Physiology of the Gastrointestinal Tract

FROM THE PREFACE:

The original purpose of the First Edition of Physiology of the Gastrointestinal Tract—to collect in one set of volumes the most current and comprehensive knowledge in our field—was also the driving force for the Fourth Edition. The explosion of information at the cellular level, made possible in part by the continued emergence of powerful molecular and cellular techniques, has resulted in a greater degree of revision than that of any other edition. The first section, now titled "Basic Cell Physiology and Growth of the Gl Tract" contains numerous new chapters on topics such as transcriptional regulation, signaling networks in development, apoptosis, and mechanisms in malignancies. Most of the chapters in this section were edited by Juanita L. Merchant. Section II has been renamed "Neural Gastroenterology and Motility" and has been expanded from seven chapters with rather classic titles to more than twenty chapters encompassing not only the movement of the various parts of the digestive tract but also cell physiology, neural regulation, stress, and the regulation of food intake. Almost all of the chapters were recruited and edited by Jackie D. Wood. The third section is entirely new and contains chapters on "Immunology and Inflammation" which were edited by Kim E. Barrett. The fourth section on the "Physiology of Secretion" consists of chapters with familiar titles, but with completely updated information to reflect the advances in our understanding of the cellular processes involved in secretion. The last section on "Digestion and Absorption" contains new chapters on the intestinal barrier, protein sorting and ion channels along with those focusing on the uptake of specific nutrients. These chapters were recruited and edited by Hamid M. Said and Fayez K. Ghishan.

· Collected in one set - the most current and comprehensive coverage of gastrointestinal physiology · Information presented in a style that is both readable and understandable · Valuable to the specialized researcher, the clinical gastroenterologist, the teacher, and the student · Features an entirely new section on Immunology and Inflammation · Each section edited by the preeminent scientist in the field

Clinical gastroenterologists, Grad-level lecturer, American College of Gastroenterology members, Internists, and Physiologists

Section I: Basic Cell Physiology and Growth of the GI Tract

1. Transcription and Epigenetic Regulation Juanita L. Merchant and Longchuan Bai
2. Translation and Posttranslational Processing of GI Peptides Cheryl E. Gariepy and Chris J. Dickinson
3. Transmembrane Receptors for Endogenous Ligands and Associated Signals Nigel Bunnett
4. Gastrointestinal Hormones: Gastrin, CCK, Somatostatin, Ghrelin Graham J. Dockray
5. Post-Pyloric Gastrointestinal Peptides Ella W. Englander and George H. Greeley
6. GI Peptide Hormones Regulating Energy and Glucose Homeostasis Daniel J. Drucker
7. Growth Factors in the GI Tract John Barnard and Kirk McHugh
8. Developmental Signaling Networks: The Wnt/APC/b-catenin pathway Eric Fearon
9. Hedgehog Signaling in Gastrointestinal Morphogenesis and Morphostasis
   Gijs R. van den Brink, Maikel P. Peppelenbosch, and Drucilla J. Roberts
10. Developmental Signaling Networks: The Notch Pathway Guy R. Sander, Hanna Krysinska, and Barry Powell
11. Physiology of Gastrointestinal Stem Cells Alda Vidrich, Jenny M. Buzan, Sarah A. De La Rue, and Steven M. Cohn
12. Apoptosis in the Gastrointestinal Tract Leonard R. Johnson
13. Molecular Aspects and Regulation of Gastrointestinal Function During Post-Natal Development James F. Collins, Liqun Bai, Hua Xu and Fayez K. Ghishan
14. Effect of Aging on the Gastrointestinal Tract Adhip P.N. Majumdar and Marc D. Basson
15. Regulation of Gastrointestinal Normal Cell Growth
    Mark R. Hellmich and B. Mark Evers
16. Mucosal Repair and Restitution Mark R. Frey and D. Brent Polk
17. Mechanisms of GI Malignancies John P. Lynch and Anil K. Rustgi

Section II: Neural Gastroenterology and Motility

18. Development of Enteric Nervous System Michael Gershon
19. Cellular Physiology of Gastrointestinal Smooth Muscle Gabriel M. Makhlouf and Karnam S. Murthy
20. Organization and Electrophysiology of Interstitial Cells of Cajal and Smooth Muscle Cells in the Gastrointestinal Tract Kenton M. Sanders, Sang Don Koh, and Sean M. Ward
21. Functional Histoanatomy of the Enteric Nervous System
    Simon JH Brookes and Marcello Costa
22. Physiology of Prevertebral Sympathetic Ganglia
    Joseph H. Szurszewski and Steven M. Miller
23. Cellular Neurophysiology of Enteric Neurons Jackie Wood
24. Integrative Functions of the Enteric Nervous System Jackie D. Wood
25. Extrinsic Sensory Afferent Nerves Innervating the Gastrointestinal Tract
    Michael J. Beyak, David C.E. Bulmer, Wen Jiang, Christopher D. Keating, Weifang Rong, and David Grundy
26. Processing of Gastrointestinal Sensory Signals in the Brain Anthony R. Hobson and Qasim Aziz
27. Enteric Neural Regulation of Mucosal Secretion Helen J. Cooke and Fievos L. Christofi
28. Effect of Stress on Intestinal Mucosal Function Johan D. Söderholm and Mary H. Perdue
29. Effect of Stress on Gastrointestinal Motility
    Michèle Gué
30. HPA-Axis In Gastrointestinal Physiology Yvette Taché
31. Neural Regulation of Gastrointestinal Blood Flow Peter Holzer
32. Neural Control of the Gallbladder and Sphincter of Oddi Gary M. Mawe, Gino T.P. Saccone, and Maria J. Pozo
33. Brainstem Control of the Gastric Function
    Richard C. Rodgers, Gerlinda E. Hermann, and R. Alberto Travagli
34. Neural and Hormonal Controls of Food Intake and Satiety Timothy H. Moran
35. Pharyngeal Motor Function
    Reza Shaker
36. Motor Function of the Esophagus Ray E. Clouse and Nicholas E. Diamant
37. Neurophysiological Mechanisms of Gastric Reservoir Function
    Jan Tack
38. Small Intestinal Motility William L. Hasler
39. Large Intestinal Motility Sushil Sarna
40. Neural Control of Pelvic Floor Muscles David B. Vodusek and Paul Enck
41. Pathophysiology Underlying the Irritable Bowel Syndrome Jackie D. Wood

