Physiology and Toxicology of Male Reproduction

Physiology and Toxicology of Male Reproduction

1st Edition - June 28, 1988

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  • Editors: James C. Lamb, Paul M. D. Foster
  • eBook ISBN: 9781483272078

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Physiology and Toxicology of Male Reproduction is a collection of papers that deals with general reproductive biology and specific aspects of reproductive toxicology, pertaining to the male sex. Some papers discuss testicular organization, reproductive toxicity testing systems, and germ-cell genetic toxicology. The use of in vitro systems by investigators to dissect the male reproductive toxicants can lead to a more scientific approach toward hazard assessment and the development of safer drugs and chemicals. Other papers explain the fundamental reproductive biology of the testis, the neuroendocrine system, the epididymis and accessory sex organs, and spermatozoal evaluation. Toxicological aspects cover the toxicological evaluation of the complete reproductive system, testicular morphology, sperm assessment, and germ-cell mutagenesis. One paper describes alternative methods in toxicology—by using new in vitro systems that should reduce or eliminate the need for tests conducted on animals. In vitro methodology embraces other systems such as from subcellular fractions to isolated intact organs. In relation to target-organ toxicity, the researcher can focus using primary cell cultures. This collection will prove helpful to toxicologists, graduate students and researchers in biology, particularly in male reproductive toxicology and fertility testing.

Table of Contents

  • Contributors


    Chapter 1 Introduction

    Chapter 2 Testicular Organization and Biochemical Function

    I. Introduction

    II. Testicular Compartments

    III. Spermatogenesis

    IV. The Key Role of the Sertoli Cell

    V. The Leydig Cell

    VI. Future Perspectives and Research


    Chapter 3 Duct System and Accessory Glands of the Male Reproductive Tract

    I. Introduction

    II. Development of Reproductive Tract and Accessory Organs

    III. Structure and Function of Duct System

    IV. Structure and Function of Accessory Glands

    V. Seminal Plasma

    VI. Conclusions


    Chapter 4 Endocrinology and Paracrinology of the Testis

    I. Introduction

    II. Endocrine Control of the Testis

    III. Paracrine Control of the Testis

    IV. Endocrinology of Puberty

    V. Endocrinology of Male Infertility

    VI. Summary and Future Prospects


    Chapter 5 Male Neuroendocrinology and Endocrine Evaluation of Reproductive Disorders

    I. Introduction

    II. Brain Control of Reproductive Functions: The Role of Luteinizing Hormone-Releasing Hormone

    III. Pituitary Factors Regulating Testicular Function

    IV. Reproductive Dysfunction and Guidelines for Endocrine Exploration of the Infertile Male


    Chapter 6 Fundamentals of Male Reproductive Toxicity Testing

    I. General Approaches to Male Reproductive Toxicity Testing

    II. Risk Assessment and Male Reproductive Toxicology


    Chapter 7 Morphologic Evaluation of Seminiferous Epithelium of the Testis

    I. Why Morphology?

    II. Considerations and Methods

    III. Media Effects and Glycol Methacrylate

    IV. Examples of Stage-Specific Lesions

    V. Functional Correlates of Pathology

    VI. Summary


    Chapter 8 Evaluation of Copulatory Behavior and Sperm in Rats: Role in Reproductive Risk Assessment

    I. Introduction

    II. Traditional Endpoints in Male Reproductive Risk Assessment

    III. Expanding the Data Base—Evaluation of Copulatory Behavior

    IV. Expanding the Data Base—Sperm Evaluations in the Rat

    V. New Approaches to Improving Quantitative Male Reproductive Risk Assessment


    Chapter 9 Genetic Toxicology of Mammalian Male Germ Cells

    I. Introduction

    II. Test Methods


    Chapter 10 Application of In Vitro Systems in Male Reproductive Toxicology

    I. Introduction

    II. In Vitro Systems from the Male Reproductive Tract

    III. Methodology for Cell Isolation

    IV. Application of In Vitro Systems in Toxicity Studies

    V. Critical Appraisal of the Usefulness of In Vitro Systems

    VI. Conclusions



Product details

  • No. of pages: 282
  • Language: English
  • Copyright: © Academic Press 1988
  • Published: June 28, 1988
  • Imprint: Academic Press
  • eBook ISBN: 9781483272078

About the Editors

James C. Lamb

Paul M. D. Foster

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