Phytochemicals as Lead Compounds for New Drug Discovery - 1st Edition - ISBN: 9780128178904

Phytochemicals as Lead Compounds for New Drug Discovery

1st Edition

Editors: Chukwuebuka Egbuna Shashank Kumar Shahira Ezzat Jonathan Ifemeje Shahira Ezzat Jonathan Ifemeje Saravanan Kaliyaperumal
Paperback ISBN: 9780128178904
Imprint: Elsevier
Published Date: 6th January 2020
Page Count: 515
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Description

Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases.

Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain.

Key Features

  • Presents fundamental concepts and factors affecting choice for plant-based products
  • Details the FDA drug candidacy acceptance criteria, including bottlenecks and way forward
  • Highlights recent advances in computational-based drug discovery
  • Focuses on the discovery of new drugs and potential druggable targets for the treatment of chronic diseases of world importance

Readership

Researchers working in drug development, phytochemists, plant biochemists, food and medicinal chemists, nutritionists, toxicologists, chemical ecologists, taxonomists, analytical chemists

Table of Contents

Part I: Plants As Natural Sources Of Drugs
1. Plant Secondary Metabolites as Lead Compounds for the Production of Potent Drugs
2. Factors Affecting the Choice for Plant-based Products in Drug Discoveries
3. Advances in Computer-Aided Drug Discovery
4. FDA drug candidacy acceptance criteria and steps: Problems and way forward

Part II: Bio-functional Leads for Drug Development
5. Bioactive lead compounds and molecular targets for the treatment of heart diseases
6. Natural bioactive lead compounds effective against haematological malignancies
7. Adjunct Therapeutic Potential of Phytochemicals Against Cancer
8. Anti-diabetic lead compounds and targets for drug development
9. Anti-obesity functional leads and targets for drug development
10. Phytochemicals as therapeutic interventions in neurodegenerative diseases
11. Organosulfur phytochemicals against metabolic and neurodegenerative diseases: Benefits and risks
12. Lead compounds with the potentials for the treatment of chronic liver diseases
13. Phytocompounds and potential target sites against skin diseases
14. Phytochemicals as emerging therapeutic agents for alopecia treatment
15. Antiviral phytocompounds for drug development: A data mining studies
16. Shikimic acid as intermediary model for the production of drugs effective against influenza virus
17. Antimicrobial Lead Compounds from Marine Plants
18. Antibacterial lead compounds and targets for drug development
19. Awareness and Current Therapeutic Strategies of Malaria
20. Bioactive lead compounds and targets for the development of anti-malarial drugs
21. Bioactive lead compounds and targets for the development of anti-inflammatory drugs
22. Functional lead compounds and targets for the development of drugs for the treatment of male infertility
23. Prenylated flavonoids as a promising drug discovery candidate: A pharmacological update

Details

No. of pages:
515
Language:
English
Copyright:
© Elsevier 2020
Published:
Imprint:
Elsevier
Paperback ISBN:
9780128178904

About the Editor

Chukwuebuka Egbuna

Chukwuebuka Egbuna is a chartered chemist, a chemical analyst, and an academic researcher. He is a member of the Institute of Chartered Chemists of Nigeria (ICCON), the Nigerian Society of Biochemistry and Molecular Biology (NSBMB), and the Society of Quality Assurance (SQA) (USA). He has been engaged in a number of roles at New Divine Favor Pharmaceutical Industry Limited, Akuzor Nkpor, Anambra State, Nigeria, and Chukwuemeka Odumegwu Ojukwu University (COOU), Nigeria. He has collaboratively worked and published quite a number of research articles in the area of phytochemistry and its applications. He is a reviewer and editorial board member of various journals, with his most recent role as a website administrator for the Tropical Journal of Applied Natural Sciences (TJANS), a journal of the faculty of Natural Sciences, COOU. His primary research interests are in phytochemistry, food and medicinal chemistry, analytical chemistry, and nutrition and toxicology. He obtained his BSc and MSc degrees in biochemistry at Chukwuemeka Odumegwu Ojukwu University. Egbuna has edited a 3-volume set book on phytochemistry to be published by Apple Academic Press/Taylor & Francis with over 100 collaborators. He is also an Associate Editor on another book to be published by Springer Nature.

