Physiology of the Gastrointestinal Tract

Physiology of the Gastrointestinal Tract

4th Edition - March 30, 2006

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  • Editors: Kim Barrett, Fayez Ghishan, Juanita Merchant, Hamid Said, Jackie Wood
  • eBook ISBN: 9780080456157

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FROM THE PREFACE:The original purpose of the First Edition of Physiology of the Gastrointestinal Tract—to collect in one set of volumes the most current and comprehensive knowledge in our field—was also the driving force for the Fourth Edition. The explosion of information at the cellular level, made possible in part by the continued emergence of powerful molecular and cellular techniques, has resulted in a greater degree of revision than that of any other edition. The first section, now titled "Basic Cell Physiology and Growth of the Gl Tract" contains numerous new chapters on topics such as transcriptional regulation, signaling networks in development, apoptosis, and mechanisms in malignancies. Most of the chapters in this section were edited by Juanita L. Merchant. Section II has been renamed "Neural Gastroenterology and Motility" and has been expanded from seven chapters with rather classic titles to more than twenty chapters encompassing not only the movement of the various parts of the digestive tract but also cell physiology, neural regulation, stress, and the regulation of food intake. Almost all of the chapters were recruited and edited by Jackie D. Wood. The third section is entirely new and contains chapters on "Immunology and Inflammation" which were edited by Kim E. Barrett. The fourth section on the "Physiology of Secretion" consists of chapters with familiar titles, but with completely updated information to reflect the advances in our understanding of the cellular processes involved in secretion. The last section on "Digestion and Absorption" contains new chapters on the intestinal barrier, protein sorting and ion channels along with those focusing on the uptake of specific nutrients. These chapters were recruited and edited by Hamid M. Said and Fayez K. Ghishan.

Key Features

· Collected in one set - the most current and comprehensive coverage of gastrointestinal physiology
· Information presented in a style that is both readable and understandable
· Valuable to the specialized researcher, the clinical gastroenterologist, the teacher, and the student
· Features an entirely new section on Immunology and Inflammation
· Each section edited by the preeminent scientist in the field


Clinical gastroenterologists, Grad-level lecturer, American College of Gastroenterology members, Internists, and Physiologists

Table of Contents

  • Section I: Basic Cell Physiology and Growth of the GI Tract

    1. Transcription and Epigenetic Regulation
    Juanita L. Merchant and Longchuan Bai
    2. Translation and Posttranslational Processing of GI Peptides
    Cheryl E. Gariepy and Chris J. Dickinson
    3. Transmembrane Receptors for Endogenous Ligands and Associated Signals
    Nigel Bunnett
    4. Gastrointestinal Hormones: Gastrin, CCK, Somatostatin, Ghrelin
    Graham J. Dockray
    5. Post-Pyloric Gastrointestinal Peptides
    Ella W. Englander and George H. Greeley
    6. GI Peptide Hormones Regulating Energy and Glucose Homeostasis
    Daniel J. Drucker
    7. Growth Factors in the GI Tract
    John Barnard and Kirk McHugh
    8. Developmental Signaling Networks: The Wnt/APC/b-catenin pathway
    Eric Fearon
    9. Hedgehog Signaling in Gastrointestinal Morphogenesis and Morphostasis
    Gijs R. van den Brink, Maikel P. Peppelenbosch, and Drucilla J. Roberts
    10. Developmental Signaling Networks: The Notch Pathway
    Guy R. Sander, Hanna Krysinska, and Barry Powell
    11. Physiology of Gastrointestinal Stem Cells
    Alda Vidrich, Jenny M. Buzan, Sarah A. De La Rue, and Steven M. Cohn
    12. Apoptosis in the Gastrointestinal Tract
    Leonard R. Johnson
    13. Molecular Aspects and Regulation of Gastrointestinal Function During Post-Natal Development
    James F. Collins, Liqun Bai, Hua Xu and Fayez K. Ghishan
    14. Effect of Aging on the Gastrointestinal Tract
    Adhip P.N. Majumdar and Marc D. Basson
    15. Regulation of Gastrointestinal Normal Cell Growth
    Mark R. Hellmich and B. Mark Evers
    16. Mucosal Repair and Restitution
    Mark R. Frey and D. Brent Polk
    17. Mechanisms of GI Malignancies
    John P. Lynch and Anil K. Rustgi

