Placenta: A Neglected Experimental Animal covers the proceedings of the 1978 round table discussion on placenta held at Bedford College, University of London, under the auspices of the Special Commission on Internal Pollution. The placenta's remarkably complete spectrum of cellular and biochemical activity, as well as its hormonal and endocrinological roles and its short life-cycle, adds to its suitability for studying the processes of cell replication, immune mechanisms, graft acceptance and rejection- and aging. This book is organized into four sections encompassing 19 chapters. Section I emphasizes the process of placental metabolism. This section particularly deals with the principles of metabolic regulation; carbohydrate, fat, and protein metabolism; placenta's endocrine functions; and in vitro and in vivo studies of placental metabolism. Section II highlights the placenta's potential to delineate cell replication processes. This section describes the origin and formation of placenta and the mechanism of carcinogenesis. Section III focuses on the relevance of placenta and its potential as a model for studying malignancy, while Section IV examine its potential as a model for organ aging. This book will be of value to cell and developmental biologists, immunologists, and oncologists.
Contributors and Invited Participants Foreword Hugo Theorell Placental Preview Rebecca Beaconsfield Section I. Placental metabolic processes A neglected experimental animal Chairman's introduction Section I. Placental metabolic processes The principles of metabolic regulation with special reference to development and aging Discussion Carbohydrate, fat and protein metabolism in the placenta: A clinician's view Discussion Nucleic acids and placental development Discussion Endocrine functions of the placenta Discussion Prostaglandins in the regulation of placental function Discussion Techniques for studying placental metabolism and transfer Discussion Drugs and the placenta — a personal view Discussion References to Section I Section II. Cell replication Neoplasia — Growth or Malignancy? Control of cell replication - lessons from embryonic and placental development Origin and formation of the placenta Choriocarcinoma and related growth anomalies Characteristics of the malignant cell and the cell cycle in tumors Discussion References to Section II Section III. Immunology 'Nature's allograft' The placenta and the tumor : variations on an immunological enigma Immune agents of the facilitation reaction : their possible role in protection of the placental allograft Role of the major histocompatibility complex in the immunobiology of trophoblast antigens Placental antibody transport and immunological protection - their cellular mechanisms Discussion References to Section III Section IV. Aging Maturation or aging? Chairman's introduction Placenta as a model for organ aging Discussion Ageing cell and malignancy Discussion New developments in immunogerontology Discussion R
- No. of pages:
- © Pergamon 1979
- 1st January 1979
- eBook ISBN: