Physical Principles and Techniques of Protein Chemistry Part C

Physical Principles and Techniques of Protein Chemistry Part C

1st Edition - January 1, 1973

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  • Editor: Sydney Leach
  • eBook ISBN: 9780323141147

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Physical Principles and Techniques of Protein Chemistry, Part C focuses on the effects of intermolecular interactions that are transmitted between ligands and proteins and from protein to protein. This book discusses the density and volume change measurements; direct volume change; osmotic pressure; and small-angle X-ray scattering. The theory of particulate scattering; pulsed nuclear magnetic resonance; absorption of water by diamagnetic molecules; and use of least squares in data analysis are also elaborated. This text likewise covers the iteration process; optical rotatory dispersion and the main chain conformation of proteins; and basic relations for optically active molecules. Other topics include the circular dichroism, secondary structure of proteins, visible rotatory dispersion, and peptide cotton effects. This publication is intended for protein chemists, but is also useful to biologists, medical practitioners, and students researching on protein chemistry.

Table of Contents

  • List of Contributors


    Contents of Other Parts

    17. Density and Volume Change Measurements

    Glossary of Symbols

    I. Introduction

    II. Definitions and Basic Considerations

    III. Direct Volume Change

    IV. Density

    Appendix A: Derivation of the Partial Specific Volume from the Density

    Appendix B: Splitting-Up of the Parameter: Exclusion of Diffusible Components


    18. Osmotic Pressure

    Glossary of Symbols

    I. Introduction and Phenomenon

    II. Elementary Theory

    III. Applications

    IV. Techniques


    19. Small-Angle X-Ray Scattering

    Glossary of Symbols

    I. Introduction

    II. Remarks on the Theory of Particulate Scattering

    III. Remarks on the Experimental Technique

    IV. Selected Examples of Applications

    V. Prospects


    20. Pulsed Nuclear Magnetic Resonance

    Glossary of Symbols

    I. Introduction

    II. Scope of the Technique

    III. Theory of Relaxation

    IV. Experimental Methods

    V. Experimental Design

    VI. Individual Enzymes

    VII. Absorption of Water by Diamagnetic Molecules


    21. The Use of Least Squares in Data Analysis

    Glossary of Symbols

    I. Introduction

    II. Outline of Theory

    III. The Iteration Process

    IV. Statistical Aspects

    V. Model Functions

    VI. Computational Procedure

    VII. Applications


    22. Optical Rotatory Dispersion and the Main Chain Conformation of Proteins

    Glossary of Symbols

    I. Introduction

    II. The Basic Relations for Optically Active Molecules

    III. Visible Rotatory Dispersion

    IV. Peptide Cotton Effects

    V. Cotton Effects Due to Side-Chain Chromophores

    VI. Other Secondary Structures

    VII. Conformational Transitions

    VIII. Experimental Considerations

    IX. The Relative Advantages of ORD and CD

    Appendix: Table I


    23. Circular Dichroism


    I. Introduction

    II. Theory of Optical Activity and Its Applications

    III. Secondary Structure of Proteins

    IV. Side-Chain Optical Activity in Model Compounds and Proteins

    V. Selected Proteins

    VI. Concluding Remarks

    Appendix: Electromagnetic Units


    Author Index

    Subject Index

Product details

  • No. of pages: 638
  • Language: English
  • Copyright: © Academic Press 1973
  • Published: January 1, 1973
  • Imprint: Academic Press
  • eBook ISBN: 9780323141147

About the Editor

Sydney Leach

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