Pigment Cell Growth - 1st Edition - ISBN: 9781483229041, 9781483274430

Pigment Cell Growth

1st Edition

Proceedings of the Third Conference on the Biology of Normal and Atypical Pigment Cell Growth

Editors: Myron Gordon
eBook ISBN: 9781483274430
Imprint: Academic Press
Published Date: 1st January 1953
Page Count: 380
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Pigment Cell Growth covers the proceedings of the Third Conference on the Biology of Normal and Atypical Pigment Cell Growth. The book focuses on the nature of the pigment cell and its contained melanin.
The selection first offers information on the origin of the mammalian pigment cell and its role in the pigmentation of hair and relations between developing melanophores and embryonic tissues in the Mexican axolotl. The book also examines the genetic control of pigmentation in the fowl; relationship of atypical pigment cell growth to gonadal development in hybrid fishes; and estrogen, thyroid hormone, and the differentiation of pigment cells in the brown leghorn. The publication takes a look at dendritic melanoblasts in metastatic squamous cell carcinoma; microscopic analysis of normal melanoblasts, nevus cells, and melanoma cells; and analysis of skin color in living human subjects by spectrophotometric means.
The selection is a dependable source of data for readers interested in pigment cell growth.

Table of Contents

Origin of the Mammalian Pigment Cell and Its Role in the Pigmentation of Hair

I. Introduction

II. Source of Pigment Cells in the Embryo

III. Migration of Precursor Pigment Cells (Melanoblasts) into the Skin

IV. Pigment Cells Essential for Pigmentation of Hair

V. Conclusion


Relations between Developing Melanophores and Embryonic Tissues in the Mexican Axolotl

I. Extrinsic Factors in Melanophore Development

II. Nature of Pigment-Promoting Influence of Epidermis

III. Inhibition of Propigmenc Cell Migration

IV. Pigment Development in Hypophysectomized Animals

V. Role of Pituitary Activity in Melanophore Pattern Development

VI. Conclusions


Genetic Control of Pigmentation in the Fowl

I. Forms of Melanin

II. Melanin in the Skin

III. Melanin in the Plumage


Relationship of Atypical Pigment Cell Growth to Gonadal Development in Hybrid Fishes

I. Introduction

II. Materials and Methods

III. Analysis of Macromelanophore Growth in Platyfish-Swordtail Hybrids of Four Generations

IV. Analysis of the Gonads in the Hybrids of Four Generations

V. Relationship of Gonadal Development to the Sex Chromosomes of the Hybrids

VI. Relationship between Atypical Pigment Cell Growth and Abnormal Gonadal Development in the Hybrids

VII. Discussion

VIII. Conclusions and Summary


Estrogen, Thyroid Hormone, and the Differentiation of Pigment Cells in the Brown Leghorn

I. Introduction

II. Pigmentary Response of Brown Leghorn to Estrogen and Thyroid Hormone

III. Role of the Epidermis

IV. Role of Thyroid Hormone in Melanoblast Response to Estrogen

V. Influence of Sex Genotype on Melanoblast Response to Estrogen

VI. General Summary and Conclusions


Growth and Pathology of Melanotic and Amelanotic Derivatives of the Cloudman Melanoma S91

Dendritic Melanoblasts in Metastatic Squamous Cell Carcinoma

I. Introduction

II. Case Report

III. Pathological Description

IV. Discussion

V. Conclusions


Microscopic Analysis of Normal Melanoblasts, Nevus Cells and Melanoma Cells

I. Normal Cutaneous Melanoblasts

II. Pigmented Nevus

III. Non-Pigmented Nevus

IV. Formation of Nevus

V. Blue Nevus

VI. Melanoma

VII. Summary


Problems Concerning Melanoma in Man

I. Introduction

II. Melanoma in Animals

III. General Features of the Disease in Man

IV. Special Features of the Disease

V. Treatment

VI. End Results of Treatment

VII. Factors for Success in Treatment


The Natural History of Melanoma in Man

Analysis of Skin Color in Living Human Subjects by Spectrophotometric Means

I. Analysis of Skin Color in Normal Human Subjects

II. Application of Spectrophotometry in Certain Endocrine Deficiencies

III. Future Possibilities of the Method


The Two Types of Acanthosis Nigricans

I. Definition of the Two Types

II. Criteria of the Two Types

III. Parallel Features of the Two Types

IV. Pathogenesis of Acanthosis Nigricans

V. Treatment of Acanthosis Nigricans

VI. Pseudo Acanthosis Nigricans


End Results in the Treatment of Malignant Melanoma: A Report of 1190 Cases

I. End Results of Treatment of Melanoma by Five-Year Periods, 1917-1950

II. Incidence of Melanoma According to Location

III. End Results in the Treatment of Melanoma According to Location

IV. End Results in the Treatment of Melanoma in Relation to Sex and Age

V. End Results in the Treatment of Melanoma According to Delay in Definitive Surgery

VI. End Results in the Treatment of Melanoma According to Surgical Procedure

VII. End Results in the Treatment of Melanoma in Relation to Lymphatic Metastases

VIII. Summary


Control of Melanization of S91 Tumors by Selective Transfer, and Biochemical Studies of the Tumors Produced

I. Introduction

II. Methods

1. Establishment of Tumor Lines

2. Biochemical Methods

III. Results

1. Gross Appearance of Tumors

2. Assays of Enzyme Activity

3. Pigment Content of Tumors

4. Characteristics of the Melanized Tumors in the Two Strains of Mice

5. Evaluation of Results

IV. Discussion

V. Summary


Melanin and Tyrosinase Association in Normal and Pathological Skin Pigmentation

Some Factors Involved in Melanin Production in Frog Skin

I. Introduction

II. The Distribution of Melanin

III. The Role of Tyrosine

IV. The Role of Enzymes and Inhibitors

V. Discussion


Oxidizing Enzymes of Mouse Melanomas: Their Influence, Enhancement, and Chromatographic Separation

I. Introduction

II. Materials and Methods

III. Enzyme Substrates: Autoxidation Phenomena of Dopa and PPDA

IV. Melanoma Enzymes: Dopa Oxidase, Succinoxidase, and Cytochrome Oxidase

V. Chromatography of Melanoma Particulates

VI. Summary


Phase Contrast and Electron Micrography of the Cloudman S91 Mouse Melanoma

I. Materials and Methods

II. Results

III. Discussion

IV. Summary


The Structure of Melanins

I. Definition of Melanins

II. Melanin-Forming Enzymes and Substrates

III. Catechol Melanin

IV. 3,4-Dihydroxyphenylalanine Melanin

V. The Structure of Natural Melanins


The in vitro Production of Pigment Granules

I. Introduction

II. Material and Methods

III. Results

V. Discussion

V. Summary


The Control of Melanogenesis in Human Pigment Cells

I. Introduction

II. Biochemical Factors Controlling Melanin Formation

III. Normal Variations in Pigmentation

IV. Inhibition of Melanin Formation

V. Therapeutic Depigmenting Agents

VI. Therapeutic Pigmenting Agents

VII. Melanogenesis in Malignant Melanomas

VIII. Summary


Glycolytic Activities of Slices and Subcellular Fractions of the Cloudman S91 Mouse Melanoma Compared to a Transplantable Hepatoma and Normal Liver

I. Introduction

II. Materials and Methods

III. Experimental Results

IV. Discussion

V. Summary




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© Academic Press 1953
Academic Press
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About the Editor

Myron Gordon

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