Posttranslational covalent modifications of proteins

Posttranslational covalent modifications of proteins

1st Edition - January 1, 1983

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  • Editor: B. Connor Johnson
  • eBook ISBN: 9780323150118

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Description

Posttranslational Covalent Modifications of Proteins focuses on the processes involved in the regulation of protein functions. Partitioned into 21 chapters, the book starts with discussions on the perspectives and prospectives of posttranslational protein modifications; protein phosphorylation and neural and hormonal control of enzymes; and research on the Rous sarcoma virus. The text also looks at studies on phosphorylation, protein kinases, and protein acetylation. The studies show the different reactions of proteins when combined under varying conditions and controlled environments. Schematic representations are presented to validate the processes involved. The book also presents experiments done on Vitamin K-dependent carboxylase from rat liver and cow. Lengthy discussions and diagrams are presented to give credence to the methodologies and results obtained. The text also focuses on studies on enzymatic activities in bacterial toxins and animals tissues. The book is a vital source of data for readers interested in the processes, techniques, and methodologies involved in the modification of proteins.

Table of Contents


  • Contributors

    Foreword

    Preface

    List of Speakers

    Posttranslational Protein Modifications: Perspectives and Prospectives

    Protein Phosphorylation and the Neural and Hormonal Control of Enzyme Activity

    The Rous Sarcoma Virus-Transforming Gene Product: In Vitro Phosphorylation with ATP and GTP as Phosphate Donors

    Calmodulin-Modulated Protein Phosphorylation

    Characterization of Neural-Specific cAMP-Dependent Protein Kinase

    Phospholipid Turnover as Transmembrane Signalling for Protein Phosphorylation and Platelet Activation

    Histone HI Phosphorylation: Purification and General Properties of a Camp Independent Histone HI Kinase

    HI Histone Phosphorylation: An Analysis of Different Phosphorylation Sites and Their Relationship to Chromosome Replication

    Effects of Phosphorylation on the Recycling of Eukaryotic Initiation Factor 2 (eIF-2)

    Affinity Probes for Protein Acetylation and Phosphorylation

    Vitamin K-Dependent Carboxylase from Rat Liver

    Studies on Vitamin K-Dependent Carboxylase from the Cow

    Vitamin K-Dependent Carboxylase: Recent Studies of the Rat Liver Enzyme System

    Utilizing Substrates with Modified Glutamyl Residues to Elucidate the Reaction Mechanism of the Vitamin K-Dependent 7-Glutamyl Carboxylase

    Vitamin K-Dependent Carboxylase: A Heme Protein?

    ADP-Ribosylation of Proteins: An Overview

    NAD: Arginine ADP-Ribosyltransferases: Enzymatic Activities in Animal Cells and Bacterial Toxins

    Mono- and Poly(ADP-Ribosylation) in Intact Cells

    Protein ADP-Ribosylation in Response to DNA Damage: Effects of Mg2+ and Ca2+ on Auto ADP-Ribosylation

    ADP-Ribosylation of the Regulatory Components of Adenylate Cyclase

    Macromolecular Properties of Poly(ADP-Ribose) and the Regulation of Its Biosynthesis and Degradation in Permeabilized Rat Brain 9L-Gliosarcoma Cells

    Index


Product details

  • No. of pages: 444
  • Language: English
  • Copyright: © Academic Press 1983
  • Published: January 1, 1983
  • Imprint: Academic Press
  • eBook ISBN: 9780323150118

About the Editor

B. Connor Johnson

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