Polymeric Micelles for Drug Delivery
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Polymeric Micelles for Drug Delivery

1st Edition - August 15, 2022

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  • Editors: Prashant Kesharwani, Khaled Greish
  • Paperback ISBN: 9780323898683
  • eBook ISBN: 9780323886291

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Description

Polymeric Micelles for Drug Delivery provides a comprehensive overview on the synthesis, characterization and application of polymeric micelles in drug delivery applications. The use of nanomedicines and carriers, such as polymeric micelles, has made it possible to deliver drugs, genes and therapeutic agents to localized disease sites to maximize clinical benefit while limiting unwanted side effects. This book thoroughly reviews the development and application of polymeric micelles for drug delivery, covering various polymer types and the synthesis, characterization and pharmacokinetics of different micelles. Subsequent chapters go on to look at the range of drug delivery applications of polymeric micelles – such as mucosal and transdermal – and the assorted stimuli-responsive micelles available. The book concludes with an important analysis of the environmental and regulatory aspects associated with micelle development and clinical translation.

Key Features

  • Explores how polymeric micelles can be utilized in a range of different drug delivery approaches, from traditional oral delivery to ocular and dermal delivery
  • Describes the various polymer types used in the synthesis and characterization of polymeric micelles
  • Covers recent advances in polymeric micelles, such as drug co-delivery, triblock polymeric micelles, delivery of genetic materials, and more

Readership

Academics and researchers in materials science, engineering and biomedical engineering. Pharmaceutical scientists

