Physical Processes in Radiation Biology

Physical Processes in Radiation Biology

Proceedings of an International Symposium Sponsored by the U.S. Atomic Energy Commission and Held at the Kellogg Center for Continuing Education, Michigan State University, on May 6 – 8, 1963

1st Edition - January 1, 1964

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  • Editors: Leroy Augenstein, Ronald Mason, Barnett Rosenberg
  • eBook ISBN: 9781483223278

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Description

Physical Processes in Radiation Biology covers the proceedings of an International Symposium on Physical Processes in Radiation Biology, held at the Kellogg Center for Continuing Education, Michigan State University on May 6-8, 1963, sponsored by the U.S. Atomic Energy Commission. The symposium aims to address the core problems of radiation biology concerning the absorption, distribution, and utilization of high energy packets in biological systems. This book is composed of 21 chapters, and begins with an introduction to the absorption, excitation, and transfer processes in molecular solids. The subsequent chapters discuss the nature of exciton processes; the mechanisms of charge transport in biological materials; the interactions of fast and slow electrons with model systems; the importance of liquid structures in determining the development of radiation damage; and the nature of the metastable species formed. The concluding chapters explore the importance of charge migration in energy transfer processes in different biological systems and the significance of higher excited levels in charge migration and energy transfer. These chapters also describe the nature of the hydration of electrons and protons in aqueous systems. This book will be of great value to radiation biologists, biophysicists, physical chemists, and physicists.

Table of Contents


  • List of Contributors

    Preface

    Chapter 1 Absorption, Excitation, and Transfer Processes in Molecular Solids

    I. Introduction

    II. Absorption by Pure Molecular Crystals

    III. Arrays of Nearly Identical Absorbing Units

    IV. Host-Guest Interactions

    V. Some Comments on the Transfer Process

    VI. Molecular Excited-State Displacements in Mixed Crystal

    References

    Discussion

    Chapter 2 Classification of Excitons

    References

    Discussion

    Chapter 3 The Molecular Exciton Model

    I. Scope and Specification of the Model

    II. Molecular Exciton Wave Functions

    III. The Intermolecular Perturbation Potential

    IV. Exciton Splitting in a Simple Dimer

    V. Linear Chain Polymers

    VI. Applications of the Model

    VII. Summary

    References

    Chapter 4 Interlocking Amide Resonance in the DNA Bases

    I. Introduction

    II. Amides

    III. Determination of Parameters

    IV. Testing of Parameters

    V. Uracil

    VI. Refinements

    References

    Discussion

    Chapter 5 Molecular Localization of Radiation Damage Relevant to Bacterial Inactivation

    I. Introduction

    II. Radiosensitivity and DNA Base Composition

    III. Synergistic Interaction between UV and X-Rays

    References

    Appendix

    Discussion

    Chapter 6 Comparison of Emission from Excited States Produced in Proteins and Amino Acids by Ultraviolet Light and Ionizing Radiation

    I. Introduction

    II. Experimental Procedures

    III. Results

    IV. Discussion

    References

    Chapter 7 Biphotonic Processes

    I. Introduction

    II. Delayed Fluorescence

    III. Double Photon Excitation

    IV. Photoconductivity

    V. Photosynthesis

    References

    Appendix

    Discussion

    Chapter 8 Charge Transport Processes in Proteins and Organic Materials

    I. Introduction

    II. The Electrical Conductivity of Hydrated Proteins

    III. The Nature of the Charge Carriers in Hydrated Proteins

    References

    Discussion

    Chapter 9 Spectrometry of Energy Losses of Electrons Transmitted through Solids

    I. Introduction

    II. Multiple Scattering

    III. Discovery of Characteristic Energy Losses

    IV. Identification of the Origin of the Characteristic Energy Losses

    V. Characteristic Energy Losses in Compounds and Alloys

    VI. Small Angle Resolution

    References

    Discussion

    Chapter 10 Energy Loss Spectra for Charged Particles Traversing Metal and Plastic Films

    I. Introduction

    II. The Bohm and Pines Model and Its Experimental Verification

    III. The Search for the Light from Plasmon Decay

    IV. Plasma Effects in Carbon and Organic Molecules

    References

    Discussion

    Chapter 11 Excited States Produced by Low-Energy Electrons

    I. Introduction

    II. Design and Construction of Apparatus

    III. General Behavior of the Apparatus

    IV. Excitation Spectra of Helium, Argon, and Hydrogen

    V. Excitation Spectra of Ethylene

    VI. Conclusions

    References

    Discussion

    Chapter 12 Reactions in the Gas Phase between Thermal Energy Electrons and Compounds of Biochemical Interest

    I. Introduction

    II. Experimental Method

    References

    Discussion

    Chapter 13 The Structure of Liquids and Solutions as it Applies to Excitation Energy and Charge Migration Processes

    I. Introduction

    II. Diffraction Studies of Structure

    III. Charge Migration

    IV. Excitation Energy Transfer

    V. Summary

    References

    Discussion

    Chapter 14 Scintillation Properties of Liquids

    I. Introduction

    II. The Dependence of the Scintillation Pulse on Solute Concentration

    III. Quenching Effects

    IV. Mechanisms of Energy Transport

    V. Relative Scintillation Efficiency

    VI. Summary

    References

    Discussion

    Chapter 15 Reactive Species in the Irradiation of Water and Aqueous Systems

    I. Introduction

    II. Hydrogen Atoms and OH Radicals

    III. Radiation-Induced Formation of "Polarons"

    IV. Excited Water Molecules

    References

    Discussion

    Chapter 16 Evidence for the Hydrated Electron from Optical Absorption and Electrical Conductivity Measurements

    References

    Chapter 17 On the Involvement of Disulfide Links in the Radiation Inactivation of Proteins

    I. Introduction

    II. Materials and Experimental Procedures

    III. Results and Discussion

    References

    Discussion

    Chapter 18 Physical Components of Radiation Damage in Cells

    I. Introduction

    II. Methods

    III. Oxygen Effects

    IV. Role of Water

    V. Physical Aspects of Radiation Protection

    VI. Discussion

    VII. Summary

    References

    Discussion

    Chapter 19 Sensitization of Chemical and Photoconductive Processes by the Fluorescein Dye Triplet States

    I. Introduction

    II. Photochemical Reactions in Solution

    III. Sensitization by Eosin Films

    IV. Summary and Some Biological Implications

    References

    Discussion

    Chapter 20 Photodynamic Effects in Biological Systems

    I. Introduction

    II. Examples of Photodynamic Effects in Biology

    III. Mechanism of Photodynamic Action

    IV. Experimental Studies

    References

    Discussion

    Chapter 21 General Discussion

    Author Index

    Subject Index


Product details

  • No. of pages: 394
  • Language: English
  • Copyright: © Academic Press 1964
  • Published: January 1, 1964
  • Imprint: Academic Press
  • eBook ISBN: 9781483223278

About the Editors

Leroy Augenstein

Ronald Mason

Barnett Rosenberg

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