Affiliations and Expertise

Department of Biochemistry, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University, Nigeria

Shashank Kumar

Shashank Kumar, PhD, obtained his BSc, MSc, and PhD degrees in biochemistry from the University of Allahabad. He has worked as a Postdoctoral Fellow at the Department of Biochemistry in King George’s Medical University. Dr. Kumar has about 60 published scientific papers, reviews, editorial articles, and book chapters in various national and international peer-reviewed journals and has been cited more than 1,200 times. His expertise is in the areas of free radical biology, cancer biology, characterization of plant products, xenobiotic metabolism, and microbiology. He is familiar with many biochemical techniques such as spectrophotometry, ELISA, electrophoresis, PCR, RT-PCR, flow cytometry, TLC, HPLC, LC-MS, cell culture, and microbiological techniques. He has presented his research findings at more than 25 national and international conferences and has attended about 30 workshops at many major universities and medical colleges throughout the India. Dr. Kumar is a life-time member of the Italo-Latin American Society of Ethnomedicine, and the Indian Sciences Congress Association, and a member of the Asian Council of Science Editors in Dubai and Publication Integrity & Ethics in London. He has been awarded junior, senior, and research associate fellowships formulated and funded by various Indian agencies, such as the Indian Council of Medical Research, University Grants Commission, and the Council of Scientific and Industrial Research India. Dr. Kumar’s laboratory has been funded by the University Grant Commission, India, and the Department of Science and Technology, India, for working on the effect of various phytochemicals on cancer cell signaling pathway inhibition.

Affiliations and Expertise

Center for Biochemistry and Microbial Sciences, Central University of Punjab, Bathinda, India

Shahira Ezzat

Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Egypt

Affiliations and Expertise

Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Egypt

Jonathan Ifemeje

Jonathan Chinenye Ifemeje, PhD, is a Senior Lecturer in the Department of Biochemistry, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University, Nigeria. He has to his credits over 40 publications and has served as an external examiner for various institutions. He is the Managing Editor of the Tropical Journal of Applied Natural Sciences and is currently serving as a reviewer and an editorial board member for various journals. He has worked extensively in the area of phytochemistry, nutrition, and toxicology. He is a member of various institutes, including the Institute of Chartered Chemists of Nigeria (ICCON), the Nigerian Society of Biochemistry and Molecular Biology (NSBMB), and Society of Quality Assurance (SQA). He obtained his PhD in applied biochemistry from Nnamdi Azikiwe University, Awka, Nigeria, and his MSc degree in nutrition and toxicology from the University of Port-Harcourt, Nigeria

Affiliations and Expertise

Department of Biochemistry, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University, Nigeria

Shahira Ezzat

Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Egypt

Affiliations and Expertise

Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Egypt

Jonathan Ifemeje

Jonathan Chinenye Ifemeje, PhD, is a Senior Lecturer in the Department of Biochemistry, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University, Nigeria. He has to his credits over 40 publications and has served as an external examiner for various institutions. He is the Managing Editor of the Tropical Journal of Applied Natural Sciences and is currently serving as a reviewer and an editorial board member for various journals. He has worked extensively in the area of phytochemistry, nutrition, and toxicology. He is a member of various institutes, including the Institute of Chartered Chemists of Nigeria (ICCON), the Nigerian Society of Biochemistry and Molecular Biology (NSBMB), and Society of Quality Assurance (SQA). He obtained his PhD in applied biochemistry from Nnamdi Azikiwe University, Awka, Nigeria, and his MSc degree in nutrition and toxicology from the University of Port-Harcourt, Nigeria

Affiliations and Expertise

Department of Biochemistry, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University, Nigeria

Saravanan Kaliyaperumal

Dr. Saravanan Kaliyaperumal has been engaged in teaching and research for 16+ years. He obtained M.Sc Wildlife Biology and Ph.D degrees at A.V.C. College, Mayiladuthurai, and obtained his M.Sc., Bioinformatics degree at Annamalai University, India. He has been awarded Har Gobind Kohorana Best Scientist Award (2016-17). He has published 55 research papers and a book and has contributed chapters to 4 other books. He has completed one major research project and has organized one national and two international conferences, as well as 3 state-level workshops. He has been engaged in a number of academic roles at Nehru Memorial College, including his most recent appoitment as Dean of Academic Affairs. He is a reviewer and editorial board member of various journals. He is a member of Indian Society of Systems for Science and Engineering (ISSE) and OISCA-International in Tokyo, Japan.

Affiliations and Expertise

Department of Zoology, Nehru Memorial College, Tamil Nadu, India

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