PNH and the GPI-Linked Proteins

1st Edition

Editors: Neal Young Joel Moss
Hardcover ISBN: 9780127729404
eBook ISBN: 9780080492094
Imprint: Academic Press
Published Date: 25th February 2000
Page Count: 279
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Paroxysmal Nocturnal Hemoglobinuria (PNH) has been recognized for over a century. This mysterious disease is now understood at the level of the gene and the protein. The pathophysiology is related to a class of cell surface proteins with distinctive biochemical and physical characteristics. Recently it has been acknowledged that PNH is not rare, and once sensitive assays--based on the chemistry of the proteins--can be applied to many patients. Written by international experts in the field, this book includes a number of distinctive characteristics, such as the clinical features of PNH, the mechanism of hemolysis, the biochemistry of glycosylphosphoinositol anchors, and the chemistry and biophysics of GPI-anchored proteins. This unique and timely volume will have a wide audience, including hematologists and oncologists with a clinical interest in this disease, as well as basic biochemists, immunologists, and cell biologists studying this class of proteins.

Key Features

@introbul:Key Features @bul:* Outlines the chemical features of PNH

  • Explains the mechanism of hemolysis
  • Includes work on the biochemistry of glycophosphoinositol anchors
  • Contains descriptions of the chemistry and biophysics of GPI-anchored proteins


Hematologists, cell biologists, human geneticists.


No. of pages:
© Academic Press 2000
Academic Press
eBook ISBN:
Hardcover ISBN:

About the Editor

Neal Young

Neal S. Young is Chief of the Hematology Branch of the National Heart, Lung, and Blood Institute at the National Institutes of Health, Bethesda, Maryland.

Affiliations and Expertise

National Institutes of Health, Bethesda, Maryland, U.S.A.

Joel Moss

Affiliations and Expertise

National Institutes of Health, Bethesda, MD, U.S.A.