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Physiology of the Gastrointestinal Tract - 4th Edition - ISBN: 9780120883943, 9780080456157

Physiology of the Gastrointestinal Tract

4th Edition

Editor in Chief: Leonard Johnson
Editors: Kim Barrett Fayez Ghishan Juanita Merchant Hamid Said Jackie Wood
eBook ISBN: 9780080456157
Imprint: Academic Press
Published Date: 30th March 2006
Page Count: 2080
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The original purpose of the First Edition of Physiology of the Gastrointestinal Tract—to collect in one set of volumes the most current and comprehensive knowledge in our field—was also the driving force for the Fourth Edition. The explosion of information at the cellular level, made possible in part by the continued emergence of powerful molecular and cellular techniques, has resulted in a greater degree of revision than that of any other edition. The first section, now titled "Basic Cell Physiology and Growth of the Gl Tract" contains numerous new chapters on topics such as transcriptional regulation, signaling networks in development, apoptosis, and mechanisms in malignancies. Most of the chapters in this section were edited by Juanita L. Merchant. Section II has been renamed "Neural Gastroenterology and Motility" and has been expanded from seven chapters with rather classic titles to more than twenty chapters encompassing not only the movement of the various parts of the digestive tract but also cell physiology, neural regulation, stress, and the regulation of food intake. Almost all of the chapters were recruited and edited by Jackie D. Wood. The third section is entirely new and contains chapters on "Immunology and Inflammation" which were edited by Kim E. Barrett. The fourth section on the "Physiology of Secretion" consists of chapters with familiar titles, but with completely updated information to reflect the advances in our understanding of the cellular processes involved in secretion. The last section on "Digestion and Absorption" contains new chapters on the intestinal barrier, protein sorting and ion channels along with those focusing on the uptake of specific nutrients. These chapters were recruited and edited by Hamid M. Said and Fayez K. Ghishan.

Key Features

· Collected in one set - the most current and comprehensive coverage of gastrointestinal physiology · Information presented in a style that is both readable and understandable · Valuable to the specialized researcher, the clinical gastroenterologist, the teacher, and the student · Features an entirely new section on Immunology and Inflammation · Each section edited by the preeminent scientist in the field


Clinical gastroenterologists, Grad-level lecturer, American College of Gastroenterology members, Internists, and Physiologists

Table of Contents

Section I: Basic Cell Physiology and Growth of the GI Tract

  1. Transcription and Epigenetic Regulation Juanita L. Merchant and Longchuan Bai
  2. Translation and Posttranslational Processing of GI Peptides Cheryl E. Gariepy and Chris J. Dickinson
  3. Transmembrane Receptors for Endogenous Ligands and Associated Signals Nigel Bunnett
  4. Gastrointestinal Hormones: Gastrin, CCK, Somatostatin, Ghrelin Graham J. Dockray
  5. Post-Pyloric Gastrointestinal Peptides Ella W. Englander and George H. Greeley
  6. GI Peptide Hormones Regulating Energy and Glucose Homeostasis Daniel J. Drucker
  7. Growth Factors in the GI Tract John Barnard and Kirk McHugh
  8. Developmental Signaling Networks: The Wnt/APC/b-catenin pathway Eric Fearon
  9. Hedgehog Signaling in Gastrointestinal Morphogenesis and Morphostasis
    Gijs R. van den Brink, Maikel P. Peppelenbosch, and Drucilla J. Roberts
  10. Developmental Signaling Networks: The Notch Pathway Guy R. Sander, Hanna Krysinska, and Barry Powell
  11. Physiology of Gastrointestinal Stem Cells Alda Vidrich, Jenny M. Buzan, Sarah A. De La Rue, and Steven M. Cohn
  12. Apoptosis in the Gastrointestinal Tract Leonard R. Johnson
  13. Molecular Aspects and Regulation of Gastrointestinal Function During Post-Natal Development James F. Collins, Liqun Bai, Hua Xu and Fayez K. Ghishan
  14. Effect of Aging on the Gastrointestinal Tract Adhip P.N. Majumdar and Marc D. Basson
  15. Regulation of Gastrointestinal Normal Cell Growth
    Mark R. Hellmich and B. Mark Evers
  16. Mucosal Repair and Restitution Mark R. Frey and D. Brent Polk
  17. Mechanisms of GI Malignancies John P. Lynch and Anil K. Rustgi

