Polymeric Micelles for Drug Delivery

Polymeric Micelles for Drug Delivery

1st Edition - August 1, 2022

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  • Editors: Prashant Kesharwani, Khaled Greish
  • Paperback ISBN: 9780323898683

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Description

Polymeric Micelles for Drug Delivery provides a comprehensive overview on the synthesis, characterization and application of polymeric micelles in drug delivery applications. The use of nanomedicines and carriers, such as polymeric micelles, has made it possible to deliver drugs, genes and therapeutic agents to localized disease sites to maximize clinical benefit while limiting unwanted side effects. This book thoroughly reviews the development and application of polymeric micelles for drug delivery, covering various polymer types and the synthesis, characterization and pharmacokinetics of different micelles. Subsequent chapters go on to look at the range of drug delivery applications of polymeric micelles – such as mucosal and transdermal – and the assorted stimuli-responsive micelles available. The book concludes with an important analysis of the environmental and regulatory aspects associated with micelle development and clinical translation.

Key Features

  • Explores how polymeric micelles can be utilized in a range of different drug delivery approaches, from traditional oral delivery to ocular and dermal delivery
  • Describes the various polymer types used in the synthesis and characterization of polymeric micelles
  • Covers recent advances in polymeric micelles, such as drug co-delivery, triblock polymeric micelles, delivery of genetic materials, and more

Readership

Academics and researchers in materials science, engineering and biomedical engineering. Pharmaceutical scientists

Table of Contents

  • Part 1. Synthesis and characterization of polymeric micelles for drug delivery
    1. Polymeric micelles: History, basic concept, recent state-of-art and prospective challenges
    2. Various polymers in the development of polymeric micelles
    3. Solubility enhancement and drug release mechanism by polymeric micelles
    4. Surface-engineering of polymeric micelles for imparting multifunctionality
    5. Biofate and cellular interactions of polymeric micelles
    6. Pharmacokinetics and in-vitro, in-vivo evaluation of polymeric micelles

    Part 2. Application of polymeric micelles in drug delivery
    7. Polymeric micelles for oral drug delivery
    8. Polymeric micelles for ocular drug delivery
    9. Polymeric Micelles in dermal and transdermal drug delivery
    10. Polymeric micelles in mucosal drug delivery
    11. Polymeric micelles for drug delivery in oncology

    Part 3. Stimuli-responsive polymeric micelles for drug delivery
    12. pH- responsive polymeric micelles for drug delivery
    13. Redox-responsive polymeric micelles for drug delivery
    14. Enzyme-responsive polymeric micelles for drug delivery
    15. Light- and temperature- responsive polymeric micelles for drug delivery
    16. Exogenous stimuli-responsive polymeric micelles for drug delivery
    17. Dual-responsive polymeric micelles for drug delivery

    Part 4. Recent advances in polymeric micelles
    18. Polymeric micelles for drug co-delivery
    19. Polymeric micelles for drug delivery of genetic materials
    20. Polymeric micelles with cleavable links for drug delivery
    21. Block copolymer micelles as long-circulating drug vehicles
    22. Triblock polymeric micelles for drug delivery

    Part 5. Environmental and regulatory aspects
    23. Biological toxicity and environmental hazards associated with polymeric micelles
    24. Clinical translation of polymeric micelles into market
    25. Regulatory pathways and federal perspectives on polymeric micelles

Product details

  • No. of pages: 510
  • Language: English
  • Copyright: © Woodhead Publishing 2022
  • Published: August 1, 2022
  • Imprint: Woodhead Publishing
  • Paperback ISBN: 9780323898683

About the Editors

Prashant Kesharwani

Dr. Prashant Kesharwani is Assistant Professor of Pharmaceutics at the School of Pharmaceutical Education and Research, Jamia Hamdard University, New Delhi, India. He has published more than 150 articles in well reputed international journals and edited 10 international books. Dr. Kesharwani has received several awards, including the ‘Ramanujan Fellowship, DST, India-2017’, ‘Excellence Research Award 2014’, ‘Young Innovator Award (Gold medal) 2012’, ‘International Travel Award/Grant from DST (New Delhi) and INSA (CCSTDS, Chennai) 2012’, as well as receiving an ICMR Senior Research Fellowship (PhD) and AICTE Junior Research Fellowship (M. Pharm.). He has presented invited talks and presentations at prestigious conferences, supervised students/junior researchers, and actively participated in outreach and scientific dissemination for the service of the wider community. Dr. Kesharwani’s current research is focused on the development of nano-engineered drug delivery systems for various diseases.

Affiliations and Expertise

Assistant Professor, Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India

Khaled Greish

Dr. Khaled Greish is Professor of Molecular Medicine, and head of the Nano-research unit, at Princes Al-Jawhara Center, Arabian Gulf University, Kingdom of Bahrain. His previous appointments included Senior lecturer of Pharmacology at the University of Otago, New Zealand, and Assistant Professor of Pharmaceutical Chemistry at University of Utah (UT, USA). He has published > 70 peer reviewed papers, and 10 book chapters in the field of targeted anticancer drug delivery. Controlled Release Society (CRS) awarded him the CRS Postdoctoral Achievement Award in 2008 and in 2010; he was elected as member of the CRS College of Fellows. In recognition of his research, University of Otago awarded him “Early Career Awards for Distinction in Research” in 2014. His research focuses on Nanomedicine, tumor vascular biology, and anticancer drug discovery/development.

Affiliations and Expertise

Professor of Molecular Medicine, Princes Al-Jawhara Center, Arabian Gulf University, Kingdom of Bahrain

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