Physiology And Pathology

Physiology And Pathology

2nd Edition - January 28, 1972

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  • Editor: Geoffrey Bourne
  • eBook ISBN: 9780323161756

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The Biochemistry and Physiology of Bone, Second Edition: Volume II: Physiology and Pathology investigates the physiological and pathological aspects of bone, including the blood vessels that nourish the bones; the mechanisms of bone formation, growth, repair, and transplantation; and the role of hormones and vitamins in the formation and maintenance of bone. It explores the circulation of bone, the pathological calcification and radiation effects on bone, the metabolism of growth hormones and skeletal tissue, enamel and dentin matrix glycoproteins, and the role of calcitonin in homeostasis. Organized into nine chapters, this edition begins with an overview of the circulation of bone, including the overall blood supply of a long bone. It discusses the phosphatase and its histological distribution in mature and developing bone, the presence of glycoproteins in the organic matrix of enamel and dentin, and human dwarfism and human growth hormone replacement therapy. It explains the roles of vitamins and the effects of calcitonin and vitamin deficiency on bone growth and development. The book concludes with a chapter on the chemistry of calcification and some types of abnormal calcification. This book is a valuable resource for biochemists, cell biologists, physiologists, anatomists, orthopedists, pathologists, clinicians, biomedical engineers, graduate students, professors, and others interested in the physiology and pathology of bone.

Table of Contents

  • List of Contributors

    Preface to Second Edition

    Preface to First Edition

    Contents of Other Volumes

    Chapter 1. Circulation of Bone

    I. Introduction

    II. Historical Concepts of the Overall Blood Supply of a Long Bone

    III. Blood Supply of Normal Compactum

    IV. Blood Supply of Healing Compactum

    V. Vascularization of Cancellous Chip Grafts and Transplants

    VI. Summary of Circulation in a Mature Long Bone


    Chapter 2. Phosphatase and Calcification

    I. Historical

    II. Identity of Bone Phosphatase and Comparison with Soft Tissue Phosphatase

    III. Histological Distribution of Phosphatase in Mature and Developing Bone

    IV. Phosphatase and Bone Repair

    V. Significance of Phosphatase in Bone Formation

    VI. Summary


    Chapter 3. Elaboration of Enamel and Dentin Matrix Glycoproteins

    I. Introduction

    II. Background

    III. Enamel Matrix

    IV. Dentin Matrix

    V. Role of Glycoproteins in Enamel and Dentin


    Chapter 4. Growth Hormone and Skeletal Tissue Metabolism

    I. Introduction

    II. Chemical Properties, Including Species Differences

    III. Assay Methods and Plasma Levels

    IV. Experimental Models, Target Tissues, and Deficiency of Growth Hormone

    V. Excessive Action of Growth Hormone

    VI. Interaction with Other Hormones

    VII. Tissue Culture

    VIII. Summary


    Chapter 5. Vitamin A and Bone

    I. The Chemistry of Vitamin A

    II. Hypovitaminosis A

    III. Hypervitaminosis A


    Chapter 6. Vitamin C and Bone

    I. Introduction

    II. Vitamin C Deficiency and Intercellular Substances in General

    III. Bone


    Chapter 7. Vitamin D and Bone

    I. Introduction

    II. Historical Review—Chemistry and Methods

    III. Metabolic Bone Disease and Vitamin D

    IV. Physiological Basis of Vitamin D Action

    V. Metabolism of Vitamin D

    VI. Mechanisms of Vitamin D Action on Calcium Absorption

    VII. Mechanism of Vitamin D Action on Bone Mineral Metabolism


    Chapter 8. Calcitonin

    I. Introduction

    II. Historical Developments

    III. Ultimobranchial Glands and C Cells

    IV. Standards and Assay

    V. Chemistry

    VI. Action

    VII. Comparative Studies

    VIII. Clinical Implications

    IX. Control of Secretion

    X. Role in Homeostasis

    XI. Summary


    Chapter 9. Pathological Calcification

    I. Introduction

    II. Chemical Principles

    III. Dystrophic Calcification

    IV. Pathogenetic Factors

    V. Metastatic Calcification

    VI. Arterial Calcification


    Author Index

    Subject Index

Product details

  • No. of pages: 424
  • Language: English
  • Copyright: © Academic Press 1972
  • Published: January 28, 1972
  • Imprint: Academic Press
  • eBook ISBN: 9780323161756

About the Editor

Geoffrey Bourne

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