Section II: Neural Gastroenterology and Motility

  1. Development of Enteric Nervous System Michael Gershon
  2. Cellular Physiology of Gastrointestinal Smooth Muscle Gabriel M. Makhlouf and Karnam S. Murthy
  3. Organization and Electrophysiology of Interstitial Cells of Cajal and Smooth Muscle Cells in the Gastrointestinal Tract Kenton M. Sanders, Sang Don Koh, and Sean M. Ward
  4. Functional Histoanatomy of the Enteric Nervous System
    Simon JH Brookes and Marcello Costa
  5. Physiology of Prevertebral Sympathetic Ganglia
    Joseph H. Szurszewski and Steven M. Miller
  6. Cellular Neurophysiology of Enteric Neurons Jackie Wood
  7. Integrative Functions of the Enteric Nervous System Jackie D. Wood
  8. Extrinsic Sensory Afferent Nerves Innervating the Gastrointestinal Tract
    Michael J. Beyak, David C.E. Bulmer, Wen Jiang, Christopher D. Keating, Weifang Rong, and David Grundy
  9. Processing of Gastrointestinal Sensory Signals in the Brain Anthony R. Hobson and Qasim Aziz
  10. Enteric Neural Regulation of Mucosal Secretion Helen J. Cooke and Fievos L. Christofi
  11. Effect of Stress on Intestinal Mucosal Function Johan D. Söderholm and Mary H. Perdue
  12. Effect of Stress on Gastrointestinal Motility
    Michèle Gué
  13. HPA-Axis In Gastrointestinal Physiology Yvette Taché
  14. Neural Regulation of Gastrointestinal Blood Flow Peter Holzer
  15. Neural Control of the Gallbladder and Sphincter of Oddi Gary M. Mawe, Gino T.P. Saccone, and Maria J. Pozo
  16. Brainstem Control of the Gastric Function
    Richard C. Rodgers, Gerlinda E. Hermann, and R. Alberto Travagli
  17. Neural and Hormonal Controls of Food Intake and Satiety Timothy H. Moran
  18. Pharyngeal Motor Function
    Reza Shaker
  19. Motor Function of the Esophagus Ray E. Clouse and Nicholas E. Diamant
  20. Neurophysiological Mechanisms of Gastric Reservoir Function
    Jan Tack
  21. Small Intestinal Motility William L. Hasler
  22. Large Intestinal Motility Sushil Sarna
  23. Neural Control of Pelvic Floor Muscles David B. Vodusek and Paul Enck
  24. Pathophysiology Underlying the Irritable Bowel Syndrome Jackie D. Wood

Section III. Gastrointestinal Immunology and Inflammation

  1. Innate Immune Responses in the GI Tract: Sensors and Effectors Lars Eckmann
  2. Biology of Gut Immunoglobulins Finn-Eirik Johansen, Elizabeth Yen, Bonny Dickinson, Massaru Yoshida, Steve Claypool, Richard S. Blumberg, and Wayne I. Lencer
  3. Mechanisms of Helicobacter pylori-induced Gastric Inflammation
    Dawn A. Israel and Richard M. Peek Jr.
  4. Mechanisms and Consequences of Intestinal Inflammation in the Gut Wallace MacNaughton
  5. Recruitment of Inflammatory and Immune Cells in the Gut: Physiology and Pathophysiology
    D. Neil Granger, Christopher Kevil, and Matthew B. Grisham
  6. Physiology of Host-Pathogen Interactions Kim Hodges, V.K. Viswanathan and Gail Hecht

