Presynaptic Receptors and Neuronal Transporters

Presynaptic Receptors and Neuronal Transporters

Official Satellite Symposium to the IUPHAR 1990 Congress Held in Rouen, France, on 26–29 June 1990

1st Edition - January 1, 1991

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  • Editors: S.Z. Langer, A.M. Galzin, J. Costentin
  • eBook ISBN: 9781483278223

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Advances in the Biosciences, Volume 82: Presynaptic Receptors and Neuronal Transporters documents the proceedings of the Official Satellite Symposium to the IUPHAR 1990 Congress held in Rouen, France on June 26-29, 1990. The first part of this book deals with the extensive and still increasing list of presynaptic release-modulating auto and heteroreceptors, emphasizing the various subtypes of presynaptic receptors that are characterized by functional studies, both in vitro and in vivo, using a number of experimental approaches. The next chapters are devoted to the molecular pharmacology of presynaptic receptors, of which can interfere with G proteins and modify the activity of adenylate cyclase, guanylate cyclase, or protein kinase C. The purification and molecular biology of transporter systems, including cloning and sequencing of the neuronal sodium-ion coupled GABA transporter are also discussed. This compilation concludes with insights on the function of presynaptic receptors and neuronal transporters both in the periphery and in the CNS, as well as their ubiquitous locations and physiological roles. This publication is a good reference for students and individuals researching on the presynaptic autoreceptors and neurotransmitters.

Table of Contents

  • Preface

    Physiological and Pharmacological Relevance of Presynaptic Receptors in Neurotransmission

    Pre- and Postjunctional Muscarinic Receptors in the Guinea-Pig Trachea

    Presynaptic α-Autoadrenoceptors on Peripheral Noradrenergic Neurones of Newborn Rabbits and Dogs

    Cholinergic-Adrenergic Presynaptic Interactions in the Heart and Characterization of the Receptors Involved

    Structural Requirements for DA2 (Peripheral) Dopamine Receptor Agonist Activity

    α2-Adrenoceptor Modulation Or Noradrenaline Release in Human and Rabbit Renal Arteries: Clonidine Acts as a Partial Agonist

    Effect of α2-Adrenoceptor Antagonists on Norephine Release and Inhibition of Insulin Secretion During Pancreatic Nerve Stimulation. Interactions at Pre- and Postsynaptic Sites

    Antagonist Activity of Sl 84.0418 and Idazoxan at Pre and Post Synaptic α2-Adrenoreceptors

    Does the Distance Between Nerve Varicosities and Adrenoceptors Play Any Role in the Relative Contribution of Atp/Noradrenaline for Postjunctional Response?

    In Vivo Presynaptic Interaction Between 5-Ht and Adrenergic Antagonists on Noradrenergic Neurotransmission

    Activity of N-Ethyl-NOR-Arecaidine Propargyl Ester and (R)-Nipecotic Acid Ethyl Ester at Pre-and Postsynaptic Muscarinic Receptor Subtypes

    Effects of Neuromuscular Blocking Agents on Neuronal Nicotine Receptors of Motor Nerves: Blockade of Nicotinic Autofacilitation and Backfiring

    A Rapid In Vitro Assay of the Histaine H3-Receptor: Inhibition of Electrically Evoked Contractions of Guinea Pig Ileum Preparations

    Factors Influencing the Function of Presynaptic α2-Adrenoceptors in Rat Brain

    Presynaptic Dopaminergic Autoreceptors as Targets for Drugs

    Dopa Itself Facilitates Noradrenaline Release Via Presynaptic ß-Adrenoceptors in Rat Hypothalamic Slices - Dopa Is Probably a Neuroactive Substance

    The Third Dopamine Receptopr (D3) as an Autoreceptor

    Terminal Dopaminergic Autoreceptors are of Minor Importance for the Sedation Produced by DA Receptor Agonists in Rats

