Description

This new volume of Current Topics in Developmental Biology covers the area of Planar Cell Polarity with contributions from an international board of authors. The 12 chapters provide a comprehensive set of reviews covering such topics as PCP in Zebra fish, the role of Dishevelled in PCP regulation, and PCP in axon pathfinding.

Key Features

  • Covers the area of planar cell polarity
  • International board of authors
  • 12 chapters provide a comprehensive set of reviews covering such topics as planar cell polarity in Zebrafish, the role of disheveled in planar cell polarity regulation, and planar cell polarity in axon path finding

Readership

Researchers in cell, developmental, and molecular biology; genetics

Table of Contents

Series Page

Contributors

Preface

Chapter One. The frizzled/stan Pathway and Planar Cell Polarity in the Drosophila Wing

1 Introduction to Drosophila Planar Cell Polarity

2 The Cellular Basis for PCP

3 PCP Genes

4 What is the Basis for the Asymmetric Localization of fz/stan Pathway Proteins?

5 Directional Cell Nonautonomy

6 Downstream Effectors

References

Note added in Proof

Chapter Two. Asymmetric Protein Localization in Planar Cell Polarity

1 Introduction

2 Revisiting the Three-Tiered Hierarchy of PCP

3 Asymmetric Protein Localization: A Hallmark of PCP

4 The Ways and Means to Planar Polarize a Cell: Mechanisms of Achieving Asymmetry

References

Chapter Three. Control of Cell Polarity and Asymmetric Division in C. elegans

1 Cortical Asymmetry of Wnt Signaling Components

2 Connecting Cell Cortex to Nuclei

3 Asymmetric Regulation of Transcription in Nuclei

4 Spindle Orientation and MTOC Positioning

5 Wnts Instructively Orient Polarity of the EMS and T Cells

6 Coordination of Spindle Orientation by MOM-2/Wnt

7 Coordination of Asymmetric Cell Divisions During Embryogenesis

8 Coordination of Asymmetric Cell Divisions During Postembryonic Development

9 Polarity Reversal in Normal Development

10 Functions of PCP Components in C. elegans

11 Summary and Perspective

References

Chapter Four. Planar Cell Polarity in Coordinated and Directed Movements

1 Introduction

2 Coordinated and Directed Movements During Vertebrate Gastrulation

3 Planar Cell Polarity Signaling in Vertebrates

4 PCP Regulating CE and Collective Cell Migration in Other Contexts

5 PCP in Mediating Collectiveness and Polarized Behaviors

6 Concluding Remarks

References

Chapter Five. Planar Cell Polarity

Details

No. of pages:
360
Language:
English
Copyright:
© 2012
Published:
Imprint:
Academic Press
Electronic ISBN:
9780123948007
Print ISBN:
9780123945921

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