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Part I: Fundamentals of porous silicon for biomedical applications
1. Thermal stabilization of porous silicon
Jarno Salonen and Ermei Mäkilä
2. Thermal properties of nanoporous silicon materials
3. Photochemical and nonthermal chemical modification of porous silicon
Kurt W. Kolasinski
4. Protein-modified porous silicon optical devices for biosensing
Monica Terracciano, Chiara Tramontano, Rosalba Moretta, Bruno Miranda, Nicola Borbone, Luca De Stefano, and Ilaria Rea
5. Biocompatibility of porous silicon
Ibukunoluwa Naiyeju and Luis Bimbo
Part II: Porous silicon for bioimaging and biosensing applications
6. Optical properties of porous silicon materials
Vicente Torres-Costa and Raúl J. Martín-Palma
7. Radiolabeled porous silicon for nuclear imaging and theranostic applications
Mirkka Sarparanta and Anu Airaksinen
8. Porous silicon for targeting microorganisms: detection and treatment
Naama Massad-Ivanir, Sofia Arshavsky Graham, and Ester Segal
9. Nanoporous silicon biosensors for DNA sensing
10. Near-infrared imaging for in vivo assessment of porous silicon-based materials
Xia Bing, Jiachen Li, and Yan Gao
11. Porous silicon-based sensors for protein detection
Edgar Eduardo Antunez, Maria Alba Martin, and Nicolas Voelcker
Part III: Porous silicon for drug delivery, cancer therapy, and tissue engineering applications
12. Nanoporous silicon to enhance oral delivery of poorly water-soluble drugs
Hayley B. Schultz, Paul Joyce, Clive A. Prestidge, and Timothy J. Barnes
13. Porous silicon for tumour targeting and imaging
14. Porous silicon–polymer composites for cell culture and tissue engineering
Steven McInnes, Nelli Klinova McMillan, and Nicolas Voelcker
15. Porous silicon and related composites as functional tissue engineering scaffolds
Nelli Klinova McMillan and Jeffery L. Coffer
16. Porous silicon in photodynamic and photothermal therapy
Liubov A. Osminkina and Maxim Gongalsky
17. Porous silicon microneedles and nanoneedles for biomedical applications
18. Porous silicon materials for cancer and immunotherapy
Hélder A. Santos
Porous Silicon for Biomedical Applications, Second Edition, provides an updated guide to the diverse range of biomedical applications of porous silicon, from biosensing and imaging to tissue engineering and cancer therapy.
Across biomedical disciplines, there is an ongoing search for biomaterials that are biocompatible, modifiable, structurally sound, and versatile. Porous silicon possesses a range of properties that make it ideal for a variety of biomedical applications, such as controllable geometry, tunable nanoporous structure, large pore volume/high specific surface area, and versatile surface chemistry.
This book provides a fully updated and detailed overview of the range of biomedical applications for porous silicon. Part One offers the reader a helpful insight into the fundamentals and beneficial properties of porous silicon, including thermal properties and stabilization, photochemical and nonthermal chemical modification, protein modification, and biocompatibility. The book then builds on the systematic detailing of each biomedical application using porous silicon, from bioimaging and sensing to drug delivery and tissue engineering. This new edition also includes new chapters on in vivo assessment of porous silicon, photodynamic and photothermal therapy, micro- and nanoneedles, Raman imaging, cancer immunotherapy, and more.
With its acclaimed editor and international team of expert contributors, Porous Silicon for Biomedical Applications, Second Edition, is a technical resource and indispensable guide for all those involved in the research, development, and application of porous silicon and other biomaterials, while providing a comprehensive introduction for students and academics interested in this field.
- Reviews the fundamental aspects of porous silicon, including the fabrication and unique properties of this useful material.
- Discusses a broad selection of biomedical applications, offering a detailed insight into the benefits of porous silicon in both research and clinical settings.
- Includes fully updated content from the previous edition, as well as brand new chapters, covering topics such as porous silicon micro- and nanoneedles, and cancer immunotherapy.
Researchers and academics working in biomedical engineering, chemical engineering, cellular biology, and materials science
- No. of pages:
- © Woodhead Publishing 2021
- 1st October 2021
- Woodhead Publishing
- Paperback ISBN:
Hélder A. Santos is a Full Professor in Pharmaceutical Nanotechnology at the Faculty of Pharmacy of the University of Helsinki (Finland), Head of the Nanomedicines and Biomedical Engineering Lab, Director of the Doctoral Program in Drug Research, Director of FinPharmaNet in Finland, Chair of the Controlled Release Society Focus Group in Nanomedicine and Nanoscale Delivery, and Chairman and co-founder of Capsamedix Oy. Prof. Santos’ research is focused on nanobiomaterials, including nanoporous silica/silicon materials and polymeric-based nanoparticles for controlled drug delivery, diagnostics, and therapy. His research interests include the development of nanoparticles/nanomedicines for biomedical and healthcare applications. His current work builds a bridge between engineering, pharmaceutical, and medical research. He is the author/co-author of more than 330 publications, including reviews, journal editorials, book chapters, 4 edited books, and more than 260 conference proceedings/abstracts. He also holds 4 patents in the field.
Full Professor, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
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