Section III. Gastrointestinal Immunology and Inflammation

42. Innate Immune Responses in the GI Tract: Sensors and Effectors Lars Eckmann
43. Biology of Gut Immunoglobulins Finn-Eirik Johansen, Elizabeth Yen, Bonny Dickinson, Massaru Yoshida, Steve Claypool, Richard S. Blumberg, and Wayne I. Lencer
44. Mechanisms of Helicobacter pylori-induced Gastric Inflammation
    Dawn A. Israel and Richard M. Peek Jr.
45. Mechanisms and Consequences of Intestinal Inflammation in the Gut Wallace MacNaughton
46. Recruitment of Inflammatory and Immune Cells in the Gut: Physiology and Pathophysiology
    D. Neil Granger, Christopher Kevil, and Matthew B. Grisham
47. Physiology of Host-Pathogen Interactions Kim Hodges, V.K. Viswanathan and Gail Hecht

Section IV. Physiology of Secretion

48. Salivary Secretion David Cook
49. Regulation of Gastric Acid Secretion Arthur Shulkes, Graham S. Baldwin, and Andrew S. Giraud
50. Gastroduodenal Mucosal Defense Marshall H. Montrose, Yasutada Akiba, Koji Takeuchi, and Jonathan D. Kaunitz
51. Genetically Engineered Mouse Models of Gastric Physiology Linda C. Samuelson
52. Structure-Function Relationships in the Pancreatic Acinar Cell
    Fred S. Gorelick and James D. Jamieson
53. Stimulus-Secretion Coupling in Pancreatic Acinar Cells
    John A. Williams and David I. Yule
54. Cell Physiology of Pancreatic Ducts B.E. Argent, M.A. Gray, M.C. Steward, and R.M. Case
55. Regulation of Pancreatic Secretion Rodger A. Liddle
56. Bile Formation and the Enterohepatic Circulation Paul Dawson, Ben Shneider and Alan Hofmann
57. Mechanisms of Hepatocyte Organic Anion Transport Allan W. Wolkoff
58. Mechanisms of Hepatocyte Detoxification
    Karen F. Murray, Donald J. Messner, and Kris V. Kowdley
59. Physiology of Cholangiocytes
    Anatoliy I. Masyuk, Tatyana V. Masyuk, and Nicholas F. LaRusso
60. Gallbladder Function Sum P. Lee and Rahul Kuver

Section V. Digestion and Absorption

61. Tight Junctions and the Intestinal Barrier
    Thomas Y. Ma, and James M. Anderson
62. Protein Sorting in the Exocytic and Endocytic Pathways in Polarized Epithelial Cells Stephen J. Hunt and W. James Nelson
63. Physiology of the Circulation of the Small Intestine Philip T. Nowicki
64. Sugar Absorption Ernest M. Wright, Donald D. F. Loo, Bruce A. Hirayama, and Eric Turk
65. Protein Digestion and Absorption Vadivel Ganapathy, Naren Gupta, and Robert G. Martindale
66. Lipid Digestion and Absorption Judy Storch and Nada Abumurad
67. Genetic Regulation of Intestinal Lipid Transport and Metabolism Zhouji Chen and Nicholas O. Davidson
68. Digestion and Intestinal Absorption of Dietary Carotenoids & Vitamin A
    Alexandrine During and Earl H. Harrison
69. Vitamin D3: Synthesis, Actions, and Mechanisms in the Intestine and Colon J. Wesley Pike, Makoto Watanuki, and Nirupama K. Shevde
70. Vitamin E and Vitamin K Metabolism Ronald J. Sokol, Richard Bruno, and Maret Traber
71. Intestinal Absorption of Water-Soluble Vitamins Hamid M. Said and Bellur Seetharam
72. Water Transport in the Gastrointestinal Tract Jay R. Thiagarajah and Alan S. Verkman
73. Na+/H+ Exchange in Mammalian Digestive Tract
    Pawel R. Kiela and Fayez K. Ghishan
74. Intestinal Anion Absorption Pradeep K. Dudeja and Krishnamurthy Ramaswamy
75. Ion Channels of the Epithelia of the Gastrointestinal Tract John Cuppoletti and Danuta H. Malinowska
76. Integrated Physiology of Intestinal Electrolyte Transport Kim Barrett and Stephen Keely
77. Molecular Mechanisms of Intestinal Transport of Calcium, Phosphate, and Magnesium
    James F. Collins and Fayez K. Ghishan
78. Iron Absorption Nancy C. Andrews
79. Trace Element Absorption and Transport Robert J. Cousins