Post-transcriptional Gene Regulation in Human Disease

Post-transcriptional Gene Regulation in Human Disease

1st Edition - August 12, 2022

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  • Editors: Buddhi Jain, Shyamal Goswami, Tapan Sharma
  • Paperback ISBN: 9780323913058
  • eBook ISBN: 9780323914246

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Description

Post-transcriptional Gene Regulation in Human Disease, a new volume in the Translational Epigenetics book series, offers a thorough overview and discussion of post-transcriptional genetic control mechanisms and their roles across various pathologies and human developmental outcomes, along with regulatory mechanisms targeted for therapeutic approaches. The book is broadly divided in two parts: early chapters describe the basics of post-transcriptional gene regulation, associated epigenetic mechanisms, the role of RNA binding proteins, the evolution of post-transcriptional gene regulation, and methods to study these mechanisms. The second half of the book includes deeper discussion of post-transcriptional gene regulation across specific diseases and therapeutics targets. Various post-transcriptional events, including alternative splicing and polyadenylation, mRNA stability, and miRNAs and their involvement in the disease progression, are examined in detail.

Key Features

  • Includes full-color imagery illustrating key concepts and post-transcriptional disease processes, as well as descriptions of methods for studying post-transcriptional gene regulation
  • Presents fundamental knowledge, molecular and biochemical mechanisms, and recent findings in concise and easily understandable formats
  • Features a summary and conclusion at the end of each chapter

Readership

Human geneticists; human genomicists; translational researchers in genomic medicine, epigenetics, biochemistry, molecular biology, oncology, and immunology; life science researchers; biotechnologists; developmental biologists. Clinicians and graduate students in the biosciences

Table of Contents

  • 1. Regulation of Gene Expression in Mammals: An Overview
    Shyamal K. Goswami.
    2. Post Transcriptional Gene Regulation: An Overview
    Shweta Pandey, Smriti Shreya, and Buddhi Prakash Jain
    3. Methods to Study Post-Transcriptional Regulation of Gene Expression
    Tapan Sharma
    4. Epigenetic Regulation of Post-Transcriptional Machinery
    Saddam Hussain, Anindita Dutta, and Rohini Muthuswami
    5. Post-Transcriptional Regulation: A Less Explored Territory in the World of Neurodegenerative Diseases
    Ayeman Amanullah
    6. Role of Post-Transcriptional Gene Regulation in Hematological Malignancies
    Hafiz M Ahmad
    7. Post-Transcriptional Gene Regulation in Solid Tumors
    Saba Tabasum and Monika Yadav
    8. A Comprehensive View of the Prostate Cancer Metastasis and Role of Androgen Receptor Splice Variants
    Yashika Jawa, Sangeeta Kumari, Gargi Bagchi, and Rakesh K. Tyagi
    9. Post-Transcriptional Gene Regulation in Cardiorenal Syndrome
    Ramandeep Singh, Anupam Mittal, Ajay Bahl, and Madhu Khullar
    10. Noncoding RNAs as Modulators of Post-Transcriptional Changes and Their Role in CVDs
    Swati Sharma, Shankar Chanchal, Yasir Khan, and Zahid Ashraf
    11. microRNAs as Critical Regulators in Heart Development and Diseases
    Vibha Rani
    12. MicroRNA Regulation in Autoimmune Diseases
    Ishani Dasgupta
    13. Post-Transcriptional Regulation of Inflammatory Disorder
    Savita Devi
    14. Post-Transcriptional Gene Regulation in Metabolic Syndrome
    Rashmi Pathak and Avinash Kumar
    15. Post-Transcriptional Regulation of HIV-1 Gene Expression: Role of Viral and Host Factors
    Anjali Tripathi, Alapani Mitra, Anindita Dasgupta, and Debashis Mitra
    16. Post-Transcriptional Regulation of Gene Expression in Entamoeba histolytica
    Sandeep Ojha and Sudha Bhattacharya
    17. Post-Transcriptional Regulation of Gene Expression in the Human Malaria Parasite Plasmodium falciparum
    Karina Simantov and Manish Goyal
    18. Hepcidin-Induced Degradation of Iron Exporter Ferroportin Determines Anemia of Chronic Diseases
    Chinmay K. Mukhopadhyay, Pragya Mishra, Ayushi Aggarwal, and Sameeksha Yadav
    19. Post-Transcriptional Regulation of Genes and Mitochondrial Disorder
    Ankit Sabharwal, and Bibekananda Kar

Product details

  • No. of pages: 394
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: August 12, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780323913058
  • eBook ISBN: 9780323914246

About the Editors

Buddhi Jain

Dr. Buddhi Prakash Jain is an Assistant Professor at the Department of Zoology, Mahatma Gandhi Central University, Motihari, Bihar, India. He completed his doctoral studies at the School of Life Sciences, Jawaharlal Nehru University (JNU) New Delhi, India. His research interests include gene expression regulation and endoplasmic reticulum stress in cancer. He is the recipient of several awards including a gold medal in Master Programme (M.Sc.), EMBO travel award, DST (Department of Science and Technology) Govt of India, Young Scientist travel award, and has published several papers in reputed international journals and a number of books and book chapters.

Affiliations and Expertise

Assistant Professor, Department of Zoology, School of Life Sciences, Mahatma Gandhi Central University Bihar, Motihari, India

Shyamal Goswami

Dr. Shyamal K. Goswami is a Professor at the School of Life Sciences, Jawaharlal Nehru University, New Delhi, India. He has held previous appointments as a Research Instructor, and Research Assistant Professor, in the Department of Anatomy and Cell Biology at State University of New York-Health Science Centre at Brooklyn, New York. His research focuses on cell signaling and gene expression in the cardiovascular system, transcription control of cardiovascular development and diseases, and redox biology of cardiovascular diseases. Dr. Goswami has published widely across such peer reviewed journals as Molecular and Cellular Biochemistry, Redox Biology, BMC Research Notes, Free Radical Biology and Medicine, and Biochim Biophys Acta.

Affiliations and Expertise

Professor at the School of Life Sciences, Jawaharlal Nehru University, New Delhi, India

Tapan Sharma

Dr. Tapan Sharma is a Postdoctoral Research Scientist at the University of Massachusetts Medical School, Worcester, MA, USA. His research focuses on understanding the epigenetic mechanisms involved in the regulation of skeletal muscle differentiation, with more than nine years of laboratory experience in the field of ATP-dependent chromatin remodelers. He has worked with mouse models and multiple primary and immortalized cell lines, having led projects independently during Ph.D. and post-doctoral associateships.

Affiliations and Expertise

Postdoctoral Research Scientist, University of Massachusetts Medical School, Worcester, MA, USA

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