    Modulation of 5-HT Release by Presynaptic Inhibitory and Facilitatory 5-Ht Receptors in Brain Slices

    Modulation of 5-Hydroxytryptamine and Noradrenaline Release in the Brain and Retina via Presynaptic Heteroreceptors: Some New Aspects

    Autoreceptors and Heteroreceptors Evidenced by Histamine H3 Receptor Ligands

    Somato-Dendritic 5-HT1A Autoreceptors in the Dorsal Raphe Nucleus; Pharmacological and Functional Properties

    Autoreceptor-Mediated Control of Serotonin Release in the Rat Brain in Vivo

    Effects of (22-Adrenoceptor Agonist and Antagonist on Spatial Memory in Rats

    Modulation of the CA2+-Evoked Release of Dopamine from Synaptosomes

    Evidence Against a Direct Link Between Serotonin Uptake Sites and Presynaptic Serotonin Autoreceptors

    A Comparison of Presynaptic Serotonin Autoreceptors in Rabbit, Rat and Guinea-Pig Brain Cortex

    Serotonergic Modulation of the Release of [3H] GABA from Guinea-Pig Hippocampal Synaptosomes

    Pre- and Post-Synaptic Location of 5-Ht3 Receptors in the Rat Spinal Cord

    Distribution of [3H]SCH 23390 Binding Sites in the Human Substantia Nigra

    Presynaptic Regulation of Dopamine Release from Synaptosomes of the Rat Striatum is Controlled by Different Types of Glutamate Receptors

    Microdialysis Studies of the Effects of Local Apomorphine Infusions on Dopamine Release in Rat Striatum

    Dopaminergic Hetero-Regulation of Striatal Μ-Opiate Receptors: Further Evidence for Their Postsynaptic Location

    Presynaptic Modulation of Striatal Dopamine Release by Enkephalins

    Modulation of Dopamine and Acetylcholine Release in the Rabbit Caudate Nucleus by Opioids: Receptor Type and Interaction with Autoreceptors

    Presynaptic Autoreceptors May Control the Release of Metenkephalin from the Rat Spinal Cord

    Involvement of NMD a Receptors in the Presynaptic Regulation of Dopamine Release in Striosome- and Matrix-Enriched Areas of the Rat Striatum

    Inhibition of Synaptosomal Tyrosine Hydroxylase by Dopamine Autoreceptors: Role Ca2+ and K+

    Dopaminergic Modulation of Striatal Sensory Responses

    Selective Presynaptic Dopamine Agonist Treatment of Schizophrenia with Bht-920

    Effects of the Antiparkinsonian Drugs Amantadine and Memantine on Striatal Neurotransmitter Release In Vitro

    Transmitter Interactions in Striatum may occur via Effects on High Affinity Transporters

    A Comparison of the Effect of Baclofen on Radio-Labeled

    Effects of Chronic Treatment with Flunitrazepam on GABAA, Adenosine and Glutamate Receptor Plasticity in Rats

    Modulation of N-Methyl-D-Aspartate (NMDA)-Stimulated Noradrenaline Release in Rat Brain Cortex by Presynaptic α2-Adrenoceptors and Histamine H3 Receptors

    Noradrenaline Release in the Pig Retina and Its Histamine H3 Receptor-Mediated Inhibition

    Structure and Function of the GABA Reuptake System

    Energizing the Vacuolar System of Eukaryotic Cells

    The Molecular Size of the Neuronal Noradenaline Carrier

    Identification and Regulation of High-Affinity-Choline Transporter

    Ketanserin as a Ligand of the Vesicular Monoamine Transporter

    Dopamine Transporter - Cocaine Receptor: Characterization and Purification

    Characterization and Purification of the Serotonin Transporter Located at the Cytoplasmic Membrane of Human Platelets: a Three-Step Strategy

    Molecular Characterization of the Neuronal Sodium-Ion Coupled 5-Hydroxytryptamine Transporter

