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Porous Silicon for Biomedical Applications - 2nd Edition - ISBN: 9780128216774

Porous Silicon for Biomedical Applications

2nd Edition

Editor: Hélder A. Santos
Paperback ISBN: 9780128216774
Imprint: Woodhead Publishing
Published Date: 29th October 2021
Page Count: 642
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Table of Contents

H.A. Santos
Part I: Fundamentals of porous silicon for biomedical applications
1. Thermal stabilization of porous silicon
J. Salonen and E. Mäkilä
2. Thermal properties of nanoporous silicon materials
N. Koshida
3. Photochemical and nonthermal chemical modification of porous silicon
K.W. Kolasinski
4. Protein-modified porous silicon optical devices for biosensing
M. Terracciano, C. Tramontano, R. Moretta, B. Miranda, N. Borbone, L. De Stefano, and I. Rea
5. Biocompatibility of porous silicon
I.S. Naiyeju and L.M. Bimbo

Part II: Porous silicon for bioimaging and biosensing applications
6. Optical properties of porous silicon materials
V. Torres-Costa and R.J. Martín-Palma
7. Radiolabeled porous silicon for nuclear imaging and theranostic applications
M. Sarparanta and A.J. Airaksinen
8. Porous silicon for targeting microorganisms: Detection and treatment
N. Massad-Ivanir, S. Arshavsky-Graham, and E. Segal
9. Porous silicon biosensors for DNA sensing
G.A. Rodriguez, J.L. Lawrie, R. Layouni, and S.M. Weiss
10. Near-infrared imaging for in vivo assessment of porous silicon-based materials
B. Xia, J. Li, and Y. Gao
11. Porous silicon-based sensors for protein detection
E.E. Antunez, M.A. Martin, and N.H. Voelcker

Part III: Porous silicon for drug delivery, cancer therapy, and tissue engineering applications
12. Nanoporous silicon to enhance oral delivery of poorly water-soluble drugs
H.B. Schultz, P. Joyce, C.A. Prestidge, and T.J. Barnes
13. Porous silicon for tumor targeting and imaging
J.-H. Park, M. Jeong, and H. Kim
14. Porous silicon-polymer composites for cell culture and tissue engineering
S.J.P. McInnes, R.B. Vasani, N.K. McMillan, and N.H. Voelcker
15. Porous silicon and related composites as functional tissue engineering scaffolds
N.K. McMillan and J.L. Coffer
16. Porous silicon in photodynamic and photothermal therapy
L.A. Osminkina and M.B. Gongalsky
17. Porous silicon microneedles and nanoneedles for biomedical applications
C. Chiappini
18. Porous silicon materials for cancer and immunotherapy
F. Fontana, Z. Liu, J. Hirvonen, and H.A. Santos


Porous Silicon for Biomedical Applications, Second Edition, provides an updated guide to the diverse range of biomedical applications of porous silicon, from biosensing and imaging to tissue engineering and cancer therapy.

Across biomedical disciplines, there is an ongoing search for biomaterials that are biocompatible, modifiable, structurally sound, and versatile. Porous silicon possesses a range of properties that make it ideal for a variety of biomedical applications, such as controllable geometry, tunable nanoporous structure, large pore volume/high specific surface area, and versatile surface chemistry.

This book provides a fully updated and detailed overview of the range of biomedical applications for porous silicon. Part One offers the reader a helpful insight into the fundamentals and beneficial properties of porous silicon, including thermal properties and stabilization, photochemical and nonthermal chemical modification, protein modification, and biocompatibility. The book then builds on the systematic detailing of each biomedical application using porous silicon, from bioimaging and sensing to drug delivery and tissue engineering. This new edition also includes new chapters on in-vivo assessment of porous silicon, photodynamic and photothermal therapy, micro- and nanoneedles, Raman imaging, cancer immunotherapy, and more.

With its acclaimed editor and international team of expert contributors, Porous Silicon for Biomedical Applications, Second Edition, is a technical resource and indispensable guide for all those involved in the research, development, and application of porous silicon and other biomaterials, while providing a comprehensive introduction for students and academics interested in this field.

Key Features

  • Reviews the fundamental aspects of porous silicon, including the fabrication and unique properties of this useful material.
  • Discusses a broad selection of biomedical applications, offering a detailed insight into the benefits of porous silicon in both research and clinical settings.
  • Includes fully updated content from the previous edition, as well as brand new chapters, covering topics such as porous silicon micro- and nanoneedles, and cancer immunotherapy.


Researchers and academics working in biomedical engineering, chemical engineering, cellular biology, and materials science.


No. of pages:
© Woodhead Publishing 2021
29th October 2021
Woodhead Publishing
Paperback ISBN:

Ratings and Reviews

About the Editor

Hélder A. Santos

Hélder A. Santos is a Full Professor in Pharmaceutical Nanotechnology at the Faculty of Pharmacy of the University of Helsinki (Finland), Head of the Nanomedicines and Biomedical Engineering Lab, Director of the Doctoral Program in Drug Research, Director of FinPharmaNet in Finland, Chair of the Controlled Release Society Focus Group in Nanomedicine and Nanoscale Delivery, and Chairman and co-founder of Capsamedix Oy. Prof. Santos’ research is focused on nanobiomaterials, including nanoporous silica/silicon materials and polymeric-based nanoparticles for controlled drug delivery, diagnostics, and therapy. His research interests include the development of nanoparticles/nanomedicines for biomedical and healthcare applications. His current work builds a bridge between engineering, pharmaceutical, and medical research. He is the author/co-author of more than 330 publications, including reviews, journal editorials, book chapters, 4 edited books, and more than 260 conference proceedings/abstracts. He also holds 4 patents in the field.

Affiliations and Expertise

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland; Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland; Department of Biomedical Engineering, University Medical Center Groningen/University of Groningen, Groningen, The Netherlands