Platelet-Activating Factor Acetylhydrolases (PAF-AH)

Platelet-Activating Factor Acetylhydrolases (PAF-AH)

1st Edition - November 24, 2015

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  • Editors: Fuyuhiko Tamanoi, Diana Stafforini, Keizo Inoue
  • Hardcover ISBN: 9780128039083
  • eBook ISBN: 9780128039465

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Description

This volume of The Enzymes summarizes the most important discoveries associated with a group of enzymes that play an important role in normal biological processes as presented and discussed by leaders authorities in the field.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field of enzymes

Readership

Scientists interested in learning more about recent developments in the field and physicians interested in understanding the mechanistic basis of diseases associated with deregulated PAF-AH functions.

Table of Contents

    • Preface
    • Chapter One: Overview of PAF-Degrading Enzymes
      • Abstract
      • 1 Introduction
      • 2 Intracellular PAF-AH I
      • 3 Intracellular PAF-AH II
      • 4 Plasma PAF-AH
      • 5 Conclusion
    • Chapter Two: Intracellular PAF-Acetylhydrolase Type I
      • Abstract
      • 1 Introduction and History
      • 2 Identification of Intracellular PAF-AH, Isoform Ib
      • 3 Nomenclature of PAF-AH Ib Subunits
      • 4 Structure of PAF-AH Ib
      • 5 Physiological Roles of PAF-AH Ib
      • 6 Remaining Questions and Future Prospects
      • Acknowledgments
    • Chapter Three: Platelet-Activating Factor Acetylhydrolase and Brain Development
      • Abstract
      • 1 Introduction
      • 2 Genetics of Human Lissencephaly and Recognition of the LIS1-Encoded Protein as PAFAH1B1
      • 3 Role of Pafah1b and Platelet-Activating Factor in Brain Development
      • 4 Coordination of Brain Platelet-Activating Factor Acetylhydrolase Signaling and Reelin Signaling in Mouse Brain
      • 5 Roles of “Brain” Platelet-Activating Factor Acetylhydrolase in Testicular Development and Spermatogenesis
      • 6 Conclusions
    • Chapter Four: Intracellular Platelet-Activating Factor Acetylhydrolase, Type II: A Unique Cellular Phospholipase A2 That Hydrolyzes Oxidatively Modified Phospholipids
      • Abstract
      • 1 Introduction
      • 2 Structure of PAF-AH (II)
      • 3 Substrate Specificity of PAF-AH (II)
      • 4 Biological Roles of PAF-AH (II)
      • 5 Regulation of PAF-AH (II)
      • 6 Future Prospects
      • Acknowledgments
    • Chapter Five: Trafficking and Oligomeric Regulation of Platelet-Activating Factor Acetylhydrolase Type II
      • Abstract
      • 1 Introduction
      • 2 Trafficking of PAFAH-II
      • 3 Oligomeric Regulation of PAFAH-II
      • 4 Conclusions and Future Work
      • Acknowledgment
    • Chapter Six: Plasma PAF-AH (PLA2G7): Biochemical Properties, Association with LDLs and HDLs, and Regulation of Expression
      • Abstract
      • 1 Introduction and Perspectives
      • 2 Biochemical Properties of Plasma PAF-AH
      • 3 Association with Lipoproteins
      • 4 Regulation of PAF-AH Expression
      • 5 Conclusions
      • Acknowledgments
    • Chapter Seven: Crystal Structure and Atomic Level Analysis of Plasma PAF-AH
      • Abstract
      • 1 Introduction
      • 2 Plasma PAF-AH Structural Overview
      • 3 Lipoprotein Particle and Membrane Interactions
      • 4 Plasma PAF-AH Ligand Complexes at the Active Site
      • 5 Conclusions
      • Acknowledgments
    • Chapter Eight: Naturally Occurring Missense Mutation in Plasma PAF-AH Among the Japanese Population
      • Abstract
      • 1 Introduction
      • 2 Effect of Plasma PAF-AH Mutation on Enzyme Substrates
      • 3 Mutation in Plasma PAF-AH and Atherosclerosis
      • 4 Mutation in Plasma PAF-AH and Asthma
      • 5 Mutation in Plasma PAF-AH and Other Diseases
      • 6 Conclusion
    • Chapter Nine: Plasma PAFAH/PLA2G7 Genetic Variability, Cardiovascular Disease, and Clinical Trials
      • Abstract
      • 1 PAFAH in Cardiovascular Disease
      • 2 Development of PAFAH-Specific Inhibitor and Preclinical Studies
      • 3 Clinical Trials with PAFAH-Specific Inhibitor Darapladib
      • 4 Genetic Variability of PAFAH/PLA2G7
      • 5 Conclusions
      • Acknowledgments
    • Chapter Ten: Diverse Functions of Plasma PAF-AH in Tumorigenesis
      • Abstract
      • 1 Introduction and Perspectives
      • 2 Biological Consequences of Altered PAF-AH Expression/Function
      • 3 Specific Examples
      • 4 PAFAH Mutations in Cancer
      • 5 PAF-AH as a Cancer Biomarker and Therapeutic Target
      • 6 Conclusions
      • Acknowledgments
    • Author Index

Product details

  • No. of pages: 222
  • Language: English
  • Copyright: © Academic Press 2015
  • Published: November 24, 2015
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128039083
  • eBook ISBN: 9780128039465

About the Serial Volume Editors

Fuyuhiko Tamanoi

Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997.

Affiliations and Expertise

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, USA

Diana Stafforini

Diana Stafforini
Dr. Diana Stafforini works at the Huntsman Cancer Institute at the University of Utah School of Medicine.

Affiliations and Expertise

University of Utah, Salt Lake City, UT, USA

Keizo Inoue

Professor Inoue works at the Teikyo University, School of Pharmacy, Japan.

Affiliations and Expertise

Teikyo University, Itabashi, Japan

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