Primer to the Immune Response - 2nd Edition - ISBN: 9780123852458, 9780123854612

Primer to the Immune Response

2nd Edition

eBook ISBN: 9780123854612
Paperback ISBN: 9780123852458
Imprint: Academic Cell
Published Date: 28th January 2014
Page Count: 702
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Description

Written in the same engaging conversational style as the acclaimed first edition, Primer to The Immune Response, 2nd Edition is a fully updated and invaluable resource for college and university students in life sciences, medicine and other health professions who need a concise but comprehensive introduction to immunology. The authors bring clarity and readability to their audience, offering a complete survey of the most fundamental concepts in basic and clinical immunology while conveying the subject’s fascinating appeal.

The content of this new edition has been completely updated to include current information on all aspects of basic and clinical immunology. The superbly drawn figures are now in full color, complemented by full color plates throughout the book. The text is further enhanced by the inclusion of numerous tables, special topic boxes and brief notes that provide interesting insights. At the end of each chapter, a self-test quiz allows students to monitor their mastery of major concepts, while a set of conceptual questions prompts them to extrapolate further and extend their critical thinking. Moreover, as part of the Academic Cell line of textbooks, Primer to The Immune Response, 2nd Edition contains research passages that shine a spotlight on current experimental work reported in Cell Press articles. These articles also form the basis of case studies that are found in the associated online study guide and are designed to reinforce clinical connections.

Key Features

  • Complete yet concise coverage of the basic and clinical principles of immunology
  • Engaging conversational writing style that is to the point and very readable
  • Over 200 clear, elegant color illustrations
  • Comprehensive glossary and list of abbreviations

Readership

Undergraduate medical students and graduate students taking the following courses: Introduction to Immunology, Immunology, Clinical Immunology, Medical Immunology, Medical Microbiology, Microbiology and Immunology, and Immunology and Disease

Table of Contents

Abbreviations

Online Study Guide

Preface

The Academic Cell Approach

Introduction to the Online Study Guide

Biographies: Authors

Contributors

Acknowledgments

Part I: Basic Immunology

Chapter 1. Introduction to the Immune Response

Abstract

A Historical Orientation

B The Nature of the Immune Response

C Types of Immune Responses: Innate and Adaptive

D Interplay between the Innate and Adaptive Responses

E Clinical Immunology

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Chapter 2. Components of the Immune System

Abstract

A Cells of the Immune System

B How Leukocytes Communicate

C Lymphoid Tissues

D Cellular Movement in the Immune System

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Chapter 3. Innate Immunity

Abstract

A Non-Inducible Innate Mechanisms

B Inducible Innate Mechanisms

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Chapter 4. The B Cell Receptor: Proteins and Genes

Abstract

A Immunoglobulin Proteins

B Immunoglobulin Genes

C Antibody–Antigen Interaction

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Chapter 5. B Cell Development, Activation and Effector Functions

Abstract

A B Cell Development: Maturation Phase

B B Cell Development: Differentiation Phase

C Effector Functions of Antibodies

D Immunoglobulin Isotypes in Biological Context

E Sources of Laboratory and Clinical Antibodies

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Chapter 6. The Major Histocompatibility Complex

Abstract

A Overview of the Major Histocompatibility Complex

B MHC Class I and Class II Proteins

C MHC Class I and Class II Genes

D Physiology of the MHC

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Chapter 7. Antigen Processing and Presentation

Abstract

A Overview of Antigen Processing and Presentation

B Nature of Cells That Can Activate T Cells

C Major Antigen Processing and Presentation Pathways

D Other Methods of Antigen Presentation

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Chapter 8. The T Cell Receptor: Proteins and Genes

Abstract

A TCR Proteins and Associated Molecules

B TCR Genes

C TCR–Antigen Interaction

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Chapter 9. T Cell Development, Activation and Effector Functions

Abstract

A T Cell Development

B T Cell Activation

C Th Cell Differentiation and Effector Function

D Tc Cell Differentiation and Effector Function

E Termination of Effector T Cell Responses

F Memory T Cells

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Chapter 10. Regulation of Immune Responses in the Periphery