    Section II: Neural Gastroenterology and Motility

    18. Development of Enteric Nervous System
    Michael Gershon
    19. Cellular Physiology of Gastrointestinal Smooth Muscle
    Gabriel M. Makhlouf and Karnam S. Murthy
    20. Organization and Electrophysiology of Interstitial Cells of Cajal and Smooth Muscle Cells in the Gastrointestinal Tract
    Kenton M. Sanders, Sang Don Koh, and Sean M. Ward
    21. Functional Histoanatomy of the Enteric Nervous System
    Simon JH Brookes and Marcello Costa
    22. Physiology of Prevertebral Sympathetic Ganglia
    Joseph H. Szurszewski and Steven M. Miller
    23. Cellular Neurophysiology of Enteric Neurons
    Jackie Wood
    24. Integrative Functions of the Enteric Nervous System
    Jackie D. Wood
    25. Extrinsic Sensory Afferent Nerves Innervating the Gastrointestinal Tract
    Michael J. Beyak, David C.E. Bulmer, Wen Jiang, Christopher D. Keating, Weifang Rong, and David Grundy
    26. Processing of Gastrointestinal Sensory Signals in the Brain
    Anthony R. Hobson and Qasim Aziz
    27. Enteric Neural Regulation of Mucosal Secretion
    Helen J. Cooke and Fievos L. Christofi
    28. Effect of Stress on Intestinal Mucosal Function
    Johan D. Söderholm and Mary H. Perdue
    29. Effect of Stress on Gastrointestinal Motility
    Michèle Gué
    30. HPA-Axis In Gastrointestinal Physiology
    Yvette Taché
    31. Neural Regulation of Gastrointestinal Blood Flow
    Peter Holzer
    32. Neural Control of the Gallbladder and Sphincter of Oddi
    Gary M. Mawe, Gino T.P. Saccone, and Maria J. Pozo
    33. Brainstem Control of the Gastric Function
    Richard C. Rodgers, Gerlinda E. Hermann, and R. Alberto Travagli
    34. Neural and Hormonal Controls of Food Intake and Satiety
    Timothy H. Moran
    35. Pharyngeal Motor Function
    Reza Shaker
    36. Motor Function of the Esophagus
    Ray E. Clouse and Nicholas E. Diamant
    37. Neurophysiological Mechanisms of Gastric Reservoir Function
    Jan Tack
    38. Small Intestinal Motility
    William L. Hasler
    39. Large Intestinal Motility
    Sushil Sarna
    40. Neural Control of Pelvic Floor Muscles
    David B. Vodusek and Paul Enck
    41. Pathophysiology Underlying the Irritable Bowel Syndrome
    Jackie D. Wood

    Section III. Gastrointestinal Immunology and Inflammation

    42. Innate Immune Responses in the GI Tract: Sensors and Effectors
    Lars Eckmann
    43. Biology of Gut Immunoglobulins
    Finn-Eirik Johansen, Elizabeth Yen, Bonny Dickinson, Massaru Yoshida, Steve Claypool, Richard S. Blumberg, and Wayne I. Lencer
    44. Mechanisms of Helicobacter pylori-induced Gastric Inflammation
    Dawn A. Israel and Richard M. Peek Jr.
    45. Mechanisms and Consequences of Intestinal Inflammation in the Gut
    Wallace MacNaughton
    46. Recruitment of Inflammatory and Immune Cells in the Gut: Physiology and Pathophysiology
    D. Neil Granger, Christopher Kevil, and Matthew B. Grisham
    47. Physiology of Host-Pathogen Interactions
    Kim Hodges, V.K. Viswanathan and Gail Hecht

    Section IV. Physiology of Secretion

    48. Salivary Secretion
    David Cook
    49. Regulation of Gastric Acid Secretion
    Arthur Shulkes, Graham S. Baldwin, and Andrew S. Giraud
    50. Gastroduodenal Mucosal Defense
    Marshall H. Montrose, Yasutada Akiba, Koji Takeuchi, and Jonathan D. Kaunitz
    51. Genetically Engineered Mouse Models of Gastric Physiology
    Linda C. Samuelson
    52. Structure-Function Relationships in the Pancreatic Acinar Cell
    Fred S. Gorelick and James D. Jamieson
    53. Stimulus-Secretion Coupling in Pancreatic Acinar Cells
    John A. Williams and David I. Yule
    54. Cell Physiology of Pancreatic Ducts
    B.E. Argent, M.A. Gray, M.C. Steward, and R.M. Case
    55. Regulation of Pancreatic Secretion
    Rodger A. Liddle
    56. Bile Formation and the Enterohepatic Circulation
    Paul Dawson, Ben Shneider and Alan Hofmann
    57. Mechanisms of Hepatocyte Organic Anion Transport
    Allan W. Wolkoff
    58. Mechanisms of Hepatocyte Detoxification
    Karen F. Murray, Donald J. Messner, and Kris V. Kowdley
    59. Physiology of Cholangiocytes
    Anatoliy I. Masyuk, Tatyana V. Masyuk, and Nicholas F. LaRusso
    60. Gallbladder Function
    Sum P. Lee and Rahul Kuver

