Primer to the Immune Response

Primer to the Immune Response effectively presents complex immunological concepts. The book is divided into two parts, which cover basic immunology and clinical immunology.

Part I presents the history and nature of immune response, and it describes the general features of the innate and adaptive immune responses. This part also explores the components of the immune system such as the cells and tissues. It also illustrates the intracellular communication through signal induction, intercellular communication through cytokines, and the cellular movement in the immune system. Furthermore, this part discusses proteins and genes, the development, activation and effector functions of both B cells and T cells.

Part II focuses on clinical immunology and covers immunity to infection caused by extracellular and intracellular bacteria, viruses, parasites and fungi. This part also describes different kinds of diseases, such as the Acquired Immunodeficiency Syndrome caused by the Human Immunodeficiency virus, tumors, autoimmune diseases, and hematopoietic cancers. This part also includes discussions on vaccination, transplantation, and different types of immune hypersensitivity.

• Color illustrations enhance key topics and concepts

Undergraduate and graduate students taking the following courses:  Introduction to Immunology, Immunology, Clinical Immunology, Medical Immunology, Medical Microbiology, Microbiology and Immunology, Immunology and Disease

Preface to the Text

Preface to the Immunomovie

Biographies

Acknowledgments

Part I: Basic Immunology

Chapter 1: Introduction to the Immune Response

A. Historical Orientation

B. The Nature of the Immune Response

C. Types Immune Responses: Innate and Adaptive

D. Interplay Between the Innate and Adaptive Responses

E. Clinical Immunology

Chapter 2: Components of the Immune System

A. Cells of the Immune System

B. How Leukocytes Communicate

C. Lymphoid Tissues

D. Cellular Movement in the Immune System

Chapter 3: Innate Immunity

A. Non-Induced Innate Mechanisms

B. Induced Innate Mechanisms

Chapter 4: The B Cell Receptor: Proteins and Genes

A. Immunoglobulin Proteins

B. Immunoglobulin Genes

C. Antigen–Antibody Interaction

Chapter 5: B Cell Development, Activation and Effector Functions

A. B Cell Development: Maturation Phase

B. B Cell Development: Differentiation Phase

C. Effector Functions of Antibodies

D. Immunoglobulin Isotopes in Biological Context

Chapter 6: The Major Histocompatibility Complex

A. Overview of the Major Histocompatibility Complex

B. MHC Class I and Class II Proteins

C. MHC Class I and Class II Genes

D. Physiology of the MHC

Chapter 7: Antigen Processing and Presentation

A. Overview of Antigen Processing and Presentation

B. Exogenous Antigen Processing

C. Endogenous Antigen Processing

D. Cross-Presentation on MHC Class I

E. Other Methods of Antigen Presentation

Chapter 8: The T Cell Receptor: Proteins and Genes

A. TCR Proteins and Associated Molecules

B. TCR Genes

C. TCR–Antigen Interaction

Chapter 9: T Cell Development, Activation and Effector Functions

A. T Cell Development

B. T Cell Activation

C. Th Cell Differentiation and Effector Function

D. Tc Cell Differentiation and Effector Function

E. Control of Effector T Cells

F. Memory T Cells

Chapter 10: Regulation of Immune Responses in the Periphery

A. Self Tolerance of Lymphocytes in the Periphery

B. Control of Lymphocyte Responses in the Periphery

C. Special Tolerance Situations

D. Experimental Tolerance

Chapter 11: NK, γδ T and NKT Cells

A. Natural Killer (NK) Cells

B. γδ T Cells

C. NKT Cells

Chapter 12: Mucosal and Cutaneous Immunity

A. Mucosal Immunity

B. Cutaneous Immunity

Part II: Clinical Immunology

Chapter 13: Immunity to Infection

A. The Nature of Pathogens and Disease

B. Innate Defense Against Pathogens

C. Immunity to Extracellular Bacteria

D. Immunity to Intracellular Bacteria

E. Immunity to Viruses

F. Immunity to Parasites

G. Immunity to Fungi

H. Prions

Chapter 14: Vaccination

A. Vaccine Design

B. Types of Vaccines

C. Adjuvants and Delivery Vehicles

D. Prophylactic Vaccines

E. The “Dark Side” of Vaccines

F. Passive Immunization

G. Future Directions

Chapter 15: HIV and Acquired Immunodeficiency Syndrome

A. What is HIV?

B. HIV Infection and Aids

C. Immune Responses During HIV Infection

D. Host Factors Influencing the Course of HIV Infection

E. Animal Models of Aids

F. HIV Vaccines

G. Treatment of HIV Infection With Anti-Retroviral Drugs

Chapter 16: Tumor Immunology

A. Tumor Biology

B. Tumor Antigens

C. Immune Responses to Tumor Cells

D. Hurdles to Effective Anti-Tumor Immunity

E. Cancer Therapy

Chapter 17: Transplantation

A. The Molecular Basis of Graft Rejection

B. Solid Organ Transplantation

C. Minimizing Graft Rejection

D. Hematopoietic Cell Transplantation

E. Blood Transfusions

Chapter 18: Immune Hypersensitivity

A. Type I Hypersensitivity: IgE-Mediated or Immediate

B. Type II Hypersensitivity: Direct Antibody-Mediated Cytotoxic Hypersensitivity

C. Type III Hypersensitivity: Immune Complex-Mediated Hypersensitivity

D. Type IV Hypersensitivity: Delayed-Type or Cell-Mediated Hypersensitivity

Chapter 19: Autoimmune Diseases

A. What is an Autoimmune Disease?

B. Mechanisms Underlying Autoimmune Diseases

C. Examples of Autoimmune Diseases

D. Determinants of Autoimmune Diseases

E. Therapy of Autoimmune Diseases

Chapter 20: Hematopoietic Cancers

A. Overview of the Biology and Treatment of Hematopoietic Cancers

B. Leukemias

C. Myelomas

D. Lymphomas

Appendix A: Selected Landmark Discoveries in Immunology

Appendix B: Nobel Prizes Awarded for Work in Immunology

Appendix C: Comparative Immunology

Appendix D: Selected CD Markers

Appendix E: Cytokines, Chemokines and Receptors

Appendix F: Laboratory Uses of Antibodies

A. Sources of Antibodies

I. Antisera

II. Monoclonal Antibodies from Hybridomas

B. Experimental Techniques Using Antibodies

I. Techniques Based on Immune Complex Formation

II. Techniques Based on “Tagging” Antigen-Antibody Pairs

IIII. Techniques for the Isolation and Characterization of Antigens

Glossary

Index