Physiology of the Gastrointestinal Tract, Two Volume Set

5th Edition

Print ISBN: 9780123820266
eBook ISBN: 9780123820273
Imprint: Academic Press
Published Date: 30th April 2012
Page Count: 2308
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The gastrointestinal system is responsible for the breakdown and absorption of various foods and liquids needed to sustain life. Diseases in the gastrointestinal system fall on the illness spectrum from minor discomfort to serious disease; a physician may see a patient with indigestion or an abdominal wall hernia. Other diseases and disorders treated by clinicians in this area include: food allergies, constipation, chronic liver disease and cirrhosis, gallstones, gastritis, GERD, hemorrhoids, IBS, lactose intolerance, pancreatic, appendicitis, celiac disease, Crohn’s disease, peptic ulcer, stomach ulcer, viral hepatitis, colorectal cancer and liver transplants. Physiology of the Gastrointestinal Tract, 5/e covers the study of the mechanical, physical, and biochemical functions of the GI Tract while linking the clinical disease or disorder, bridging the gap between clinical and laboratory medicine.

"It is the most useful reference that I have found in the areas of GI physiology, anatomy, endocrinology, development, and molecular biology."

Michael Goy, PhD; Professor, Dept. Cell and Molecular Physiology, University of North Carolina

With the following updates Physiology of the Gastrointestinal Tract, 5/e will continue to be the foremost publication in gastrointestinal physiology: updated, four color illustrations for improved visual representation of content and inclusion of the most recent advances in cellular and molecular biology, stem cell development and research.

Table of Contents


Preface to the First Edition




Section I Basic Cell Physiology, Genetics, and Growth of the GI Tract

Chapter 1. Transcription and Epigenetic Regulation

1.1 Overview of Gene Organization

1.2 Epigenetic Influences

1.3 Anatomy of a Gene Promoter

1.4 Methodology

1.5 Transcriptional Control of Gastrointestinal Peptides

1.6 Post-Transcriptional Processing

1.7 Transport Across the Nuclear Membrane

1.8 Concluding Remarks



Chapter 2. Post-translational Processing of Gastrointestinal Peptides

2.1 Introduction

2.2 Translation and Passage into the Endoplasmic Reticulum

2.3 Processing in the Endoplasmic Reticulum

2.4 Sorting to the Golgi

2.5 Processing in the Golgi

2.6 Sorting to the Secretory Vesicle

2.7 Processing in the Secretory Vesicle

2.8 Examples of Processing

2.9 Summary


Chapter 3. Genetic Tools in Gastrointestinal Diseases

3.1 The Genetic Architecture of Mendelian and Non-Mendelian Diseases

3.2 Genome-Wide Association Studies

3.3 DNA Sequencing and Disease Association Studies of Uncommon Variants

3.4 DNA-RNA Translation Mappings

3.5 Epigenetic Regulation of Gene Expression

3.6 Integrating Genetic and Environmental Factors

3.7 Clinical Applications

3.8 Future Directions


Chapter 4. Signaling Pathways Induced by G-protein-coupled Receptors

4.1 Introduction

4.2 GPCR Structure, Oligomerization, and Heterotrimeric G Proteins

4.3 GPCR Phosphorylation, Conformational Changes, Arrestin Recruitment, and G-Protein-Independent Signaling

4.4 GPCR-Induced Actin Remodeling and Phosphorylation of Focal Adhesion Proteins

4.5 GPCR-Induced Fak Phosphorylation at Tyrosine and Serine Residues



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BMA Medical Book Award 2013: Internal Medicine - Highly Commended, British Medical Association