    Kinetic Analyses of the Na+ and Cl Dependences of the Synaptosomal Specific Uptake of 3H Dopamine

    Localization of Dopamine Uptake Complex by BTCP on Rat Brain Sections and Dopaminergic Neurons In Vitro

    In Vivo Binding of [3H]GBR 12783 in Mouse Brain - Characteristics of the Labeling of Striatal Dopamine Uptake Sites

    [3H]GBR 12935 Binds to Membrane from the Human Platelet

    Dopamine Transporter in Aging

    Sodium Dependent, High Affinity Choline Transport Expressed in Oocytes

    Comparison of the Effects of Vesamicol and of Cetiedil Analogues on Acetylcholine Release and Vesicular Acetylcholine Transport

    Dopamine Modulates [3H]BTCP (a Phencyclidine Derivative) Binding to the Dopamine Uptake Complex

    The Heterogeneous Labeling with 3H-Noradrenaline of the Incubated Vas Deferens of the Rat

    Alterations in Platelet [3H]-Imipramine Binding, 5HT Uptake and Plasma Ori-Acid Glycoprotein Concentrations in Patients with Major Depression

    Ionic and Temperature Dependences of the 3H Dopamine Specific Uptake and 3H GBR 12783 Or 3H Mazindol Specific Binding on the Dopamine Neuronal Carrier

    Dynamic Properties of Monamine Storage Vesicles: Pharmacological and Physiological Implications

    GABA Uptake Inhibitors: Kinetics and Molecular Pharmacology

    Coexistance of More than One Neurotransitter Uptake System on the Same Nerve Terminal in the Brain

    Peptidergic Regulation of Striatal Dopamine Transporter Complex

    Different Interactions of Citalopram with the Prejunctional Effects of Serotonin in Perpheral Tissues

    Evolution of the Vesicular Monoamine Transporter During Aging in the Rat Brain: a Quantitative Autoradiographic Study with 3H Dihydrotetrabenazine

    Influence of the Oxygen Disponibility on the Efficiency of the Neuronal Dopamine Uptake Complex

    Differences in Behavioral Responses Elicited by Dexaphetamine and the Pure Dopamine Uptake Inhibitor GBR 12783

    Protection of the Synaptosomal 5-HT Uptake System by a Ginkgo Biloba Extract (GBR 761)

    The Binding of Noradenaline to the Substrate Recognition Site of the Neuronal Noradrenaline Carrier (Uptake1) Depends on Sodium and Chloride

    In Vivo Distribution of Radiolabeled Citalopram in Brain as a Marker of 5-HT Uptake Sites for PET

    Relationship of [3H] Paroxetine Binding and 5-HT Recognition Sites on the Neuronal Serotonin Transporter

    Effects of Repeated Administration of Antidepressants on Serotonin Uptake Sites Measured Using [3H] Cyanoimipramine Autoradiography

    Rapid Changes in 3H-Imipramine Binding in Platelets of Depressed Patients after Amineptine Treatment

    Brain 5-HT Uptake Sites, Labeled with [3H]Paroxetine, in Depressed Suicides

    Pinoline, the Natural Ligand of Serotonin Transporter in Retina and Pineal Gland

    Differential Interaction of Phencyclidine (PCP) with the Dopamine Uptake Complex and the PCP Receptor In Vivo

    The Uptake of the Amino Acid L-Alanine on Its Inhibitory Presynaptic Effects in Rat Isolated Atria

    Role of Omega (BZD) Sites of the GABAA Receptor Macromolecular Complex in the Modulation of Serotonin Release

    Mechanisms of Inhibition of Transmitter Release by Adenosine Analogs

    Dependence of the A1-Adenosine Receptor-Mediated Inhibition of [3H] Noradrenaline Release in Hippocampus on the Stimulation Conditions

    Modulation of [3H]-Serotonin Release in Rat Spinal Cord Synaptosome via Dihydropyridine-Sensitive Calcium Channels and Protein Kinase C

