Table of Contents

Contributors

Preface to the First Edition

Preface

Acknowledgments

VOLUME 1

Section I Basic Cell Physiology, Genetics, and Growth of the GI Tract

Chapter 1. Transcription and Epigenetic Regulation

1.1 Overview of Gene Organization

1.2 Epigenetic Influences

1.3 Anatomy of a Gene Promoter

1.4 Methodology

1.5 Transcriptional Control of Gastrointestinal Peptides

1.6 Post-Transcriptional Processing

1.7 Transport Across the Nuclear Membrane

1.8 Concluding Remarks

Acknowledgments

References

Chapter 2. Post-translational Processing of Gastrointestinal Peptides

2.1 Introduction

2.2 Translation and Passage into the Endoplasmic Reticulum

2.3 Processing in the Endoplasmic Reticulum

2.4 Sorting to the Golgi

2.5 Processing in the Golgi

2.6 Sorting to the Secretory Vesicle

2.7 Processing in the Secretory Vesicle

2.8 Examples of Processing

2.9 Summary

References

Chapter 3. Genetic Tools in Gastrointestinal Diseases

3.1 The Genetic Architecture of Mendelian and Non-Mendelian Diseases

3.2 Genome-Wide Association Studies

3.3 DNA Sequencing and Disease Association Studies of Uncommon Variants

3.4 DNA-RNA Translation Mappings

3.5 Epigenetic Regulation of Gene Expression

3.6 Integrating Genetic and Environmental Factors

3.7 Clinical Applications

3.8 Future Directions

References

Chapter 4. Signaling Pathways Induced by G-protein-coupled Receptors

4.1 Introduction

4.2 GPCR Structure, Oligomerization, and Heterotrimeric G Proteins

4.3 GPCR Phosphorylation, Conformational Changes, Arrestin Recruitment, and G-Protein-Independent Signaling

4.4 GPCR-Induced Actin Remodeling and Phosphorylation of Focal Adhesion Proteins

4.5 GPCR-Induced Fak Phosphorylation at Tyrosine and Serine Residues

4

Details

No. of pages:
2308
Language:
English
Copyright:
© 2012
Published:
Imprint:
Academic Press
Print ISBN:
9780123820266
Electronic ISBN:
9780123820273

About the author

Hamid Said

Dr. Said is a Professor of Medicine, Physiology and Biophysics at the University of California School of Medicine Irvine, CA. He is also a Senior Research Career Scientist at the VA Medical Center, Long Beach, CA; and Chairman for the Southern California Institute for Research and Education (VALBHS affiliated non-profit). He serves as a reviewer on a variety of NIH, VA and other national study sections as well as international (European) study sections dealing with medical research in internal medicine and nutrition. He is also a member of Editorial Boards of a number of prestigious medical research journals. Research in Dr. Said laboratory focuses on understanding cellular and molecular mechanisms involved in the transport of water-soluble vitamins (folate (vit. B), thiamine (vit. B1), riboflavin (vit. B2), pyridoxine (vit. B6), ascorbic acid (vit. C), biotin (vit. H) and niacin (vit. B3)) in the intestine, kidney, liver and pancreas. Dr. Said's laboratory has published over 160 original research papers in the gastrointestinal and nutrition fields. He has authored many chapters in scientific textbooks as well as a book in these areas. His laboratory has contributed many original discoveries to the field over the years. His research activities are funded by the VA and National Institutes of Health over the past twenty four years.

Awards

BMA Medical Book Award 2013: Internal Medicine - Highly Commended, British Medical Association