Abstract

A Lymphocyte Tolerance in the Periphery

B Regulation of Lymphocyte Responses in the Periphery

C Special Tolerance Situations

D Experimental Tolerance

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Chapter 11. NK, γδ T and NKT Cells

Abstract

A Natural Killer (NK) Cells

B γδ T Cells

C NKT Cells

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Chapter 12. Mucosal and Cutaneous Immunity

Abstract

A Mucosal Immunity

B Cutaneous Immunity

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Part II: Clinical Immunology

Chapter 13. Immunity to Infection

Abstract

A General Features of Host–Pathogen Encounters

B Immunity to Extracellular Bacteria

C Immunity to Intracellular Bacteria

D Immunity to Viruses

E Immunity to Parasites

F Immunity to Fungi

G Prions

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Chapter 14. Vaccination

Abstract

A Introduction

B Vaccine Design

C Types of Vaccines

D Adjuvants and Delivery Vehicles

E Prophylactic Vaccines

F Vaccines in the Real World

G Future Directions

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Chapter 15. Immunodeficiency

Abstract

A Primary Immunodeficiency

B HIV Infection and Acquired Immunodeficiency Syndrome (AIDS)

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Chapter 16. Tumor Immunology

Abstract

A Tumor Biology

B Tumor Antigens

C Immune System Function in the Tumor Microenvironment

D Conventional Cancer Therapy

E Immunotherapy

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Chapter 17. Transplantation

Abstract

A The Nature of Transplantation

B The Molecular Basis of Graft Rejection

C Solid Organ Transplantation

D Minimizing Graft Rejection

E Hematopoietic Stem Cell Transplantation

F Blood Transfusions

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Chapter 18. Immune Hypersensitivity

Abstract

A Type I Hypersensitivity: IgE-Mediated or Immediate

B Type II Hypersensitivity: Direct Antibody-Mediated Cytotoxic Hypersensitivity

C Type III Hypersensitivity: Immune Complex-Mediated Hypersensitivity

D Type IV Hypersensitivity: Delayed Type or Cell-Mediated Hypersensitivity

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Chapter 19. Autoimmune Diseases

Abstract

A What is an Autoimmune Disease?

B Mechanisms Underlying Autoimmune Diseases

C Examples of Autoimmune Diseases

D Determinants of Autoimmune Diseases

E Therapy of Autoimmune Diseases

F Autoinflammatory Disorders

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Chapter 20. Hematopoietic Cancers

Abstract

A Overview of the Biology and Treatment of Hematopoietic Cancers

B Leukemias

C Myelomas

D Lymphomas

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Appendix A. Selected Landmark Discoveries in Immunology

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Appendix B. Nobel Prizes Awarded for Work in Immunology

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Appendix C. Comparative Immunology

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Appendix D. Selected CD Markers

Appendix E. Cytokines, Chemokines and Receptors

Appendix F. Selected Immunological Techniques

I Experimental Techniques Using Antibodies

II The Polymerase Chain Reaction

III HLA Typing Techniques

IV Laboratory Mouse Strains

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Glossary

Index

Details

No. of pages:
702
Language:
English
Copyright:
© Academic Cell 2014
Published:
Imprint:
Academic Cell
eBook ISBN:
9780123854612
Paperback ISBN:
9780123852458

Awards

Society of Biology Book Awards 2014: Postgraduate Textbook, Society of Authors

Reviews

"This immensely useful book will be of great value to students studying immunology modules within a wide range of undergraduate programmes, as well as those with a biological background who are keen to update themselves..."--The Biologist,Vol 61, No 6

"…a great resource for college and university students in life sciences, medicine and other health professions who need a concise but comprehensive introduction to immunology…The content of this new edition has been updated to include current information on all aspects of basic and clinical immunology. Drawn figures are now in full color, complemented by full color plates throughout the book."--Anticancer Research 34, 2014
"Primer to The Immune Response contains all the essential knowledge the undergraduate and medical student needs to know on B cell development, activation and effector functions."--Zhenyu Hao, University of Toronto
"Medical students, in particular, will find it a valuable guide and friendly companion in finding their way through the maze of complications surrounding the autoimmune diseases."--Noel Rose, Director, Johns Hopkins Center for Autoimmune Disease Research

Ratings and Reviews