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Dedication
  • List of contributors
  • About the editors
  • Preface
  • Acknowledgments
  • Part A: Synthesis and characterization of polymeric micelles for drug delivery
  • Chapter 1. Polymeric micelles: précis for past, present and future
  • Abstract
  • Conflict of interest
  • 1.1 History and general features
  • 1.2 Structure
  • 1.3 Properties
  • 1.4 Characterization of polymeric micelles
  • 1.5 Conclusions and perspective
  • Acknowledgments
  • References
  • Chapter 2. Various polymers in the development of polymeric micelles
  • Abstract
  • 2.1 Introduction
  • 2.2 The structure of polymeric micelles
  • 2.3 Key features of polymeric micelles
  • 2.4 Various polymers used in polymeric micelles
  • 2.5 Various types of polymeric micelles
  • 2.6 Preparation method of drug-loaded polymeric micelles
  • 2.7 Characterization of polymeric micelles
  • 2.8 Applications of polymeric micelles
  • 2.9 Conclusion and prospects
  • References
  • Further reading
  • Chapter 3. Solubility enhancement and drug release mechanism of polymeric micelles
  • Abstract
  • 3.1 Introduction
  • 3.2 Polymeric micelles as a drug delivery system
  • 3.3 Polymeric micelle applications in treating cancer
  • 3.4 Drug release enhancement by polymeric micelle
  • 3.5 Conclusion and future prospects
  • Disclosures
  • References
  • Chapter 4. Polymeric micellar nanomedicine for enhanced permeability and retention effect–based tumor-targeted delivery
  • Abstract
  • 4.1 Introduction
  • 4.2 Pharmacokinetics and in vitro, in vivo evaluation of polymeric micelles
  • 4.3 The enhanced permeability and retention effect, a novel principle of anticancer drug design
  • 4.4 Challenges and factors in enhanced permeability and retention effect–based drug delivery
  • 4.5 Strategies to improve the therapeutic effect of nanomedicines with regard to the enhanced permeability and retention effect
  • 4.6 Conclusion
  • References
  • Chapter 5. Polymeric micelles for oral drug delivery
  • Abstract
  • 5.1 Motivation of oral delivery
  • 5.2 Anatomy and physiology of the gastrointestinal tract
  • 5.3 Challenges of oral delivery
  • 5.4 Polymeric micelles
  • 5.5 Polymeric micelle applications
  • 5.6 Mucoadhesion as a strategy for oral delivery
  • 5.7 Conclusion
  • References
  • Chapter 6. Polymeric micellar nanocarriers: topical treatment of inflammatory diseases
  • Abstract
  • 6.1 Introduction
  • 6.2 Inflammatory diseases
  • 6.3 Topical drug delivery and its obstacles
  • 6.4 Nanocarrier-based drug delivery
  • 6.5 Polymeric micelles
  • 6.6 Topical polymeric micelles in the treatment of inflammatory diseases
  • 6.7 Future directions and conclusion
  • References
  • Further reading
  • Part B: Application of polymeric micelles in drug delivery
  • Chapter 7. Polymeric micelles in dermal and transdermal drug delivery
  • Abstract
  • 7.1 Introduction
  • 7.2 The essentials of polymeric micelles
  • 7.3 Types of polymeric micelles used in skin drug delivery
  • 7.4 Nanocarrier-facilitated cutaneous drug delivery
  • 7.5 Skin barrier properties in skin disease and disorders
  • 7.6 Polymeric micelle fate after topical application
  • 7.7 Conclusion
  • References
  • Chapter 8. Polymeric micelles as delivery systems for anticancer immunotherapy
  • Abstract
  • 8.1 Introduction
  • 8.2 Polymeric micelles as agents for immunotherapy
  • 8.3 Conclusion and prospects
  • References
  • Chapter 9. Polymeric micelles for drug delivery in oncology with an emphasis on siRNA conveyance
  • Abstract
  • Graphical abstract
  • 9.1 Introduction
  • 9.2 Toward selective release of small interfering RNA to tumors
  • 9.3 Polymeric micelles as small interfering RNA delivery carriers
  • 9.4 Conclusions and perspective
  • Acknowledgments
  • References
  • Chapter 10. Surface engineering of polymeric micelles for imparting multifunctionality
  • Abstract
  • 10.1 Introduction
  • 10.2 Hyaluronic acid–coated or functionalized polymeric micelles
  • 10.3 Folic acid–coated or functionalized polymeric micelles
  • 10.4 Glycyrrhetinic acid– or phenylboronic acid–coated polymeric micelles
  • 10.5 Biotin-coated polymeric micelles
  • 10.6 Antibody-coated polymeric micelles
  • 10.7 Peptide-coated polymeric micelles
  • 10.8 Aptamer-coated polymeric micelles
  • 10.9 Conclusion
  • References
  • Chapter 11. Cellular interaction of polymeric micelles in targeted drug delivery systems: the road from tissue to cell
  • Abstract
  • 11.1 Introduction
  • 11.2 The cell membrane
  • 11.3 Cellular uptake
  • 11.4 Physiochemical characteristics of polymer micelles and internalization into the cell
  • 11.5 Lipid membrane alterations and polymer micelles
  • 11.6 Polymeric micelle targeting of and internalization to cells
  • 11.7 Conclusion
  • References
  • Part C: Stimuli-responsive polymeric micelles for drug delivery
  • Chapter 12. pH-responsive polymeric micelles for drug delivery
  • Abstract
  • 12.1 Introduction
  • 12.2 Polymeric micelles
  • 12.3 pH-responsive polymeric micelles
  • 12.4 Polymeric excipients for pH-responsive micelle preparation
  • 12.5 Conclusion and future direction
  • References
  • Chapter 13. Enzyme-responsive polymeric micelles for drug delivery applications
