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Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the… Read more
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Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases.
Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain.
Researchers working in drug development, phytochemists, plant biochemists, food and medicinal chemists, nutritionists, toxicologists, chemical ecologists, taxonomists, and analytical chemists
Part I: Plants As Natural Sources Of Drugs
1. Plant Secondary Metabolites as Lead Compounds for the Production of Potent Drugs
2. Factors Affecting the Choice for Plant-based Products in Drug Discoveries
3. Advances in Computer-Aided Drug Discovery
4. FDA drug candidacy acceptance criteria and steps: Problems and way forward
Part II: Bio-functional Leads for Drug Development
5. Bioactive lead compounds and molecular targets for the treatment of heart diseases
6. Natural bioactive lead compounds effective against haematological malignancies
7. Adjunct Therapeutic Potential of Phytochemicals Against Cancer
8. Anti-diabetic lead compounds and targets for drug development
9. Anti-obesity functional leads and targets for drug development
10. Phytochemicals as therapeutic interventions in neurodegenerative diseases
11. Organosulfur phytochemicals against metabolic and neurodegenerative diseases: Benefits and risks
12. Lead compounds with the potentials for the treatment of chronic liver diseases
13. Phytocompounds and potential target sites against skin diseases
14. Phytochemicals as emerging therapeutic agents for alopecia treatment
15. Antiviral phytocompounds for drug development: A data mining studies
16. Shikimic acid as intermediary model for the production of drugs effective against influenza virus
17. Antimicrobial Lead Compounds from Marine Plants
18. Antibacterial lead compounds and targets for drug development
19. Awareness and Current Therapeutic Strategies of Malaria
20. Bioactive lead compounds and targets for the development of anti-malarial drugs
21. Bioactive lead compounds and targets for the development of anti-inflammatory drugs
22. Functional lead compounds and targets for the development of drugs for the treatment of male infertility
23. Prenylated flavonoids as a promising drug discovery candidate: A pharmacological update
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Chukwuebuka Egbuna (PhD) is a chartered chemist and academic researcher. He is a member of the Institute of Chartered Chemists of Nigeria (ICCON), the Nigerian Society of Biochemistry and Molecular Biology (NSBMB), and the Royal Society of Chemistry (RSC) (United Kingdom). Dr. Egbuna is the founder and editor of the Elsevier book series on Drug Discovery Update. The series includes books, monographs, and edited collections from all areas of drug discovery including emerging therapeutic claims for the treatment of diseases. He has published research articles in many international journals of repute and is ranked among the top 500 Nigerian scientists in SciVal/SCOPUS. He has edited more than 25 books with Elsevier, Springer, Wiley, and Taylor & Francis. His most recent book is the three volume Coronavirus Drug Discovery, published by Elsevier. Dr. Egbuna is the founder and the publishing director of IPS Intelligentsia Publishing Services.
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