    G-Proteins and Prejunctional α-Adrenoceptors

    Opioid Inhibition of Oxytocin Release, But Not Autoinhibition of Dopamine Release May Involve Activation of Potassium (K+) Channels

    3,4-Diaminopyridine-Evoked Noradrenaline Release in Hippocampal Slices: Further Properties and Involvement of Adenylate Cyclase

    Interneuronal Cyclic GMP and 'EDRF-Life Substance' Modulate Norepinephrine Release from Peripheral Sympathetic Nerves

    Modulatory Role of Neuropeptide Y and Peptide YY at the NMDA Receptor Complex

    Prejunctional Neuropeptide Y Receptors Are Linked to a G-Protein: A Study with N-Ethylmaleimide and Pertussis Toxin

    Protein Kinase C and Modulation of Neurotransmission: Studies with Protein Kinase Inhibitors

    Intrasynaptosomal Protein Phosphorylation and Its Inhibition by Plasma Membrane Oxidoreductases

    Functional and Regulatory Properties of Presynaptic Autoreceptors of the 5-HTIA Subtype on Dorsal Raphe Neurons in Brain Stem Slices

    Do Schwann Cells Play a Role in 'Upstream' Regulation of the Release Probability in Sympathetic Nerve Varicosities?

    Changes in α2 Presynaptic Receptor Sensitivity During Production of Dependence to Morphine in Conscious Rats

    Role of Presynaptic α2 Heteroreceptors in Nonsynaptic Modulation of Transmitter Release

    Autoregulation of Catecholamine Release at Central and Sympathetic Nerve Terminals: Common Features

    Autoreceptor Mediated Changes in Dopaminergic Terminal Excitability In Vivo

    Prejunctional Autoreceptors in Mouse Vas Deferens

    SK&F 104078 Identifies Subtypes of Prejunctional α2-Adrenoceptors in the Rat Vas Deferens

    Clonidine Inhibition of Norepinephrine Release from Normal and Morphine-Tolerant Guinea Pig Cortical Slices

    Human Caki-1 Cells are the First Clonai Cell Line Known to Possess the Extraneuronal Transport Mechanism for Noradrenaline (Uptake 2)

    Inhibition of NA Uptake by (+)-Oxaprotimine Inhibits Sympathetic Nerve Activity

    Autoregulation of Evoked Noradrenaline Release at the Surface of the Isolated Rat Tail Artery Studied by Electrochemistry

    Autoregulation of Evoked Noradrenaline Release in the Rat Hypothalamic Paraventncular Nucleus Studied In Vivo by Electrochemistry

    Clonidine Early in Life: Effect on Brain Morphofunctional Disturbances Induced by Neonatal Malutrition in the Rat

    Mu and Kappa Agonists Inhibit Carbachol-Evoked Release of Catecholamines and [Met]Enkephalin from Ex Situ Perfused Dog Adrenals

    Electrophysiological Evidences for the Preferential Location of D2 Autoreceptors on Dendrites of DA Neurons in the Rat Substantia Nigra

    Increase of Postsynaptic Dopaminergic Transmission by Presynaptic Actions of Cocaine

    Autoregulation of Evoked Dopamine Release in the Rat at Central Terminal Sites Studied In Vivo by Electrochemistry

    Combined Effect of (-)-Vesamicol and (+)-Tubocurarine on Endplate Current Amplitude in Rat Skeletal Muscle at High Frequencies of Nerve Stimulation

    Effect of (-)-Vesamicol on Miniature Endplate Current and Endplate Current Amplitudes in Rat Skeletal Muscle

    Subject Index

Product details

  • No. of pages: 372
  • Language: English
  • Copyright: © Pergamon 1992
  • Published: January 1, 1991
  • Imprint: Pergamon
  • eBook ISBN: 9781483278223

About the Editors

S.Z. Langer

A.M. Galzin

J. Costentin

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