Planar Cell Polarity During Development

Planar Cell Polarity During Development

1st Edition - November 21, 2012

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  • Editor: Yingzi Yang
  • Hardcover ISBN: 9780123945921
  • eBook ISBN: 9780123948007

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This new volume of Current Topics in Developmental Biology covers the area of Planar Cell Polarity with contributions from an international board of authors. The 12 chapters provide a comprehensive set of reviews covering such topics as PCP in Zebra fish, the role of Dishevelled in PCP regulation, and PCP in axon pathfinding.

Key Features

  • Covers the area of planar cell polarity
  • International board of authors
  • 12 chapters provide a comprehensive set of reviews covering such topics as planar cell polarity in Zebrafish, the role of disheveled in planar cell polarity regulation, and planar cell polarity in axon path finding


Researchers in cell, developmental, and molecular biology; genetics

Table of Contents

  • Series Page



    Chapter One. The frizzled/stan Pathway and Planar Cell Polarity in the Drosophila Wing

    1 Introduction to Drosophila Planar Cell Polarity

    2 The Cellular Basis for PCP

    3 PCP Genes

    4 What is the Basis for the Asymmetric Localization of fz/stan Pathway Proteins?

    5 Directional Cell Nonautonomy

    6 Downstream Effectors


    Note added in Proof

    Chapter Two. Asymmetric Protein Localization in Planar Cell Polarity

    1 Introduction

    2 Revisiting the Three-Tiered Hierarchy of PCP

    3 Asymmetric Protein Localization: A Hallmark of PCP

    4 The Ways and Means to Planar Polarize a Cell: Mechanisms of Achieving Asymmetry


    Chapter Three. Control of Cell Polarity and Asymmetric Division in C. elegans

    1 Cortical Asymmetry of Wnt Signaling Components

    2 Connecting Cell Cortex to Nuclei

    3 Asymmetric Regulation of Transcription in Nuclei

    4 Spindle Orientation and MTOC Positioning

    5 Wnts Instructively Orient Polarity of the EMS and T Cells

    6 Coordination of Spindle Orientation by MOM-2/Wnt

    7 Coordination of Asymmetric Cell Divisions During Embryogenesis

    8 Coordination of Asymmetric Cell Divisions During Postembryonic Development

    9 Polarity Reversal in Normal Development

    10 Functions of PCP Components in C. elegans

    11 Summary and Perspective


    Chapter Four. Planar Cell Polarity in Coordinated and Directed Movements

    1 Introduction

    2 Coordinated and Directed Movements During Vertebrate Gastrulation

    3 Planar Cell Polarity Signaling in Vertebrates

    4 PCP Regulating CE and Collective Cell Migration in Other Contexts

    5 PCP in Mediating Collectiveness and Polarized Behaviors

    6 Concluding Remarks


    Chapter Five. Planar Cell Polarity in the Inner Ear

    1 Introduction to the Inner Ear

    2 Development of the Inner Ear

    3 Molecular Mechanism of Planar Cell Polarity

    4 Upstream Regulators of PCP

    5 Cilia and Their Role in PCP

    6 Looking Forward: PCP Signaling in the Inner Ear, Where Do We Go from Here?


    Chapter Six. Does Planar Cell Polarity Signaling Steer Growth Cones?

    1 Outline of Review

    2 PCP Signaling Components Mediate Axon Guidance

    3 Can PCP Signaling Be Used in Motile Growth Cones?

    4 Is the Growth Cone Polarized?

    5 Biochemistry and Cell Biology of PCP Signaling

    6 Localization of Vangl2 Puncta on Filopodia Tips Suggests That PCP Signaling May Steer Growth Cones

    7 Are There Growth Cone–Growth Cone Interactions During PCP-Mediated Turning?

    8 Is This Cell Polarity-Based Signaling System a General Growth Cone Steering Mechanism?

    9 Summary


    Chapter Seven. Celsr1–3 Cadherins in PCP and Brain Development

    1 Celsr1–3 Expression Patterns

    2 Celsr1: A Major Player in Vertebrate PCP

    3 Celsr2 and 3 in Ciliogenesis

    4 Celsr1–3 in Neuronal Migration

    5 Celsr2 and Celsr3 in Brain Wiring


    Chapter Eight. The Kidney and Planar Cell Polarity

    1 Introduction

    2 Planar Cell Polarity

    3 Kidney Development

    4 PCP in Kidney Development

    5 PCP and Tubular Repair

    6 Conclusion


    Chapter Nine. Dishevelled: In Vivo Roles of a Multifunctional Gene Family During Development

    1 Canonical Wnt Pathway

    2 PCP Pathway, a Noncanonical Wnt Pathway

    3 Conserved Mammalian PCP Pathway

    4 Dvl Genes: Crossroads of Wnt and PCP Pathways

    5 Single Mutants for Dvl Genes in the Mouse: Unique Phenotypes (Fig. 9.1)

    6 Dvl1 Null Mice: Social Interaction Defects

    7 Dvl2 Mutant Mice: Cardiac, Neurulation, and Skeletal Defects

    8 Dvl3 Mutant Mice

    9 Dvl Double Mutants: Redundancy Among the Dvl Genes (Fig. 9.1)

    10 Dvl1/2 Double Mutants

    11 Dvl1/3 Double Mutants

    12 Dvl2/3 Double Mutants

    13 Dvl1,2,3 Triple Mutants Display Defects in the Posterior Placement of Nodal Cilia (Fig. 9.1)

    14 Dvl Conditional Tagged Alleles

    15 Dvl Transgenes Demonstrate Functional Redundancy

    16 Dvl2 Allelic Series to Distinguish Wnt and PCP Pathway Phenotypes In Vivo

    17 Conclusions and Future Studies


    Chapter Ten. An Expanding Role of Vangl Proteins in Embryonic Development

    1 Vangl Proteins, Neurulation, and Neural Tube Defects

    2 Vangl Proteins, Planar Cell Polarity, and Tissue Patterning

    3 Role of Vangl2 in Structure and Function of Ciliated Cells

    4 Cellular and Molecular Mechanism of Action of Vangl2 in Vertebrates

    5 Conclusions


    Chapter Eleven. Wnt Regulation of Planar Cell Polarity (PCP)

    1 Introduction

    2 Wnt and Planar Cell Polarity

    3 Missing Link Between Wnt and PCP

    4 Conclusion



    Contents of Previous Volumes

Product details

  • No. of pages: 360
  • Language: English
  • Copyright: © Academic Press 2012
  • Published: November 21, 2012
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123945921
  • eBook ISBN: 9780123948007

About the Serial Volume Editor

Yingzi Yang

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