FROM THE PREFACE: The original purpose of the First Edition of Physiology of the Gastrointestinal Tract—to collect in one set of volumes the most current and comprehensive knowledge in our field—was also the driving force for the Fourth Edition. The explosion of information at the cellular level, made possible in part by the continued emergence of powerful molecular and cellular techniques, has resulted in a greater degree of revision than that of any other edition. The first section, now titled "Basic Cell Physiology and Growth of the Gl Tract" contains numerous new chapters on topics such as transcriptional regulation, signaling networks in development, apoptosis, and mechanisms in malignancies. Most of the chapters in this section were edited by Juanita L. Merchant. Section II has been renamed "Neural Gastroenterology and Motility" and has been expanded from seven chapters with rather classic titles to more than twenty chapters encompassing not only the movement of the various parts of the digestive tract but also cell physiology, neural regulation, stress, and the regulation of food intake. Almost all of the chapters were recruited and edited by Jackie D. Wood. The third section is entirely new and contains chapters on "Immunology and Inflammation" which were edited by Kim E. Barrett. The fourth section on the "Physiology of Secretion" consists of chapters with familiar titles, but with completely updated information to reflect the advances in our understanding of the cellular processes involved in secretion. The last section on "Digestion and Absorption" contains new chapters on the intestinal barrier, protein sorting and ion channels along with those focusing on the uptake of specific nutrients. These chapters were recruited and edited by Hamid M. Said and Fayez K. Ghishan.

Key Features

· Collected in one set - the most current and comprehensive coverage of gastrointestinal physiology · Information presented in a style that is both readable and understandable · Valuable to the specialized researcher, the clinical gastroenterologist, the teacher, and the student · Features an entirely new section on Immunology and Inflammation · Each section edited by the preeminent scientist in the field


Clinical gastroenterologists, Grad-level lecturer, American College of Gastroenterology members, Internists, and Physiologists

Table of Contents

Section I: Basic Cell Physiology and Growth of the GI Tract 1. Transcription and Epigenetic Regulation Juanita L. Merchant and Longchuan Bai 2. Translation and Posttranslational Processing of GI Peptides Cheryl E. Gariepy and Chris J. Dickinson 3. Transmembrane Receptors for Endogenous Ligands and Associated Signals Nigel Bunnett 4. Gastrointestinal Hormones: Gastrin, CCK, Somatostatin, Ghrelin Graham J. Dockray 5. Post-Pyloric Gastrointestinal Peptides Ella W. Englander and George H. Greeley 6. GI Peptide Hormones Regulating Energy and Glucose Homeostasis Daniel J. Drucker 7. Growth Factors in the GI Tract John Barnard and Kirk McHugh 8. Developmental Signaling Networks: The Wnt/APC/b-catenin pathway Eric Fearon 9. Hedgehog Signaling in Gastrointestinal Morphogenesis and Morphostasis Gijs R. van den Brink, Maikel P. Peppelenbosch, and Drucilla J. Roberts 10. Developmental Signaling Networks: The Notch Pathway Guy R. Sander, Hanna Krysinska, and Barry Powell 11. Physiology of Gastrointestinal Stem Cells Alda Vidrich, Jenny M. Buzan, Sarah A. De La Rue, and Steven M. Cohn 12. Apoptosis in the Gastrointestinal Tract Leonard R. Johnson 13. Molecular Aspects and Regulation of Gastrointestinal Function During Post-Natal Development James F. Collins, Liqun Bai, Hua Xu and Fayez K. Ghishan 14. Effect of Aging on the Gastrointestinal Tract Adhip P.N. Majumdar and Marc D. Basson 15. Regulation of Gastrointestinal Normal Cell Growth


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© 2006
Academic Press
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About the editors

Hamid Said

Dr. Said is a Professor of Medicine, Physiology and Biophysics at the University of California School of Medicine Irvine, CA. He is also a Senior Research Career Scientist at the VA Medical Center, Long Beach, CA; and Chairman for the Southern California Institute for Research and Education (VALBHS affiliated non-profit). He serves as a reviewer on a variety of NIH, VA and other national study sections as well as international (European) study sections dealing with medical research in internal medicine and nutrition. He is also a member of Editorial Boards of a number of prestigious medical research journals. Research in Dr. Said laboratory focuses on understanding cellular and molecular mechanisms involved in the transport of water-soluble vitamins (folate (vit. B), thiamine (vit. B1), riboflavin (vit. B2), pyridoxine (vit. B6), ascorbic acid (vit. C), biotin (vit. H) and niacin (vit. B3)) in the intestine, kidney, liver and pancreas. Dr. Said's laboratory has published over 160 original research papers in the gastrointestinal and nutrition fields. He has authored many chapters in scientific textbooks as well as a book in these areas. His laboratory has contributed many original discoveries to the field over the years. His research activities are funded by the VA and National Institutes of Health over the past twenty four years.


PRAISE FOR THE THIRD EDITION: “The encyclopedic nature of the book continues to make this an invaluable asset to anyone interested in gastrointestinal physiology and related fields. The extensive expansion of the section on regulation and the overall diversity of chapters from those on signal transduction to those on intestinal adaptation is very useful. … Rating: 4 Stars!” —Doody Review Service PRAISE FOR THE FOURTH EDITION: "The writing is clear and the illustrations informative. Each chapter covers a subject in a thorough manner and there are extensive reference lists to document the points made in the text...The text is very detailed enabling readers to feel that they are current with the field after finishing a chapter." - Charles M. Mansbach, II, M.D., Professor of Medicine and Physiology, University of Tennessee, Memphis "Physiology of the Gastrointestinal Tract has been the benchmark text related to this specific topic for years, yet the last (third) edition was published more than a decade ago. During this period there have been many discoveries in GI pathobiology and, simultaneously, a recognition that this organ system is an elegant one for basic molecular discovery. That a relatively recent issue of Science was completely devoted to alimentary tract biology, speaks to this previous point. Thus the newly minted fourth edition of this work comes at an auspicious time. It does not disappoint. Basic chapters on physiology and growth are outstanding; examples being new contributions focused on the Wnt/Catenin and Notch pathways. Chapters are authored by leaders in the subfields, are clearly written, scientifically rigorous, and tend toward the comprehensive. This work imparts the flavor of organ function but does so by building up basic understanding such that it culminates in a more holistic picture; doing so based on science,