Porous Silicon for Biomedical Applications

Porous Silicon for Biomedical Applications

2nd Edition - October 23, 2021

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  • Editor: Hélder A. Santos
  • eBook ISBN: 9780128225240
  • Paperback ISBN: 9780128216774

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Description

Porous Silicon for Biomedical Applications, Second Edition, provides an updated guide to the diverse range of biomedical applications of porous silicon, from biosensing and imaging to tissue engineering and cancer therapy. Across biomedical disciplines, there is an ongoing search for biomaterials that are biocompatible, modifiable, structurally sound, and versatile. Porous silicon possesses a range of properties that make it ideal for a variety of biomedical applications, such as controllable geometry, tunable nanoporous structure, large pore volume/high specific surface area, and versatile surface chemistry. This book provides a fully updated and detailed overview of the range of biomedical applications for porous silicon. Part One offers the reader a helpful insight into the fundamentals and beneficial properties of porous silicon, including thermal properties and stabilization, photochemical and nonthermal chemical modification, protein modification, and biocompatibility. The book then builds on the systematic detailing of each biomedical application using porous silicon, from bioimaging and sensing to drug delivery and tissue engineering. This new edition also includes new chapters on in-vivo assessment of porous silicon, photodynamic and photothermal therapy, micro- and nanoneedles, Raman imaging, cancer immunotherapy, and more. With its acclaimed editor and international team of expert contributors, Porous Silicon for Biomedical Applications, Second Edition, is a technical resource and indispensable guide for all those involved in the research, development, and application of porous silicon and other biomaterials, while providing a comprehensive introduction for students and academics interested in this field.

Key Features

  • Reviews the fundamental aspects of porous silicon, including the fabrication and unique properties of this useful material.
  • Discusses a broad selection of biomedical applications, offering a detailed insight into the benefits of porous silicon in both research and clinical settings.
  • Includes fully updated content from the previous edition, as well as brand new chapters, covering topics such as porous silicon micro- and nanoneedles, and cancer immunotherapy.

Readership

Researchers and academics working in biomedical engineering, chemical engineering, cellular biology, and materials science.

