections on ethics, as well as social and future aspects of ovarian tissue freezing and transplantation. It even provides several appendices where even the instrument lists and instructional videos are presented to guide readers through setting up ovarian cryopreservation and transplantation and a fertility preservation program. This is a highly recommended, very thorough, and substantive textbook written by the best in the field.