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Plant Cyclotides - 1st Edition - ISBN: 9780128000304, 9780128007976

Plant Cyclotides, Volume 76

1st Edition

Serial Volume Editor: David Craik
eBook ISBN: 9780128007976
Hardcover ISBN: 9780128000304
Imprint: Academic Press
Published Date: 24th November 2015
Page Count: 370
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Table of Contents

  • Contributors
  • Preface
  • Chapter One. Overview on the Discovery and Applications of Cyclotides
    • 1. Introduction
  • Chapter Two. Cyclotides in the Violaceae
    • 1. The Discovery of Cyclotides in Violaceae
    • 2. Unlocking the Cyclotide Library
    • 3. The Violaceae
    • 4. Violaceae—The Pharmacopoeia
    • 5. Growing Needs and Sources of Cyclotides
    • 6. Completing the Circle
  • Chapter Three. Cyclotides in the Rubiaceae
    • 1. Introduction
    • 2. Discovery of Cyclotides
    • 3. Distribution of Cyclotides in Rubiaceae
    • 4. Evolution of Cyclotides
    • 5. Bioactivities of Rubiaceae Cyclotides
    • 6. Conclusion and Outlook
  • Chapter Four. Cyclotides from Chinese Plants
    • 1. Introduction
    • 2. Chemical Detection Method for Cyclotides
    • 3. Distribution and Chemotaxonomy of Cyclotides in Chinese Plants
    • 4. Extraction, Isolation and Structural Elucidation of Cyclotides in Chinese Plants
    • 5. Biological Activity of Cyclotides in Chinese Plants
  • Chapter Five. Primary Structural Analysis of Cyclotides
    • 1. Cyclotide Discovery—Untangling the Cystine Knot
    • 2. Tools for Peptide Sequence Assignment
    • 3. Mass Spectrometry
    • 4. Application of Mass Spectrometry to Cyclotide Sequencing
    • 5. Challenges and Complexities
    • 6. Future Prospects
    • 7. Concluding Remarks
  • Chapter Six. Structural Studies of Cyclotides
    • 1. The Cyclic Cystine Knot
    • 2. Structural Features of Cyclotides
    • 3. Importance of the Cyclic Backbone
    • 4. Dynamics of Cyclotide Structures
    • 5. Self-Association of Cyclotides
    • 6. Membrane Interactions of Cyclotides
    • 7. Grafting of Non-native Sequences
    • 8. Conclusions
  • Chapter Seven. Natural Functions and Structure–Activity Relationships of Cyclotides
    • 1. Introduction
    • 2. Pesticidal Activities of Cyclotides
    • 3. Pharmaceutical Activities of Cyclotides
    • 4. Cytotoxic Activities of Cyclotides
    • 5. Structure–Activity Relationships
    • 6. Concluding Remarks
  • Chapter Eight. Biosynthesis of Cyclotides
    • 1. Introduction
    • 2. Cyclotides are Gene Products
    • 3. The Cyclotide Processing Pathway
    • 4. Sequence Requirements for Cyclization
    • 5. Circularization of Cyclotides is Mediated by a Vacuolar Processing Enzyme (VPE)
    • 6. Vacuolar Processing Enzymes (VPEs)
    • 7. Circularization of Other Backbone Cyclized Peptides
    • 8. Conclusion
  • Chapter Nine. Chemical and Biological Production of Cyclotides
    • 1. Introduction
    • 2. Chemical Synthesis of Cyclotides
    • 3. Biological Synthesis of Cyclotides
    • 4. Summary and Concluding Remarks
  • Chapter Ten. Cyclotides in a Biotechnological Context: Opportunities and Challenges
    • 1. Cyclotides in a Biotechnological Context
    • 2. Cyclotide Production Systems
    • 3. Market Analysis of Cyclotides in Plant Biotechnology
    • 4. Future Prospects for Cyclotides and Plant Biotechnology
  • Subject Index
  • Author Index


Advances in Botanical Research publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences. Currently in its 76th volume, the series features several reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology and ecology.

Key Features

  • Publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences
  • Contains commentary by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology, and ecology
  • This volume features reviews of the fast moving field of plant cyclotides


Postgraduates and researchers in plant sciences, including botany, plant biochemistry, plant physiology, plant pathology, virology, entomology, and molecular biology


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© Academic Press 2015
24th November 2015
Academic Press
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About the Serial Volume Editor

David Craik

David Craik

David Craik is a professor at the Institute for Molecular Bioscience, The University of Queensland. He obtained his PhD in organic chemistry from La Trobe University in Melbourne, Australia (1981) and undertook postdoctoral studies at Florida State and Syracuse Universities before taking up a lectureship at the Victorian College of Pharmacy in 1983. He was appointed Professor of Medicinal Chemistry and head of School in 1988. He moved to University of Queensland in 1995 to set up a new biomolecular NMR laboratory. His research has a particular focus on structural studies of disulfide-rich proteins, and on the discovery and applications of circular proteins and novel protein topologies. He has trained more than 60 PhD students and is the author of 540 scientific publications.

Affiliations and Expertise

The University of Queensland, QLD, Australia