Table of Contents


Preface to the First Edition




Section I Basic Cell Physiology, Genetics, and Growth of the GI Tract

Chapter 1. Transcription and Epigenetic Regulation

1.1 Overview of Gene Organization

1.2 Epigenetic Influences

1.3 Anatomy of a Gene Promoter

1.4 Methodology

1.5 Transcriptional Control of Gastrointestinal Peptides

1.6 Post-Transcriptional Processing

1.7 Transport Across the Nuclear Membrane

1.8 Concluding Remarks



Chapter 2. Post-translational Processing of Gastrointestinal Peptides

2.1 Introduction

2.2 Translation and Passage into the Endoplasmic Reticulum

2.3 Processing in the Endoplasmic Reticulum

2.4 Sorting to the Golgi

2.5 Processing in the Golgi

2.6 Sorting to the Secretory Vesicle

2.7 Processing in the Secretory Vesicle

2.8 Examples of Processing

2.9 Summary


Chapter 3. Genetic Tools in Gastrointestinal Diseases

3.1 The Genetic Architecture of Mendelian and Non-Mendelian Diseases

3.2 Genome-Wide Association Studies

3.3 DNA Sequencing and Disease Association Studies of Uncommon Variants

3.4 DNA-RNA Translation Mappings

3.5 Epigenetic Regulation of Gene Expression

3.6 Integrating Genetic and Environmental Factors

3.7 Clinical Applications

3.8 Future Directions


Chapter 4. Signaling Pathways Induced by G-protein-coupled Receptors

4.1 Introduction

4.2 GPCR Structure, Oligomerization, and Heterotrimeric G Proteins

4.3 GPCR Phosphorylation, Conformational Changes, Arrestin Recruitment, and G-Protein-Independent Signaling

4.4 GPCR-Induced Actin Remodeling and Phosphorylation of Focal Adhesion Proteins

4.5 GPCR-Induced Fak Phosphorylation at Tyrosine and Serine Residues



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© 2012
Academic Press
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About the editor

Hamid Said

Dr. Said is a Professor of Medicine, Physiology and Biophysics at the University of California School of Medicine Irvine, CA. He is also a Senior Research Career Scientist at the VA Medical Center, Long Beach, CA; and Chairman for the Southern California Institute for Research and Education (VALBHS affiliated non-profit). He serves as a reviewer on a variety of NIH, VA and other national study sections as well as international (European) study sections dealing with medical research in internal medicine and nutrition. He is also a member of Editorial Boards of a number of prestigious medical research journals. Research in Dr. Said laboratory focuses on understanding cellular and molecular mechanisms involved in the transport of water-soluble vitamins (folate (vit. B), thiamine (vit. B1), riboflavin (vit. B2), pyridoxine (vit. B6), ascorbic acid (vit. C), biotin (vit. H) and niacin (vit. B3)) in the intestine, kidney, liver and pancreas. Dr. Said's laboratory has published over 160 original research papers in the gastrointestinal and nutrition fields. He has authored many chapters in scientific textbooks as well as a book in these areas. His laboratory has contributed many original discoveries to the field over the years. His research activities are funded by the VA and National Institutes of Health over the past twenty four years.

Affiliations and Expertise

Professor of Medicine, Physiology and Biophysics, Departments of Medicine and Physiology/Biophysics, University of California School of Medicine, Irvine, California, U.S.A.


BMA Medical Book Award 2013: Internal Medicine - Highly Commended, British Medical Association