Section IV. Physiology of Secretion

  1. Salivary Secretion David Cook
  2. Regulation of Gastric Acid Secretion Arthur Shulkes, Graham S. Baldwin, and Andrew S. Giraud
  3. Gastroduodenal Mucosal Defense Marshall H. Montrose, Yasutada Akiba, Koji Takeuchi, and Jonathan D. Kaunitz
  4. Genetically Engineered Mouse Models of Gastric Physiology Linda C. Samuelson
  5. Structure-Function Relationships in the Pancreatic Acinar Cell
    Fred S. Gorelick and James D. Jamieson
  6. Stimulus-Secretion Coupling in Pancreatic Acinar Cells
    John A. Williams and David I. Yule
  7. Cell Physiology of Pancreatic Ducts B.E. Argent, M.A. Gray, M.C. Steward, and R.M. Case
  8. Regulation of Pancreatic Secretion Rodger A. Liddle
  9. Bile Formation and the Enterohepatic Circulation Paul Dawson, Ben Shneider and Alan Hofmann
  10. Mechanisms of Hepatocyte Organic Anion Transport Allan W. Wolkoff
  11. Mechanisms of Hepatocyte Detoxification
    Karen F. Murray, Donald J. Messner, and Kris V. Kowdley
  12. Physiology of Cholangiocytes
    Anatoliy I. Masyuk, Tatyana V. Masyuk, and Nicholas F. LaRusso
  13. Gallbladder Function Sum P. Lee and Rahul Kuver

Section V. Digestion and Absorption

  1. Tight Junctions and the Intestinal Barrier
    Thomas Y. Ma, and James M. Anderson
  2. Protein Sorting in the Exocytic and Endocytic Pathways in Polarized Epithelial Cells Stephen J. Hunt and W. James Nelson
  3. Physiology of the Circulation of the Small Intestine Philip T. Nowicki
  4. Sugar Absorption Ernest M. Wright, Donald D. F. Loo, Bruce A. Hirayama, and Eric Turk
  5. Protein Digestion and Absorption Vadivel Ganapathy, Naren Gupta, and Robert G. Martindale
  6. Lipid Digestion and Absorption Judy Storch and Nada Abumurad
  7. Genetic Regulation of Intestinal Lipid Transport and Metabolism Zhouji Chen and Nicholas O. Davidson
  8. Digestion and Intestinal Absorption of Dietary Carotenoids & Vitamin A
    Alexandrine During and Earl H. Harrison
  9. Vitamin D3: Synthesis, Actions, and Mechanisms in the Intestine and Colon J. Wesley Pike, Makoto Watanuki, and Nirupama K. Shevde
  10. Vitamin E and Vitamin K Metabolism Ronald J. Sokol, Richard Bruno, and Maret Traber
  11. Intestinal Absorption of Water-Soluble Vitamins Hamid M. Said and Bellur Seetharam
  12. Water Transport in the Gastrointestinal Tract Jay R. Thiagarajah and Alan S. Verkman
  13. Na+/H+ Exchange in Mammalian Digestive Tract
    Pawel R. Kiela and Fayez K. Ghishan
  14. Intestinal Anion Absorption Pradeep K. Dudeja and Krishnamurthy Ramaswamy
  15. Ion Channels of the Epithelia of the Gastrointestinal Tract John Cuppoletti and Danuta H. Malinowska
  16. Integrated Physiology of Intestinal Electrolyte Transport Kim Barrett and Stephen Keely
  17. Molecular Mechanisms of Intestinal Transport of Calcium, Phosphate, and Magnesium
    James F. Collins and Fayez K. Ghishan
  18. Iron Absorption Nancy C. Andrews
  19. Trace Element Absorption and Transport Robert J. Cousins


No. of pages:
© Academic Press 2006
30th March 2006
Academic Press
eBook ISBN:

About the Editor in Chief

Leonard Johnson

Leonard R. Johnson received a Ph.D. in physiology from the University of Michigan and then trained with Dr. Morton I. Grossman at UCLA. He spent 17 years as a Professor of Physiology at the University of Texas Medical School in Houston before moving to the University of Tennessee Health Science Center as the Thomas A. Gerwin Professor and Chairman of the Department of Physiology. He is the author or coauthor of over 250 papers on gastrointestinal physiology and holds an NIH MERIT Award. Currently he is the Vice Chancellor for Research at Tennessee.

Affiliations and Expertise

Thomas A. Gerwin Professor and Chairman, Department of Physiology, The University of Tennessee Health Sciences Center, Memphis, TN; Vice Chancellor for Research and Thomas A. Gerwin Professor of Physiology, University of Tennessee, Memphis, TN, USA

About the Editors

Kim Barrett

Affiliations and Expertise

Professor of Medicine and Vice-Chair for Research, Department of Medicine, University of California, San Diego, San Diego, California, U.S.A.

