Polymers and Nanomaterials for Gene Therapy - 1st Edition - ISBN: 9780081005200, 9780081005217

Polymers and Nanomaterials for Gene Therapy

1st Edition

Editors: Ravin Narain
eBook ISBN: 9780081005217
Hardcover ISBN: 9780081005200
Imprint: Woodhead Publishing
Published Date: 11th January 2016
Page Count: 302
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Description

Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy.

The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and nanoparticles, are potential routes for compacting DNA for systemic delivery. However, unlike viral analogues that have no difficulty in overcoming cellular barriers and immune defense mechanisms, non-viral gene carriers consistently exhibit significant reduced transfection efficiency due to numerous extra- and intracellular obstacles. Therefore, biocompatibility and potential for large-scale production make these compounds increasingly attractive for gene therapy.

This book contains chapters on the engineering of polymers and nanomaterials for gene therapy, and how they can form complexes with DNA and avoid both in vitro and in vivo barriers. Other chapters describe in vitro, ex vivo, in vivo gene therapy studies, and the current issues affecting non-viral gene therapy.

Key Features

  • Explores current challenges in the research of genetic diseases
  • Discusses polymers for gene therapy and their function in designing advanced materials
  • Provides examples of organic and inorganic nanomaterials for gene therapy
  • Includes labeling, targeting, and assays
  • Looks at characterization, physico-(bio)chemical properties, and applications

Readership

Academics and graduate students researching gene therapy, and clinical scientists investigating cancer and other genetic diseases.  

Table of Contents

  • Current challenges of gene therapy
  • Engineering of polymers and nanomaterials for gene therapy
  • Detailed description of in vitro, ex vivo and in vivo gene therapy studies using polymers and nanomaterials

Details

No. of pages:
302
Language:
English
Copyright:
© Woodhead Publishing 2016
Published:
Imprint:
Woodhead Publishing
eBook ISBN:
9780081005217
Hardcover ISBN:
9780081005200

About the Editor

Ravin Narain

Ravin Narain PhD, is Associate Professor in the Department of Chemical and Materials Engineering at the University of Alberta. He has published more than 100 articles in peer-reviewed journals.

Affiliations and Expertise

Associate Professor, Department of Chemical and Materials Engineering, University of Alberta, Edmonton, AB, Canada