Post-Genomic Cardiology

Post-Genomic Cardiology

2nd Edition - May 9, 2014

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  • Author: José Marín-García
  • eBook ISBN: 9780124046429
  • Hardcover ISBN: 9780124045996

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Description

In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the “epigenome,” comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach. This book, written by respected cardiologist José Marín-García, features discussion on the Hap-Map: the largest international effort to date aiming to define the differences between our individual genomes. This unique reference further reviews and investigates genome sequences from our evolutionary relatives that could help us decipher the signals of genes, and offers a comprehensive and critical evaluation of regulatory elements from the complicated network of the background DNA.

Key Features

  • Offers updated discussion of cutting-edge molecular techniques including new genomic sequencing / NGS / Hap-Map / bioinformatics / systems biology approaches
  • Analyzes mitochondria dynamics and their role in cardiac dysfunction, up-to-date analysis of cardio-protection, and cardio-metabolic syndrome
  • Presents recent translational studies, gene therapy, transplantation of stem cells, and pharmacological treatments in CVDs

Readership

Cardiologists, geneticists, physiologists, cell and developmental biologists as well as clinicians with interests in metabolic disease, neonatal medicine and aging specialists.

Table of Contents

  • Section I: Post-Genomic Cardiology

    Chapter 1. Introduction to the Molecular Biology of the Cell

    • Nucleic Acids, Genes, Chromatin, and Chromosomes
    • DNA Transacting Processes: Replication, Transcription, and Repair
    • Genetic Variability Associated with Human Diseases
    • Cell Cycle
    • References

    Chapter 2. Methodologies in the Era of Cardiovascular “Omics”

    • Introduction
    • Genomics Approaches: NGS and GWAS
    • Transcriptomics
    • Proteomics and Interactomics
    • Metabolomics
    • Cardiac Imaging
    • Translational Bioinformatics
    • Conclusions
    • Summary
    • References

    Chapter 3. Post-Genomics Cardiovascular Signaling Pathways

    • Introduction
    • Cardiac Signaling in Physiological Growth
    • Ca2+-Mediated Signaling
    • Signaling at the Plasma Membrane
    • Signaling at the Mitochondria
    • Cell-Cycle signaling, cell proliferation, and apoptosis
    • Stress, Survival, and Metabolic Signaling
    • Signaling in Cardiac Development and Aging
    • Conclusion
    • Summary
    • References

    Section II: Pediatric Cardiology in the Post-Genomic Era

    Chapter 4. Molecular Determinants of Cardiac Development

    • Introduction
    • Overview of Cardiac Morphogenesis
    • MicroRNAs in Cardiovascular Development
    • Conclusions
    • Summary
    • References

    Chapter 5. Molecular Determinants of Congenital Heart Disease

    • Introduction
    • Etiology of CHD: Interplay of Genetic and Environmental Factors
    • Molecular Mechanisms of CHD
    • Syndromic CHDs Caused by Point Mutations
    • Nonsyndromic CHDs Caused by Point Mutations
    • Non-Syndromic CHD Caused by Impaired Signaling Pathways
    • Nonsyndromic CHD Caused by Point Mutations in Transcription Factors
    • Nonsyndromic CHDs Caused by Point Mutations in Structural Proteins
    • Noncoding RNAs and CHD
    • Conclusions
    • Summary
    • References

    Section III: Post-Genomic Assessment of Coronary Artery Disease, Angiogenesis, and Hypertension

    Chapter 6. Molecular Determinants of Atherosclerosis

    • Overview of Atherogenesis
    • Lipoproteins
    • Endothelial Dysfunction
    • Rho Kinases and Statins in Atherosclerosis
    • Tumor Necrosis Factor (TNF) in Atherogenesis
    • Monocytes and Macrophages
    • Antiinflammatory Factors
    • Conclusion
    • Summary
    • References

    Chapter 7. Molecular Genetics of Coronary Artery Disease and Myocardial Infarction

    • Introduction
    • Animal Studies
    • Linkage and Genome-Wide Association Studies in Myocardial Ischemia
    • Candidate Gene Identification Approach
    • Genes and Inflammatory Signaling Pathways Involved in CAD/MI
    • Other Signaling Pathways in CAD/MI
    • Additional Gene LOCI Associated with MI
    • Sex Hormone and MI
    • Gene Profiling in Myocardial Ischemia/Infarct
    • Genetics and Ethnic Differences in Coronary Artery Disease
    • Beyond GWAS
    • MicroRNAs Markers in CAD/MI
    • Conclusions
    • Summary
    • References