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Contributors
  • Preface
  • References
  • Introduction
  • References
  • Part 1: Fundamentals of porous silicon for biomedical applications
  • Chapter 1: Thermal stabilization of porous silicon
  • Abstract
  • 1.1: Introduction
  • 1.2: Thermal oxidation
  • 1.3: Thermal carbonization
  • 1.4: Thermal nitridation
  • 1.5: Structural effects of thermal annealing
  • 1.6: Analytical aspects
  • 1.7: Conclusions and future trends
  • References
  • Chapter 2: Thermal properties of nanoporous silicon materials
  • Abstract
  • Acknowledgments
  • 2.1: Introduction
  • 2.2: Thermal constants of PSi
  • 2.3: Application studies
  • 2.4: Conclusion and future trends
  • References
  • Chapter 3: Photochemical and nonthermal chemical modification of porous silicon
  • Abstract
  • 3.1: Introduction
  • 3.2: Hydrosilylation and controlled surface modification of Si
  • 3.3: Surface photochemistry: An introduction
  • 3.4: Photochemical mechanisms on H/Si surfaces
  • 3.5: Laser ablation
  • 3.6: Electrochemical grafting
  • 3.7: Sonochemistry
  • 3.8: Microwave-induced chemistry
  • 3.9: Mechanochemistry
  • 3.10: Conclusions and future trends
  • References
  • Chapter 4: Protein-modified porous silicon optical devices for biosensing
  • Abstract
  • Acknowledgments
  • 4.1: Introduction
  • 4.2: Proteins on surfaces
  • 4.3: Porous silicon monolayers and multilayers
  • 4.4: Characterization methods
  • 4.5: Protein-modified PSi
  • 4.6: Conclusions and future trends
  • References
  • Chapter 5: Biocompatibility of porous silicon
  • Abstract
  • 5.1: Biocompatibility
  • 5.2: Biodegradability
  • 5.3: Cytotoxicity
  • 5.4: The fate of porous silicon in the body
  • 5.5: In vivo behavior of PSi implants
  • 5.6: Porous silicon for biomimetic reactors and biohybrid systems
  • 5.7: Porous silicon for the design of targeted nanocarriers
  • 5.8: Porous silicon for radiation theranostics
  • 5.9: Porous silicon for tissue engineering
  • 5.10: Missing links
  • 5.11: Conclusion
  • References
  • Part 2: Porous silicon for bioimaging and biosensing applications
  • Chapter 6: Optical properties of porous silicon materials
  • Abstract
  • 6.1: Introduction
  • 6.2: Morphology of PSi
  • 6.3: Effective medium models
  • 6.4: Optical constants of nano-PSi
  • 6.5: Stability of the optical properties of nano-PSi
  • 6.6: Multilayer structures
  • 6.7: Optical applications of PSi optical filters
  • 6.8: Conclusion and future trends
  • References
  • Chapter 7: Radiolabeled porous silicon for nuclear imaging and theranostic applications
  • Abstract
  • 7.1: Introduction
  • 7.2: Methods for tracing drug delivery
  • 7.3: Radiolabeled PSi materials
  • 7.4: Conclusions and future trends
  • References
  • Chapter 8: Porous silicon for targeting microorganisms: Detection and treatment
  • Abstract
  • 8.1: Introduction
  • 8.2: Advancements in microorganism detection
  • 8.3: PSi as an antibacterial agent
  • 8.4: Conclusions and future trends
  • References
  • Chapter 9: Porous silicon biosensors for DNA sensing
  • Abstract
  • 9.1: Introduction
  • 9.2: PSi sensor preparation
  • 9.3: PSi DNA sensor structures, measurement techniques, and sensitivity
  • 9.4: Corrosion of PSi DNA sensors
  • 9.5: Effect of pore size on DNA infiltration and detection
  • 9.6: Control of DNA surface density in nanoscale pores
  • 9.7: Kinetics for real-time sensing
  • 9.8: Conclusions and future trends
  • References
  • Chapter 10: Near-infrared imaging for in vivo assessment of porous silicon-based materials
  • Abstract
  • 10.1: Introduction
  • 10.2: Fabrication of PSi-based composited materials with NIR PL
  • 10.3: Assessment of the fate of PSi-based composited materials using in vivo imaging
  • 10.4: Monitoring the physiological microenvironments of pathological tissues in vivo
  • 10.5: Conclusions and future perspectives
  • References
  • Chapter 11: Porous silicon-based sensors for protein detection
  • Abstract
  • Acknowledgments
  • 11.1: Introduction
  • 11.2: Preparation of PSi protein biosensors
  • 11.3: Optical biosensing
  • 11.4: Electrochemical biosensing
  • 11.5: Conclusions and future trends
  • References
  • Part 3: Porous silicon for drug delivery, cancer therapy and tissue engineering applications
  • Chapter 12: Nanoporous silicon to enhance oral delivery of poorly water-soluble drugs
  • Abstract
  • 12.1: Introduction
  • 12.2: Loading poorly water-soluble drugs into PSi
  • 12.3: In vitro studies of drug dissolution
  • 12.4: In vivo oral drug delivery studies
  • 12.5: Conclusions and future perspectives
  • References
  • Chapter 13: Porous silicon for tumor targeting and imaging
  • Abstract
  • 13.1: Introduction
  • 13.2: Tumor targeting and imaging
  • 13.3: Preparation of PSi particles
  • 13.4: PSi particles for in vivo tumor targeting
  • 13.5: PSi particles for in vivo tumor imaging
  • 13.6: Conclusion and future trends
  • References
  • Chapter 14: Porous silicon-polymer composites for cell culture and tissue engineering
  • Abstract
  • Acknowledgments
  • 14.1: Introduction
  • 14.2: Fundamentals of PSi and composite fabrication
  • 14.3: Polymers for tissue engineering
  • 14.4: The grafting of biopolymers to PSi
  • 14.5: PSi and tissue engineering
  • 14.6: Applications of PSi-polymer composites in tissue culture and bioengineering
  • 14.7: Conclusions and future trends
  • 14.8: Sources of further information and advice
  • References
  • Chapter 15: Porous silicon and related composites as functional tissue engineering scaffolds
  • Abstract
  • Acknowledgment
  • 15.1: Introduction
  • 15.2: Role of PSi biodegradability and biocompatibility for tissue engineering
  • 15.3: Strategies for PSi/polymer composite formulation (fabrication)
  • 15.4: PSi and related composites in orthopedic tissue engineering
  • 15.5: Semiconducting PSi-containing scaffolds: Bias-induced effects
  • 15.6: Tissue engineering of the eye
  • 15.7: Conclusions and future trends
  • References
  • Chapter 16: Porous silicon in photodynamic and photothermal therapy
  • Abstract
  • Acknowledgment
  • 16.1: Introduction
  • 16.2: PSi nanoparticles in photothermal therapy
  • 16.3: PSi nanoparticles in photodynamic therapy
  • 16.4: Conclusions and future trends
  • References
  • Chapter 17: Porous silicon microneedles and nanoneedles for biomedical applications
  • Abstract
  • 17.1: Introduction
  • 17.2: The design of micro- and nanoneedles
  • 17.3: The interfacing of micro- and nanoneedles
  • 17.4: Biocompatibility and cellular interactions
  • 17.5: Drug delivery
  • 17.6: Biosensing
  • 17.7: Conclusions and future trends
  • References
  • Chapter 18: Porous silicon materials for cancer and immunotherapy
  • Abstract
  • 18.1: Introduction
  • 18.2: PSi-based particulates
  • 18.3: The interaction between PSi and the immune system
  • 18.4: Therapeutic applications in immunotherapy
  • 18.5: Conclusions and future trends
  • References
  • Index

Product details

  • No. of pages: 644
  • Language: English
  • Copyright: © Woodhead Publishing 2021
  • Published: October 23, 2021
  • Imprint: Woodhead Publishing
  • eBook ISBN: 9780128225240
  • Paperback ISBN: 9780128216774

About the Editor

Hélder A. Santos

Hélder A. Santos is a Full Professor in Pharmaceutical Nanotechnology at the Faculty of Pharmacy of the University of Helsinki (Finland), Head of the Nanomedicines and Biomedical Engineering Lab, Director of the Doctoral Program in Drug Research, Director of FinPharmaNet in Finland, Chair of the Controlled Release Society Focus Group in Nanomedicine and Nanoscale Delivery, and Chairman and co-founder of Capsamedix Oy. Prof. Santos’ research is focused on nanobiomaterials, including nanoporous silica/silicon materials and polymeric-based nanoparticles for controlled drug delivery, diagnostics, and therapy. His research interests include the development of nanoparticles/nanomedicines for biomedical and healthcare applications. His current work builds a bridge between engineering, pharmaceutical, and medical research. He is the author/co-author of more than 330 publications, including reviews, journal editorials, book chapters, 4 edited books, and more than 260 conference proceedings/abstracts. He also holds 4 patents in the field.

Affiliations and Expertise

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland; Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland; Department of Biomedical Engineering, University Medical Center Groningen/University of Groningen, Groningen, The Netherlands

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