    Section V. Digestion and Absorption

    61. Tight Junctions and the Intestinal Barrier
    Thomas Y. Ma, and James M. Anderson
    62. Protein Sorting in the Exocytic and Endocytic Pathways in Polarized Epithelial Cells
    Stephen J. Hunt and W. James Nelson
    63. Physiology of the Circulation of the Small Intestine
    Philip T. Nowicki
    64. Sugar Absorption
    Ernest M. Wright, Donald D. F. Loo, Bruce A. Hirayama, and Eric Turk
    65. Protein Digestion and Absorption
    Vadivel Ganapathy, Naren Gupta, and Robert G. Martindale
    66. Lipid Digestion and Absorption
    Judy Storch and Nada Abumurad
    67. Genetic Regulation of Intestinal Lipid Transport and Metabolism
    Zhouji Chen and Nicholas O. Davidson
    68. Digestion and Intestinal Absorption of Dietary Carotenoids & Vitamin A
    Alexandrine During and Earl H. Harrison
    69. Vitamin D3: Synthesis, Actions, and Mechanisms in the Intestine and Colon
    J. Wesley Pike, Makoto Watanuki, and Nirupama K. Shevde
    70. Vitamin E and Vitamin K Metabolism
    Ronald J. Sokol, Richard Bruno, and Maret Traber
    71. Intestinal Absorption of Water-Soluble Vitamins
    Hamid M. Said and Bellur Seetharam
    72. Water Transport in the Gastrointestinal Tract
    Jay R. Thiagarajah and Alan S. Verkman
    73. Na+/H+ Exchange in Mammalian Digestive Tract
    Pawel R. Kiela and Fayez K. Ghishan
    74. Intestinal Anion Absorption
    Pradeep K. Dudeja and Krishnamurthy Ramaswamy
    75. Ion Channels of the Epithelia of the Gastrointestinal Tract
    John Cuppoletti and Danuta H. Malinowska
    76. Integrated Physiology of Intestinal Electrolyte Transport
    Kim Barrett and Stephen Keely
    77. Molecular Mechanisms of Intestinal Transport of Calcium, Phosphate, and Magnesium
    James F. Collins and Fayez K. Ghishan
    78. Iron Absorption
    Nancy C. Andrews
    79. Trace Element Absorption and Transport
    Robert J. Cousins

Product details

  • No. of pages: 2080
  • Language: English
  • Copyright: © Academic Press 2006
  • Published: March 30, 2006
  • Imprint: Academic Press
  • eBook ISBN: 9780080456157

About the Editors

Kim Barrett

Affiliations and Expertise

Professor of Medicine and Vice-Chair for Research, Department of Medicine, University of California, San Diego, San Diego, California, USA

Fayez Ghishan

Affiliations and Expertise

Horace W. Steele Endowed Chair in Pediatric Research Head, Department of Pediatrics and Director, Steele Children's Research Center, Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, Arizona, USA

Juanita Merchant

Affiliations and Expertise

Professor of Internal Medicine and Integrative and Molecular Physiology, University of Michigan, Ann Arbor, Michigan, USA

Hamid Said

Dr. Said is a Professor of Medicine, Physiology and Biophysics at the University of California School of Medicine Irvine, CA. He is also a Senior Research Career Scientist at the VA Medical Center, Long Beach, CA; and Chairman for the Southern California Institute for Research and Education (VALBHS affiliated non-profit).

He serves as a reviewer on a variety of NIH, VA and other national study sections as well as international (European) study sections dealing with medical research in internal medicine and nutrition. He is also a member of Editorial Boards of a number of prestigious medical research journals.

Research in Dr. Said laboratory focuses on understanding cellular and molecular mechanisms involved in the transport of water-soluble vitamins (folate (vit. B), thiamine (vit. B1), riboflavin (vit. B2), pyridoxine (vit. B6), ascorbic acid (vit. C), biotin (vit. H) and niacin (vit. B3)) in the intestine, kidney, liver and pancreas. Dr. Said's laboratory has published over 160 original research papers in the gastrointestinal and nutrition fields. He has authored many chapters in scientific textbooks as well as a book in these areas. His laboratory has contributed many original discoveries to the field over the years. His research activities are funded by the VA and National Institutes of Health over the past twenty four years.

Affiliations and Expertise

Professor of Medicine, Physiology and Biophysics, Departments of Medicine and Physiology/Biophysics, University of California School of Medicine, Irvine, CA, USA

Jackie Wood

Affiliations and Expertise

Professor of Physiology and Cell Biology and Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio, USA

About the Editor in Chief

Leonard Johnson

Leonard R. Johnson received a Ph.D. in physiology from the University of Michigan and then trained with Dr. Morton I. Grossman at UCLA. He spent 17 years as a Professor of Physiology at the University of Texas Medical School in Houston before moving to the University of Tennessee Health Science Center as the Thomas A. Gerwin Professor and Chairman of the Department of Physiology. He is the author or coauthor of over 250 papers on gastrointestinal physiology and holds an NIH MERIT Award. Currently he is the Vice Chancellor for Research at Tennessee.

Affiliations and Expertise

Thomas A. Gerwin Professor and Chairman, Department of Physiology, The University of Tennessee Health Sciences Center, Memphis, TN, USA

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