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Chapter One. The frizzled/stan Pathway and Planar Cell Polarity in the Drosophila Wing
1 Introduction to Drosophila Planar Cell Polarity
2 The Cellular Basis for PCP
3 PCP Genes
4 What is the Basis for the Asymmetric Localization of fz/stan Pathway Proteins?
5 Directional Cell Nonautonomy
6 Downstream Effectors
Note added in Proof
Chapter Two. Asymmetric Protein Localization in Planar Cell Polarity
2 Revisiting the Three-Tiered Hierarchy of PCP
3 Asymmetric Protein Localization: A Hallmark of PCP
4 The Ways and Means to Planar Polarize a Cell: Mechanisms of Achieving Asymmetry
Chapter Three. Control of Cell Polarity and Asymmetric Division in C. elegans
1 Cortical Asymmetry of Wnt Signaling Components
2 Connecting Cell Cortex to Nuclei
3 Asymmetric Regulation of Transcription in Nuclei
4 Spindle Orientation and MTOC Positioning
5 Wnts Instructively Orient Polarity of the EMS and T Cells
6 Coordination of Spindle Orientation by MOM-2/Wnt
7 Coordination of Asymmetric Cell Divisions During Embryogenesis
8 Coordination of Asymmetric Cell Divisions During Postembryonic Development
9 Polarity Reversal in Normal Development
10 Functions of PCP Components in C. elegans
11 Summary and Perspective
Chapter Four. Planar Cell Polarity in Coordinated and Directed Movements
2 Coordinated and Directed Movements During Vertebrate Gastrulation
3 Planar Cell Polarity Signaling in Vertebrates
4 PCP Regulating CE and Collective Cell Migration in Other Contexts
5 PCP in Mediating Collectiveness and Polarized Behaviors
6 Concluding Remarks
Chapter Five. Planar Cell Polarity in the Inner Ear
1 Introduction to the Inner Ear
2 Development of the Inner Ear
3 Molecular Mechanism of Planar Cell Polarity
4 Upstream Regulators of PCP
5 Cilia and Their Role in PCP
6 Looking Forward: PCP Signaling in the Inner Ear, Where Do We Go from Here?
Chapter Six. Does Planar Cell Polarity Signaling Steer Growth Cones?
1 Outline of Review
2 PCP Signaling Components Mediate Axon Guidance
3 Can PCP Signaling Be Used in Motile Growth Cones?
4 Is the Growth Cone Polarized?
5 Biochemistry and Cell Biology of PCP Signaling
6 Localization of Vangl2 Puncta on Filopodia Tips Suggests That PCP Signaling May Steer Growth Cones
7 Are There Growth Cone–Growth Cone Interactions During PCP-Mediated Turning?
8 Is This Cell Polarity-Based Signaling System a General Growth Cone Steering Mechanism?
Chapter Seven. Celsr1–3 Cadherins in PCP and Brain Development
1 Celsr1–3 Expression Patterns
2 Celsr1: A Major Player in Vertebrate PCP
3 Celsr2 and 3 in Ciliogenesis
4 Celsr1–3 in Neuronal Migration
5 Celsr2 and Celsr3 in Brain Wiring
Chapter Eight. The Kidney and Planar Cell Polarity
2 Planar Cell Polarity
3 Kidney Development
4 PCP in Kidney Development
5 PCP and Tubular Repair
Chapter Nine. Dishevelled: In Vivo Roles of a Multifunctional Gene Family During Development
1 Canonical Wnt Pathway
2 PCP Pathway, a Noncanonical Wnt Pathway
3 Conserved Mammalian PCP Pathway
4 Dvl Genes: Crossroads of Wnt and PCP Pathways
5 Single Mutants for Dvl Genes in the Mouse: Unique Phenotypes (Fig. 9.1)
6 Dvl1 Null Mice: Social Interaction Defects
7 Dvl2 Mutant Mice: Cardiac, Neurulation, and Skeletal Defects
8 Dvl3 Mutant Mice
9 Dvl Double Mutants: Redundancy Among the Dvl Genes (Fig. 9.1)
10 Dvl1/2 Double Mutants
11 Dvl1/3 Double Mutants
12 Dvl2/3 Double Mutants
13 Dvl1,2,3 Triple Mutants Display Defects in the Posterior Placement of Nodal Cilia (Fig. 9.1)
14 Dvl Conditional Tagged Alleles
15 Dvl Transgenes Demonstrate Functional Redundancy
16 Dvl2 Allelic Series to Distinguish Wnt and PCP Pathway Phenotypes In Vivo
17 Conclusions and Future Studies
Chapter Ten. An Expanding Role of Vangl Proteins in Embryonic Development
1 Vangl Proteins, Neurulation, and Neural Tube Defects
2 Vangl Proteins, Planar Cell Polarity, and Tissue Patterning
3 Role of Vangl2 in Structure and Function of Ciliated Cells
4 Cellular and Molecular Mechanism of Action of Vangl2 in Vertebrates
Chapter Eleven. Wnt Regulation of Planar Cell Polarity (PCP)
2 Wnt and Planar Cell Polarity
3 Missing Link Between Wnt and PCP
Contents of Previous Volumes
This new volume of Current Topics in Developmental Biology covers the area of Planar Cell Polarity with contributions from an international board of authors. The 12 chapters provide a comprehensive set of reviews covering such topics as PCP in Zebra fish, the role of Dishevelled in PCP regulation, and PCP in axon pathfinding.
- Covers the area of planar cell polarity
- International board of authors
- 12 chapters provide a comprehensive set of reviews covering such topics as planar cell polarity in Zebrafish, the role of disheveled in planar cell polarity regulation, and planar cell polarity in axon path finding
Researchers in cell, developmental, and molecular biology; genetics
- No. of pages:
- © Academic Press 2012
- 21st November 2012
- Academic Press
- Hardcover ISBN:
- eBook ISBN:
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