Fayez Ghishan

Affiliations and Expertise

Horace W. Steele Endowed Chair in Pediatric Research Head, Department of Pediatrics and Director, Steele Children's Research Center, Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, Arizona, U.S.A.

Juanita Merchant

Affiliations and Expertise

Professor of Internal Medicine and Integrative and Molecular Physiology, University of Michigan, Ann Arbor, Michigan, U.S.A.

Hamid Said

Dr. Said is a Professor of Medicine, Physiology and Biophysics at the University of California School of Medicine Irvine, CA. He is also a Senior Research Career Scientist at the VA Medical Center, Long Beach, CA; and Chairman for the Southern California Institute for Research and Education (VALBHS affiliated non-profit).

He serves as a reviewer on a variety of NIH, VA and other national study sections as well as international (European) study sections dealing with medical research in internal medicine and nutrition. He is also a member of Editorial Boards of a number of prestigious medical research journals.

Research in Dr. Said laboratory focuses on understanding cellular and molecular mechanisms involved in the transport of water-soluble vitamins (folate (vit. B), thiamine (vit. B1), riboflavin (vit. B2), pyridoxine (vit. B6), ascorbic acid (vit. C), biotin (vit. H) and niacin (vit. B3)) in the intestine, kidney, liver and pancreas. Dr. Said's laboratory has published over 160 original research papers in the gastrointestinal and nutrition fields. He has authored many chapters in scientific textbooks as well as a book in these areas. His laboratory has contributed many original discoveries to the field over the years. His research activities are funded by the VA and National Institutes of Health over the past twenty four years.

Affiliations and Expertise

Professor of Medicine, Physiology and Biophysics, Departments of Medicine and Physiology/Biophysics, University of California School of Medicine, Irvine, CA, USA

Jackie Wood

Affiliations and Expertise

Professor of Physiology and Cell Biology and Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio, U.S.A.


PRAISE FOR THE THIRD EDITION: “The encyclopedic nature of the book continues to make this an invaluable asset to anyone interested in gastrointestinal physiology and related fields. The extensive expansion of the section on regulation and the overall diversity of chapters from those on signal transduction to those on intestinal adaptation is very useful. … Rating: 4 Stars!” —Doody Review Service PRAISE FOR THE FOURTH EDITION: "The writing is clear and the illustrations informative. Each chapter covers a subject in a thorough manner and there are extensive reference lists to document the points made in the text...The text is very detailed enabling readers to feel that they are current with the field after finishing a chapter." - Charles M. Mansbach, II, M.D., Professor of Medicine and Physiology, University of Tennessee, Memphis "Physiology of the Gastrointestinal Tract has been the benchmark text related to this specific topic for years, yet the last (third) edition was published more than a decade ago. During this period there have been many discoveries in GI pathobiology and, simultaneously, a recognition that this organ system is an elegant one for basic molecular discovery. That a relatively recent issue of Science was completely devoted to alimentary tract biology, speaks to this previous point. Thus the newly minted fourth edition of this work comes at an auspicious time. It does not disappoint. Basic chapters on physiology and growth are outstanding; examples being new contributions focused on the Wnt/Catenin and Notch pathways. Chapters are authored by leaders in the subfields, are clearly written, scientifically rigorous, and tend toward the comprehensive. This work imparts the flavor of organ function but does so by building up basic understanding such that it culminates in a more holistic picture; doing so based on science, not simply phenomena. This new edition is a delight and represents a critical resource for all serious students of the alimentary tract." —James L. Madara, M.D., Dean, Division of Biological Sciences and the Pritzker School of Medicine University; Vice-President for Medical Affairs, The University of Chicago “The table of contents of the fourth edition of the Physiology of the Gastrointestinal Tract is impressive, and brings together a wide range of true experts in their fields. The chapters are authoritative and up to date. There has been a real attempt to cover the entire field of GI Physiology. There is no other text that currently offers this degree of depth of coverage with monographs by leaders in their fields. This will be a wonderful resource for investigators in GI Physiology and for those educators who teach that subject." -David H. Alpers, MD, William B. Kountz Professor of Medicine, Washington University School of Medicine, St. Louis, Missouri

Ratings and Reviews