Premature Rupture of Membranes, An Issue of Obstetrics and Gynecology Clinics

Premature Rupture of Membranes, An Issue of Obstetrics and Gynecology Clinics

1st Edition - November 7, 2020

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  • Editor: Edward Chien
  • Hardcover ISBN: 9780323776592
  • eBook ISBN: 9780323776608

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Description

In collaboration with Consulting Editor, Dr. William Rayburn, Guest Editor Dr. Edward Chien has created a state-of-the-art monograph that focuses on Premature Rupture of Membranes. The issue separates articles into three sections: Prediction and Prevention, Interventions, and Special Topics, with articles on the following topics: Vaginal Microbiome; Cervical and Fetal Membrane Biomechanics; Management of the Short Cervix, Prolapsing Membranes, and Rescue Cerclage; Time to Deliver: Early - Late Preterm Management; Tocolysis; Use of Corticosteroids in Premature Rupture of Membranes; Antibiotics Prophylaxis for PPROM; Viral Infections (HIV, Hep B, Herpes, HCV); Antenatal Monitoring after PPROM; Periviable PROM; PPROM in Multiple Gestations and after Fetal Surgery; and Neonatal Issues after PPROM. Readers will come away with the current and clinical information they need to improve patient outcomes.

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Contributors
  • Forthcoming Issues
  • Foreword
  • Preface
  • Prediction and Prevention
  • Vaginal Microbiome in Preterm Rupture of Membranes
  • Key points
  • Introduction
  • DNA sequencing-based interrogation of the microbiome
  • The pregnancy vaginal microbiome
  • The vaginal microbiota and preterm birth
  • Vaginal microbiota and the subsequent risk of preterm premature rupture of membranes
  • Vaginal microbiota at the time of preterm premature rupture of membranes
  • Effects of antibiotics on the vaginal microbiota at the time of preterm premature rupture of membranes
  • Vaginal microbiota and neonatal outcome following preterm premature rupture of membranes
  • Cervical cerclage, large loop excision of the transformation zone of the cervix, cervical intraepithelial neoplasia, and preterm premature rupture of membranes
  • Summary
  • Clinics care points
  • Mechanism of Human Fetal Membrane Biomechanical Weakening, Rupture and Potential Targets for Therapeutic Intervention
  • Key points
  • Background
  • Fetal membrane rupture and the onset of labor
  • Measurement of fetal membrane strength
  • Fetal membranes have a physiologic weak zone
  • The pathway of human fetal membrane weakening
  • Evaluation of inhibitors of the fetal membrane weakening pathway as possible therapeutic agents for preterm premature rupture of membranes
  • Nonprogestin agents
  • Summary
  • The Short Cervix: A Critical Analysis of Diagnosis and Treatment
  • Key points
  • Background
  • Pathophysiology of a short cervix
  • Short cervix and other biomarkers
  • Infection and inflammation
  • Surgical treatment with cerclage
  • Timing of cerclage procedures
  • History-indicated/prophylactic cerclage
  • Ultrasound-indicated cerclage
  • Multiple gestation and ultrasound-indicated cerclage
  • Examination-indicated/rescue cerclage
  • Cerclage revision
  • Preterm premature rupture of membranes with a cerclage in place
  • Medical therapy with progesterone
  • Weekly injections of 17 alpha-hydroxyprogesterone caproate
  • Daily vaginal progesterone
  • Pessary
  • Combination treatments
  • Summary
  • Clinics care points
  • Interventions
  • Tocolytic Therapy in Preterm Premature Rupture of Membranes
  • Key points
  • Introduction
  • Relevant studies and trials
  • Meta-analyses
  • Summary
  • Clinics care points
  • Use of Antenatal Corticosteroids in Preterm Prelabor Rupture of Membranes
  • Key points
  • Introduction
  • Antenatal corticosteroids reduce neonatal morbidity and mortality after preterm prelabor rupture of membranes without increasing the risk of maternal or neonatal infection
  • Antenatal corticosteroids after preterm prelabor rupture of membranes at different gestational ages
  • Repeat courses of antenatal corticosteroids after preterm prelabor rupture of membranes
  • Summary and future directions
  • Clinics care points
  • Antibiotics for Prophylaxis in the Setting of Preterm Prelabor Rupture of Membranes
  • Key points
  • Background
  • What bacteria are we treating?
  • What is the evidence behind the use of antibiotics at all in the setting of preterm prelabor rupture of membranes?
  • What antibiotics are recommended for the treatment of preterm prelabor rupture of membranes?
  • Gestational age variations
  • Special considerations: multiple gestations
  • Special considerations: penicillin allergy or macrolide allergy
  • Special considerations: known group beta strep negative at time of preterm prelabor rupture of membranes
  • Special considerations: onset of labor within 7 days of rupture?
  • Summary
  • Clinics care points
  • Premature Rupture of Membranes with Concurrent Viral Infection
  • Key points
  • Introduction
  • Hepatitis B virus
  • Hepatitis C virus
  • Human immunodeficiency virus
  • Herpes simplex virus
  • Clinical Guidelines
  • Antenatal Monitoring After Preterm Prelabor Rupture of Membranes
  • Key points
  • Introduction and definitions
  • Fetal and maternal complications necessitating antenatal monitoring and surveillance
  • Antenatal assessment and fetal monitoring
  • Summary
  • Clinics care points
  • Special Topics
  • Periviable Premature Rupture of Membranes
  • Key points
  • Introduction
  • Background
  • Diagnosis
  • Evaluation and clinical course
  • Standard Interventions
  • Debated Interventions
  • Special Circumstances
  • Discussion: future directions for study
  • Summary
  • Disclosure
  • Unique Considerations: Preterm Prelabor Rupture of Membranes in the Setting of Fetal Surgery and Higher Order Pregnancies
  • Key points
  • Introduction
  • Unique considerations in the mechanism and risk of preterm prelabor rupture of membranes after fetal intervention
  • Preterm prelabor rupture of membranes in the setting of fetoamniotic shunt placement
  • Fetoscopic laser ablation of placental vessels
  • Radiofrequency ablation
  • Fetoscopic myelomeningocele repair
  • Fetoscopic tracheal balloon occlusion for congenital diaphragmatic hernias
  • Preterm prelabor rupture of membranes in the setting of open fetal surgery
  • Interventions to treat or prevent preterm prelabor rupture of membranes in the setting of fetal surgery
  • Other unique considerations—preterm prelabor rupture of membranes in the setting of multiple gestation
  • Clinics care points
  • Neonatal and Childhood Outcomes Following Preterm Premature Rupture of Membranes
  • Key points
  • Introduction
  • Pathophysiology of morbidity
  • Summary

Product details

  • No. of pages: 240
  • Language: English
  • Copyright: © Elsevier 2020
  • Published: November 7, 2020
  • Imprint: Elsevier
  • Hardcover ISBN: 9780323776592
  • eBook ISBN: 9780323776608

About the Editor

Edward Chien

Affiliations and Expertise

Case Western Reserve University

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