Physiology of the Gastrointestinal Tract, Two Volume Set

5th Edition

Editors: Hamid Said
Hardcover ISBN: 9780123820266
eBook ISBN: 9780123820273
Imprint: Academic Press
Published Date: 30th April 2012
Page Count: 2308
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Physiology of the Gastrointestinal Tract, Fifth Edition — winner of a 2013 Highly Commended BMA Medical Book Award for Internal Medicine — covers the study of the mechanical, physical, and biochemical functions of the GI Tract while linking the clinical disease or disorder, bridging the gap between clinical and laboratory medicine.

The gastrointestinal system is responsible for the breakdown and absorption of various foods and liquids needed to sustain life. Other diseases and disorders treated by clinicians in this area include: food allergies, constipation, chronic liver disease and cirrhosis, gallstones, gastritis, GERD, hemorrhoids, IBS, lactose intolerance, pancreatic, appendicitis, celiac disease, Crohn’s disease, peptic ulcer, stomach ulcer, viral hepatitis, colorectal cancer and liver transplants.

The new edition is a highly referenced and useful resource for gastroenterologists, physiologists, internists, professional researchers, and instructors teaching courses for clinical and research students.

Key Features

  • 2013 Highly Commended BMA Medical Book Award for Internal Medicine
  • Discusses the multiple processes governing gastrointestinal function
  • Each section edited by preeminent scientist in the field
  • Updated, four-color illustrations


Clinical gastroenterologists, physiologists, and internists, as well as, professional researchers in gastroenterology, physiology, internal medicine, translational medicine and biomedicine.

Table of Contents


Preface to the First Edition




Section I Basic Cell Physiology, Genetics, and Growth of the GI Tract

Chapter 1. Transcription and Epigenetic Regulation

1.1 Overview of Gene Organization

1.2 Epigenetic Influences

1.3 Anatomy of a Gene Promoter

1.4 Methodology

1.5 Transcriptional Control of Gastrointestinal Peptides

1.6 Post-Transcriptional Processing

1.7 Transport Across the Nuclear Membrane

1.8 Concluding Remarks



Chapter 2. Post-translational Processing of Gastrointestinal Peptides

2.1 Introduction

2.2 Translation and Passage into the Endoplasmic Reticulum

2.3 Processing in the Endoplasmic Reticulum

2.4 Sorting to the Golgi

2.5 Processing in the Golgi

2.6 Sorting to the Secretory Vesicle

2.7 Processing in the Secretory Vesicle

2.8 Examples of Processing

2.9 Summary


Chapter 3. Genetic Tools in Gastrointestinal Diseases

3.1 The Genetic Architecture of Mendelian and Non-Mendelian Diseases

3.2 Genome-Wide Association Studies

3.3 DNA Sequencing and Disease Association Studies of Uncommon Variants

3.4 DNA-RNA Translation Mappings

3.5 Epigenetic Regulation of Gene Expression

3.6 Integrating Genetic and Environmental Factors

3.7 Clinical Applications

3.8 Future Directions


Chapter 4. Signaling Pathways Induced by G-protein-coupled Receptors

4.1 Introduction

4.2 GPCR Structure, Oligomerization, and Heterotrimeric G Proteins

4.3 GPCR Phosphorylation, Conformational Changes, Arrestin Recruitment, and G-Protein-Independent Signaling

4.4 GPCR-Induced Actin Remodeling and Phosphorylation of Focal Adhesion Proteins

4.5 GPCR-Induced Fak Phosphorylation at Tyrosine and Serine Residues



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Academic Press
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About the Editor

Hamid Said

Dr. Said is a Professor of Medicine, Physiology and Biophysics at the University of California School of Medicine Irvine, CA. He is also a Senior Research Career Scientist at the VA Medical Center, Long Beach, CA; and Chairman for the Southern California Institute for Research and Education (VALBHS affiliated non-profit). He serves as a reviewer on a variety of NIH, VA and other national study sections as well as international (European) study sections dealing with medical research in internal medicine and nutrition. He is also a member of Editorial Boards of a number of prestigious medical research journals. Research in Dr. Said laboratory focuses on understanding cellular and molecular mechanisms involved in the transport of water-soluble vitamins (folate (vit. B), thiamine (vit. B1), riboflavin (vit. B2), pyridoxine (vit. B6), ascorbic acid (vit. C), biotin (vit. H) and niacin (vit. B3)) in the intestine, kidney, liver and pancreas. Dr. Said's laboratory has published over 160 original research papers in the gastrointestinal and nutrition fields. He has authored many chapters in scientific textbooks as well as a book in these areas. His laboratory has contributed many original discoveries to the field over the years. His research activities are funded by the VA and National Institutes of Health over the past twenty four years.

Affiliations and Expertise

Professor of Medicine, Physiology and Biophysics, Departments of Medicine and Physiology/Biophysics, University of California School of Medicine, Irvine, California, U.S.A.


BMA Medical Book Award 2013: Internal Medicine - Highly Commended, British Medical Association