A Neglected Experimental Animal

First published on January 1, 1979

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  • Editors: Peter Beaconsfield, Claude Villee
  • eBook ISBN: 9781483279756

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Placenta: A Neglected Experimental Animal covers the proceedings of the 1978 round table discussion on placenta held at Bedford College, University of London, under the auspices of the Special Commission on Internal Pollution. The placenta's remarkably complete spectrum of cellular and biochemical activity, as well as its hormonal and endocrinological roles and its short life-cycle, adds to its suitability for studying the processes of cell replication, immune mechanisms, graft acceptance and rejection- and aging. This book is organized into four sections encompassing 19 chapters. Section I emphasizes the process of placental metabolism. This section particularly deals with the principles of metabolic regulation; carbohydrate, fat, and protein metabolism; placenta's endocrine functions; and in vitro and in vivo studies of placental metabolism. Section II highlights the placenta's potential to delineate cell replication processes. This section describes the origin and formation of placenta and the mechanism of carcinogenesis. Section III focuses on the relevance of placenta and its potential as a model for studying malignancy, while Section IV examine its potential as a model for organ aging. This book will be of value to cell and developmental biologists, immunologists, and oncologists.

Table of Contents

  • Contributors and Invited Participants

    Foreword Hugo Theorell

    Placental Preview Rebecca Beaconsfield

    Section I. Placental metabolic processes

    A neglected experimental animal

    Chairman's introduction

    Section I. Placental metabolic processes

    The principles of metabolic regulation with special reference to development and aging


    Carbohydrate, fat and protein metabolism in the placenta: A clinician's view


    Nucleic acids and placental development


    Endocrine functions of the placenta


    Prostaglandins in the regulation of placental function


    Techniques for studying placental metabolism and transfer


    Drugs and the placenta — a personal view


    References to Section I

    Section II. Cell replication

    Neoplasia — Growth or Malignancy?

    Control of cell replication - lessons from embryonic and placental development

    Origin and formation of the placenta

    Choriocarcinoma and related growth anomalies

    Characteristics of the malignant cell and the cell cycle in tumors


    References to Section II

    Section III. Immunology

    'Nature's allograft'

    The placenta and the tumor : variations on an immunological enigma

    Immune agents of the facilitation reaction : their possible role in protection of the placental allograft

    Role of the major histocompatibility complex in the immunobiology of trophoblast antigens

    Placental antibody transport and immunological protection - their cellular mechanisms


    References to Section III

    Section IV. Aging

    Maturation or aging?

    Chairman's introduction

    Placenta as a model for organ aging


    Ageing cell and malignancy


    New developments in immunogerontology


    References to Section IV

    Looking ahead


Product details

  • No. of pages: 458
  • Language: English
  • Copyright: © Pergamon 2013
  • Published: January 1, 1979
  • Imprint: Pergamon
  • eBook ISBN: 9781483279756

About the Editors

Peter Beaconsfield

Claude Villee

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