  • Abstract
  • 13.1 Introduction
  • 13.2 Enzyme-responsive polymeric micelles for drug delivery applications
  • 13.3 Conclusions
  • Acknowledgment
  • References
  • Chapter 14. Light- and temperature-responsive polymeric micelles for drug delivery
  • Abstract
  • 14.1 Introduction
  • 14.2 Polymeric micelles and their types
  • 14.3 Stimuli-responsive micelles
  • 14.4 Conclusions
  • References
  • Chapter 15. Exogenous stimuli–responsive polymeric micelles for drug delivery
  • Abstract
  • 15.1 Introduction
  • 15.2 Various exogenous stimuli
  • 15.3 Exogenous stimuli–responsive polymeric systems
  • 15.4 Conclusion
  • Acknowledgment
  • Conflict of interest
  • References
  • Chapter 16. Dual-responsive polymeric micelles for drug delivery
  • Abstract
  • 16.1 Overview
  • 16.2 Drug delivery systems for dual polymeric micelles
  • 16.3 Polymeric drug delivery systems
  • 16.4 Dual-responsive polymeric micelles for drug delivery
  • 16.5 Conclusion
  • References
  • Part D: Recent advances in polymeric micelles
  • Chapter 17. Polymeric micelles for drug codelivery
  • Abstract
  • 17.1 Introduction
  • 17.2 RNA-mediated codelivery of drugs using polymeric micelles
  • 17.3 Cellular uptake of polymeric micelles for the codelivery of drugs
  • 17.4 Passive and active targeting of polymeric micelles for the codelivery of drugs
  • 17.5 Conclusions and perspectives
  • References
  • Chapter 18. Nose-to-brain delivery
  • Abstract
  • 18.1 Introduction
  • 18.2 Polymeric micelles for nose-to-brain delivery
  • 18.3 Cell-penetrating peptide–modified polymer micelles for nose-to-brain delivery
  • 18.4 Glioma-specific ligand/cell-penetrating peptide–comodified polymer micelles for nose-to-brain delivery
  • 18.5 Conclusions and prospects
  • References
  • Chapter 19. The application of a drug–poly(lactic-co-glycolic acid) hybrid micellar system for drug delivery
  • Abstract
  • 19.1 Introduction
  • 19.2 Preparation of drug–poly(lactic-co-glycolic acid) hybrid
  • 19.3 Small interfering RNA delivery into the tumor cells using small interfering RNA–poly(lactic-co-glycolic acid) hybrid micelles in a murine ovarian cancer model
  • 19.4 Targeting micellar system using small interfering RNA–poly(lactic-co-glycolic acid)/Fab′–poly(lactic-co-glycolic acid) mixed micelles in vitro
  • 19.5 Peptide delivery system using CKR12–poly(lactic-co-glycolic acid) hybrid micelles in four types of cancer cells
  • 19.6 Conclusion
  • Acknowledgments
  • References
  • Chapter 20. Polymeric micelles with cleavable links for drug delivery
  • Abstract
  • 20.1 Introduction
  • 20.2 Conclusion
  • References
  • Chapter 21. Block copolymer micelles as long-circulating drug delivery vehicles
  • Abstract
  • 21.1 Introduction
  • 21.2 Block copolymer micelles for drug delivery
  • 21.3 Strategies to promote micellar stability and circulation time
  • 21.4 Functionalization with targeting ligands
  • 21.5 Stimuli responsiveness
  • 21.6 Conclusion
  • References
  • Chapter 22. Triblock polymeric micelles as an emerging nanocarrier for drug delivery
  • Abstract
  • 22.1 Introduction
  • 22.2 Preparations of various types of triblock polymeric micelles
  • 22.3 Triblock polymeric micelles for oral drug delivery
  • 22.4 Triblock polymeric micelles for ocular drug delivery
  • 22.5 Triblock polymeric micelles for pulmonary drug delivery
  • 22.6 Applications of triblock polymeric micelles for anticancer drug therapy and other disease treatment
  • 22.7 Conclusion and prospects
  • Acknowledgment
  • Disclosures
  • References
  • Part E: Environmental and regulatory aspects
  • Chapter 23. Biological toxicity and environmental hazards associated with polymeric micelles
  • Abstract
  • 23.1 Introduction
  • 23.2 Route of exposure and toxicity
  • 23.3 Mechanisms of nanoparticle toxicity
  • 23.4 Studies of nanoparticle toxicity
  • 23.5 Effects of nanoparticles on plants
  • 23.6 Effects of nanoparticles on terrestrial species
  • 23.7 Effects of nanoparticles on Amphibia (semiaquatic animals)
  • 23.8 Effects of nanoparticles on aquatic animals
  • 23.9 Conclusion
  • References
  • Chapter 24. Clinical translation of polymeric micelles into market
  • Abstract
  • 24.1 Introduction
  • 24.2 Polymeric micelles in sustained-release profiles
  • 24.3 Stimulus-responsive drug release micelles (pH-sensitive polymeric micelles)
  • 24.4 Micelles in photodynamic therapy
  • 24.5 Diagnostic and imaging application of polymeric micelles
  • 24.6 Evolution of polymeric micelles into multifunctional nanocarriers
  • 24.7 Polymeric micelles in mucosal drug delivery
  • 24.8 Clinical application of polymeric micelles for the treatment of cancer
  • 24.9 Polymeric micelles: recent advancements in the delivery of anticancer drugs
  • 24.10 Use of micelles in COVID-19 therapies
  • References
  • Chapter 25. Regulatory pathways and prospects for polymeric micelles
  • Abstract
  • 25.1 Introduction
  • 25.2 The importance of regulation
  • 25.3 Current regulatory pathways
  • 25.4 Nanomedicine regulatory approaches
  • 25.5 Major gaps and challenges in nanomicelle regulation
  • 25.6 Nanomicelles in the pharmaceutical market
  • 25.7 Conclusion and prospects
  • References
  • Index

