Chapter headings: 1. Structure of triglyceride-rich lipoproteins: an analysis of core and surface phases (K.W. Miller and D.M. Small). 2. The complete structures of human apolipoprotein B-100 and its messenger RNA (C.-Y. Yang, L. Chan and A.M. Gotto, Jr.). 3. Lipid-protein interactions and lipoprotein reassembly (H.J. Pownall, J.B. Massey, J.T. Sparrow and A.M. Gotto, Jr.). 4. Lipoprotein(a): structure, metabolism and epidemiology (J.D. Morrisett, J.R. Guyton, J.W. Gaubatz and A.M. Gotto, Jr.). 5. The regulation of lipoprotein metabolism (P.J. Nestel). 6. Lipoprotein receptors (S.H. Gianturco and W.A. Bradley). 7. Metabolism of high density lipoproteins (J.R. Patsch and A.M. Gotto, Jr.). 8. Cellular regulation of cholesterol metabolism (C.F. Clarke, P.A. Edwards and A.M. Fogelman). 9. Mechanisms of facilitated lipid transfer mediated by plasma lipid transfer proteins (A. Tall, T. Swenson, C. Hesler and E. Granot). 10. Lecithin cholesterol acyltransferase (A. Jonas). 11. Lipoprotein lipase (A.S. Garfinkel and M.C. Schotz). 12. Lipoprotein genetics and molecular biology (J.L. Breslow).
In this rapidly evolving field of research, an enormous amount of new knowledge of lipoprotein structure, function and metabolism has emerged. The 1985 Nobel Prize-winning pioneering work of Brown and Goldstein on the LDL receptor has had a profound impact on developments in the field. This work is one of the many subjects reviewed in detail in this book.
The volume begins with chapters on structure, then proceeds to analysis of lipid and lipoprotein dynamics, metabolism, function, genetics, and molecular biology. Lipoprotein genetics in molecular biology, the role of lipoprotein receptors, and Lp(a) - a topic underrepresented in volumes on lipoproteins, are another three such topics in an impressive volume.
This work will mainly be of interest to researchers interested in lipid and lipoprotein structure and metabolism, but will also be of great value to clinical medicine and biology in general.
- © Elsevier Science 1987
- 1st January 1987
- Elsevier Science
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