    Chapter 8. Cellular and Molecular Aspects of Cardioprotection

    • Introduction
    • Cellular and Molecular Events in IPC
    • IPC and Potassium Channels
    • Signaling Pathways
    • Cell Death
    • Early and Late IPC Pathways
    • IPC and Cell Death
    • Mitochondrial Activity and ATP Levels in IPC
    • Mitochondria and Antioxidants
    • Gene Expression in Early IPC (Signaling Book)
    • Postconditioning and Cardioprotection
    • Remote Conditioning
    • Application in Humans
    • microRNAs in Cardioprotection
    • Conclusions and Future Perspective
    • Summary
    • References

    Chapter 9. Molecular Determinants of Cardiac Neovascularization

    • Introduction
    • Vasculogenesis
    • Angiogenesis
    • Arteriogenesis
    • Molecular Mechanisms of Neovascularization
    • Therapy
    • Conclusions and Future Perspectives
    • Summary
    • References

    Chapter 10. Post-Genomics Appraisal of Systemic and Pulmonary Hypertension

    • Introduction
    • Animal Models of Hypertension
    • Gene Expression and Profiling in Primary Systemic Hypertension
    • Genetics of PPH
    • Conclusions and Future Directions
    • Summary
    • References

    Section IV: Post-Genomic Analysis of the Myocardium

    Chapter 11. Post-Genomic Appraisal of Myocarditis

    • Introduction
    • Pathogenesis of Autoimmune Myocarditis
    • Signaling Pathways of Innate and Acquired Immunity
    • Treatment
    • Conclusions
    • Summary
    • References

    Chapter 12. Cardiomyopathies: A Comparative Analysis of Phenotypes and Genotypes

    • Introduction
    • Hypertrophic Cardiomyopathy
    • Genetics of HCM
    • Animal Models of Genetic HCM
    • Dilated Cardiomyopathy
    • Transgenic Models of Dilated Cardiomyopathy
    • Mechanistic Hypotheses of DCM
    • Restrictive Cardiomyopathy
    • Arrhythmogenic Right Ventricular Dysplasia
    • Unclassified Cardiomyopathies
    • Cardiomyopathy and Diabetes Mellitus
    • Genetics in Diabetes
    • Conclusion
    • Summary
    • References

    Section V: Heart Failure, Cell Death, and Mitochondria Dynamics

    Chapter 13. Gene Profiling, Energy Metabolism, and Remodeling of the Failing Heart

    • Introduction
    • The Profiling of Gene Expression in Heart Failure
    • Global and Specific Analysis of Gene Expression
    • Epigenetics and HF
    • Histone/Chromatin Modifications; Epigenetic Control of Gene Expression
    • DNA modification/methylation
    • Transcriptional Coactivator p300 and Cardiac Hypertrophy
    • Energy Metabolism Profiling
    • Intracellular Calcium-Cycling Profiling
    • The Genetics of Human HF
    • Bioenergetics and Metabolic Changes in the Failing Heart
    • Mitochondrial DNA Integrity and HF in Transgenic Mice
    • Peroxisome proliferator activated receptor gamma coactivator 1 (PGC1)
    • Peroxisome Proliferator Activated Receptor (PPAR)
    • Mitochondrial Gene Profiling
    • Implication of Metabolic Genes in HF
    • From Cardiac Remodeling to Overt HF
    • Conclusion
    • Summary
    • References

    Chapter 14. Oxidative Stress and Cell Death in Cardiovascular Disease: A Post-Genomic Appraisal

    • Introduction
    • Oxidative Stress
    • Cell Death
    • Conclusions
    • Summary
    • References

    Chapter 15. The Emerging Role of Mitochondrial Dynamics in Cardiovascular Disease

    • Introduction
    • Mechanisms of Mitochondrial Fusion and Fission
    • Physiological Roles of Mitochondrial Dynamics
    • Mitochondrial Dynamics in the Normal and Diseased Heart
    • Conclusions
    • Summary
    • References

    Section VI: Molecular and Genetic Analysis of Metabolic Disorders

    Chapter 16. Post-Genomic Analysis of Fatty Acid and Glucose Metabolism in Cardiovascular Disease

    • Introduction
    • Metabolism of Fatty Acids and Glucose in Normal Cardiomyocytes
    • Regulatory Elements of Cardiac Bioenergy Molecules Metabolism
    • Metabolic Dysfunction and Cardiovascular Disease Phenotypes
    • Metabolic Therapies: Current Status and Perspectives
    • Summary
    • References

    Section VII: Molecular Genetics of Dysrhythmias

    Chapter 17. Post-Genomic Analysis of Dysrhythmias and Sudden Death

    • Introduction
    • Etiology of Cardiac Dysrhythmias
    • Ventricular Action Potential and Ion Currents
    • Cardiac Ion Channels
    • Properties of Ion Channels
    • Inherited Cardiac Dysrhythmias
    • Acquired Dysrhythmias
    • Mitochondria and Heart Rhythm Disorders
    • Animals Models for Cardiac Dysrhythmias
    • Post-Genomic Approaches to Rhythm Disorders
    • Conclusions and Future Prospects
    • Summary
    • References

