Physiology and Toxicology of Male Reproduction

1st Edition - June 28, 1988
Editors: James C. Lamb, Paul M. D. Foster
Language: English
eBook ISBN:
9 7 8 - 1 - 4 8 3 2 - 7 2 0 7 - 8

Physiology and Toxicology of Male Reproduction is a collection of papers that deals with general reproductive biology and specific aspects of reproductive toxicology, pertaining to… Read more

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Physiology and Toxicology of Male Reproduction is a collection of papers that deals with general reproductive biology and specific aspects of reproductive toxicology, pertaining to the male sex. Some papers discuss testicular organization, reproductive toxicity testing systems, and germ-cell genetic toxicology. The use of in vitro systems by investigators to dissect the male reproductive toxicants can lead to a more scientific approach toward hazard assessment and the development of safer drugs and chemicals. Other papers explain the fundamental reproductive biology of the testis, the neuroendocrine system, the epididymis and accessory sex organs, and spermatozoal evaluation. Toxicological aspects cover the toxicological evaluation of the complete reproductive system, testicular morphology, sperm assessment, and germ-cell mutagenesis. One paper describes alternative methods in toxicology—by using new in vitro systems that should reduce or eliminate the need for tests conducted on animals. In vitro methodology embraces other systems such as from subcellular fractions to isolated intact organs. In relation to target-organ toxicity, the researcher can focus using primary cell cultures. This collection will prove helpful to toxicologists, graduate students and researchers in biology, particularly in male reproductive toxicology and fertility testing.

Contributors

Preface

Chapter 1 Introduction

Chapter 2 Testicular Organization and Biochemical Function

I. Introduction

II. Testicular Compartments

III. Spermatogenesis

IV. The Key Role of the Sertoli Cell

V. The Leydig Cell

VI. Future Perspectives and Research

References

Chapter 3 Duct System and Accessory Glands of the Male Reproductive Tract

I. Introduction

II. Development of Reproductive Tract and Accessory Organs

III. Structure and Function of Duct System

IV. Structure and Function of Accessory Glands

V. Seminal Plasma

VI. Conclusions

References

Chapter 4 Endocrinology and Paracrinology of the Testis

I. Introduction

II. Endocrine Control of the Testis

III. Paracrine Control of the Testis

IV. Endocrinology of Puberty

V. Endocrinology of Male Infertility

VI. Summary and Future Prospects

References

Chapter 5 Male Neuroendocrinology and Endocrine Evaluation of Reproductive Disorders

I. Introduction

II. Brain Control of Reproductive Functions: The Role of Luteinizing Hormone-Releasing Hormone

III. Pituitary Factors Regulating Testicular Function

IV. Reproductive Dysfunction and Guidelines for Endocrine Exploration of the Infertile Male

References

Chapter 6 Fundamentals of Male Reproductive Toxicity Testing

I. General Approaches to Male Reproductive Toxicity Testing

II. Risk Assessment and Male Reproductive Toxicology

References

Chapter 7 Morphologic Evaluation of Seminiferous Epithelium of the Testis

I. Why Morphology?

II. Considerations and Methods

III. Media Effects and Glycol Methacrylate

IV. Examples of Stage-Specific Lesions

V. Functional Correlates of Pathology

VI. Summary

References

Chapter 8 Evaluation of Copulatory Behavior and Sperm in Rats: Role in Reproductive Risk Assessment

I. Introduction

II. Traditional Endpoints in Male Reproductive Risk Assessment

III. Expanding the Data Base—Evaluation of Copulatory Behavior

IV. Expanding the Data Base—Sperm Evaluations in the Rat

V. New Approaches to Improving Quantitative Male Reproductive Risk Assessment

References

Chapter 9 Genetic Toxicology of Mammalian Male Germ Cells

I. Introduction

II. Test Methods

Bibliography

Chapter 10 Application of In Vitro Systems in Male Reproductive Toxicology

I. Introduction

II. In Vitro Systems from the Male Reproductive Tract

III. Methodology for Cell Isolation

IV. Application of In Vitro Systems in Toxicity Studies

V. Critical Appraisal of the Usefulness of In Vitro Systems

VI. Conclusions

References

Index