Precision Medicine and Artificial Intelligence

Precision Medicine and Artificial Intelligence

The Perfect Fit for Autoimmunity

1st Edition - March 12, 2021

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  • Editor: Michael Mahler
  • eBook ISBN: 9780323854320
  • Paperback ISBN: 9780128202395

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Precision Medicine and Artificial Intelligence: The Perfect Fit for Autoimmunity covers background on artificial intelligence (AI), its link to precision medicine (PM), and examples of AI in healthcare, especially autoimmunity. The book highlights future perspectives and potential directions as AI has gained significant attention during the past decade. Autoimmune diseases are complex and heterogeneous conditions, but exciting new developments and implementation tactics surrounding automated systems have enabled the generation of large datasets, making autoimmunity an ideal target for AI and precision medicine. More and more diagnostic products utilize AI, which is also starting to be supported by regulatory agencies such as the Food and Drug Administration (FDA). Knowledge generation by leveraging large datasets including demographic, environmental, clinical and biomarker data has the potential to not only impact the diagnosis of patients, but also disease prediction, prognosis and treatment options.

Key Features

  • Allows the readers to gain an overview on precision medicine for autoimmune diseases leveraging AI solutions
  • Provides background, milestone and examples of precision medicine
  • Outlines the paradigm shift towards precision medicine driven by value-based systems
  • Discusses future applications of precision medicine research using AI
  • Other aspects covered in the book include regulatory insights, data analytics and visualization, types of biomarkers as well as the role of the patient in precision medicine


This book targets the scientific community at the interface between medicine, biotechnology as well as computer science (i.e., artificial intelligence). From the readers profile perspective, the book is geared towards scientist in academia and in the biotech as well as in the pharmaceutical industry (translational research and biomarker discovery groups / small molecules / drug target discovery). Some of the higher-level chapters of the book provide valuable information for functional heads in the industry (e.g., C-suite, executive level, business development).

Table of Contents

  • 1. History, current status, and future directions of artificial intelligence
    Olga Kubassova, Faiq Shaikh, Carlos Melus, and Michael Mahler
    2. Precision medicine as an approach to autoimmune diseases
    Marvin J. Fritzler and Michael Mahler
    3. Biomarker and data science as integral part of precision medicine
    Carlos Melus, Brenden Rossin, Mary Ann Aure, and Michael Mahler
    4. Companion and complementary diagnostics: A key to precision medicine
    Jan Trøst Jørgensen
    5. Checkpoint inhibitors: Interface of cancer and autoimmunity: Opportunity for second level precision medicine
    Savino Sciascia, Marie Hudson, Marvin J. Fritzler, Minoru Satoh, and Michael Mahler
    6. The evolving potential of precision medicine in the management of autoimmune liver disease
    Gary L. Norman, Nicola Bizzaro, Danilo Villalta, Diego Vergani, Giorgina Mieli-Vergani, Gideon M. Hirschfield, and Michael Mahler
    7. Precision medicine in autoimmune disease
    Kevin D. Deane
    8. Development of multi-omics approach in autoimmune diseases
    May Y. Choi, Marvin J. Fritzler, and Michael Mahler
    9. N-of-1 trials: Implications for clinical practice and personalized clinical trials
    Joanne Bradbury and Michael Mahler
    10. Health risk assessment and family history: Toward disease prevention
    Lily W. Martin, Lauren C. Prisco, Laura Martinez-Prat, Michael Mahler, and Jeffrey A. Sparks
    11. Regulatory aspects of artificial intelligence and machine learning-enabled software as medical devices (SaMD)
    Michael Mahler, Carolina Auza, Roger Albesa, Carlos Melus, and Jungen Andrew Wu
    12. Precision medicine from the patient’s perspective: More opportunities and increasing responsibilities
    Kim MacMartin-Moglia and Michael Mahler

Product details

  • No. of pages: 300
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: March 12, 2021
  • Imprint: Academic Press
  • eBook ISBN: 9780323854320
  • Paperback ISBN: 9780128202395

About the Editor

Michael Mahler

Michael Mahler received his Ph.D. from the institute of molecular genetics at the University of Heidelberg (Germany). During his Ph.D. thesis, Michael Mahler worked at The Scripps Research Institute in the laboratory of Prof. Mike Pollard and Prof. Eng Tan. He is currently Vice President of Research at Inova Diagnostics. His research is focused on the B-cell autoimmune response in autoimmune diseases and the discovery of novel autoantigens which resulted in more than 300 peer reviewed journal articles as well as several patents. In addition, he works on the development and characterization of novel diagnostic assays for the diagnosis of autoimmune diseases. In the scientific community, he serves as Editor of different scientific journals and as reviewer for more than 40 journals. Michael Mahler became exposed to and interested in Artificial Intelligence as well as Precision Medicine and as a consequence, co-founded the Precision Medicine in Autoimmunity (PMA) ( conference.

Affiliations and Expertise

Inova Diagnostics, San Diego, CA, USA

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