Product details

  • No. of pages: 714
  • Language: English
  • Copyright: © Woodhead Publishing 2022
  • Published: August 15, 2022
  • Imprint: Woodhead Publishing
  • Paperback ISBN: 9780323898683
  • eBook ISBN: 9780323886291

About the Editors

Prashant Kesharwani

Dr. Prashant Kesharwani is Assistant Professor of Pharmaceutics at the School of Pharmaceutical Education and Research, Jamia Hamdard University, New Delhi, India. He has more than 250 international publications in well reputed journals and 13 international books (Elsevier). He is a recipient of several internationally acclaimed awards viz ‘Ramanujan Fellowship, DST, India-2017’, ‘Excellence Research Award 2014’, ‘Young Innovator Award (Gold medal) 2012’, ‘International Travel Award/Grant from DST (New Delhi) and INSA (CCSTDS, Chennai) 2012’. He has received an ICMR Senior Research Fellowship (PhD) and AICTE Junior Research Fellowship (M. Pharm.). He has presented many invited talks and oral presentations at prestigious scientific peer-conferences, received international acclaims and awards for research contribution, supervised students/junior researchers and actively participated in outreach and scientific dissemination for the service of wider community.

Affiliations and Expertise

Prashant Kesharwani, Assistant Professor, School of Pharmaceutical Education and Research, Jamia Hamdard University, New Delhi, India

Khaled Greish

Dr. Khaled Greish is Professor of Molecular Medicine, and head of the Nano-research unit, at Princes Al-Jawhara Center, Arabian Gulf University, Kingdom of Bahrain. His previous appointments included Senior lecturer of Pharmacology at the University of Otago, New Zealand, and Assistant Professor of Pharmaceutical Chemistry at University of Utah (UT, USA). He has published > 70 peer reviewed papers, and 10 book chapters in the field of targeted anticancer drug delivery. Controlled Release Society (CRS) awarded him the CRS Postdoctoral Achievement Award in 2008 and in 2010; he was elected as member of the CRS College of Fellows. In recognition of his research, University of Otago awarded him “Early Career Awards for Distinction in Research” in 2014. His research focuses on Nanomedicine, tumor vascular biology, and anticancer drug discovery/development.

Affiliations and Expertise

Professor of Molecular Medicine, Princes Al-Jawhara Center, Arabian Gulf University, Kingdom of Bahrain

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