    Section VIII: Genes, Gender, and Epigenetics

    Chapter 18. Gender and Cardiovascular Disease in the Post-Genomic Era

    • Introduction
    • Sex Steroid Hormones
    • Role of Gonadal Hormones in Cardiac Pathology
    • Animal and In Vitro Studies
    • Studies in Humans
    • Gender-Related Gene Regulation and Cardiovascular Disease
    • Epigenetic and Environmental Factors of Sex-Related Specifics of Cardiovascular Disease
    • Conclusion
    • Summary
    • References

    Section IX: Aging and the Cardiovascular System

    Chapter 19. The Aging Heart: A Post-Genomic Appraisal

    • Introduction
    • Telomere Analysis
    • Telomeres and CV Aging
    • Signaling Pathways in the Aging Heart
    • Signaling in the Endothelium in Aging
    • Cellular Damage/Cell Loss, Mitochondria, and CV Aging
    • Reactive Oxidative Species Generation and Aging in the Heart
    • Inflammation and CV Aging
    • Neurohormonal Signaling in CV Aging
    • Prodeath and Prosurvival Signaling Pathways in Aging
    • Signaling Factors in Cell Regeneration of the Aging Heart
    • Genetic Makeup of the Aging Heart
    • Epigenetic and Environmental Factors in Cardiac Aging
    • Gene Transfer in Cardiovascular Tissue
    • Knockout Transgenic Animal Models of Aging
    • Gene Profiling: Transcriptome and Proteomic Analysis
    • Proteomic Analysis
    • DNA Damage and Mutations in Aging
    • Conclusion
    • Summary
    • References

    Chapter 20. Targeted Strategies to Fight Cardiac Aging

    • Introduction
    • Attenuating Cell Death and Remodeling
    • Initiating Prosurvival Pathways
    • Removing “Biological Garbage” in Aging: Targeting Lysosomes, Proteasomes and Other Approaches to Enhance Catabolic Gain
    • Genomic Instability
    • Conclusion
    • Summary
    • References

    Chapter 21. Aging and the Cardiovascular System: The Road Ahead

    • Introduction
    • Genetic Analysis in Aging Research
    • Advances in Human Genotyping and Human Gene Analysis
    • Search for Biomarkers of Human Aging
    • Reversing Aging and/or Dysfunction of Age-Associated Diseases
    • Targeting Specific Organelles in Aging: Mitochondria/Lysosome
    • Diastolic Dysfunction in Aging
    • Pharmacogenomics and Nutrigenomics
    • Conclusions and Future Perspective
    • Summary
    • References

    Section X: Genetics, Epigenetics, and New Approaches to Treatment

    Chapter 22. Epigenetics and Cardiovascular Disease

    • Introduction
    • Basic Epigenetic Mechanisms
    • Cardiovascular Epigenetics
    • Conclusions
    • Summary
    • References

    Chapter 23. Gene- and Cell-Based Therapy for Cardiovascular Disease

    • Introduction
    • Gene Therapy
    • Potential Molecular Targets
    • MicroRNA Therapeutics for CVD
    • Cell-Based Therapy
    • Cell Sources
    • Cardiac Progenitor Cells
    • Epicardial Progenitor Cells
    • Strategies for Cell Purification, Delivery, and Engrafting
    • Mechanisms of Heart Regeneration
    • Empowering Human Heart Regeneration
    • Conclusions
    • Summary
    • References

    Section XI: Looking to the Future

    Chapter 24. The Path to Personalized Cardiovascular Medicine

    • Introduction
    • Genomic and Epigenomic Analysis
    • Transcriptomics
    • Proteomics and Metabolomics
    • Cardiovascular Pharmacogenetics and Pharmacogenomics
    • Integrating “Omics”: Systems Biology and Network Medicine
    • Conclusions
    • Summary
    • References

Product details

  • No. of pages: 944
  • Language: English
  • Copyright: © Academic Press 2014
  • Published: May 9, 2014
  • Imprint: Academic Press
  • eBook ISBN: 9780124046429
  • Hardcover ISBN: 9780124045996

About the Author

José Marín-García

Dr.José Marín-García, highly respected cardiologist, is the current Director of Molecular Cardiology and Neuromuscular Institute in Highland Park, NJ. He has 189 listed publications and an H-index of 30. He has written and edited Mitochondria and the heart (2005), Aging and the Heart (2008), Signaling in the Heart (2008). Heart Failure (2010), Post-Genomic Cardiology (2007), and Mitochondria and Their Role in Cardiovascular Disease (2012).

Affiliations and Expertise

Director, The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA

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