Physiological and Clinical Aspects of Oxygenator Design

Physiological and Clinical Aspects of Oxygenator Design

Proceedings of the Seminar on Advances in Oxygenator Design, Copenhagen, June 15-20, 1975

1st Edition - January 1, 1976

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  • Editor: S. G. Dawids
  • eBook ISBN: 9781483165127

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Description

Physiological and Clinical Aspects of Oxygenator Design documents the proceedings of the Seminar on Advances in Oxygenator Design held at Rungstedgaard in Copenhagen, on 15-20 June 1975. It has been the triple purpose of this seminar to promote interdisciplinary contact between European scientists in the field of extracorporeal oxygenation, to give a picture of the state of the art, and to give indications for the trends for future research. This volume is organized into seven parts. Part I contains papers on the dimensional conditions for oxygenators. Part II presents studies on oxygenator construction. Part III is devoted to experimental methods of oxygenation. The presentations in Part IV focus on hematological aspects such as the microrheology of erythrocytes and platelets, and the effect of unphysiological blood flow on circulating cells. Part V deals with tissue factors, including oxygen consumption at the cellular level. Part VI covers measurements during extracorporeal circulation. Part VII discusses compatibility problems of foreign surfaces, covering materials from membrane oxygenators and approaches to blood-compatible materials.

Table of Contents


  • Preface

    Introductory remarks

    List of Contributors

    Advances in oxygenator design: past, present and future

    Dimensional Conditions for Oxygenators

    Operational conditions underlying the design of membrane oxygenators

    Scaling rules for flat plate and hollow fiber membrane oxygenators for total bypass

    Introduction

    Notations

    Model definition and related gas transfer parameters

    Scaling rules

    Membrane oxygenator performance under varying conditions

    Discussion

    Appendix

    References

    Correlation of effects of blood flow rate, viscosity and design features on artificial lung performance

    Introduction

    Effects of blood flow rate

    Viscosity

    Design features: Compliance effects

    Design features: Port resistance

    Morphological evidence by casting

    Thrombus formation

    Cannulae

    Discussion

    Summary

    Acknowledgments

    References

    Fluid mechanical problems in membrane oxygenators

    Introduction

    Symbols

    Multiple pipe membrane oxygenator

    Hydrophilic membrane oxygenator

    Electromagnetic mixing

    Conclusions

    References

    Oxygenator Construction

    The Taylor-Vortex membrane oxygenator: design analysis based on a predictive correlation for oxygen transfer

    Introduction

    Symbols

    Experimental methods

    Mass transfer correlation

    Design analysis

    Discussion

    Acknowledgments

    References

    Annular membrane oxygenator with tangential flow. Oxygen transfer analysis and scaling rules

    Introduction

    Notations

    Methods

    Characteristics of the tangential flow oxygenator

    Hydrodynamic model

    Oxygen transfer analysis; theory and experiment

    Design criteria for the tangential flow oxygenator

    Acknowledgments

    References

    Fluid mechanics of the Oxford membrane oxygenator and its evaluation in animal experiments

    Introduction

    Fluid mechanics of the furrowed membrane oxygenator; dye studies

    Design of the Oxford membrane oxygenator

    Conclusion

    Acknowledgments

    References

    Observations with a membrane oxygenator model combining tubes and sheets

    Material and methods

    Results

    Discussion

    Conclusion

    Acknowledgments

    References

    Experimental Methods of Oxygenation

    A fluid oxygenator using shear flow dispersion of blood in fluorocarbon

    The oxygenator

    Methods

    Results

    Discussion

    Summary

    References

    Supersaturated fluorocarbon as an oxygen source

    Methods

    Results

    Discussion

    Summary

    Acknowledgments

    References

    Use of hyperbaric oxygen as oxygen source in extracorporeal oxygenation of blood

    High-pressure oxygenation of stagnant blood film

    High-pressure oxygenation of flowing blood film

    Oxygenation with pressure-saturated dialysate

    In vivo experiments using high-pressure oxygenation in batch operation

    References

    Use of hydrogen peroxide as oxygen source in extracorporeal oxygenation of blood

    Methods

    Apparatus

    Results

    Discussion

    Conclusions

    References

    Hematological Aspects

    Microrheology of erythrocytes and platelets: physiological basis and consequences for the design and the operation of extracorporeal circulatory devices

    Introduction

    Methods

    Results and discussion

    Summary

    References

    Effect of unphysiological blood flow on circulating cells

    Platelet adhesion and aggregation

    Platelet activation by erythrocytes

    References

    Platelets, foreign surfaces, and heparin

    Introduction

    Materials and methods

    Experiments and results

    Discussion

    Acknowledgments

    References

    Hematologic abnormalities in extracorporeal circuits (ECC)

    Introduction

    Materials and methods

    Discussion of results

    References

    Scanning electron microscopical observations on microporous membrane oxygenators

    Material and methods

    Results

    Discussion

    Conclusions

    Acknowledgments

    References

    Extracorporeal circulation and the effect of bubble oxygenation on plasma proteins

    Introduction

    Equipment testing and bodily responses

    Techniques and methods

    Results

    Comments

    Conclusion

    References

    Tissue Factors

    Oxygen consumption at the cellular level

    What is the oxygen used for?

    References

    Hemoglobin oxygen affinity in patients with acute myocardial infarction and angina pectoris

    References

    Measurements during Extracorporeal Circulation

    Problems of measuring blood gases

    References

    Continuous monitoring of PaO2 of intensive care patients in view of its application during prolonged extracorporeal perfusion

    Introduction

    Discussion and conclusions

    Summary

    References

    Monitoring hemodynamics, gas exchange, and pulmonary mechanics during veno-arterial bypass with extracorporeal oxygenation

    Introduction

    Conclusions and summary

    References

    Automatic oxygen and acid-base control during organ perfusion as a model for extracorporeal circulation

    Introduction

    Strategy of control

    Perfusion system

    Results

    Discussion and conclusions

    References

    A computer-operated system for the evaluation of extracorporeal oxygenators

    Introduction

    Hardware organization

    Operating sequence — software structure

    Performance test

    Acknowledgments

    References

    Compatibility Problems of Foreign Surfaces

    Materials for membrane oxygenators

    Introduction

    Blood flow

    Membranes

    Conclusions

    References

    What has been done with regard to blood compatibility?

    Some approaches to blood-compatible materials

    Introduction

    Extruded silicone tubings

    Amphipathic polyelectrolyte complexes

    References

    Comment

    Concluding remarks

    Subject index




Product details

  • No. of pages: 348
  • Language: English
  • Copyright: © Elsevier 1976
  • Published: January 1, 1976
  • Imprint: Elsevier
  • eBook ISBN: 9781483165127

About the Editor

S. G. Dawids

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